Exd2 (exonuclease 3'-5' domain containing 2) - Rat Genome Database

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Gene: Exd2 (exonuclease 3'-5' domain containing 2) Rattus norvegicus
Analyze
Symbol: Exd2
Name: exonuclease 3'-5' domain containing 2
RGD ID: 1311087
Description: Predicted to enable 3'-5' exonuclease activity; metal ion binding activity; and protein homodimerization activity. Predicted to be involved in DNA double-strand break processing; double-strand break repair via homologous recombination; and replication fork processing. Predicted to be located in intermediate filament cytoskeleton; mitochondrial outer membrane; and site of DNA damage. Predicted to be active in cytoplasm and nucleus. Orthologous to human EXD2 (exonuclease 3'-5' domain containing 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Exdl2; exonuclease 3''-5'' domain-like 2; exonuclease 3'-5' domain-containing protein 2; LOC362759; RGD1311087; similar to expressed sequence C85658
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86105,847,931 - 105,881,780 (+)NCBIGRCr8
mRatBN7.26100,116,867 - 100,150,452 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6100,116,867 - 100,150,442 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6100,282,295 - 100,316,178 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06100,581,990 - 100,615,873 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0699,957,060 - 99,990,674 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06104,017,620 - 104,051,442 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6104,017,607 - 104,051,446 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06112,192,441 - 112,226,159 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46104,231,115 - 104,265,354 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16104,234,693 - 104,268,073 (+)NCBI
Celera697,974,785 - 98,008,358 (+)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:22871113   PMID:26807646   PMID:29599527   PMID:31127291   PMID:31255466  


Genomics

Comparative Map Data
Exd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86105,847,931 - 105,881,780 (+)NCBIGRCr8
mRatBN7.26100,116,867 - 100,150,452 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6100,116,867 - 100,150,442 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6100,282,295 - 100,316,178 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06100,581,990 - 100,615,873 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0699,957,060 - 99,990,674 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06104,017,620 - 104,051,442 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6104,017,607 - 104,051,446 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06112,192,441 - 112,226,159 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46104,231,115 - 104,265,354 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16104,234,693 - 104,268,073 (+)NCBI
Celera697,974,785 - 98,008,358 (+)NCBICelera
Cytogenetic Map6q24NCBI
EXD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381469,191,498 - 69,244,018 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1469,191,498 - 69,244,020 (+)EnsemblGRCh38hg38GRCh38
GRCh371469,658,215 - 69,710,735 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361468,746,231 - 68,778,825 (+)NCBINCBI36Build 36hg18NCBI36
Build 341468,746,230 - 68,778,825NCBI
Celera1449,722,349 - 49,774,877 (+)NCBICelera
Cytogenetic Map14q24.1NCBI
HuRef1449,828,887 - 49,881,419 (+)NCBIHuRef
CHM1_11469,596,430 - 69,648,894 (+)NCBICHM1_1
T2T-CHM13v2.01463,404,602 - 63,457,085 (+)NCBIT2T-CHM13v2.0
Exd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391280,509,869 - 80,544,909 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1280,509,869 - 80,547,001 (+)EnsemblGRCm39 Ensembl
GRCm381280,463,095 - 80,498,135 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1280,463,095 - 80,500,227 (+)EnsemblGRCm38mm10GRCm38
MGSCv371281,564,082 - 81,599,122 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361281,394,842 - 81,416,970 (+)NCBIMGSCv36mm8
Celera1281,928,182 - 81,963,154 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1236.73NCBI
Exd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554661,110,395 - 1,169,242 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554661,114,299 - 1,169,124 (-)NCBIChiLan1.0ChiLan1.0
EXD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21570,313,041 - 70,366,036 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11469,527,465 - 69,582,549 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01449,783,072 - 49,835,645 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11468,656,455 - 68,708,773 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1468,656,669 - 68,707,834 (+)Ensemblpanpan1.1panPan2
EXD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1843,028,537 - 43,082,038 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl843,042,563 - 43,187,969 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha842,717,745 - 42,773,001 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0843,257,837 - 43,313,332 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl843,257,911 - 43,316,242 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1842,872,325 - 42,927,784 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0842,946,902 - 43,002,520 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0843,306,406 - 43,361,842 (+)NCBIUU_Cfam_GSD_1.0
Exd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864061,711,892 - 61,758,994 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649512,432,731 - 12,479,876 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649512,432,752 - 12,479,807 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EXD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl792,848,032 - 92,913,771 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1792,847,958 - 92,909,044 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2799,038,091 - 99,131,917 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EXD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12446,431,309 - 46,480,500 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2446,444,282 - 46,482,845 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605334,655,161 - 34,706,362 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Exd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473431,819,440 - 31,866,937 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473431,822,927 - 31,866,678 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Exd2
324 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:495
Count of miRNA genes:243
Interacting mature miRNAs:290
Transcripts:ENSRNOT00000033378
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1300076Glom8Glomerulus QTL 879e-09kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000033378   ⟹   ENSRNOP00000030862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6100,116,978 - 100,150,442 (+)Ensembl
Rnor_6.0 Ensembl6104,017,607 - 104,051,446 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094099   ⟹   ENSRNOP00000079247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6100,116,867 - 100,146,009 (+)Ensembl
RefSeq Acc Id: NM_001108715   ⟹   NP_001102185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86105,848,202 - 105,881,777 (+)NCBI
mRatBN7.26100,116,867 - 100,150,444 (+)NCBI
Rnor_6.06104,017,889 - 104,051,434 (+)NCBI
Rnor_5.06112,192,441 - 112,226,159 (+)NCBI
RGSC_v3.46104,231,115 - 104,265,354 (+)RGD
Celera697,974,785 - 98,008,358 (+)RGD
Sequence:
RefSeq Acc Id: XM_006240286   ⟹   XP_006240348
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86105,847,931 - 105,881,780 (+)NCBI
mRatBN7.26100,116,901 - 100,150,452 (+)NCBI
Rnor_6.06104,017,620 - 104,051,442 (+)NCBI
Rnor_5.06112,192,441 - 112,226,159 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039112511   ⟹   XP_038968439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86105,847,931 - 105,881,780 (+)NCBI
mRatBN7.26100,116,901 - 100,150,452 (+)NCBI
RefSeq Acc Id: NP_001102185   ⟸   NM_001108715
- Sequence:
RefSeq Acc Id: XP_006240348   ⟸   XM_006240286
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000030862   ⟸   ENSRNOT00000033378
RefSeq Acc Id: XP_038968439   ⟸   XM_039112511
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000079247   ⟸   ENSRNOT00000094099
Protein Domains
3'-5' exonuclease

