Ubxn8 (UBX domain protein 8) - Rat Genome Database

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Gene: Ubxn8 (UBX domain protein 8) Rattus norvegicus
Analyze
Symbol: Ubxn8
Name: UBX domain protein 8
RGD ID: 1306023
Description: Predicted to enable ubiquitin binding activity. Predicted to be involved in ERAD pathway. Predicted to be located in endoplasmic reticulum membrane; nucleolus; and nucleoplasm. Orthologous to human UBXN8 (UBX domain protein 8); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC290802; RGD1306023; similar to reproduction 8; UBX domain containing 6; UBX domain-containing protein 8; Ubxd6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81665,239,149 - 65,260,743 (+)NCBIGRCr8
GRCr8 Ensembl1665,240,062 - 65,260,639 (+)EnsemblGRCr8 Ensembl
mRatBN7.21658,536,086 - 58,557,684 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1658,536,086 - 58,557,684 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1663,873,647 - 63,895,266 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01667,287,312 - 67,308,931 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01662,507,878 - 62,529,497 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01662,251,243 - 62,272,838 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1662,251,243 - 62,272,838 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01661,911,951 - 61,933,546 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41662,308,482 - 62,330,075 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1656,572,162 - 56,593,770 (+)NCBICelera
RGSC_v3.11662,309,492 - 62,328,941 (+)NCBI
Cytogenetic Map16q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ERAD pathway  (IEA,ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21949850  


Genomics

Comparative Map Data
Ubxn8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81665,239,149 - 65,260,743 (+)NCBIGRCr8
GRCr8 Ensembl1665,240,062 - 65,260,639 (+)EnsemblGRCr8 Ensembl
mRatBN7.21658,536,086 - 58,557,684 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1658,536,086 - 58,557,684 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1663,873,647 - 63,895,266 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01667,287,312 - 67,308,931 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01662,507,878 - 62,529,497 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01662,251,243 - 62,272,838 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1662,251,243 - 62,272,838 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01661,911,951 - 61,933,546 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41662,308,482 - 62,330,075 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1656,572,162 - 56,593,770 (+)NCBICelera
RGSC_v3.11662,309,492 - 62,328,941 (+)NCBI
Cytogenetic Map16q12.3NCBI
UBXN8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38830,729,135 - 30,767,006 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl830,729,131 - 30,767,006 (+)EnsemblGRCh38hg38GRCh38
GRCh37830,601,681 - 30,624,522 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36830,721,232 - 30,744,064 (+)NCBINCBI36Build 36hg18NCBI36
Celera829,561,773 - 29,584,614 (+)NCBICelera
Cytogenetic Map8p12NCBI
HuRef829,148,014 - 29,170,971 (+)NCBIHuRef
CHM1_1830,803,863 - 30,825,966 (+)NCBICHM1_1
T2T-CHM13v2.0831,008,589 - 31,048,026 (+)NCBIT2T-CHM13v2.0
Ubxn8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39834,109,614 - 34,135,515 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl834,109,614 - 34,131,995 (-)EnsemblGRCm39 Ensembl
GRCm38833,619,586 - 33,645,476 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl833,619,586 - 33,641,967 (-)EnsemblGRCm38mm10GRCm38
MGSCv37834,730,058 - 34,752,448 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36835,085,521 - 35,107,911 (-)NCBIMGSCv36mm8
Celera836,253,546 - 36,278,148 (-)NCBICelera
Cytogenetic Map8A4NCBI
cM Map820.65NCBI
Ubxn8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554637,190,390 - 7,217,254 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554637,189,822 - 7,213,083 (+)NCBIChiLan1.0ChiLan1.0
UBXN8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2749,300,668 - 49,340,043 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1825,016,584 - 25,056,067 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0830,057,469 - 30,080,778 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1827,247,044 - 27,269,348 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl827,234,039 - 27,268,741 (+)Ensemblpanpan1.1panPan2
UBXN8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11633,590,905 - 33,622,752 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1633,591,273 - 33,679,673 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1634,050,244 - 34,145,336 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01635,616,980 - 35,711,899 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1635,616,283 - 35,648,690 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11633,715,579 - 33,810,676 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01634,288,046 - 34,382,336 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01634,406,943 - 34,501,444 (-)NCBIUU_Cfam_GSD_1.0
Ubxn8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494356,747,356 - 56,804,646 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936792588,474 - 618,030 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936792588,698 - 616,288 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UBXN8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1554,339,563 - 54,367,605 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11554,342,575 - 54,367,610 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21561,714,643 - 61,740,032 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UBXN8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1828,862,081 - 28,884,985 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl828,862,069 - 28,885,415 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605213,213,916 - 13,237,134 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ubxn8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478013,378,206 - 13,409,745 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ubxn8
230 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:152
Count of miRNA genes:107
Interacting mature miRNAs:127
Transcripts:ENSRNOT00000020347
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164445512389455123Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)163692878281928782Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)164199206486992064Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162846870173468701Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164909919691442908Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)166241446475736480Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)163236104377361043Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)163105803976058039Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165942871491442908Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163439829479398294Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)163188527176885271Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164445512389455123Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165942871491442908Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165942871491442908Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 218 97 11 93 45 60 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000020347   ⟹   ENSRNOP00000020347
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1658,536,086 - 58,557,684 (+)Ensembl
Rnor_6.0 Ensembl1662,251,243 - 62,272,838 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000165631   ⟹   ENSRNOP00000111844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1665,240,062 - 65,260,639 (+)Ensembl
RefSeq Acc Id: NM_001106086   ⟹   NP_001099556
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81665,239,149 - 65,260,743 (+)NCBI
mRatBN7.21658,536,086 - 58,557,684 (+)NCBI
Rnor_6.01662,251,243 - 62,272,838 (+)NCBI
Rnor_5.01661,911,951 - 61,933,546 (+)NCBI
RGSC_v3.41662,308,482 - 62,330,075 (+)RGD
Celera1656,572,162 - 56,593,770 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099556 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM09141 (Get FASTA)   NCBI Sequence Viewer  
  EDM09142 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000020347.5
  ENSRNOP00000111844
RefSeq Acc Id: NP_001099556   ⟸   NM_001106086
- UniProtKB: D3ZUE3 (UniProtKB/TrEMBL),   A6IVT0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020347   ⟸   ENSRNOT00000020347
Ensembl Acc Id: ENSRNOP00000111844   ⟸   ENSRNOT00000165631
Protein Domains
UBX

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZUE3-F1-model_v2 AlphaFold D3ZUE3 1-276 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700141
Promoter ID:EPDNEW_R10665
Type:initiation region
Name:Ubxn8_1
Description:UBX domain protein 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01662,252,648 - 62,252,708EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306023 AgrOrtholog
BioCyc Gene G2FUF-11119 BioCyc
Ensembl Genes ENSRNOG00000015109 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000091028 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000020347.6 UniProtKB/TrEMBL
  ENSRNOT00000165631 ENTREZGENE
Gene3D-CATH Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
InterPro Ubiquitin-rel_dom UniProtKB/TrEMBL
  UBX UniProtKB/TrEMBL
  UBX_domain-protein UniProtKB/TrEMBL
  UBXN8 UniProtKB/TrEMBL
KEGG Report rno:290802 UniProtKB/TrEMBL
NCBI Gene 290802 ENTREZGENE
PANTHER FAS-ASSOCIATED PROTEIN UniProtKB/TrEMBL
  UBX DOMAIN-CONTAINING PROTEIN 8 UniProtKB/TrEMBL
Pfam UBX UniProtKB/TrEMBL
PhenoGen Ubxn8 PhenoGen
PIRSF UBX_Rep6 UniProtKB/TrEMBL
PROSITE UBX UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015109 RatGTEx
  ENSRNOG00000091028 RatGTEx
Superfamily-SCOP SSF54236 UniProtKB/TrEMBL
UniProt A6IVT0 ENTREZGENE, UniProtKB/TrEMBL
  A6IVT1_RAT UniProtKB/TrEMBL
  D3ZUE3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-05-07 Ubxn8  UBX domain protein 8  Ubxd6  UBX domain containing 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ubxd6  UBX domain containing 6   Ubxd6_predicted  UBX domain containing 6 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Ubxd6_predicted  UBX domain containing 6 (predicted)  RGD1306023_predicted  similar to reproduction 8 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1306023_predicted  similar to reproduction 8 (predicted)  LOC290802_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC290802_predicted  similar to reproduction 8 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL