RASAL1 (RAS protein activator like 1) - Rat Genome Database

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Gene: RASAL1 (RAS protein activator like 1) Homo sapiens
Analyze
Symbol: RASAL1
Name: RAS protein activator like 1
RGD ID: 1323476
HGNC Page HGNC:9873
Description: Predicted to enable GTPase activator activity and phospholipid binding activity. Involved in positive regulation of dendrite extension. Located in cytosol and plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: GAP1 like protein; RAS protein activator like 1 (GAP1 like); RAS-GTPase-activating protein-like; RASAL; rasGAP-activating-like protein 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812113,099,278 - 113,136,756 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12113,098,819 - 113,136,239 (-)EnsemblGRCh38hg38GRCh38
GRCh3712113,537,083 - 113,574,044 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612112,021,701 - 112,058,404 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412112,000,037 - 112,036,741NCBI
Celera12113,163,615 - 113,201,034 (-)NCBICelera
Cytogenetic Map12q24.13NCBI
HuRef12110,549,290 - 110,586,742 (-)NCBIHuRef
CHM1_112113,504,941 - 113,542,306 (-)NCBICHM1_1
T2T-CHM13v2.012113,075,920 - 113,113,399 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RASAL1HumanHereditary Neoplastic Syndromes  IAGPRGD:4049975498554872ClinVar Annotator: match by term: Hereditary cancerClinVarPMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RASAL1Humankidney disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:23665422

1 to 20 of 85 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RASAL1Human1,2-dimethylhydrazine increases expressionISORGD:132347764804641,2-Dimethylhydrazine results in increased expression of RASAL1 mRNACTDPMID:22206623
RASAL1Human17alpha-ethynylestradiol affects expressionISORGD:13234776480464Ethinyl Estradiol affects the expression of RASAL1 mRNACTDPMID:17555576
RASAL1Human17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of RASAL1 mRNACTDPMID:30165855
RASAL1Human17beta-estradiol increases expressionISORGD:13118206480464Estradiol results in increased expression of RASAL1 mRNACTDPMID:32145629
RASAL1Human17beta-estradiol multiple interactionsEXP 6480464[Estradiol co-treated with TGFB1 protein] results in decreased expression of RASAL1 mRNACTDPMID:30165855
RASAL1Human2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of RASAL1 mRNACTDPMID:20064835
RASAL1Human2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:13118206480464Tetrachlorodibenzodioxin results in increased expression of RASAL1 mRNACTDPMID:33387578
RASAL1Human2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:13234776480464Tetrachlorodibenzodioxin affects the expression of RASAL1 mRNACTDPMID:21570461
RASAL1Human3,3',4,4',5-pentachlorobiphenyl increases expressionEXP 64804643,4,5,3',4'-pentachlorobiphenyl results in increased expression of RASAL1 mRNACTDPMID:23146750
RASAL1Human3-chloropropane-1,2-diol increases expressionISORGD:13234776480464alpha-Chlorohydrin results in increased expression of RASAL1 mRNACTDPMID:33187795
RASAL1Human3-isobutyl-1-methyl-7H-xanthine multiple interactionsEXP 6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ...CTDPMID:28628672
RASAL1Human4,4'-sulfonyldiphenol decreases methylationISORGD:13234776480464bisphenol S results in decreased methylation of RASAL1 exonCTDPMID:33297965
RASAL1Human4,4'-sulfonyldiphenol affects methylationISORGD:13234776480464bisphenol S affects the methylation of RASAL1 geneCTDPMID:31683443
RASAL1Human5-aza-2'-deoxycytidine multiple interactionsISORGD:13118206480464Decitabine inhibits the reaction [PDGFB protein results in decreased expression of RASAL1 mRNA]; Decitabine inhibits more ...CTDPMID:22056649
RASAL1Human6-propyl-2-thiouracil increases expressionISORGD:13118206480464Propylthiouracil results in increased expression of RASAL1 mRNACTDPMID:24780913
RASAL1Humanactinomycin D multiple interactionsEXP 6480464[Dactinomycin co-treated with nutlin 3] results in increased expression of RASAL1 mRNACTDPMID:38460933
RASAL1Humanactinomycin D increases expressionEXP 6480464Dactinomycin results in increased expression of RASAL1 mRNACTDPMID:38460933
RASAL1Humanaflatoxin B1 increases expressionEXP 6480464Aflatoxin B1 results in increased expression of RASAL1 mRNACTDPMID:21641981
RASAL1Humanaflatoxin B1 increases methylationEXP 6480464Aflatoxin B1 results in increased methylation of RASAL1 intron; Aflatoxin B1 results in increased methylation more ...CTDPMID:30157460
RASAL1HumanAflatoxin B2 alpha increases methylationEXP 6480464aflatoxin B2 results in increased methylation of RASAL1 intronCTDPMID:30157460

1 to 20 of 85 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RASAL1Humancell differentiation involved_inIEAUniProtKB-KW:KW-0221150520179 UniProtGO_REF:0000043
RASAL1Humancellular response to calcium ion involved_inIEAInterPro:IPR037776150520179 InterProGO_REF:0000002
RASAL1Humanintracellular signal transduction involved_inIEAInterPro:IPR001562150520179 InterProGO_REF:0000002
RASAL1Humannegative regulation of Ras protein signal transduction involved_inIEAInterPro:IPR037776150520179 InterProGO_REF:0000002
RASAL1Humanpositive regulation of dendrite extension involved_inIDA 150520179 PMID:23999003UniProtPMID:23999003
RASAL1Humansignal transduction involved_inTAS 150520179 PMID:9751798PINCPMID:9751798

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RASAL1Humancytosol located_inIDA 150520179 PMID:16009725UniProtPMID:16009725
RASAL1Humancytosol located_inTAS 150520179 ReactomeReactome:R-HSA-5658231|Reactome:R-HSA-5658435
RASAL1Humanplasma membrane located_inIDA 150520179 PMID:16009725UniProtPMID:16009725

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RASAL1HumanGTPase activator activity enablesIEAInterPro:IPR037776150520179 InterProGO_REF:0000002
RASAL1HumanGTPase activator activity enablesIEAUniProtKB-KW:KW-0343150520179 UniProtGO_REF:0000043
RASAL1HumanGTPase activator activity enablesTAS 150520179 PMID:9751798PINCPMID:9751798
RASAL1Humanmetal ion binding enablesIEAUniProtKB-KW:KW-0479150520179 UniProtGO_REF:0000043
RASAL1Humanphospholipid binding enablesTAS 150520179 PMID:9751798PINCPMID:9751798
RASAL1Humanzinc ion binding enablesIEAUniProtKB-KW:KW-0863150520179 UniProtGO_REF:0000043

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RASAL1HumanAbnormality of the upper limb  IAGPRGD:1517275128554872ClinVar Annotator: match by term: Abnormality of the upper limbClinVar 

#
Reference Title
Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:9751798   PMID:11230166   PMID:12221082   PMID:12477932   PMID:15489334   PMID:15960973   PMID:16009725   PMID:17640920   PMID:18992247   PMID:20473946   PMID:22589738   PMID:22825043  
PMID:22863883   PMID:23251034   PMID:23665422   PMID:23999003   PMID:24136889   PMID:24377515   PMID:24531877   PMID:24712574   PMID:24925056   PMID:25616414   PMID:25735335   PMID:26008146  
PMID:26344197   PMID:26997440   PMID:27012941   PMID:27124111   PMID:27878301   PMID:28011578   PMID:28885980   PMID:33961781   PMID:35748872   PMID:39118077   PMID:39358380  



RASAL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812113,099,278 - 113,136,756 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12113,098,819 - 113,136,239 (-)EnsemblGRCh38hg38GRCh38
GRCh3712113,537,083 - 113,574,044 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612112,021,701 - 112,058,404 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412112,000,037 - 112,036,741NCBI
Celera12113,163,615 - 113,201,034 (-)NCBICelera
Cytogenetic Map12q24.13NCBI
HuRef12110,549,290 - 110,586,742 (-)NCBIHuRef
CHM1_112113,504,941 - 113,542,306 (-)NCBICHM1_1
T2T-CHM13v2.012113,075,920 - 113,113,399 (-)NCBIT2T-CHM13v2.0
Rasal1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395120,786,105 - 120,817,662 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5120,786,877 - 120,817,662 (+)EnsemblGRCm39 Ensembl
GRCm385120,648,040 - 120,679,597 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5120,648,812 - 120,679,597 (+)EnsemblGRCm38mm10GRCm38
MGSCv375121,098,831 - 121,129,602 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365120,909,439 - 120,940,210 (+)NCBIMGSCv36mm8
Celera5117,733,997 - 117,765,218 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map560.63NCBI
Rasal1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81241,541,865 - 41,574,957 (-)NCBIGRCr8
mRatBN7.21235,881,269 - 35,913,727 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,881,270 - 35,913,727 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1237,060,900 - 37,093,354 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01237,672,113 - 37,704,566 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01236,724,584 - 36,757,037 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01241,416,218 - 41,449,445 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1241,416,218 - 41,448,668 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01243,274,639 - 43,307,356 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41237,047,909 - 37,080,129 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11236,911,885 - 36,943,519 (-)NCBI
Celera1237,542,753 - 37,575,150 (-)NCBICelera
Cytogenetic Map12q16NCBI
Rasal1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554829,447,984 - 9,472,453 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554829,447,984 - 9,471,852 (-)NCBIChiLan1.0ChiLan1.0
RASAL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210121,188,448 - 121,224,450 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112121,181,843 - 121,220,847 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012110,703,420 - 110,741,025 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112114,087,715 - 114,124,540 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12114,087,715 - 114,124,540 (-)Ensemblpanpan1.1panPan2
RASAL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12610,503,309 - 10,532,217 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2610,504,236 - 10,533,071 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2610,623,675 - 10,653,746 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02610,745,717 - 10,775,853 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2610,745,767 - 10,775,843 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12610,719,225 - 10,749,519 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02610,782,407 - 10,812,352 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02610,831,027 - 10,861,100 (-)NCBIUU_Cfam_GSD_1.0
Rasal1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118148,523,195 - 148,547,441 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366683,022,084 - 3,045,578 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366683,022,088 - 3,045,817 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RASAL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1438,601,394 - 38,633,425 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11438,598,901 - 38,633,190 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21441,059,508 - 41,092,592 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RASAL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111108,344,753 - 108,385,009 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11108,342,809 - 108,384,530 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037136,711,942 - 136,748,914 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rasal1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474719,296,259 - 19,320,595 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474719,297,008 - 19,320,968 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

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Variants in RASAL1
104 total Variants

Predicted Target Of
Summary Value
Count of predictions:3577
Count of miRNA genes:924
Interacting mature miRNAs:1141
Transcripts:ENST00000261729, ENST00000418411, ENST00000446861, ENST00000546530, ENST00000546727, ENST00000547810, ENST00000548055, ENST00000548972, ENST00000549444, ENST00000551051
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 9 of 9 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597144438GWAS1240512_Hhigh density lipoprotein cholesterol measurement QTL GWAS1240512 (human)5e-13high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)12113127578113127579Human
1559125SPSL2_HSerum P-selectin level QTL 2 (human)2.59Serum P-selectin level1289897665115897665Human
1298449UAE2_HUrinary albumin excretion QTL 2 (human)20.005Urinary albumin excretionurine albumin:creatinine ratio (ACR)12102836889128836889Human
1643258BW205_HBody weight QTL 205 (human)4.080.00001Body fat amountpercent body fat1296630114122630114Human
1643452BW104_HBody weight QTL 104 (human)1.890.005Body fat amountabdominal visceral12102395874128395874Human
1357361BW37_HBody weight QTL 37 (human)4.080.00001Body fat amount12102836889116423339Human
1643264BW195_HBody weight QTL 195 (human)0.0151Body weightBMI1289897665115897665Human
1357387BW58_HBody weight QTL 58 (human)2.30.0001Body weightfat free mass after exercise training1289438856115438856Human
1358827MULTSCL22_HMultiple sclerosis susceptibility QTL 22 (human)Multiple sclerosis susceptibility1289897665115897665Human

1 to 9 of 9 rows



adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1114 2288 2434 1832 4896 1675 2259 4 580 1823 423 2196 6403 5766 28 3685 832 1675 1570 171


1 to 30 of 54 rows
RefSeq Transcripts NG_047089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001193520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001193521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001301202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001394081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001394082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001394083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001394084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001394085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001394086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001394087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001394088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001394089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005253950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006719641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006719642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011538852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011538853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011538854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017020028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017020029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017020030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017020031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047429676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047429677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047429678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047429679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054373489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054373490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 54 rows