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2GUW4-F1-model_v2 AlphaFold B2GUW4 1-648 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311087 AgrOrtholog
BioCyc Gene G2FUF-36912 BioCyc
Ensembl Genes ENSRNOG00000027707 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033378.6 UniProtKB/TrEMBL
  ENSRNOT00000094099.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7135396 IMAGE-MGC_LOAD
InterPro 3-5_Exonuclease_domain UniProtKB/TrEMBL
  3_5_exonuclease UniProtKB/TrEMBL
  PolynucTfrase_RNaseH_fold UniProtKB/TrEMBL
  RNaseH_sf UniProtKB/TrEMBL
KEGG Report rno:362759 UniProtKB/TrEMBL
MGC_CLONE MGC:187466 IMAGE-MGC_LOAD
NCBI Gene 362759 ENTREZGENE
PANTHER 3-5 EXONUCLEASE UniProtKB/TrEMBL
  EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
Pfam 3_5_exonuc UniProtKB/TrEMBL
PhenoGen Exd2 PhenoGen
RatGTEx ENSRNOG00000027707 RatGTEx
SMART 35EXOc UniProtKB/TrEMBL
Superfamily-SCOP RNaseH_fold UniProtKB/TrEMBL
UniProt A0A8I5ZQG7_RAT UniProtKB/TrEMBL
  B2GUW4 ENTREZGENE, UniProtKB/TrEMBL
  F7FEI8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-03-24 Exd2  exonuclease 3'-5' domain containing 2  Exdl2  exonuclease 3''-5'' domain-like 2   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Exdl2  exonuclease 3''-5'' domain-like 2   Exdl2_predicted  exonuclease 3''-5'' domain-like 2 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Exdl2_predicted  exonuclease 3''-5'' domain-like 2 (predicted)  RGD1311087_predicted  similar to expressed sequence C85658 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1311087_predicted  similar to expressed sequence C85658 (predicted)  LOC362759_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC362759_predicted  similar to expressed sequence C85658 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL