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Gene: THOC5 (THO complex 5) Homo sapiens
Symbol: THOC5
Name: THO complex 5
Description: Predicted to have mRNA binding activity. Involved in several processes, including monocyte differentiation; negative regulation of DNA damage checkpoint; and viral mRNA export from host cell nucleus. Localizes to the THO complex part of transcription export complex and nucleoplasm. Colocalizes with the nuclear chromosome, telomeric region. Implicated in breast carcinoma; PARTICIPATES IN NXF1-NXT1 export pathway; INTERACTS WITH 2-methylcholine; 3-isobutyl-1-methyl-7H-xanthine; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C22orf19; Fmip; Fms-interacting protein; fSAP79; functional spliceosome-associated protein 79; hTREX90; NF2/meningioma region protein pK1.3; PK1.3; placental protein 39.2; PP39.2; THO complex subunit 5 homolog
Mus musculus (house mouse) : Thoc5 (THO complex 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Thoc5 (THO complex 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Thoc5 (THO complex 5)
Pan paniscus (bonobo/pygmy chimpanzee) : THOC5 (THO complex 5)
Canis lupus familiaris (dog) : THOC5 (THO complex 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Thoc5 (THO complex 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2229,505,879 - 29,555,216 (-)Ensembl
GRCh382229,505,879 - 29,553,760 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372229,904,156 - 29,949,749 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362228,234,156 - 28,279,736 (-)NCBINCBI36hg18NCBI36
Celera2213,703,995 - 13,749,471 (-)NCBI
Cytogenetic Map22q12.2NCBI
HuRef2212,867,987 - 12,913,507 (-)NCBIHuRef
CHM1_12229,863,485 - 29,909,025 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on THOC5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1349222
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.