Ensembl Acc Id: ENST00000261729   ⟹   ENSP00000261729
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12113,099,278 - 113,136,239 (-)Ensembl
Ensembl Acc Id: ENST00000418411
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12113,103,040 - 113,136,239 (-)Ensembl
Ensembl Acc Id: ENST00000446861   ⟹   ENSP00000395920
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12113,099,508 - 113,135,750 (-)Ensembl
Ensembl Acc Id: ENST00000546530   ⟹   ENSP00000450244
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12113,098,819 - 113,136,224 (-)Ensembl
Ensembl Acc Id: ENST00000546727
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12113,099,892 - 113,135,504 (-)Ensembl
Ensembl Acc Id: ENST00000547810
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12113,115,682 - 113,135,754 (-)Ensembl
Ensembl Acc Id: ENST00000548055   ⟹   ENSP00000448510
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12113,099,278 - 113,135,761 (-)Ensembl
Ensembl Acc Id: ENST00000548972
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12113,107,216 - 113,135,750 (-)Ensembl
Ensembl Acc Id: ENST00000549444
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12113,099,512 - 113,103,099 (-)Ensembl
Ensembl Acc Id: ENST00000551051
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12113,099,888 - 113,135,738 (-)Ensembl
RefSeq Acc Id: NM_001193520   ⟹   NP_001180449
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,099,278 - 113,136,239 (-)NCBI
GRCh3712113,536,624 - 113,574,044 (-)RGD
GRCh3712113,536,624 - 113,574,044 (-)NCBI
Celera12113,163,615 - 113,201,034 (-)RGD
HuRef12110,549,290 - 110,586,742 (-)RGD
CHM1_112113,504,941 - 113,542,306 (-)NCBI
T2T-CHM13v2.012113,075,920 - 113,112,882 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001193521   ⟹   NP_001180450
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,099,278 - 113,135,761 (-)NCBI
GRCh3712113,536,624 - 113,574,044 (-)RGD
GRCh3712113,536,624 - 113,574,044 (-)NCBI
Celera12113,163,615 - 113,201,034 (-)RGD
HuRef12110,549,290 - 110,586,742 (-)RGD
CHM1_112113,504,941 - 113,541,821 (-)NCBI
T2T-CHM13v2.012113,075,920 - 113,112,404 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001301202   ⟹   NP_001288131
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,099,278 - 113,135,761 (-)NCBI
CHM1_112113,504,941 - 113,541,666 (-)NCBI
T2T-CHM13v2.012113,075,920 - 113,112,404 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001394081   ⟹   NP_001381010
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,099,278 - 113,135,761 (-)NCBI
T2T-CHM13v2.012113,075,920 - 113,112,404 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001394082   ⟹   NP_001381011
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,099,278 - 113,136,239 (-)NCBI
T2T-CHM13v2.012113,075,920 - 113,112,882 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001394083   ⟹   NP_001381012
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,099,278 - 113,136,239 (-)NCBI
T2T-CHM13v2.012113,075,920 - 113,112,882 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001394084   ⟹   NP_001381013
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,099,278 - 113,135,902 (-)NCBI
T2T-CHM13v2.012113,075,920 - 113,112,545 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001394085   ⟹   NP_001381014
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,099,278 - 113,135,761 (-)NCBI
T2T-CHM13v2.012113,075,920 - 113,112,404 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001394086   ⟹   NP_001381015
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,099,278 - 113,135,761 (-)NCBI
T2T-CHM13v2.012113,075,920 - 113,112,404 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001394087   ⟹   NP_001381016
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,099,278 - 113,135,761 (-)NCBI
T2T-CHM13v2.012113,075,920 - 113,112,404 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001394088   ⟹   NP_001381017
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,099,278 - 113,135,761 (-)NCBI
T2T-CHM13v2.012113,075,920 - 113,112,404 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001394089   ⟹   NP_001381018
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,099,278 - 113,135,761 (-)NCBI
T2T-CHM13v2.012113,075,920 - 113,112,404 (-)NCBI
Sequence:
RefSeq Acc Id: NM_004658   ⟹   NP_004649
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,099,278 - 113,136,239 (-)NCBI
GRCh3712113,536,624 - 113,574,044 (-)RGD
GRCh3712113,536,624 - 113,574,044 (-)NCBI
Build 3612112,021,701 - 112,058,404 (-)NCBI Archive
Celera12113,163,615 - 113,201,034 (-)RGD
HuRef12110,549,290 - 110,586,742 (-)RGD
CHM1_112113,504,941 - 113,542,306 (-)NCBI
T2T-CHM13v2.012113,075,920 - 113,112,882 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005253950   ⟹   XP_005254007
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,099,278 - 113,136,239 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006719641   ⟹   XP_006719704
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,099,278 - 113,135,902 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006719642   ⟹   XP_006719705
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,099,278 - 113,135,761 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011538854   ⟹   XP_011537156
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,099,278 - 113,115,264 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047429676   ⟹   XP_047285632
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,099,278 - 113,136,756 (-)NCBI
RefSeq Acc Id: XM_047429677   ⟹   XP_047285633
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,099,278 - 113,135,761 (-)NCBI
RefSeq Acc Id: XM_047429678   ⟹   XP_047285634
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,101,894 - 113,135,761 (-)NCBI
RefSeq Acc Id: XM_047429679   ⟹   XP_047285635
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,101,894 - 113,136,239 (-)NCBI
RefSeq Acc Id: XM_054373489   ⟹   XP_054229464
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012113,075,920 - 113,112,882 (-)NCBI
RefSeq Acc Id: XM_054373490   ⟹   XP_054229465
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012113,075,920 - 113,112,545 (-)NCBI
RefSeq Acc Id: XM_054373491   ⟹   XP_054229466
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012113,075,920 - 113,113,399 (-)NCBI
RefSeq Acc Id: XM_054373492   ⟹   XP_054229467
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012113,075,920 - 113,112,404 (-)NCBI
RefSeq Acc Id: XM_054373493   ⟹   XP_054229468
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012113,075,920 - 113,112,404 (-)NCBI
RefSeq Acc Id: XM_054373494   ⟹   XP_054229469
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012113,078,536 - 113,112,404 (-)NCBI
RefSeq Acc Id: XM_054373495   ⟹   XP_054229470
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012113,078,536 - 113,112,882 (-)NCBI
RefSeq Acc Id: XM_054373496   ⟹   XP_054229471
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012113,075,920 - 113,091,910 (-)NCBI
RefSeq Acc Id: XR_007063139
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,101,921 - 113,135,761 (-)NCBI
RefSeq Acc Id: XR_008488702
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.012113,078,563 - 113,112,404 (-)NCBI
1 to 30 of 52 rows
Protein RefSeqs NP_001180449 (Get FASTA)   NCBI Sequence Viewer  
  NP_001180450 (Get FASTA)   NCBI Sequence Viewer  
  NP_001288131 (Get FASTA)   NCBI Sequence Viewer  
  NP_001381010 (Get FASTA)   NCBI Sequence Viewer  
  NP_001381011 (Get FASTA)   NCBI Sequence Viewer  
  NP_001381012 (Get FASTA)   NCBI Sequence Viewer  
  NP_001381013 (Get FASTA)   NCBI Sequence Viewer  
  NP_001381014 (Get FASTA)   NCBI Sequence Viewer  
  NP_001381015 (Get FASTA)   NCBI Sequence Viewer  
  NP_001381016 (Get FASTA)   NCBI Sequence Viewer  
  NP_001381017 (Get FASTA)   NCBI Sequence Viewer  
  NP_001381018 (Get FASTA)   NCBI Sequence Viewer  
  NP_004649 (Get FASTA)   NCBI Sequence Viewer  
  XP_005254007 (Get FASTA)   NCBI Sequence Viewer  
  XP_006719704 (Get FASTA)   NCBI Sequence Viewer  
  XP_006719705 (Get FASTA)   NCBI Sequence Viewer  
  XP_011537156 (Get FASTA)   NCBI Sequence Viewer  
  XP_047285632 (Get FASTA)   NCBI Sequence Viewer  
  XP_047285633 (Get FASTA)   NCBI Sequence Viewer  
  XP_047285634 (Get FASTA)   NCBI Sequence Viewer  
  XP_047285635 (Get FASTA)   NCBI Sequence Viewer  
  XP_054229464 (Get FASTA)   NCBI Sequence Viewer  
  XP_054229465 (Get FASTA)   NCBI Sequence Viewer  
  XP_054229466 (Get FASTA)   NCBI Sequence Viewer  
  XP_054229467 (Get FASTA)   NCBI Sequence Viewer  
  XP_054229468 (Get FASTA)   NCBI Sequence Viewer  
  XP_054229469 (Get FASTA)   NCBI Sequence Viewer  
  XP_054229470 (Get FASTA)   NCBI Sequence Viewer  
  XP_054229471 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD09006 (Get FASTA)   NCBI Sequence Viewer  
1 to 30 of 52 rows
1 to 5 of 33 rows
1 to 5 of 33 rows
RefSeq Acc Id: NP_001180449   ⟸   NM_001193520
- Peptide Label: isoform 1
- UniProtKB: B4DG06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_004649   ⟸   NM_004658
- Peptide Label: isoform 2
- UniProtKB: Q59H24 (UniProtKB/Swiss-Prot),   Q52M03 (UniProtKB/Swiss-Prot),   F8VQX1 (UniProtKB/Swiss-Prot),   C9JFK5 (UniProtKB/Swiss-Prot),   B7ZKM4 (UniProtKB/Swiss-Prot),   Q96CC7 (UniProtKB/Swiss-Prot),   O95294 (UniProtKB/Swiss-Prot),   B4DG06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001180450   ⟸   NM_001193521
- Peptide Label: isoform 3
- UniProtKB: B4DG06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005254007   ⟸   XM_005253950
- Peptide Label: isoform X1
- UniProtKB: B4DG06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006719704   ⟸   XM_006719641
- Peptide Label: isoform X1
- UniProtKB: B4DG06 (UniProtKB/TrEMBL)
- Sequence:
C2   PH   Ras-GAP

Name Modeler Protein Id AA Range Protein Structure
AF-O95294-F1-model_v2 AlphaFold O95294 1-804 view protein structure

RGD ID:6810386
Promoter ID:HG_ACW:19002
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour
Transcripts:RASAL1.EAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 3612112,026,031 - 112,026,531 (-)MPROMDB
RGD ID:6790427
Promoter ID:HG_KWN:16728
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell
Transcripts:NM_004658,   UC001TUL.2,   UC001TUN.1,   UC001TUO.2
Position:
Human AssemblyChrPosition (strand)Source
Build 3612112,057,626 - 112,058,126 (-)MPROMDB
RGD ID:7225477
Promoter ID:EPDNEW_H18484
Type:initiation region
Name:RASAL1_1
Description:RAS protein activator like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18485  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,135,736 - 113,135,796EPDNEW
RGD ID:7225479
Promoter ID:EPDNEW_H18485
Type:initiation region
Name:RASAL1_2
Description:RAS protein activator like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18484  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,136,233 - 113,136,293EPDNEW


1 to 40 of 64 rows
Database
Acc Id
Source(s)
COSMIC RASAL1 COSMIC
Ensembl Genes ENSG00000111344 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000261729 ENTREZGENE
  ENST00000261729.9 UniProtKB/Swiss-Prot
  ENST00000418411 ENTREZGENE
  ENST00000446861 ENTREZGENE
  ENST00000446861.7 UniProtKB/Swiss-Prot
  ENST00000546530 ENTREZGENE
  ENST00000546530.5 UniProtKB/Swiss-Prot
  ENST00000548055 ENTREZGENE
  ENST00000548055.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
  2.60.40.150 UniProtKB/Swiss-Prot
  GTPase Activation - p120gap, domain 1 UniProtKB/Swiss-Prot
GTEx ENSG00000111344 GTEx
HGNC ID HGNC:9873 ENTREZGENE
Human Proteome Map RASAL1 Human Proteome Map
InterPro C2_dom UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  Ras_GTPase UniProtKB/Swiss-Prot
  RASAL_RasGAP UniProtKB/Swiss-Prot
  RasGAP_CS UniProtKB/Swiss-Prot
  RasGAP_dom UniProtKB/Swiss-Prot
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot
  Znf_Btk_motif UniProtKB/Swiss-Prot
KEGG Report hsa:8437 UniProtKB/Swiss-Prot
NCBI Gene 8437 ENTREZGENE
OMIM 604118 OMIM
PANTHER PTHR10194 UniProtKB/Swiss-Prot
  PTHR10194:SF3 UniProtKB/Swiss-Prot
Pfam BTK UniProtKB/Swiss-Prot
  PF00168 UniProtKB/Swiss-Prot
  PF00169 UniProtKB/Swiss-Prot
  RasGAP UniProtKB/Swiss-Prot
PharmGKB PA34234 PharmGKB
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot
  PS50004 UniProtKB/Swiss-Prot
  RAS_GTPASE_ACTIV_1 UniProtKB/Swiss-Prot
1 to 40 of 64 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-14 RASAL1  RAS protein activator like 1    RAS protein activator like 1 (GAP1 like)  Symbol and/or name change 5135510 APPROVED