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Gene: PLA2G12A (phospholipase A2 group XIIA) Homo sapiens

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Symbol:

PLA2G12A

Name:

phospholipase A2 group XIIA

RGD ID:

1312232

HGNC Page

HGNC:18554

Description:

Predicted to enable phospholipase A2 activity. Predicted to be involved in arachidonate secretion; lipid catabolic process; and phospholipid metabolic process. Predicted to be located in extracellular region.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

group XII secreted phospholipase A2; group XIIA secreted phospholipase A2; group XIIA secretory phospholipase A2; GXII; GXII sPLA2; phosphatidylcholine 2-acylhydrolase 12A; phospholipase A2, group XII; phospholipase A2, group XIIA; PLA2G12; ROSSY; sPLA2-XII

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Pla2g12a (phospholipase A2, group XIIA)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Pla2g12a (phospholipase A2, group XIIA)	HGNC	Ensembl, NCBI, Panther
Chinchilla lanigera (long-tailed chinchilla):	Pla2g12a (phospholipase A2 group XIIA)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	PLA2G12A (phospholipase A2 group XIIA)	NCBI	Ortholog
Canis lupus familiaris (dog):	PLA2G12A (phospholipase A2 group XIIA)	HGNC	HomoloGene, NCBI
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pla2g12a (phospholipase A2 group XIIA)	NCBI	Ortholog
Sus scrofa (pig):	PLA2G12A (phospholipase A2 group XIIA)	HGNC	EggNOG, Ensembl, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (green monkey):	PLA2G12A (phospholipase A2 group XIIA)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Pla2g12a (phospholipase A2 group XIIA)	NCBI	Ortholog
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Pla2g12a (phospholipase A2, group XIIA)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pla2g12a (phospholipase A2, group XIIA)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pla2g12a (phospholipase A2, group XIIA)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Drosophila melanogaster (fruit fly):	GXIVsPLA2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C31H1.5	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	F44B9.10	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus laevis (African clawed frog):	pla2g12a.S	Alliance	DIOPT (Xenbase)
Xenopus tropicalis (tropical clawed frog):	pla2g12a	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Related Pseudogenes:

PLA2G12AP1 PLA2G12AP2

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	109,709,989 - 109,730,070 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	109,709,989 - 109,730,070 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	110,631,145 - 110,651,226 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	110,854,139 - 110,870,660 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	110,992,294 - 111,008,815	NCBI
Celera	4	107,924,808 - 107,944,904 (-)	NCBI		Celera
Cytogenetic Map	4	q25	NCBI
HuRef	4	106,364,111 - 106,384,202 (-)	NCBI		HuRef
CHM1_1	4	110,607,720 - 110,627,824 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	113,011,930 - 113,031,980 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (EXP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+/-)-Aegeline (ISO)

(1->4)-beta-D-glucan (ISO)

(RS)-coclaurine (ISO)

(RS)-norcoclaurine (ISO)

(S)-coclaurine (ISO)

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-trinitrobenzenesulfonic acid (ISO)

2,6-dinitrotoluene (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

4,4'-diaminodiphenylmethane (ISO)

6-propyl-2-thiouracil (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (EXP)

antirheumatic drug (EXP)

Aroclor 1254 (ISO)

atrazine (ISO)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

beta-hexachlorocyclohexane (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

buspirone (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

cannabidiol (ISO)

carbamazepine (EXP)

carbon nanotube (ISO)

chlordecone (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

cobalt dichloride (EXP)

copper(II) sulfate (EXP)

coumarin (ISO)

cyclosporin A (EXP)

cyproconazole (ISO)

DDE (EXP)

dextran sulfate (ISO)

Dibutyl phosphate (EXP)

dibutyl phthalate (ISO)

diclofenac (EXP)

difenoconazole (ISO)

dioxygen (ISO)

diquat (ISO)

dorsomorphin (EXP)

elemental selenium (EXP)

entinostat (EXP)

epoxiconazole (ISO)

ethanol (ISO)

flutamide (ISO)

folic acid (ISO)

fulvestrant (EXP)

furan (ISO)

Heptachlor epoxide (ISO)

indole-3-methanol (ISO)

inulin (ISO)

lead(0) (EXP)

leflunomide (ISO)

levofloxacin (ISO)

metformin (ISO)

methapyrilene (ISO)

methotrexate (EXP)

methylmercury chloride (EXP)

mono(2-ethylhexyl) phthalate (EXP)

N-nitrosodiethylamine (ISO)

N-nitrosodimethylamine (ISO)

nefazodone (ISO)

nevirapine (ISO)

nicotine (ISO)

nimesulide (ISO)

nitrofen (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenformin (ISO)

phenobarbital (ISO)

piperonyl butoxide (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propiconazole (ISO)

rotenone (ISO)

SB 431542 (EXP)

selenium atom (EXP)

sodium dichromate (ISO)

sunitinib (EXP)

tacrolimus hydrate (ISO)

tetrachloromethane (ISO)

thioacetamide (ISO)

thiram (EXP)

titanium dioxide (ISO)

trichloroethene (ISO)

trichostatin A (EXP)

triphenyl phosphate (EXP)

valdecoxib (ISO)

valproic acid (EXP)

vinclozolin (ISO)

vitamin E (EXP)

yohimbine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

arachidonate secretion (IEA)

lipid catabolic process (IEA)

phospholipid metabolic process (IEA)

Cellular Component

cytoplasm (IEA)

extracellular region (IEA,NAS,TAS)

Molecular Function

calcium ion binding (IEA)

calcium-dependent phospholipase A2 activity (IEA,NAS)

calcium-independent phospholipase A2 activity (IEA)

hydrolase activity (IEA)

metal ion binding (IEA)

phospholipase A2 activity (IBA,IEA)

protein binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

arachidonic acid metabolic pathway (IEA)

glutamate signaling pathway (IEA)

glycerophospholipid metabolic pathway (IEA)

gonadotropin-releasing hormone signaling pathway (IEA)

linoleic acid metabolic pathway (IEA)

long term depression (IEA)

mitogen activated protein kinase signaling pathway (IEA)

toxoplasmosis pathway (IEA)

vascular endothelial growth factor signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	GOAs Human GO annotations	GOA_HUMAN data from the GO Consortium
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9377118	PMID:9745929	PMID:11031251	PMID:11278438	PMID:12477932	PMID:12522102	PMID:12975309	PMID:14516201	PMID:15489334	PMID:16303743	PMID:19773279	PMID:19913121
PMID:20332099	PMID:20385819	PMID:20628086	PMID:21873635	PMID:21988832	PMID:24366813	PMID:27434078	PMID:28514442	PMID:29117863	PMID:29527719	PMID:31938050	PMID:32814053
PMID:33961781	PMID:38580884	PMID:38703030

Genomics

Comparative Map Data

PLA2G12A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	109,709,989 - 109,730,070 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	109,709,989 - 109,730,070 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	110,631,145 - 110,651,226 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	110,854,139 - 110,870,660 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	110,992,294 - 111,008,815	NCBI
Celera	4	107,924,808 - 107,944,904 (-)	NCBI		Celera
Cytogenetic Map	4	q25	NCBI
HuRef	4	106,364,111 - 106,384,202 (-)	NCBI		HuRef
CHM1_1	4	110,607,720 - 110,627,824 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	113,011,930 - 113,031,980 (-)	NCBI		T2T-CHM13v2.0

Pla2g12a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	129,672,255 - 129,689,474 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	129,672,255 - 129,689,474 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	129,878,606 - 129,895,825 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	129,878,606 - 129,895,825 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	129,581,540 - 129,598,739 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	129,870,655 - 129,887,833 (+)	NCBI		MGSCv36	mm8
Celera	3	136,393,151 - 136,410,249 (+)	NCBI		Celera
Cytogenetic Map	3	G3	NCBI
cM Map	3	59.4	NCBI

Pla2g12a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	221,110,722 - 221,126,966 (+)	NCBI		GRCr8
mRatBN7.2	2	218,436,497 - 218,452,742 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	218,436,513 - 218,452,740 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	226,114,877 - 226,131,062 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	224,014,574 - 224,030,755 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	218,872,216 - 218,888,402 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	235,311,664 - 235,327,972 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	235,311,719 - 235,327,972 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	74,606,722 - 74,623,019 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	227,331,049 - 227,348,091 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	227,317,743 - 227,335,090 (+)	NCBI
Celera	2	210,718,740 - 210,735,042 (+)	NCBI		Celera
Cytogenetic Map	2	q43	NCBI

Pla2g12a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955496	557,379 - 568,100 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955496	557,379 - 568,100 (+)	NCBI	ChiLan1.0	ChiLan1.0

PLA2G12A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	107,802,389 - 107,821,403 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	108,095,907 - 108,114,919 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	102,207,312 - 102,226,307 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	112,773,886 - 112,794,063 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	112,773,886 - 112,794,063 (-)	Ensembl	panpan1.1		panPan2

PLA2G12A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	29,913,223 - 29,929,802 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	29,916,191 - 29,929,725 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	12,100,236 - 12,116,769 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	30,132,532 - 30,149,083 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	30,132,535 - 30,149,116 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	30,126,951 - 30,143,465 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	29,871,452 - 29,888,004 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	9,961,446 - 9,977,979 (+)	NCBI		UU_Cfam_GSD_1.0

Pla2g12a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	11,002,113 - 11,017,422 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936563	933,912 - 948,657 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936563	932,900 - 948,860 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PLA2G12A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	112,483,392 - 112,512,419 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	112,483,322 - 112,512,520 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	120,566,827 - 120,596,000 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PLA2G12A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	57,617,901 - 57,629,767 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	57,618,725 - 57,629,703 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	36,269,109 - 36,281,007 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pla2g12a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624830	157,734 - 166,273 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624830	157,705 - 166,139 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in PLA2G12A
19 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 4q22.2-32.3(chr4:92913386-165299707)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]\|See cases [RCV000051775]	Chr4:92913386..165299707 [GRCh38] Chr4:93834537..166220859 [GRCh37] Chr4:94053560..166440309 [NCBI36] Chr4:4q22.2-32.3	pathogenic
GRCh38/hg38 4q22.3-28.3(chr4:96092893-136410207)x3	copy number gain	See cases [RCV000051776]	Chr4:96092893..136410207 [GRCh38] Chr4:97014044..137331362 [GRCh37] Chr4:97233067..137550812 [NCBI36] Chr4:4q22.3-28.3	pathogenic
GRCh38/hg38 4q24-25(chr4:105778347-110206873)x3	copy number gain	See cases [RCV000051777]	Chr4:105778347..110206873 [GRCh38] Chr4:106699504..111128029 [GRCh37] Chr4:106918953..111347478 [NCBI36] Chr4:4q24-25	pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3	copy number gain	See cases [RCV000446653]	Chr4:12440..190904441 [GRCh37] Chr4:4p16.3-q35.2	pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)	copy number gain	See cases [RCV000510453]	Chr4:68346..190957473 [GRCh37] Chr4:4p16.3-q35.2	pathogenic
GRCh37/hg19 4q25-35.2(chr4:109199664-189752726)x3	copy number gain	See cases [RCV000511945]	Chr4:109199664..189752726 [GRCh37] Chr4:4q25-35.2	pathogenic
GRCh37/hg19 4q22.1-35.2(chr4:93071152-190957473)x3	copy number gain	See cases [RCV000510970]	Chr4:93071152..190957473 [GRCh37] Chr4:4q22.1-35.2	pathogenic
NM_030821.5(PLA2G12A):c.490A>G (p.Ile164Val)	single nucleotide variant	not specified [RCV004286646]	Chr4:109714457 [GRCh38] Chr4:110635613 [GRCh37] Chr4:4q25	uncertain significance
NM_030821.5(PLA2G12A):c.392G>T (p.Cys131Phe)	single nucleotide variant	not specified [RCV004325471]	Chr4:109717607 [GRCh38] Chr4:110638763 [GRCh37] Chr4:4q25	uncertain significance
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3	copy number gain	See cases [RCV000512241]	Chr4:68346..190957473 [GRCh37] Chr4:4p16.3-q35.2	pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3	copy number gain	not provided [RCV000743155]	Chr4:49450..190915650 [GRCh37] Chr4:4p16.3-q35.2	pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3	copy number gain	not provided [RCV000743156]	Chr4:49450..190963766 [GRCh37] Chr4:4p16.3-q35.2	pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3	copy number gain	not provided [RCV000743147]	Chr4:11525..191028879 [GRCh37] Chr4:4p16.3-q35.2	pathogenic
NM_030821.5(PLA2G12A):c.290A>G (p.Asn97Ser)	single nucleotide variant	not specified [RCV004282031]	Chr4:109717709 [GRCh38] Chr4:110638865 [GRCh37] Chr4:4q25	uncertain significance
GRCh37/hg19 4q25(chr4:110386827-110660498)x3	copy number gain	not provided [RCV000847516]	Chr4:110386827..110660498 [GRCh37] Chr4:4q25	uncertain significance
GRCh37/hg19 4q12-31.21(chr4:52866944-143582507)x3	copy number gain	not provided [RCV001827738]	Chr4:52866944..143582507 [GRCh37] Chr4:4q12-31.21	pathogenic
GRCh37/hg19 4q24-31.21(chr4:104715235-145252595)	copy number gain	not specified [RCV002053446]	Chr4:104715235..145252595 [GRCh37] Chr4:4q24-31.21	pathogenic
NM_030821.5(PLA2G12A):c.178G>A (p.Asp60Asn)	single nucleotide variant	not specified [RCV004322720]	Chr4:109729632 [GRCh38] Chr4:110650788 [GRCh37] Chr4:4q25	uncertain significance
NM_030821.5(PLA2G12A):c.239A>G (p.Lys80Arg)	single nucleotide variant	not specified [RCV004302901]	Chr4:109718729 [GRCh38] Chr4:110639885 [GRCh37] Chr4:4q25	uncertain significance
NM_030821.5(PLA2G12A):c.162C>G (p.Asp54Glu)	single nucleotide variant	not specified [RCV004129874]	Chr4:109729648 [GRCh38] Chr4:110650804 [GRCh37] Chr4:4q25	uncertain significance
NM_030821.5(PLA2G12A):c.351T>G (p.Cys117Trp)	single nucleotide variant	not specified [RCV004093310]	Chr4:109717648 [GRCh38] Chr4:110638804 [GRCh37] Chr4:4q25	uncertain significance
NM_030821.5(PLA2G12A):c.160G>A (p.Asp54Asn)	single nucleotide variant	not specified [RCV004201259]	Chr4:109729650 [GRCh38] Chr4:110650806 [GRCh37] Chr4:4q25	uncertain significance
NM_030821.5(PLA2G12A):c.17G>T (p.Arg6Leu)	single nucleotide variant	not specified [RCV004250655]	Chr4:109729793 [GRCh38] Chr4:110650949 [GRCh37] Chr4:4q25	uncertain significance
NM_030821.5(PLA2G12A):c.226C>T (p.Arg76Cys)	single nucleotide variant	not specified [RCV004269706]	Chr4:109718742 [GRCh38] Chr4:110639898 [GRCh37] Chr4:4q25	uncertain significance
NM_030821.5(PLA2G12A):c.437C>T (p.Thr146Ile)	single nucleotide variant	not specified [RCV004342262]	Chr4:109717562 [GRCh38] Chr4:110638718 [GRCh37] Chr4:4q25	uncertain significance
NM_030821.5(PLA2G12A):c.292A>G (p.Ile98Val)	single nucleotide variant	not specified [RCV004356935]	Chr4:109717707 [GRCh38] Chr4:110638863 [GRCh37] Chr4:4q25	uncertain significance
GRCh37/hg19 4q24-35.2(chr4:101203509-190957473)x3	copy number gain	not specified [RCV003986496]	Chr4:101203509..190957473 [GRCh37] Chr4:4q24-35.2	pathogenic
GRCh37/hg19 4p12-q35.2(chr4:45455621-191003541)x3	copy number gain	not provided [RCV003885507]	Chr4:45455621..191003541 [GRCh37] Chr4:4p12-q35.2	pathogenic
NM_030821.5(PLA2G12A):c.315G>C (p.Lys105Asn)	single nucleotide variant	not specified [RCV004511422]	Chr4:109717684 [GRCh38] Chr4:110638840 [GRCh37] Chr4:4q25	uncertain significance
NC_000004.11:g.(?_110481494)_(111554154_?)dup	duplication	not provided [RCV004580809]	Chr4:110481494..111554154 [GRCh37] Chr4:4q25	uncertain significance
NM_030821.5(PLA2G12A):c.554A>G (p.Glu185Gly)	single nucleotide variant	not specified [RCV004661959]	Chr4:109714393 [GRCh38] Chr4:110635549 [GRCh37] Chr4:4q25	uncertain significance
NM_030821.5(PLA2G12A):c.373G>A (p.Asp125Asn)	single nucleotide variant	not specified [RCV004661960]	Chr4:109717626 [GRCh38] Chr4:110638782 [GRCh37] Chr4:4q25	uncertain significance
NM_030821.5(PLA2G12A):c.140C>T (p.Thr47Met)	single nucleotide variant	not specified [RCV004648538]	Chr4:109729670 [GRCh38] Chr4:110650826 [GRCh37] Chr4:4q25	uncertain significance

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	1941
Count of miRNA genes:	919
Interacting mature miRNAs:	1082
Transcripts:	ENST00000243501, ENST00000502283, ENST00000502772, ENST00000507961
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCh38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
407129927	GWAS778903_H	triglycerides:total lipids ratio, high density lipoprotein cholesterol measurement QTL GWAS778903 (human)		1e-09	triglycerides:total lipids ratio, high density lipoprotein cholesterol measurement	blood high density lipoprotein cholesterol level (CMO:0000052)	4	109717668	109717669	Human
407307649	GWAS956625_H	high density lipoprotein cholesterol measurement QTL GWAS956625 (human)		2e-08	high density lipoprotein cholesterol measurement	blood high density lipoprotein cholesterol level (CMO:0000052)	4	109717608	109717609	Human
407287297	GWAS936273_H	high density lipoprotein cholesterol measurement QTL GWAS936273 (human)		1e-25	high density lipoprotein cholesterol measurement	blood high density lipoprotein cholesterol level (CMO:0000052)	4	109717668	109717669	Human
407028491	GWAS677467_H	sex hormone-binding globulin measurement QTL GWAS677467 (human)		5e-25	sex hormone-binding globulin measurement		4	109717668	109717669	Human
407302793	GWAS951769_H	sex hormone-binding globulin measurement QTL GWAS951769 (human)		9e-41	sex hormone-binding globulin measurement		4	109717668	109717669	Human
407202250	GWAS851226_H	lipoprotein A measurement QTL GWAS851226 (human)		1e-11	lipoprotein A measurement		4	109717668	109717669	Human
407304468	GWAS953444_H	triglyceride measurement QTL GWAS953444 (human)		1e-12	triglyceride measurement	blood triglyceride level (CMO:0000118)	4	109717608	109717609	Human
407213591	GWAS862567_H	high density lipoprotein cholesterol measurement QTL GWAS862567 (human)		2e-44	high density lipoprotein cholesterol measurement	blood high density lipoprotein cholesterol level (CMO:0000052)	4	109717668	109717669	Human
407323163	GWAS972139_H	high density lipoprotein cholesterol measurement QTL GWAS972139 (human)		3e-09	high density lipoprotein cholesterol measurement	blood high density lipoprotein cholesterol level (CMO:0000052)	4	109717608	109717609	Human
407089565	GWAS738541_H	triglycerides:total lipids ratio, high density lipoprotein cholesterol measurement QTL GWAS738541 (human)		6e-12	triglycerides:total lipids ratio, high density lipoprotein cholesterol measurement	blood high density lipoprotein cholesterol level (CMO:0000052)	4	109717668	109717669	Human
1643256	BW127_H	Body Weight QTL 127 (human)	1.31	0.007	Body weight	body mass index	4	106319694	132319694	Human
407333221	GWAS982197_H	triglyceride measurement QTL GWAS982197 (human)		1e-44	triglyceride measurement	blood triglyceride level (CMO:0000118)	4	109717668	109717669	Human
407216161	GWAS865137_H	apolipoprotein A 1 measurement QTL GWAS865137 (human)		3e-67	apolipoprotein A 1 measurement	blood apolipoprotein AI level (CMO:0000520)	4	109717668	109717669	Human
407216160	GWAS865136_H	apolipoprotein A 1 measurement QTL GWAS865136 (human)		3e-23	apolipoprotein A 1 measurement	blood apolipoprotein AI level (CMO:0000520)	4	109717608	109717609	Human
407312866	GWAS961842_H	total cholesterol measurement, very low density lipoprotein cholesterol measurement QTL GWAS961842 (human)		4e-08	total cholesterol measurement, very low density lipoprotein cholesterol measurement	blood very low density lipoprotein cholesterol level (CMO:0000648)	4	109717668	109717669	Human
407296480	GWAS945456_H	testosterone measurement QTL GWAS945456 (human)		2e-11	testosterone measurement	serum testosterone level (CMO:0000568)	4	109717668	109717669	Human
407145955	GWAS794931_H	age-related macular degeneration QTL GWAS794931 (human)		0.0000003	age-related macular degeneration		4	109717654	109717655	Human
407324718	GWAS973694_H	very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio QTL GWAS973694 (human)		1e-08	very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	blood very low density lipoprotein cholesterol level (CMO:0000648)	4	109717668	109717669	Human
407202217	GWAS851193_H	sex hormone-binding globulin measurement QTL GWAS851193 (human)		3e-16	sex hormone-binding globulin measurement		4	109717608	109717609	Human
407206761	GWAS855737_H	triglyceride measurement QTL GWAS855737 (human)		2e-17	triglyceride measurement	blood high density lipoprotein cholesterol level (CMO:0000052)	4	109717608	109717609	Human
407330858	GWAS979834_H	non-high density lipoprotein cholesterol measurement QTL GWAS979834 (human)		5e-12	non-high density lipoprotein cholesterol measurement	blood non-high density lipoprotein cholesterol level (CMO:0003967)	4	109717668	109717669	Human
407217067	GWAS866043_H	sex hormone-binding globulin measurement QTL GWAS866043 (human)		1e-34	sex hormone-binding globulin measurement		4	109717668	109717669	Human
407202218	GWAS851194_H	sex hormone-binding globulin measurement QTL GWAS851194 (human)		2e-52	sex hormone-binding globulin measurement		4	109717668	109717669	Human
407206762	GWAS855738_H	triglyceride measurement QTL GWAS855738 (human)		1e-38	high density lipoprotein cholesterol measurement	blood high density lipoprotein cholesterol level (CMO:0000052)	4	109717668	109717669	Human
407221237	GWAS870213_H	sex hormone-binding globulin measurement QTL GWAS870213 (human)		6e-26	sex hormone-binding globulin measurement		4	109717668	109717669	Human
407316790	GWAS965766_H	non-high density lipoprotein cholesterol measurement QTL GWAS965766 (human)		2e-13	non-high density lipoprotein cholesterol measurement	blood non-high density lipoprotein cholesterol level (CMO:0003967)	4	109717668	109717669	Human
407328944	GWAS977920_H	very low density lipoprotein cholesterol measurement QTL GWAS977920 (human)		1e-08	very low density lipoprotein cholesterol measurement	blood very low density lipoprotein cholesterol level (CMO:0000648)	4	109717709	109717710	Human
407337855	GWAS986831_H	triglyceride measurement QTL GWAS986831 (human)		9e-33	triglyceride measurement	blood triglyceride level (CMO:0000118)	4	109717668	109717669	Human
407238904	GWAS887880_H	apolipoprotein A 1 measurement QTL GWAS887880 (human)		9e-13	apolipoprotein A 1 measurement	blood apolipoprotein AI level (CMO:0000520)	4	109717608	109717609	Human
407182328	GWAS831304_H	mean corpuscular volume QTL GWAS831304 (human)		4e-11	mean corpuscular volume	mean corpuscular volume (CMO:0000038)	4	109717668	109717669	Human

