ZRANB1 (zinc finger RANBP2-type containing 1) - Rat Genome Database

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Gene: ZRANB1 (zinc finger RANBP2-type containing 1) Homo sapiens
Analyze
Symbol: ZRANB1
Name: zinc finger RANBP2-type containing 1
RGD ID: 1318817
HGNC Page HGNC:18224
Description: Enables K63-linked polyubiquitin modification-dependent protein binding activity and cysteine-type deubiquitinase activity. Involved in several processes, including positive regulation of Wnt signaling pathway; protein deubiquitination; and regulation of cell morphogenesis. Located in cytosol and nucleoplasm. Is active in cytoplasm and nucleus.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DKFZp762P2216; hTrabid; RP11-298J20.4; TRABID; TRAF-binding domain-containing protein; TRAF-binding protein domain; ubiquitin thioesterase ZRANB1; zinc finger Ran-binding domain-containing protein 1; zinc finger, RAN-binding domain containing 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810124,916,894 - 124,988,189 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10124,942,123 - 124,988,189 (+)EnsemblGRCh38hg38GRCh38
GRCh3710126,630,692 - 126,676,758 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610126,620,682 - 126,665,995 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410126,620,681 - 126,663,759NCBI
Celera10120,404,500 - 120,449,814 (+)NCBICelera
Cytogenetic Map10q26.13NCBI
HuRef10120,317,070 - 120,363,002 (+)NCBIHuRef
CHM1_110126,912,463 - 126,957,768 (+)NCBICHM1_1
T2T-CHM13v2.010125,823,167 - 125,869,209 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
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Original Reference(s)
ZRANB1Human1,2-dimethylhydrazine decreases expressionISORGD:155109364804641,2-Dimethylhydrazine results in decreased expression of ZRANB1 mRNACTDPMID:22206623
ZRANB1Human17beta-estradiol decreases expressionISORGD:15510936480464Estradiol results in decreased expression of ZRANB1 mRNACTDPMID:39298647
ZRANB1Human2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:15510936480464Tetrachlorodibenzodioxin affects the expression of ZRANB1 mRNACTDPMID:21570461|PMID:24680724
ZRANB1Human2-hydroxypropanoic acid decreases expressionEXP 6480464Lactic Acid results in decreased expression of ZRANB1 mRNACTDPMID:30851411
ZRANB1Human4,4'-diaminodiphenylmethane decreases expressionISORGD:232175164804644,4'-diaminodiphenylmethane results in decreased expression of ZRANB1 mRNACTDPMID:30723492
ZRANB1Human4,4'-sulfonyldiphenol decreases expressionISORGD:15510936480464bisphenol S results in decreased expression of ZRANB1 mRNACTDPMID:39298647
ZRANB1Humanaflatoxin B1 increases expressionISORGD:15510936480464Aflatoxin B1 results in increased expression of ZRANB1 mRNACTDPMID:19770486
ZRANB1Humanall-trans-retinoic acid increases expressionEXP 6480464Tretinoin results in increased expression of ZRANB1 mRNACTDPMID:23724009
ZRANB1Humanantirheumatic drug increases expressionEXP 6480464Antirheumatic Agents results in increased expression of ZRANB1 mRNACTDPMID:24449571
ZRANB1Humanarsenite(3-) multiple interactionsEXP 6480464arsenite inhibits the reaction [G3BP1 protein binds to ZRANB1 mRNA]CTDPMID:32406909
ZRANB1Humanarsenous acid increases expressionEXP 6480464Arsenic Trioxide results in increased expression of ZRANB1 mRNACTDPMID:20458559
ZRANB1Humanbisphenol A decreases methylationISORGD:15510936480464bisphenol A results in decreased methylation of ZRANB1 promoterCTDPMID:27312807
ZRANB1Humanbisphenol A decreases expressionISORGD:15510936480464bisphenol A results in decreased expression of ZRANB1 mRNACTDPMID:33221593
ZRANB1Humanbisphenol F decreases expressionISORGD:15510936480464bisphenol F results in decreased expression of ZRANB1 mRNACTDPMID:38685157
ZRANB1Humanbutanal decreases expressionEXP 6480464butyraldehyde results in decreased expression of ZRANB1 mRNACTDPMID:26079696
ZRANB1Humancadmium dichloride increases expressionEXP 6480464Cadmium Chloride results in increased expression of ZRANB1 mRNACTDPMID:21457566
ZRANB1Humancadmium dichloride decreases expressionEXP 6480464Cadmium Chloride results in decreased expression of ZRANB1 mRNACTDPMID:38568856
ZRANB1Humancarbon nanotube decreases expressionISORGD:15510936480464Nanotubes, Carbon analog results in decreased expression of ZRANB1 mRNA; Nanotubes, Carbon results in decreased more ...CTDPMID:25554681
ZRANB1HumanCGP 52608 multiple interactionsEXP 6480464CGP 52608 promotes the reaction [RORA protein binds to ZRANB1 gene]CTDPMID:28238834
ZRANB1Humancopper(II) sulfate increases expressionEXP 6480464Copper Sulfate results in increased expression of ZRANB1 mRNACTDPMID:19549813

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Biological Process
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Original Reference(s)
ZRANB1Humancell migration involved_inIMP 150520179 PMID:21834987UniProtPMID:21834987
ZRANB1Humancell migration involved_inIBAPANTHER:PTN000332188|UniProtKB:Q9UGI0150520179 GO_CentralGO_REF:0000033
ZRANB1Humancytoskeleton organization involved_inIMP 150520179 PMID:21834987UniProtPMID:21834987
ZRANB1Humancytoskeleton organization involved_inIBAPANTHER:PTN000332188|UniProtKB:Q9UGI0150520179 GO_CentralGO_REF:0000033
ZRANB1Humanpositive regulation of Wnt signaling pathway involved_inIMP 150520179 PMID:18281465UniProtPMID:18281465
ZRANB1Humanpositive regulation of Wnt signaling pathway involved_inIBAFB:FBgn0037734|PANTHER:PTN000332188|UniProtKB:Q9UGI0150520179 GO_CentralGO_REF:0000033
ZRANB1Humanprotein deubiquitination involved_inIDA 150520179 PMID:33637724UniProtPMID:33637724
ZRANB1Humanprotein deubiquitination involved_inIEAARBA:ARBA00027879150520179 UniProtGO_REF:0000117
ZRANB1Humanprotein deubiquitination involved in ubiquitin-dependent protein catabolic process involved_inIMP 150520179 PMID:18281465BHF-UCLPMID:18281465
ZRANB1Humanprotein deubiquitination involved in ubiquitin-dependent protein catabolic process involved_inIBAPANTHER:PTN001001090|UniProtKB:Q9UGI0150520179 GO_CentralGO_REF:0000033
ZRANB1Humanprotein K29-linked deubiquitination involved_inIDA 150520179 PMID:23827681, PMID:25752573, PMID:25752577UniProtPMID:23827681|PMID:25752573|PMID:25752577
ZRANB1Humanprotein K33-linked deubiquitination involved_inIDA 150520179 PMID:23827681, PMID:24768539, PMID:25752573, PMID:25752577UniProtPMID:23827681|PMID:24768539|PMID:25752573|PMID:25752577
ZRANB1Humanprotein K63-linked deubiquitination involved_inIDA 150520179 PMID:23827681UniProtPMID:23827681
ZRANB1Humanprotein K63-linked deubiquitination involved_inIMP 150520179 PMID:18281465UniProtPMID:18281465
ZRANB1Humanproteolysis involved_inIEAUniProtKB-KW:KW-0645150520179 UniProtGO_REF:0000043
ZRANB1Humanregulation of cell morphogenesis involved_inIMP 150520179 PMID:21834987UniProtPMID:21834987
ZRANB1HumanWnt signaling pathway involved_inIEAUniProtKB-KW:KW-0879150520179 UniProtGO_REF:0000043
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Cellular Component
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Original Reference(s)
ZRANB1Humancytoplasm located_inIDA 150520179 PMID:11463333, PMID:21834987UniProtPMID:11463333|PMID:21834987
ZRANB1Humancytoplasm is_active_inIDA 150520179 PMID:25752577UniProtPMID:25752577
ZRANB1Humancytoplasm located_inIEAUniProtKB-SubCell:SL-0086150520179 UniProtGO_REF:0000044
ZRANB1Humancytoplasm is_active_inIBAMGI:1196377|MGI:2654703|PANTHER:PTN001001090|UniProtKB:Q6GQQ9|UniProtKB:Q9UGI0150520179 GO_CentralGO_REF:0000033
ZRANB1Humancytoplasm located_inIEAUniProtKB-KW:KW-0963150520179 UniProtGO_REF:0000043
ZRANB1Humancytosol located_inTAS 150520179 ReactomeReactome:R-HSA-5690870|Reactome:R-HSA-6781905|Reactome:R-HSA-8869506
ZRANB1Humancytosol located_inIDA 150520179 HPAGO_REF:0000052
ZRANB1Humannucleoplasm located_inIDA 150520179 HPAGO_REF:0000052
ZRANB1Humannucleus is_active_inIBAPANTHER:PTN001001090|UniProtKB:P21580|UniProtKB:Q6GQQ9|UniProtKB:Q9UGI0150520179 GO_CentralGO_REF:0000033
ZRANB1Humannucleus is_active_inIDA 150520179 PMID:25752577UniProtPMID:25752577
ZRANB1Humannucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044
ZRANB1Humannucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
ZRANB1Humannucleus located_inIDA 150520179 PMID:11463333MGIPMID:11463333
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Molecular Function
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Original Reference(s)
ZRANB1Humancatalytic activity enablesIEAARBA:ARBA00027533150520179 UniProtGO_REF:0000117
ZRANB1Humancysteine-type deubiquitinase activity enablesIEAEC:3.4.19.12150520179 UniProtGO_REF:0000003
ZRANB1Humancysteine-type deubiquitinase activity enablesIBAMGI:2654703|PANTHER:PTN001001090|UniProtKB:P21580|UniProtKB:Q6GQQ9|UniProtKB:Q8TE49|UniProtKB:Q9UGI0150520179 GO_CentralGO_REF:0000033
ZRANB1Humancysteine-type deubiquitinase activity enablesIMP 150520179 PMID:18281465UniProtPMID:18281465
ZRANB1Humancysteine-type deubiquitinase activity enablesIDA 150520179 PMID:18281465, PMID:23827681, PMID:25752573, PMID:25752577BHF-UCLPMID:18281465|PMID:23827681|PMID:25752573|PMID:25752577
ZRANB1Humancysteine-type peptidase activity enablesIEAUniProtKB-KW:KW-0788150520179 UniProtGO_REF:0000043
ZRANB1Humandeubiquitinase activity enablesIDA 150520179 PMID:33637724UniProtPMID:33637724
ZRANB1Humanhydrolase activity enablesIEAUniProtKB-KW:KW-0378150520179 UniProtGO_REF:0000043
ZRANB1HumanK63-linked polyubiquitin modification-dependent protein binding enablesIDA 150520179 PMID:18281465BHF-UCLPMID:18281465
ZRANB1HumanK63-linked polyubiquitin modification-dependent protein binding enablesIBAMGI:2654703|PANTHER:PTN001001090|UniProtKB:Q9UGI0150520179 GO_CentralGO_REF:0000033
ZRANB1Humanmetal ion binding enablesIEAUniProtKB-KW:KW-0479150520179 UniProtGO_REF:0000043
ZRANB1Humanpeptidase activity enablesIEAUniProtKB-KW:KW-0645150520179 UniProtGO_REF:0000043
ZRANB1Humanpolyubiquitin modification-dependent protein binding enablesIDA 150520179 PMID:25752573, PMID:25752577UniProtPMID:25752573|PMID:25752577
ZRANB1Humanprotein binding enablesIPIUniProtKB:P25054150520179 PMID:18281465UniProtPMID:18281465
ZRANB1Humanprotein binding enablesIPIUniProtKB:P0DTD1-PRO_0000449633150520179 PMID:36217029IntActPMID:36217029
ZRANB1Humanprotein binding enablesIPIUniProtKB:Q9Y4K3150520179 PMID:11463333IntActPMID:11463333
ZRANB1Humanprotein binding enablesIPIUniProtKB:Q96PC2|UniProtKB:Q96PV4|UniProtKB:Q96SQ5|UniProtKB:Q99459|UniProtKB:Q99633|UniProtKB:Q9BRJ7|UniProtKB:Q9BSW7|UniProtKB:Q9BT49|UniProtKB:Q9BU76|UniProtKB:Q9BUZ4|UniProtKB:Q9BVG8-5|UniProtKB:Q9BVV2|UniProtKB:Q9BXS5|UniProtKB:Q9BZE0|UniProtKB:Q9C086|UniProtKB:Q9H0E2|UniProtKB:Q9H0I2|UniProtKB:Q9H257-2|UniProtKB:Q9H5Z6-2|UniProtKB:Q9H707|UniProtKB:Q9H9D4|UniProtKB:Q9HAQ2|UniProtKB:Q9HC52|UniProtKB:Q9HC98-4|UniProtKB:Q9NVQ4-2|UniProtKB:Q9P0T4|UniProtKB:Q9P2K5-2|UniProtKB:Q9UBL6-2|UniProtKB:Q9UEG4|UniProtKB:Q9UFB7|UniProtKB:Q9UGP5-2|UniProtKB:Q9UII6|UniProtKB:Q9UJ04|UniProtKB:Q9UJV3-2|UniProtKB:Q9UK58|UniProtKB:Q9UKW4|UniProtKB:Q9ULM2|UniProtKB:Q9Y228|UniProtKB:Q9Y247|UniProtKB:Q9Y2I9-2|UniProtKB:Q9Y4K3|UniProtKB:X5D778150520179 PMID:32296183IntActPMID:32296183
ZRANB1Humanprotein binding enablesIPIUniProtKB:A6NER0|UniProtKB:B7ZLI8|UniProtKB:O00560|UniProtKB:O15160|UniProtKB:O15371|UniProtKB:O15442-2|UniProtKB:O15481|UniProtKB:O43167|UniProtKB:O43189|UniProtKB:O43395|UniProtKB:O43463|UniProtKB:O43602-2|UniProtKB:O43809|UniProtKB:O60941-5|UniProtKB:O75419|UniProtKB:O75564-2|UniProtKB:O75604|UniProtKB:O94955|UniProtKB:O95363|UniProtKB:O95696|UniProtKB:O95872|UniProtKB:O95931|UniProtKB:P09067|UniProtKB:P0DI81-3|UniProtKB:P13010|UniProtKB:P15622-3|UniProtKB:P17021|UniProtKB:P19544-6|UniProtKB:P26196|UniProtKB:P30039|UniProtKB:P31273|UniProtKB:P35590|UniProtKB:P47897|UniProtKB:P50548|UniProtKB:P53582|UniProtKB:P55040|UniProtKB:P55081|UniProtKB:P57075-2|UniProtKB:P59910|UniProtKB:P61326|UniProtKB:Q07002|UniProtKB:Q08117-2|UniProtKB:Q08426|UniProtKB:Q12774|UniProtKB:Q13895|UniProtKB:Q14005-2|UniProtKB:Q14119|UniProtKB:Q15287|UniProtKB:Q15560|UniProtKB:Q15973|UniProtKB:Q16512|UniProtKB:Q2TBE0|UniProtKB:Q3B820|UniProtKB:Q3KQV3|UniProtKB:Q3SY00|UniProtKB:Q494U1-3|UniProtKB:Q5T619|UniProtKB:Q5T6S3|UniProtKB:Q5T7W7|UniProtKB:Q63ZY3|UniProtKB:Q6DHY5|UniProtKB:Q6NYC8|UniProtKB:Q6ZNH5|UniProtKB:Q7L5A3|UniProtKB:Q7Z4V0|UniProtKB:Q86XF7|UniProtKB:Q86YV0|UniProtKB:Q8IVT4|UniProtKB:Q8IVW4|UniProtKB:Q8IYE1|UniProtKB:Q8IZW8|UniProtKB:Q8N715|UniProtKB:Q8N8B7-2|UniProtKB:Q8NA54|UniProtKB:Q8NE01|UniProtKB:Q8NHY3|UniProtKB:Q8TAE8|UniProtKB:Q8TAP4-4|UniProtKB:Q8TAU3|UniProtKB:Q8TBB1|UniProtKB:Q8TBE0|UniProtKB:Q8TBH0|UniProtKB:Q8WUT1|UniProtKB:Q8WWY3|UniProtKB:Q8WXB1|UniProtKB:Q8WXF1-2|UniProtKB:Q92917|UniProtKB:Q96B67|UniProtKB:Q96BV0|UniProtKB:Q96BZ8|UniProtKB:Q96C24|UniProtKB:Q96EG3|UniProtKB:Q96EZ8|UniProtKB:Q96FJ0|UniProtKB:Q96H86|UniProtKB:Q96HB5|UniProtKB:Q96MY7|UniProtKB:Q96NL3150520179 PMID:32296183IntActPMID:32296183
ZRANB1Humanprotein binding enablesIPIUniProtKB:P0CG48150520179 PMID:19373254IntActPMID:19373254
ZRANB1Humanprotein binding enablesIPIUniProtKB:P30039150520179 PMID:28514442, PMID:33961781IntActPMID:28514442|PMID:33961781
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Reference Title
Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:11463333   PMID:12477932   PMID:18029348   PMID:18281465   PMID:19373254   PMID:19615732   PMID:20622874   PMID:21834987   PMID:21873635   PMID:22157957   PMID:22658674   PMID:23277359  
PMID:23827681   PMID:24768539   PMID:25429064   PMID:25527291   PMID:25752573   PMID:25752577   PMID:26186194   PMID:28190767   PMID:28514442   PMID:28611215   PMID:29507755   PMID:29669287  
PMID:29748601   PMID:30021006   PMID:30686098   PMID:31911859   PMID:32296183   PMID:32694731   PMID:33637724   PMID:33711283   PMID:33853758   PMID:33961781   PMID:34597346   PMID:34765294  
PMID:34798260   PMID:35906200   PMID:35915203   PMID:35944360   PMID:36217029   PMID:36949045   PMID:37002234   PMID:37831441   PMID:38099646   PMID:38870935  



ZRANB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810124,916,894 - 124,988,189 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10124,942,123 - 124,988,189 (+)EnsemblGRCh38hg38GRCh38
GRCh3710126,630,692 - 126,676,758 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610126,620,682 - 126,665,995 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410126,620,681 - 126,663,759NCBI
Celera10120,404,500 - 120,449,814 (+)NCBICelera
Cytogenetic Map10q26.13NCBI
HuRef10120,317,070 - 120,363,002 (+)NCBIHuRef
CHM1_110126,912,463 - 126,957,768 (+)NCBICHM1_1
T2T-CHM13v2.010125,823,167 - 125,869,209 (+)NCBIT2T-CHM13v2.0
Zranb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397132,532,905 - 132,588,127 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7132,532,871 - 132,588,120 (+)EnsemblGRCm39 Ensembl
GRCm387132,931,176 - 132,986,398 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7132,931,142 - 132,986,391 (+)EnsemblGRCm38mm10GRCm38
MGSCv377140,141,305 - 140,175,634 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367132,787,965 - 132,822,294 (+)NCBIMGSCv36mm8
Celera7132,755,614 - 132,789,937 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map776.32NCBI
Zranb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,155,048 - 197,211,518 (+)NCBIGRCr8
mRatBN7.21187,725,354 - 187,780,129 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1187,724,320 - 187,779,655 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01204,938,444 - 205,000,163 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1204,959,174 - 204,998,019 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01211,931,252 - 211,991,353 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41192,458,649 - 192,461,208 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1185,469,920 - 185,525,817 (+)NCBICelera
Cytogenetic Map1q41NCBI
Zranb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554772,873,170 - 2,922,069 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554772,864,737 - 2,922,069 (+)NCBIChiLan1.0ChiLan1.0
ZRANB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28136,766,528 - 136,837,960 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110136,772,160 - 136,843,311 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010121,477,916 - 121,549,296 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110125,766,209 - 125,814,015 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10125,766,178 - 125,814,768 (+)Ensemblpanpan1.1panPan2
ZRANB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12834,220,596 - 34,259,642 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2834,220,596 - 34,256,620 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2834,264,304 - 34,321,513 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02834,759,763 - 34,817,033 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2834,718,820 - 34,814,205 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12834,316,924 - 34,374,155 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02834,308,002 - 34,365,164 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02834,560,074 - 34,617,303 (+)NCBIUU_Cfam_GSD_1.0
Zranb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721312,390,881 - 12,439,746 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648613,135,740 - 13,170,462 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648613,135,759 - 13,170,462 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZRANB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14134,254,000 - 134,329,064 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114134,253,927 - 134,327,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214145,804,215 - 145,880,481 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZRANB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19117,561,468 - 117,634,226 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9117,561,226 - 117,631,817 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604878,918,277 - 78,989,747 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zranb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473722,165,011 - 22,228,635 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473722,168,025 - 22,228,990 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in ZRANB1
39 total Variants

1 to 10 of 105 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 10q25.2-26.3(chr10:111313099-133620674)x3 copy number gain See cases [RCV000051218] Chr10:111313099..133620674 [GRCh38]
Chr10:113072857..135434178 [GRCh37]
Chr10:113062847..135284168 [NCBI36]
Chr10:10q25.2-26.3
pathogenic
GRCh38/hg38 10q26.13-26.3(chr10:123307835-133620674)x1 copy number loss See cases [RCV000051150] Chr10:123307835..133620674 [GRCh38]
Chr10:125067351..135434178 [GRCh37]
Chr10:125057341..135284168 [NCBI36]
Chr10:10q26.13-26.3
pathogenic
GRCh38/hg38 10q26.12-26.3(chr10:120454430-133620674)x1 copy number loss See cases [RCV000051103] Chr10:120454430..133620674 [GRCh38]
Chr10:122213942..135434178 [GRCh37]
Chr10:122203932..135284168 [NCBI36]
Chr10:10q26.12-26.3
pathogenic
GRCh38/hg38 10q26.13-26.3(chr10:122265252-133620674)x1 copy number loss See cases [RCV000051069] Chr10:122265252..133620674 [GRCh38]
Chr10:124024767..135434178 [GRCh37]
Chr10:124014757..135284168 [NCBI36]
Chr10:10q26.13-26.3
pathogenic
GRCh38/hg38 10q26.13-26.2(chr10:122826743-126730948)x1 copy number loss See cases [RCV000052609] Chr10:122826743..126730948 [GRCh38]
Chr10:124586259..128419517 [GRCh37]
Chr10:124576249..128409507 [NCBI36]
Chr10:10q26.13-26.2
pathogenic
GRCh38/hg38 10q26.13-26.2(chr10:122973296-128210291)x1 copy number loss See cases [RCV000052610] Chr10:122973296..128210291 [GRCh38]
Chr10:124732812..130008555 [GRCh37]
Chr10:124722802..129898545 [NCBI36]
Chr10:10q26.13-26.2
pathogenic
GRCh38/hg38 10q26.13-26.3(chr10:123580320-133558988)x1 copy number loss See cases [RCV000052611] Chr10:123580320..133558988 [GRCh38]
Chr10:125339836..135372492 [GRCh37]
Chr10:125329826..135222482 [NCBI36]
Chr10:10q26.13-26.3
pathogenic
GRCh38/hg38 10q23.31-26.3(chr10:91048545-133620674)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|See cases [RCV000053560] Chr10:91048545..133620674 [GRCh38]
Chr10:92808302..135434178 [GRCh37]
Chr10:92798282..135284168 [NCBI36]
Chr10:10q23.31-26.3
pathogenic
GRCh38/hg38 10q24.31-26.3(chr10:100194215-132432797)x3 copy number gain See cases [RCV000053564] Chr10:100194215..132432797 [GRCh38]
Chr10:101953972..134246301 [GRCh37]
Chr10:101943962..134096291 [NCBI36]
Chr10:10q24.31-26.3
pathogenic
GRCh38/hg38 10q25.1-26.3(chr10:106925303-133620815)x3 copy number gain See cases [RCV000053588] Chr10:106925303..133620815 [GRCh38]
Chr10:108685061..135434319 [GRCh37]
Chr10:108675051..135284309 [NCBI36]
Chr10:10q25.1-26.3
pathogenic
1 to 10 of 105 rows

Predicted Target Of
Summary Value
Count of predictions:1237
Count of miRNA genes:781
Interacting mature miRNAs:890
Transcripts:ENST00000359653, ENST00000471421
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 17 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597512476GWAS1608550_Hbody mass index QTL GWAS1608550 (human)1e-09body mass indexbody mass index (BMI) (CMO:0000105)10124919170124919171Human
597025203GWAS1121277_Hblood urea nitrogen measurement QTL GWAS1121277 (human)1e-08blood urea nitrogen measurementblood urea nitrogen level (CMO:0000049)10124975597124975598Human
597407699GWAS1503773_Hbody mass index QTL GWAS1503773 (human)1e-09body mass indexbody mass index (BMI) (CMO:0000105)10124941039124941040Human
597488118GWAS1584192_Hbody weight QTL GWAS1584192 (human)2e-16body mass (VT:0001259)body weight (CMO:0000012)10124941039124941040Human
597503158GWAS1599232_Hage-related hearing impairment QTL GWAS1599232 (human)1e-08age-related hearing impairment10124938711124938712Human
597220051GWAS1316125_Hlung cancer QTL GWAS1316125 (human)0.000001lung cancer10124961380124961381Human
597229746GWAS1325820_Hage at menopause QTL GWAS1325820 (human)1e-47age at menopause10124969506124969507Human
597380564GWAS1476638_Hbody mass index QTL GWAS1476638 (human)8e-10body mass indexbody mass index (BMI) (CMO:0000105)10124928251124928252Human
597466348GWAS1562422_Hcreatine kinase measurement QTL GWAS1562422 (human)4e-08creatine kinase measurementblood creatine kinase activity level (CMO:0002242)10124922340124922341Human
597049765GWAS1145839_Herythrocyte count QTL GWAS1145839 (human)6e-13erythrocyte countred blood cell count (CMO:0000025)10124969506124969507Human

1 to 10 of 17 rows
STS-H24463  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710126,675,651 - 126,675,898UniSTSGRCh37
Build 3610126,665,641 - 126,665,888RGDNCBI36
Celera10120,449,460 - 120,449,707RGD
Cytogenetic Map10q26.13UniSTS
HuRef10120,362,648 - 120,362,895UniSTS
GeneMap99-GB4 RH Map10548.52UniSTS
SGC38118  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710126,639,845 - 126,640,105UniSTSGRCh37
Build 3610126,629,835 - 126,630,095RGDNCBI36
Celera10120,413,652 - 120,413,912RGD
Cytogenetic Map10q26.13UniSTS
HuRef10120,326,300 - 120,326,560UniSTS
GeneMap99-GB4 RH Map10547.73UniSTS
Whitehead-RH Map10654.8UniSTS
SHGC-30414  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710126,675,104 - 126,675,253UniSTSGRCh37
Build 3610126,665,094 - 126,665,243RGDNCBI36
Celera10120,448,911 - 120,449,060RGD
Cytogenetic Map10q26.13UniSTS
HuRef10120,362,099 - 120,362,248UniSTS
Stanford-G3 RH Map106045.0UniSTS
GeneMap99-GB4 RH Map10548.52UniSTS
Whitehead-RH Map10654.7UniSTS
NCBI RH Map101358.5UniSTS
GeneMap99-G3 RH Map106281.0UniSTS
SHGC-36008  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710126,675,869 - 126,675,969UniSTSGRCh37
Build 3610126,665,859 - 126,665,959RGDNCBI36
Celera10120,449,678 - 120,449,778RGD
Cytogenetic Map10q26.13UniSTS
HuRef10120,362,866 - 120,362,966UniSTS
GeneMap99-G3 RH Map106281.0UniSTS
RH47020  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710126,674,826 - 126,675,001UniSTSGRCh37
Build 3610126,664,816 - 126,664,991RGDNCBI36
Celera10120,448,633 - 120,448,808RGD
Cytogenetic Map10q26.13UniSTS
HuRef10120,361,825 - 120,361,996UniSTS
GeneMap99-GB4 RH Map10547.83UniSTS
SHGC-36286  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710126,674,059 - 126,674,162UniSTSGRCh37
Build 3610126,664,049 - 126,664,152RGDNCBI36
Celera10120,447,866 - 120,447,969RGD
Cytogenetic Map10q26.13UniSTS
HuRef10120,361,057 - 120,361,160UniSTS
GeneMap99-G3 RH Map106272.0UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1204 2432 2788 2245 4942 1723 2345 4 622 1948 464 2268 7281 6454 52 3708 847 1731 1612 170



Ensembl Acc Id: ENST00000359653   ⟹   ENSP00000352676
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl10124,942,123 - 124,988,189 (+)Ensembl
Ensembl Acc Id: ENST00000471421
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl10124,981,411 - 124,983,496 (+)Ensembl
RefSeq Acc Id: NM_017580   ⟹   NP_060050
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810124,942,123 - 124,988,189 (+)NCBI
GRCh3710126,605,704 - 126,676,005 (+)NCBI
Build 3610126,620,682 - 126,665,995 (+)NCBI Archive
Celera10120,404,500 - 120,449,814 (+)RGD
HuRef10120,317,070 - 120,363,002 (+)RGD
CHM1_110126,912,463 - 126,957,768 (+)NCBI
T2T-CHM13v2.010125,823,167 - 125,869,209 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006717907   ⟹   XP_006717970
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810124,916,894 - 124,988,189 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047425383   ⟹   XP_047281339
