Thoc5 (THO complex 5) - Rat Genome Database

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Gene: Thoc5 (THO complex 5) Mus musculus
Analyze
Symbol: Thoc5
Name: THO complex 5
RGD ID: 1312750
MGI Page MGI
Description: Enables mRNA binding activity. Involved in primitive hemopoiesis. Acts upstream of or within several processes, including negative regulation of macrophage differentiation; regulation of mRNA export from nucleus; and regulation of stem cell division. Located in nucleus. Is expressed in early conceptus and inner cell mass. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human THOC5 (THO complex subunit 5).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1700060C24Rik; A430085L24Rik; Fm; Fmip; Fms interacting protein; fms-interacting protein; MGC49541; PK1.; PK1.3; RP23-64E17.4; serum/glucocorticoid regulated kinase 2; Sgk2; THO complex subunit 5 homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,845,339 - 4,878,867 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl114,845,320 - 4,878,867 (+)EnsemblGRCm39 Ensembl
GRCm38114,895,283 - 4,928,867 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,895,320 - 4,928,867 (+)EnsemblGRCm38mm10GRCm38
MGSCv37114,795,346 - 4,828,868 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36114,795,346 - 4,828,868 (+)NCBIMGSCv36mm8
Celera115,392,170 - 5,426,353 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.09NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. mRNA export and the TREX complex. Katahira J Biochim Biophys Acta. 2012 Jun;1819(6):507-13. doi: 10.1016/j.bbagrm.2011.12.001. Epub 2011 Dec 8.
2. THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo. Mancini A, etal., BMC Biol. 2010 Jan 5;8:1.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. The consensus coding sequences of human breast and colorectal cancers. Sjoblom T, etal., Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10597251   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15221008   PMID:15368895  
PMID:15782199   PMID:16141072   PMID:16141073   PMID:16909111   PMID:17967808   PMID:18799693   PMID:21267068   PMID:21525145   PMID:21589869   PMID:21677750   PMID:21873635   PMID:22442722  
PMID:22802532   PMID:24157873   PMID:24267292   PMID:24315442   PMID:24618812   PMID:26167872   PMID:26206133   PMID:27568557   PMID:30146163   PMID:38331934  


Genomics

Comparative Map Data
Thoc5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,845,339 - 4,878,867 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl114,845,320 - 4,878,867 (+)EnsemblGRCm39 Ensembl
GRCm38114,895,283 - 4,928,867 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,895,320 - 4,928,867 (+)EnsemblGRCm38mm10GRCm38
MGSCv37114,795,346 - 4,828,868 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36114,795,346 - 4,828,868 (+)NCBIMGSCv36mm8
Celera115,392,170 - 5,426,353 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.09NCBI
THOC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382229,505,879 - 29,553,757 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2229,505,879 - 29,555,216 (-)EnsemblGRCh38hg38GRCh38
GRCh372229,901,868 - 29,949,746 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362228,234,156 - 28,279,736 (-)NCBINCBI36Build 36hg18NCBI36
Celera2213,703,995 - 13,749,471 (-)NCBICelera
Cytogenetic Map22q12.2NCBI
HuRef2212,867,987 - 12,913,507 (-)NCBIHuRef
CHM1_12229,863,485 - 29,909,025 (-)NCBICHM1_1
T2T-CHM13v2.02229,969,253 - 30,017,117 (-)NCBIT2T-CHM13v2.0
Thoc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81483,982,302 - 84,016,193 (+)NCBIGRCr8
mRatBN7.21479,758,805 - 79,792,718 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1479,758,917 - 79,792,718 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1484,189,540 - 84,223,312 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01485,429,616 - 85,463,386 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01481,879,283 - 81,913,206 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01485,138,219 - 85,171,729 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1485,142,279 - 85,171,726 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01485,816,054 - 85,849,564 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41485,561,381 - 85,612,915 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11485,580,525 - 85,607,648 (+)NCBI
Celera1478,667,519 - 78,697,308 (+)NCBICelera
Cytogenetic Map14q21NCBI
Thoc5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554553,761,874 - 3,795,517 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554553,761,933 - 3,795,517 (-)NCBIChiLan1.0ChiLan1.0
THOC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22339,481,933 - 39,528,384 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12242,183,149 - 42,229,624 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02210,553,665 - 10,599,948 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12228,357,644 - 28,405,148 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2228,357,644 - 28,404,346 (-)Ensemblpanpan1.1panPan2
THOC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12622,748,857 - 22,785,288 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2622,748,895 - 22,784,143 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2622,620,394 - 22,656,869 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02623,122,931 - 23,158,983 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2623,104,476 - 23,173,587 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12622,832,277 - 22,868,802 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02623,095,597 - 23,131,788 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02623,154,953 - 23,191,708 (-)NCBIUU_Cfam_GSD_1.0
Thoc5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118112,366,675 - 112,406,795 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366573,461,789 - 3,503,976 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366573,465,707 - 3,503,966 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THOC5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11912,386,742 - 12,427,980 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1912,385,431 - 12,427,090 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045113,711,741 - 113,752,521 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Thoc5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247475,840,862 - 5,874,334 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247475,840,862 - 5,874,350 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Thoc5
1284 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:899
Count of miRNA genes:499
Interacting mature miRNAs:587
Transcripts:ENSMUST00000038237, ENSMUST00000101615, ENSMUST00000142543, ENSMUST00000144371, ENSMUST00000148117, ENSMUST00000155872
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123880487Mouse
1300768Tshp9_mtooth shape 9 (mouse)Not determined11125976374Mouse
1301765Skull15_mskull morphology 15 (mouse)Not determined11125976374Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11125976374Mouse
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
27095914Pglq16_mpelvic girdle length QTL 16, 16 week (mouse)11325000018150000Mouse
27095919Pglq10_mpelvic girdle length QTL 10, 10 week (mouse)11325000018450000Mouse
27095925Pglq5_mpelvic girdle length QTL 5, 5 week (mouse)11325000019750000Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11325000034495048Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
10053676Eae44a_mexperimental allergic encephalomyelitis susceptibility 44a (mouse)Not determined11450789621379532Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse

Markers in Region
AJ001260  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38114,893,445 - 4,893,526UniSTSGRCm38
MGSCv37114,793,448 - 4,793,529UniSTSGRCm37
Celera115,390,288 - 5,390,369UniSTS
Cytogenetic Map11A1UniSTS
Whitehead/MRC_RH1117.49UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001418151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_172438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK006840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK087099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK173078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL645522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC021779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC039758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000038237   ⟹   ENSMUSP00000045580
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,845,343 - 4,878,865 (+)Ensembl
GRCm38.p6 Ensembl114,895,343 - 4,928,865 (+)Ensembl
RefSeq Acc Id: ENSMUST00000101615   ⟹   ENSMUSP00000099137
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,845,320 - 4,878,867 (+)Ensembl
GRCm38.p6 Ensembl114,895,320 - 4,928,867 (+)Ensembl
RefSeq Acc Id: ENSMUST00000142543   ⟹   ENSMUSP00000118940
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,852,212 - 4,868,225 (+)Ensembl
GRCm38.p6 Ensembl114,902,212 - 4,918,225 (+)Ensembl
RefSeq Acc Id: ENSMUST00000144371
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,852,212 - 4,864,310 (+)Ensembl
GRCm38.p6 Ensembl114,902,212 - 4,914,310 (+)Ensembl
RefSeq Acc Id: ENSMUST00000148117
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,852,212 - 4,854,465 (+)Ensembl
GRCm38.p6 Ensembl114,902,212 - 4,904,465 (+)Ensembl
RefSeq Acc Id: ENSMUST00000155872
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,865,306 - 4,870,485 (+)Ensembl
GRCm38.p6 Ensembl114,915,306 - 4,920,485 (+)Ensembl
RefSeq Acc Id: NM_001418151   ⟹   NP_001405080
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39114,845,339 - 4,878,867 (+)NCBI
RefSeq Acc Id: NM_172438   ⟹   NP_766026
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39114,845,339 - 4,878,867 (+)NCBI
GRCm38114,895,343 - 4,928,865 (+)NCBI
MGSCv37114,795,346 - 4,828,868 (+)RGD
Celera115,392,170 - 5,426,353 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_766026   ⟸   NM_172438
- Peptide Label: isoform 1
- UniProtKB: Q8CHR3 (UniProtKB/Swiss-Prot),   Q69ZU0 (UniProtKB/Swiss-Prot),   Q8BKT7 (UniProtKB/Swiss-Prot),   A0A0R4J0J6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000099137   ⟸   ENSMUST00000101615
RefSeq Acc Id: ENSMUSP00000118940   ⟸   ENSMUST00000142543
RefSeq Acc Id: ENSMUSP00000045580   ⟸   ENSMUST00000038237
RefSeq Acc Id: NP_001405080   ⟸   NM_001418151
- Peptide Label: isoform 2
- UniProtKB: Q8CHR3 (UniProtKB/Swiss-Prot),   Q8BKT7 (UniProtKB/Swiss-Prot),   Q69ZU0 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BKT7-F1-model_v2 AlphaFold Q8BKT7 1-683 view protein structure

Promoters
RGD ID:6822307
Promoter ID:MM_KWN:6257
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000101615,   ENSMUST00000109903,   NM_172438
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36114,795,031 - 4,795,531 (+)MPROMDB
RGD ID:8673816
Promoter ID:EPDNEW_M14939
Type:multiple initiation site
Name:Thoc5_1
Description:Mus musculus THO complex 5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38114,895,339 - 4,895,399EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1351333 AgrOrtholog
Ensembl Genes ENSMUSG00000034274 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000038237 ENTREZGENE
  ENSMUST00000038237.8 UniProtKB/TrEMBL
  ENSMUST00000101615.9 UniProtKB/TrEMBL
  ENSMUST00000142543.3 UniProtKB/TrEMBL
InterPro THO_Thoc5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:107829 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1351333 ENTREZGENE
NCBI Gene 107829 ENTREZGENE
PANTHER PTHR13375 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THO COMPLEX SUBUNIT 5 HOMOLOG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FmiP_Thoc5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB THOC5 RGD
PhenoGen Thoc5 PhenoGen
UniProt A0A0R4J0J6 ENTREZGENE, UniProtKB/TrEMBL
  Q5SVF8_MOUSE UniProtKB/TrEMBL
  Q5SVF9_MOUSE UniProtKB/TrEMBL
  Q69ZU0 ENTREZGENE
  Q8BKT7 ENTREZGENE
  Q8CHR3 ENTREZGENE
  THOC5_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q69ZU0 UniProtKB/Swiss-Prot
  Q8CHR3 UniProtKB/Swiss-Prot