Markers in Region

A009Q08

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	110,633,971 - 110,634,137	UniSTS	GRCh37
Build 36	4	110,853,420 - 110,853,586	RGD	NCBI36
Celera	4	107,927,634 - 107,927,800	RGD
Cytogenetic Map	4	q25	UniSTS
HuRef	4	106,366,936 - 106,367,102	UniSTS
GeneMap99-GB4 RH Map	4	515.92	UniSTS

SHGC-67334

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	110,631,178 - 110,631,278	UniSTS	GRCh37
Build 36	4	110,850,627 - 110,850,727	RGD	NCBI36
Celera	4	107,924,841 - 107,924,941	RGD
Cytogenetic Map	4	q25	UniSTS
HuRef	4	106,364,144 - 106,364,244	UniSTS
TNG Radiation Hybrid Map	4	67917.0	UniSTS
GeneMap99-GB4 RH Map	4	526.9	UniSTS

SHGC-36185

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	110,635,417 - 110,635,528	UniSTS	GRCh37
Build 36	4	110,854,866 - 110,854,977	RGD	NCBI36
Celera	4	107,929,080 - 107,929,192	RGD
Cytogenetic Map	4	q25	UniSTS
HuRef	4	106,368,382 - 106,368,494	UniSTS

PLA2G12_1916

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	110,634,597 - 110,635,450	UniSTS	GRCh37
Build 36	4	110,854,046 - 110,854,899	RGD	NCBI36
Celera	4	107,928,260 - 107,929,113	RGD
HuRef	4	106,367,562 - 106,368,415	UniSTS

A005A08

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	110,632,242 - 110,632,428	UniSTS	GRCh37
Build 36	4	110,851,691 - 110,851,877	RGD	NCBI36
Celera	4	107,925,905 - 107,926,091	RGD
Cytogenetic Map	4	q25	UniSTS
HuRef	4	106,365,207 - 106,365,393	UniSTS
TNG Radiation Hybrid Map	4	68144.0	UniSTS
GeneMap99-GB4 RH Map	4	515.61	UniSTS

STS-N92558

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	110,631,186 - 110,631,315	UniSTS	GRCh37
Build 36	4	110,850,635 - 110,850,764	RGD	NCBI36
Celera	4	107,924,849 - 107,924,978	RGD
Cytogenetic Map	4	q25	UniSTS
HuRef	4	106,364,152 - 106,364,281	UniSTS
GeneMap99-GB4 RH Map	4	515.71	UniSTS

SHGC-24817

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	110,647,626 - 110,647,750	UniSTS	GRCh37
Build 36	4	110,867,075 - 110,867,199	RGD	NCBI36
Celera	4	107,941,288 - 107,941,412	RGD
Cytogenetic Map	4	q25	UniSTS
HuRef	4	106,380,585 - 106,380,709	UniSTS
TNG Radiation Hybrid Map	4	67901.0	UniSTS
GeneMap99-GB4 RH Map	4	506.65	UniSTS
Whitehead-RH Map	4	568.4	UniSTS
GeneMap99-G3 RH Map	4	6277.0	UniSTS

SHGC-24776

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	110,635,121 - 110,635,225	UniSTS	GRCh37
Build 36	4	110,854,570 - 110,854,674	RGD	NCBI36
Celera	4	107,928,784 - 107,928,888	RGD
Cytogenetic Map	4	q25	UniSTS
HuRef	4	106,368,086 - 106,368,190	UniSTS
TNG Radiation Hybrid Map	4	67901.0	UniSTS
GeneMap99-GB4 RH Map	4	515.71	UniSTS
Whitehead-RH Map	4	563.4	UniSTS
GeneMap99-G3 RH Map	4	6275.0	UniSTS

SHGC-67246

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	110,652,659 - 110,652,902	UniSTS	GRCh37
Build 36	4	110,872,108 - 110,872,351	RGD	NCBI36
Celera	4	107,946,321 - 107,946,564	RGD
Cytogenetic Map	4	q25	UniSTS
HuRef	4	106,385,620 - 106,385,863	UniSTS
TNG Radiation Hybrid Map	4	67966.0	UniSTS
GeneMap99-GB4 RH Map	4	528.43	UniSTS
NCBI RH Map	4	1180.9	UniSTS

WI-21562

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	110,632,243 - 110,632,519	UniSTS	GRCh37
Build 36	4	110,851,692 - 110,851,968	RGD	NCBI36
Celera	4	107,925,906 - 107,926,182	RGD
Cytogenetic Map	4	q25	UniSTS
HuRef	4	106,365,208 - 106,365,484	UniSTS
GeneMap99-GB4 RH Map	4	526.17	UniSTS
Whitehead-RH Map	4	572.8	UniSTS

MARC_5155-5156:966894589:1

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	1	52,834,581 - 52,834,702	UniSTS	GRCh37
GRCh37	4	110,638,800 - 110,639,890	UniSTS	GRCh37
Build 36	1	52,607,169 - 52,607,290	RGD	NCBI36
Celera	4	107,932,464 - 107,933,554	UniSTS
Celera	1	51,121,275 - 51,121,396	RGD
HuRef	1	50,950,584 - 50,950,705	UniSTS
HuRef	4	106,371,762 - 106,372,852	UniSTS

G32211

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	110,632,242 - 110,632,428	UniSTS	GRCh37
Celera	4	107,925,905 - 107,926,091	UniSTS
Cytogenetic Map	4	q25	UniSTS
HuRef	4	106,365,207 - 106,365,393	UniSTS

G32765

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	110,633,971 - 110,634,137	UniSTS	GRCh37
Celera	4	107,927,634 - 107,927,800	UniSTS
Cytogenetic Map	4	q25	UniSTS
HuRef	4	106,366,936 - 106,367,102	UniSTS

SHGC-60101

Human Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	4	q25	UniSTS
TNG Radiation Hybrid Map	1	29127.0	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	pharyngeal arch	renal system	reproductive system	respiratory system	sensory system	visual system
1204	2439	2788	2250	4972	1726	2351	6	624	1950	465	2270	7299	6466	52	3734	1	851	1743	1616	175	1

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_030821	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC004067	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF306567	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF332892	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK075389	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK313081	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY359024	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC017218	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BI667755	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471057	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068274	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CS051187	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000243501 ⟹ ENSP00000243501

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	4	109,709,989 - 109,730,070 (-)	Ensembl

Ensembl Acc Id:

ENST00000502283 ⟹ ENSP00000425274

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	4	109,713,917 - 109,729,974 (-)	Ensembl

Ensembl Acc Id:

ENST00000502772

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	4	109,717,548 - 109,718,761 (-)	Ensembl

Ensembl Acc Id:

ENST00000507961 ⟹ ENSP00000424021

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	4	109,714,262 - 109,729,956 (-)	Ensembl

RefSeq Acc Id:

NM_030821 ⟹ NP_110448

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	4	109,709,989 - 109,730,070 (-)	NCBI
GRCh37	4	110,631,145 - 110,651,242 (-)	RGD
Build 36	4	110,854,139 - 110,870,660 (-)	NCBI Archive
Celera	4	107,924,808 - 107,944,904 (-)	RGD
HuRef	4	106,364,111 - 106,384,202 (-)	RGD
CHM1_1	4	110,607,720 - 110,627,824 (-)	NCBI
T2T-CHM13v2.0	4	113,011,930 - 113,031,980 (-)	NCBI

Sequence:

show sequence

GCACAGGGGACGGTTGCTGGCCCAGGTGAGCGGGCGCGCTGGTCCAGGTGAGCGGGCGCGTCCC
CGCGACGGCGCTGCCTGCCCGAGGCGGTTCACGTAAAGACAGCGAGATCCTGAGGGCCAGCCGG
GAAGGAGGCGTGGATATGGAGCTGGCTGCTGCCAAGTCCGGGGCCCGCGCCGCTGCCTAGCGCG
TCCTGGGGACTCTGTGGGGACGCGCCCCGCGCCGCGGCTCGGGGACCCGTAGAGCCCGGCGCTG
CGCGCATGGCCCTGCTCTCGCGCCCCGCGCTCACCCTCCTGCTCCTCCTCATGGCCGCTGTTGT
CAGGTGCCAGGAGCAGGCCCAGACCACCGACTGGAGAGCCACCCTGAAGACCATCCGGAACGGC
GTTCATAAGATAGACACGTACCTGAACGCCGCCTTGGACCTCCTGGGAGGCGAGGACGGTCTCT
GCCAGTATAAATGCAGTGACGGATCTAAGCCTTTCCCACGTTATGGTTATAAACCCTCCCCACC
GAATGGATGTGGCTCTCCACTGTTTGGTGTTCATCTTAACATTGGTATCCCTTCCCTGACAAAG
TGTTGCAACCAACACGACAGGTGCTATGAGACCTGTGGCAAAAGCAAGAATGACTGTGATGAAG
AATTCCAGTATTGCCTCTCCAAGATCTGCCGAGATGTACAGAAAACACTAGGACTAACTCAGCA
TGTTCAGGCATGTGAAACAACAGTGGAGCTCTTGTTTGACAGTGTTATACATTTAGGTTGTAAA
CCATATCTGGACAGCCAACGAGCCGCATGCAGGTGTCATTATGAAGAAAAAACTGATCTTTAAA
GGAGATGCCGACAGCTAGTGACAGATGAAGATGGAAGAACATACCTTTGACAAATAACTAATGT
TTTTACAACATAAAACTGTCTTATTTTTGTGAAAGGATTATTTTGAGACCTTAAAATAATTTAT
ATCTTGATGTTAAAACCTCAAAGCAAAAAAAGTGAGGGAGATAGTGAGGGGAGGGCACGCTTGT
CTTCTCAGGTATCTTCCCCAGCATTGCTCCCTTACTTAGTATGCCAAATGTCTTGACCAATATC
AAAAACAAGTGCTTGTTTAGCGGAGAATTTTGAAAAGAGGAATATATAACTCAATTTTCACAAC
CACATTTACCAAAAAAAGAGATCAAATATAAAATTCATCATAATGTCTGTTCAACATTATCTTA
TTTGGAAAATGGGGAAATTATCACTTACAAGTATTTGTTTACTATGAAATTTTAAATACACATT
TATGCCTAGAAGGAACGGACTTTTTTTTTCTATTTTAATTACACATAATATGTAATTAAAGTAC
AACATAATATGTTGTTTCTCTGTAGCCCGTTGAGCATATGAGTAAGTCACATTTCTATTAGGAC
TACTTACAAGGACAAGGTTTCCATTTTTCCAGTTGTAAAATTGGAACCATCAGCTGATAACCTC
GTAGGGAGCAACCCCAGGATAGCTAAGTGTTATGTAATATGCCTAGAAGGTGATGTGAATGCGA
TTCAGAAGCATAGCCACTCCCATTTTATGAGCTACTCACATGACAAATGTCATCTTTTGCTATA
ACCTTTGCCAAGTTAGAGAAAAGATGGATTTAATGAGATAAATGAAAAGATATTTAACCTAATA
TATCAAGGCACTATTTGCTGTTATGCTTTGTTATTTATTTCCCAGCACTTGTTCCTTATTGTAG
ATTTTTTAAAGACTGTAACCTTTTACTAACTGTGGTCTTACTAAAATTTGTGCTTGATACTGCT
TTTCAAAAAGCCTTTAATTAGAGCCAAAAGGATGGAAAAGGCAAGATATAAATGCCTTTTATAG
ATCTCTTATTTACATTGAAAATTATTACCATATGTTTAGAGCAAATCCAAGAAAACTTCAACAG
CTTCTGAAGATGTCTATGAATGTTGAAAACTTTTCAATCTCTTGGAATGCTCAGTTATGTTCCT
AGACCGGTCTTTGCTGACTACTGGTTGTTAACCTTTCCCTAGCCTGGGACCTCAAGCCATATAT
ATCCTTTGGGTGACCCATGGCCAAAGTTATTAAGATGAACTGACTTTCAAAGTCAGAGAAGGAC
AGCATAGGGAGAGGCGGTTATTTGTAAGTCATTACAGGTAGAACAGGGCAGAAGGAAAAGTATG
TTCTGGAGAAAGGGCCATGTTCCTAACTTTGGAGATATGTCATTGCCGGGAACCTAGTATCTTC
CAACTTGAATTGGTGGCAGCTGTTCCAGTGAGACAAGGCACATGTATGCCTTGTGGCTAAGTGA
GCAAACTGGGTTTCCACTTAAATGTTTGGGACCCTCAATTGATTCTTTATTTCAAACCTTTATA
AAAGGTACAGTTTTGTAAGCCATTATTAATAATTAATGCTTATCGGCTGGGCACAGTGGCTCAC
ACCTATAATCCCAGCACTTTGGGAGGCTGAGGCGGTTGGATCACTTGAGGTCAGGAGTTTGAGA
CCAGCTGGCCAACATGGTGAAACAGCGTCTCTACTAAAAATACAAAAATTTGCCGGGCGTGGTG
GCGCATGCTTATAGTCTCAGCTACTCAGGAAGCTGAGGTACGAGAATCACTTGAACCCAGGAGG
TGGAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTGCAGCCTGGGCAACAGAGCAAGACTCT
AAAAAAAAAATGGTTTATCAATATTTACTATTGAAATATTTGTCCAGGTAACTTTACACTTACA
ATGAATTCATGGATTTTGTTAGCAGCATTGGCTTTCTCAAAAGGACAAACTCAATATCGTTATA
AAATATAATTCGTGATCACAAATTATACAAAAATCAGTAGAAACAGTTTTTTATGTTCAGATTA
AAAAAAAAAACTTGGGATAATTTTAGATTTACAGAAAAGTTGCAAAGATACATGGAGAGCTTCT
GTGACCACTCACCCAGTTCCCCCAGTGTTAACCTTTTATTTAACCATGAAGCATTTGTCAGAAG
CTAAGTAACCAGCAATGGCAATTACTATTAACGGAACTTTGACTTTATTTTTCAGATTGTACTA
GTTTTTTAATTAATGTCATTTTTCTTTTCCAGGATCCAATCTAGGATACCACACTGAATTAGTC
GTCATGCCTAATTAGCCTCTGGTCTGTGATAGTTCCACAGTCTTTCTTTTTCATAACCTTGACA
GTTTTGAGGAGTACTGGTCAGGTGTTTTGTAGAATATTCCTCAATTTGGGTTTGTCTGATGTTT
TCCTCATGGTTAGAGTGGGGTTATAGATTTTTAGGAAGAATACCAGAGGTGAAGGTCCTTCTCA
CTGCATCATGTCAGGAGTTACATGCTATCAGCTTGATGGTGTATTAACTTTGGACACTTGGTTA
AGGTAGTGTGTGTTGGTTTTTTGCTGCTGAAAATTACTGTTATTTTCCCTTTCCATACTTCTGT
TCTTTGGAAAACAGTCACTAAGTCCAGTCATGGGAGGTGGTGGGTGGGAAAGATTACATTCAAC
CCCCTGGAAGTGGGAATATCCATATGTAGTATTTGGAATTTTTCTATATGGAAAATTTGTTTCT
CCCTCCCACCCTAATTTGTTTACATCAGTATGGACTCATGTATATTTTGTATTTTGGGTAACAC
AGTATTTATTTTGTTGCTTAAGTTGTCCAGCTTGGCTATTAGGAGTTCTGCCAGGTTGGCTACT
ATGTCCCTTTGATGTGCCCATCCTTTTGATTTTTGAGCACTTCTTACTTTCTGGCACTACAAGA
TGCTCCAGGTTCATCTTGGATATTCCCTGCCCCAACCCTAGAATCCCTAGAATCAACCCCTGCT
CCAAAGAGCCCTGGTTCCTTTTGTTGGAGAATCATACTTAGAAACCAAGATCTGGGCATTAGAT
GTGCTTGTTGCTACTGGGATGTCACTGTTTGTAGCAGAGTTGAGAAATATGTATGTATATTAAT
CCATGCATATGTACACATCTATAATTATTTATGTGTGTACAAAGCTAAACATGAGTTTGTACTG
CCGTCTTCAACTCAAAATTTGTCCCAAAATTTTGTGGCATATGTTTAGATTTTAAAGTTGATAT
TTTCCCTATTGACAGAATAAACTCATTAAAAGAGCAAAAAAAAAAAAAAAAAAAAAAAGGCAAG
AACTAACTGTCAGCAGCTCTTTGCAAGAAATGTAATATTGATACTTTAAAATAATACTGCCTTC
AAATGATGCCTGTCTCTTTAAAATCTTTTGACATAGTTCTTCCAGGGACAGATATGGCTGTATT
TATTTCATAGATGGAGAAACTGAGCACAGAGCTGTAATGAAGACAGAATTGAGATATAAGGGCA
AAAGCTAATTAAACGCATCCTCACAGGTAGCCTTTCTTTCAGTGAACCTGTAGACTAGTCCAGT
AATACTTATTAAAATTAGTTGTTAGAGGCTGGGCATGGTGGTTCAAGCCTGTAATCTCAGCACT
GTGGGAGGCCAAGGCGGACAGATCACTCAAAGTCAGAAGTTCGAGACCAGCTTGGCCAACATGG
CAAAACCCTGTCTCTACTAAAAATACAAAAATTAGTTGGGTGTGGTGGCACATGCCTGTAATCC
CAGCCACTCGGGAGGTGAAGGCACAAGAATTGGTTGAACCTGGGAAGCAGAGGTTGCAGTGAGC
TGAGATTGCACTGCTGCACTCCAGCATAGGCGTCAGAATAAGACTCTGTCTTGGAAAGAAGAAA
AAAAATTGTTAGCCTAAAACCAACTCTCTCTAAATTTAAAAGAGTGATTATTTATCTTAGTATT
TATAGAAGTATGAGATTATCAGAAGGTGCGATGCACAATGCTCATTATTTTATCCTAGTACAAG
ACACGTATAACATCTAACAGTAAAGAAGATGGAATCTTTCTATAAAAACAATTCTGTTATTAAT
AGTTGACTGACTTCAGTAACTTTGAGGAGTAGAATGAAACTTATTAGGCAAGATCTTTCCACAT
ACACTACATTGTATTGTTCAAAATTCATAGAAATTACTTGCAATATATTGATTTAAGCCTTATG
TAGTGACTGTTGCTATATTTGAAGTAGCATTTTTAGTTTGCTGTTTTTCCTCACTGCTTAATCC
TACAAAAACCAGCCATCTGCCTAAAAAATAAAAGAGCAAAAATGAATCAGTGCAACCGGTATAC
GAAAAATAATAATTATTAATAAAACTGTAAAGGGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_110448	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAG50243	(Get FASTA)	NCBI Sequence Viewer
	AAG50289	(Get FASTA)	NCBI Sequence Viewer
	AAH17218	(Get FASTA)	NCBI Sequence Viewer
	AAQ89383	(Get FASTA)	NCBI Sequence Viewer
	BAC11589	(Get FASTA)	NCBI Sequence Viewer
	BAG35907	(Get FASTA)	NCBI Sequence Viewer
	CAI72089	(Get FASTA)	NCBI Sequence Viewer
	EAX06246	(Get FASTA)	NCBI Sequence Viewer
	EAX06247	(Get FASTA)	NCBI Sequence Viewer
	EAX06248	(Get FASTA)	NCBI Sequence Viewer
	EAX06249	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000243501
	ENSP00000243501.5
	ENSP00000424021.1
	ENSP00000425274.1
GenBank Protein	Q9BZM1	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_110448 ⟸ NM_030821
- Peptide Label:	precursor
- UniProtKB:	Q9BZ89 (UniProtKB/Swiss-Prot), Q9BZM1 (UniProtKB/Swiss-Prot), Q542Y6 (UniProtKB/TrEMBL), A0A0C4DGC6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MALLSRPALTLLLLLMAAVVRCQEQAQTTDWRATLKTIRNGVHKIDTYLNAALDLLGGEDGLCQ YKCSDGSKPFPRYGYKPSPPNGCGSPLFGVHLNIGIPSLTKCCNQHDRCYETCGKSKNDCDEEF QYCLSKICRDVQKTLGLTQHVQACETTVELLFDSVIHLGCKPYLDSQRAACRCHYEEKTDL hide sequence

