BW37_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: BW37_H (Body weight QTL 37 (human)) Homo sapiens

Symbol: BW37_H
Name: Body weight QTL 37 (human)
RGD ID: 1357361
Trait: Body fat amount
LOD Score: 4.08
P Value: 1.0E-5
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712103,230,667 - 119,104,618RGD_MAPPER_PIPELINEGRCh37
Build 361291,589,001 - 117,589,001RGDNCBI36
Build 341293,430,474 - 123,430,474RGD
RGSC_v3.11224,196,183 - 117,667,466RGD
Cross Type: Not Available
Population Stats: 260 European-American families (1297 individuals) analyzed; probands had BMI >/= 40 kg/m2 with at least one obese (BMI >30 kg/m2) sibling and at least one parent and one sibling of normal weight (BMI < 27 kg/m2)



Disease Annotations     Click to see Annotation Detail View
obesity  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. An obesity-related locus in chromosome region 12q23-24. Li WD, etal., Diabetes 2004 Mar;53(3):812-20.

Region

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
Position Markers

Flank 1: (PAH)
Human AssemblyChrPosition (strand)Source
GRCh3812102,836,889 - 102,958,441 (-)NCBI
GRCh38.p14 Ensembl12102,836,889 - 102,958,410 (-)Ensembl
GRCh3712103,230,667 - 103,352,219 (-)NCBI
Build 3612101,756,234 - 101,835,511 (-)NCBI
Build 3412101,734,570 - 101,813,848NCBI
Celera12102,896,051 - 102,975,653 (-)NCBI
Cytogenetic Map12q23.2NCBI
HuRef12100,291,597 - 100,370,682 (-)NCBI
CHM1_112103,199,004 - 103,278,175 (-)NCBI
T2T-CHM13v2.012102,797,868 - 102,919,265 (-)NCBI
Peak: (D12S1339)
Human AssemblyChrPosition (strand)Source
GRCh3812109,629,981 - 109,630,248RGD
Marshfield Genetic Map12 RGD
Flank 2: (D12S349)
Human AssemblyChrPosition (strand)Source
GRCh3712119,104,440 - 119,104,618UniSTS
Build 3612117,588,823 - 117,589,001RGD
Celera12118,737,681 - 118,737,857RGD
HuRef12116,113,462 - 116,113,636UniSTS
Marshfield Genetic Map12134.54RGD
Marshfield Genetic Map12134.54UniSTS
Genethon Genetic Map12135.1UniSTS
deCODE Assembly Map12138.06UniSTS
GeneMap99-GB4 RH Map12467.11UniSTS
Whitehead-RH Map12578.8UniSTS
Whitehead-YAC Contig Map12 UniSTS


Additional Information

Database Acc Id Source(s)
NCBI Gene BW37_H
OMIM 216550

RGD Curation Notes
Note Type Note Reference
qtl_cand_genes IGF1, ACACB, PMCH 1334490
qtl_map suggestive linkage for obesity-related traits also found on chromosomes 2,3,7,8,9,13,21 1334490
qtl_population 260 European-American families (1297 individuals) analyzed; probands had BMI >/= 40 kg/m2 with at least one obese (BMI >30 kg/m2) sibling and at least one parent and one sibling of normal weight (BMI < 27 kg/m2) 1334490
qtl_statistics_details significant LOD scores for this QTL also obtained for BMI (LOD=3.57, P=0.00003) and waist circumference (LOD=3.05, P=0.00009) 1334490
qtl_statistics_details nonparametric multipoint linkage analysis conducted with Genehunter (v1.3); Mendelian inheritance errors resolved with Merlin and Genehunter 1334490