Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Gramd1b | Mouse | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | GRAMD1B (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GRAMD1B mRNA | CTD | PMID:22079256 | Gramd1b | Mouse | (S)-nicotine | increases expression | ISO | GRAMD1B (Homo sapiens) | 6480464 | Nicotine results in increased expression of GRAMD1B mRNA | CTD | PMID:23825647 | Gramd1b | Mouse | 1,2-dichloroethane | decreases expression | EXP | | 6480464 | ethylene dichloride results in decreased expression of GRAMD1B mRNA | CTD | PMID:28189721 | Gramd1b | Mouse | 1,2-dichloroethane | affects expression | EXP | | 6480464 | ethylene dichloride affects the expression of GRAMD1B mRNA | CTD | PMID:28960355 | Gramd1b | Mouse | 17beta-estradiol | multiple interactions | ISO | GRAMD1B (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of GRAMD1B mRNA | CTD | PMID:30165855 | Gramd1b | Mouse | 17beta-estradiol | increases expression | ISO | GRAMD1B (Homo sapiens) | 6480464 | Estradiol results in increased expression of GRAMD1B mRNA | CTD | PMID:31614463 | Gramd1b | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of GRAMD1B mRNA | CTD | PMID:19933214 | Gramd1b | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Gramd1b (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of GRAMD1B mRNA | CTD | PMID:34747641 | Gramd1b | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of GRAMD1B mRNA | CTD | PMID:21570461 | Gramd1b | Mouse | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Gramd1b (Rattus norvegicus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of GRAMD1B mRNA | CTD | PMID:30071829 | Gramd1b | Mouse | 4-hydroxyphenyl retinamide | increases expression | EXP | | 6480464 | Fenretinide results in increased expression of GRAMD1B mRNA | CTD | PMID:28973697 | Gramd1b | Mouse | 6-propyl-2-thiouracil | increases expression | ISO | Gramd1b (Rattus norvegicus) | 6480464 | Propylthiouracil results in increased expression of GRAMD1B mRNA | CTD | PMID:30047161 | Gramd1b | Mouse | acetamide | increases expression | ISO | Gramd1b (Rattus norvegicus) | 6480464 | acetamide results in increased expression of GRAMD1B mRNA | CTD | PMID:31881176 | Gramd1b | Mouse | acrolein | multiple interactions | ISO | GRAMD1B (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of GRAMD1B mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of GRAMD1B mRNA | CTD | PMID:32699268 | Gramd1b | Mouse | Aflatoxin B2 alpha | increases methylation | ISO | GRAMD1B (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of GRAMD1B intron | CTD | PMID:30157460 | Gramd1b | Mouse | all-trans-retinoic acid | increases expression | ISO | GRAMD1B (Homo sapiens) | 6480464 | Tretinoin results in increased expression of GRAMD1B mRNA | CTD | PMID:33167477 | Gramd1b | Mouse | alpha-pinene | multiple interactions | ISO | GRAMD1B (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of GRAMD1B mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of GRAMD1B mRNA | CTD | PMID:32699268 | Gramd1b | Mouse | amitrole | increases expression | ISO | Gramd1b (Rattus norvegicus) | 6480464 | Amitrole results in increased expression of GRAMD1B mRNA | CTD | PMID:30047161 | Gramd1b | Mouse | arsenite(3-) | multiple interactions | ISO | GRAMD1B (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to GRAMD1B mRNA] | CTD | PMID:32406909 | Gramd1b | Mouse | atrazine | affects methylation | ISO | Gramd1b (Rattus norvegicus) | 6480464 | Atrazine affects the methylation of GRAMD1B gene | CTD | PMID:35440735 | Gramd1b | Mouse | benzo[a]pyrene | affects methylation | ISO | GRAMD1B (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of GRAMD1B intron | CTD | PMID:30157460 | Gramd1b | Mouse | benzo[e]pyrene | increases methylation | ISO | GRAMD1B (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of GRAMD1B intron | CTD | PMID:30157460 | Gramd1b | Mouse | bis(2-ethylhexyl) phthalate | decreases expression | ISO | GRAMD1B (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in decreased expression of GRAMD1B mRNA | CTD | PMID:31163220 | Gramd1b | Mouse | bisphenol A | increases expression | ISO | Gramd1b (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of GRAMD1B mRNA | CTD | PMID:25181051 more ... | Gramd1b | Mouse | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of GRAMD1B mRNA | CTD | PMID:32156529 | Gramd1b | Mouse | bisphenol A | multiple interactions | ISO | GRAMD1B (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of GRAMD1B gene | CTD | PMID:31601247 | Gramd1b | Mouse | bisphenol A | decreases expression | ISO | GRAMD1B (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of GRAMD1B mRNA | CTD | PMID:29275510 | Gramd1b | Mouse | bisphenol A | increases methylation | ISO | Gramd1b (Rattus norvegicus) | 6480464 | bisphenol A results in increased methylation of GRAMD1B gene | CTD | PMID:28505145 | Gramd1b | Mouse | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of GRAMD1B mRNA | CTD | PMID:26063408 and PMID:34585602 | Gramd1b | Mouse | butanal | increases expression | ISO | GRAMD1B (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of GRAMD1B mRNA | CTD | PMID:26079696 | Gramd1b | Mouse | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | Gramd1b | Mouse | CGP 52608 | multiple interactions | ISO | GRAMD1B (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to GRAMD1B gene] | CTD | PMID:28238834 | Gramd1b | Mouse | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GRAMD1B mRNA | CTD | PMID:20938992 | Gramd1b | Mouse | chromium(6+) | affects expression | EXP | | 6480464 | chromium hexavalent ion affects the expression of GRAMD1B mRNA | CTD | PMID:28472532 | Gramd1b | Mouse | coumarin | affects phosphorylation | ISO | GRAMD1B (Homo sapiens) | 6480464 | coumarin affects the phosphorylation of GRAMD1B protein | CTD | PMID:35688186 | Gramd1b | Mouse | DDE | decreases expression | ISO | GRAMD1B (Homo sapiens) | 6480464 | Dichlorodiphenyl Dichloroethylene results in decreased expression of GRAMD1B mRNA | CTD | PMID:38568856 | Gramd1b | Mouse | Dibutyl phosphate | affects expression | ISO | GRAMD1B (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of GRAMD1B mRNA | CTD | PMID:37042841 | Gramd1b | Mouse | dibutyl phthalate | decreases expression | ISO | Gramd1b (Rattus norvegicus) | 6480464 | Dibutyl Phthalate results in decreased expression of GRAMD1B mRNA | CTD | PMID:21266533 | Gramd1b | Mouse | disodium selenite | decreases expression | ISO | GRAMD1B (Homo sapiens) | 6480464 | Sodium Selenite results in decreased expression of GRAMD1B mRNA | CTD | PMID:18175754 | Gramd1b | Mouse | ethanol | affects expression | EXP | | 6480464 | Ethanol affects the expression of GRAMD1B mRNA | CTD | PMID:30319688 | Gramd1b | Mouse | fluoranthene | multiple interactions | EXP | | 6480464 | [1-methylanthracene co-treated with fluoranthene] results in increased expression of GRAMD1B mRNA | CTD | PMID:28329830 | Gramd1b | Mouse | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GRAMD1B mRNA | CTD | PMID:20938992 | Gramd1b | Mouse | folic acid | decreases expression | ISO | GRAMD1B (Homo sapiens) | 6480464 | Folic Acid results in decreased expression of GRAMD1B mRNA | CTD | PMID:21867686 | Gramd1b | Mouse | fulvestrant | multiple interactions | ISO | GRAMD1B (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of GRAMD1B gene | CTD | PMID:31601247 | Gramd1b | Mouse | hydrogen cyanide | increases expression | EXP | | 6480464 | Hydrogen Cyanide results in increased expression of GRAMD1B mRNA | CTD | PMID:33914522 | Gramd1b | Mouse | ivermectin | decreases expression | ISO | GRAMD1B (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of GRAMD1B protein | CTD | PMID:32959892 | Gramd1b | Mouse | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GRAMD1B mRNA | CTD | PMID:20938992 | Gramd1b | Mouse | lead diacetate | decreases expression | EXP | | 6480464 | lead acetate results in decreased expression of GRAMD1B mRNA | CTD | PMID:36183778 | Gramd1b | Mouse | lead(0) | affects expression | ISO | GRAMD1B (Homo sapiens) | 6480464 | Lead affects the expression of GRAMD1B mRNA | CTD | PMID:28903495 | Gramd1b | Mouse | mercury dichloride | increases expression | ISO | Gramd1b (Rattus norvegicus) | 6480464 | Mercuric Chloride results in increased expression of GRAMD1B mRNA | CTD | PMID:16507785 | Gramd1b | Mouse | methapyrilene | increases methylation | ISO | GRAMD1B (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of GRAMD1B intron | CTD | PMID:30157460 | Gramd1b | Mouse | methimazole | increases expression | ISO | Gramd1b (Rattus norvegicus) | 6480464 | Methimazole results in increased expression of GRAMD1B mRNA | CTD | PMID:30047161 | Gramd1b | Mouse | methoxychlor | affects methylation | ISO | Gramd1b (Rattus norvegicus) | 6480464 | Methoxychlor affects the methylation of GRAMD1B gene | CTD | PMID:35440735 | Gramd1b | Mouse | methyl methanesulfonate | decreases expression | ISO | GRAMD1B (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of GRAMD1B mRNA | CTD | PMID:23649840 | Gramd1b | Mouse | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of GRAMD1B mRNA | CTD | PMID:24535843 | Gramd1b | Mouse | nicotine | increases expression | ISO | GRAMD1B (Homo sapiens) | 6480464 | Nicotine results in increased expression of GRAMD1B mRNA | CTD | PMID:23825647 | Gramd1b | Mouse | ozone | multiple interactions | ISO | GRAMD1B (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of GRAMD1B mRNA more ... | CTD | PMID:32699268 | Gramd1b | Mouse | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of GRAMD1B mRNA | CTD | PMID:17562736 | Gramd1b | Mouse | paracetamol | decreases expression | ISO | GRAMD1B (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of GRAMD1B mRNA | CTD | PMID:29067470 | Gramd1b | Mouse | perfluorooctanoic acid | decreases expression | ISO | Gramd1b (Rattus norvegicus) | 6480464 | perfluorooctanoic acid results in decreased expression of GRAMD1B mRNA | CTD | PMID:35163327 | Gramd1b | Mouse | phenobarbital | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of GRAMD1B mRNA | CTD | PMID:24535843 | Gramd1b | Mouse | phenobarbital | increases expression | ISO | Gramd1b (Rattus norvegicus) | 6480464 | Phenobarbital results in increased expression of GRAMD1B mRNA | CTD | PMID:30047161 | Gramd1b | Mouse | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of GRAMD1B mRNA | CTD | PMID:20813756 and PMID:23811191 | Gramd1b | Mouse | potassium chromate | decreases expression | ISO | GRAMD1B (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of GRAMD1B mRNA | CTD | PMID:22079256 | Gramd1b | Mouse | potassium chromate | multiple interactions | ISO | GRAMD1B (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GRAMD1B mRNA | CTD | PMID:22079256 | Gramd1b | Mouse | potassium cyanide | increases expression | EXP | | 6480464 | Potassium Cyanide results in increased expression of GRAMD1B mRNA | CTD | PMID:33914522 | Gramd1b | Mouse | propiconazole | increases expression | ISO | Gramd1b (Rattus norvegicus) | 6480464 | propiconazole results in increased expression of GRAMD1B mRNA | CTD | PMID:30047161 | Gramd1b | Mouse | sodium arsenite | decreases expression | ISO | GRAMD1B (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of GRAMD1B mRNA | CTD | PMID:29301061 | Gramd1b | Mouse | sotorasib | multiple interactions | ISO | GRAMD1B (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GRAMD1B mRNA | CTD | PMID:36139627 | Gramd1b | Mouse | succimer | multiple interactions | EXP | | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in increased expression of GRAMD1B mRNA | CTD | PMID:21641980 | Gramd1b | Mouse | sunitinib | decreases expression | ISO | GRAMD1B (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of GRAMD1B mRNA | CTD | PMID:31533062 | Gramd1b | Mouse | titanium dioxide | increases expression | EXP | | 6480464 | titanium dioxide results in increased expression of GRAMD1B mRNA | CTD | PMID:23557971 | Gramd1b | Mouse | titanium dioxide | decreases methylation | EXP | | 6480464 | titanium dioxide results in decreased methylation of GRAMD1B gene and titanium dioxide results in decreased methylation of GRAMD1B promoter | CTD | PMID:35295148 | Gramd1b | Mouse | trametinib | multiple interactions | ISO | GRAMD1B (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GRAMD1B mRNA | CTD | PMID:36139627 | Gramd1b | Mouse | triadimefon | increases expression | ISO | Gramd1b (Rattus norvegicus) | 6480464 | triadimefon results in increased expression of GRAMD1B mRNA | CTD | PMID:30047161 | Gramd1b | Mouse | trichostatin A | decreases expression | ISO | GRAMD1B (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of GRAMD1B mRNA | CTD | PMID:24935251 | Gramd1b | Mouse | troglitazone | increases expression | EXP | | 6480464 | troglitazone results in increased expression of GRAMD1B mRNA | CTD | PMID:28973697 | Gramd1b | Mouse | valproic acid | decreases expression | ISO | Gramd1b (Rattus norvegicus) | 6480464 | Valproic Acid results in decreased expression of GRAMD1B mRNA | CTD | PMID:29427782 | |