Ensembl Acc Id:

ENSP00000425274 ⟸ ENST00000502283

Ensembl Acc Id:

ENSP00000424021 ⟸ ENST00000507961

Ensembl Acc Id:

ENSP00000243501 ⟸ ENST00000243501

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9BZM1-F1-model_v2	AlphaFold	Q9BZM1	1-189	view protein structure

Promoters

RGD ID:

6868258

Promoter ID:

EPDNEW_H7294

Type:

initiation region

Name:

PLA2G12A_1

Description:

phospholipase A2 group XIIA

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	4	109,730,070 - 109,730,130	EPDNEW

RGD ID:

6802530

Promoter ID:

HG_KWN:48904

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, HeLa_S3, K562, Lymphoblastoid, NB4

Transcripts:

NM_030821, UC010IMG.1

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	4	110,870,521 - 110,871,147 (-)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:18554	AgrOrtholog
COSMIC	PLA2G12A	COSMIC
Ensembl Genes	ENSG00000123739	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENST00000243501	ENTREZGENE
	ENST00000243501.10	UniProtKB/Swiss-Prot
	ENST00000502283.1	UniProtKB/TrEMBL
	ENST00000507961.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.90.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx	ENSG00000123739	GTEx
HGNC ID	HGNC:18554	ENTREZGENE
Human Proteome Map	PLA2G12A	Human Proteome Map
InterPro	PLA2G12	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PLipase_A2_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PLipase_A2_His_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	hsa:81579	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	81579	ENTREZGENE
OMIM	611652	OMIM
PANTHER	GROUP XIIA SECRETORY PHOSPHOLIPASE A2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR12824	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	PLA2G12	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	PA38347	PharmGKB
PROSITE	PA2_HIS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF48619	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0C4DGC6	ENTREZGENE, UniProtKB/TrEMBL
	D6RBP5_HUMAN	UniProtKB/TrEMBL
	PG12A_HUMAN	UniProtKB/Swiss-Prot
	Q542Y6	ENTREZGENE, UniProtKB/TrEMBL
	Q9BZ89	ENTREZGENE
	Q9BZM1	ENTREZGENE
UniProt Secondary	Q9BZ89	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-11-24	PLA2G12A	phospholipase A2 group XIIA	PLA2G12A	phospholipase A2, group XIIA	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)