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810124,916,894 - 124,988,189 (+)NCBI
RefSeq Acc Id: XM_047425384   ⟹   XP_047281340
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810124,917,513 - 124,988,189 (+)NCBI
RefSeq Acc Id: XM_047425385   ⟹   XP_047281341
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810124,927,250 - 124,988,189 (+)NCBI
RefSeq Acc Id: XR_007061968
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810124,933,396 - 124,981,794 (+)NCBI
RefSeq Acc Id: NP_060050   ⟸   NM_017580
- UniProtKB: Q5SQP6 (UniProtKB/Swiss-Prot),   D3DRF4 (UniProtKB/Swiss-Prot),   B4DZ98 (UniProtKB/Swiss-Prot),   Q69YK3 (UniProtKB/Swiss-Prot),   Q9UGI0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006717970   ⟸   XM_006717907
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSP00000352676   ⟸   ENST00000359653
RefSeq Acc Id: XP_047281339   ⟸   XM_047425383
- Peptide Label: isoform X2
- UniProtKB: Q9UGI0 (UniProtKB/Swiss-Prot),   Q5SQP6 (UniProtKB/Swiss-Prot),   D3DRF4 (UniProtKB/Swiss-Prot),   B4DZ98 (UniProtKB/Swiss-Prot),   Q69YK3 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_047281340   ⟸   XM_047425384
- Peptide Label: isoform X2
- UniProtKB: Q9UGI0 (UniProtKB/Swiss-Prot),   Q5SQP6 (UniProtKB/Swiss-Prot),   D3DRF4 (UniProtKB/Swiss-Prot),   B4DZ98 (UniProtKB/Swiss-Prot),   Q69YK3 (UniProtKB/Swiss-Prot)
OTU

Name Modeler Protein Id AA Range Protein Structure
AF-Q9UGI0-F1-model_v2 AlphaFold Q9UGI0 1-708 view protein structure

RGD ID:7218949
Promoter ID:EPDNEW_H15221
Type:initiation region
Name:ZRANB1_1
Description:zinc finger RANBP2-type containing 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810124,917,172 - 124,917,232EPDNEW
RGD ID:6788406
Promoter ID:HG_KWN:11565
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:OTTHUMT00000050898
Position:
Human AssemblyChrPosition (strand)Source
Build 3610126,621,114 - 126,621,614 (+)MPROMDB


1 to 38 of 38 rows
Database
Acc Id
Source(s)
COSMIC ZRANB1 COSMIC
Ensembl Genes ENSG00000019995 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000359653 ENTREZGENE
  ENST00000359653.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.560 UniProtKB/Swiss-Prot
  Zinc finger, RanBP2-type UniProtKB/Swiss-Prot
GTEx ENSG00000019995 GTEx
HGNC ID HGNC:18224 ENTREZGENE
Human Proteome Map ZRANB1 Human Proteome Map
InterPro AnkUBD UniProtKB/Swiss-Prot
  OTU_Deubiquitinase UniProtKB/Swiss-Prot
  OTU_dom UniProtKB/Swiss-Prot
  Znf_RanBP2 UniProtKB/Swiss-Prot
  Znf_RanBP2_sf UniProtKB/Swiss-Prot
  ZRANB1_OTU UniProtKB/Swiss-Prot
KEGG Report hsa:54764 UniProtKB/Swiss-Prot
NCBI Gene 54764 ENTREZGENE
OMIM 611749 OMIM
PANTHER UBIQUITIN THIOESTERASE UniProtKB/Swiss-Prot
  UBIQUITIN THIOESTERASE ZRANB1 UniProtKB/Swiss-Prot
Pfam AnkUBD UniProtKB/Swiss-Prot
  OTU UniProtKB/Swiss-Prot
  zf-RanBP UniProtKB/Swiss-Prot
PharmGKB PA134933584 PharmGKB
PROSITE OTU UniProtKB/Swiss-Prot
  ZF_RANBP2_1 UniProtKB/Swiss-Prot
  ZF_RANBP2_2 UniProtKB/Swiss-Prot
SMART ZnF_RBZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF90209 UniProtKB/Swiss-Prot
UniProt B4DZ98 ENTREZGENE
  D3DRF4 ENTREZGENE
  Q5SQP6 ENTREZGENE
  Q69YK3 ENTREZGENE
  Q9UGI0 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B4DZ98 UniProtKB/Swiss-Prot
  D3DRF4 UniProtKB/Swiss-Prot
  Q5SQP6 UniProtKB/Swiss-Prot
  Q69YK3 UniProtKB/Swiss-Prot
1 to 38 of 38 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-16 ZRANB1  zinc finger RANBP2-type containing 1    zinc finger, RAN-binding domain containing 1  Symbol and/or name change 5135510 APPROVED