Sfrp2 (secreted frizzled related protein 2) - Rat Genome Database

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Gene: Sfrp2 (secreted frizzled related protein 2) Ictidomys tridecemlineatus
Analyze
Symbol: Sfrp2
Name: secreted frizzled related protein 2
RGD ID: 12723367
Description: ENCODES a protein that exhibits fibronectin binding (ortholog); integrin binding (ortholog); INVOLVED IN anterior/posterior pattern specification (ortholog); apoptotic process (ortholog); BMP signaling pathway (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); Colorectal Neoplasms (ortholog); inflammatory bowel disease (ortholog); FOUND IN collagen-containing extracellular matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: secreted frizzled-related protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530138,934,030 - 38,942,739 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936576604,069 - 613,021 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936576604,174 - 612,440 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (IEA,ISO)
apoptotic process  (IEA,ISO)
BMP signaling pathway  (IEA,ISO)
branching involved in blood vessel morphogenesis  (IEA)
canonical Wnt signaling pathway  (IEA,ISO)
cardiac left ventricle morphogenesis  (IEA)
cardiac muscle cell apoptotic process  (IEA,ISO)
cartilage development  (IEA,ISO)
cell differentiation  (IEA)
cell-cell signaling  (ISO)
cellular response to X-ray  (IEA)
chondrocyte development  (IEA,ISO)
collagen fibril organization  (IEA,ISO)
convergent extension involved in axis elongation  (IEA,ISO)
development of primary male sexual characteristics  (IEA,ISO)
developmental process  (IEA)
digestive tract morphogenesis  (IEA,ISO)
embryonic digit morphogenesis  (IEA,ISO)
hematopoietic stem cell proliferation  (IEA)
male gonad development  (IEA,ISO)
mesodermal cell fate specification  (IEA,ISO)
negative regulation of BMP signaling pathway  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of cardiac muscle cell apoptotic process  (IEA,ISO)
negative regulation of cell growth  (IEA)
negative regulation of cell migration  (IEA)
negative regulation of cell population proliferation  (IEA)
negative regulation of cysteine-type endopeptidase activity  (ISO)
negative regulation of dermatome development  (IEA)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of epithelial cell proliferation  (IEA)
negative regulation of epithelial to mesenchymal transition  (IEA)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA)
negative regulation of gene expression  (IEA)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
negative regulation of JUN kinase activity  (ISO)
negative regulation of mesodermal cell fate specification  (IEA,ISO)
negative regulation of peptidyl-tyrosine phosphorylation  (ISO)
negative regulation of Wnt signaling pathway  (IEA)
neural tube closure  (IEA,ISO)
neural tube development  (IEA,ISO)
non-canonical Wnt signaling pathway  (IEA)
outflow tract morphogenesis  (IEA)
positive regulation of angiogenesis  (IEA)
positive regulation of apoptotic process  (IEA)
positive regulation of canonical Wnt signaling pathway  (IEA,ISO)
positive regulation of cell adhesion mediated by integrin  (ISO)
positive regulation of cell growth  (IEA)
positive regulation of cell population proliferation  (IEA)
positive regulation of endopeptidase activity  (ISO)
positive regulation of fat cell differentiation  (IEA,ISO)
positive regulation of osteoblast differentiation  (IEA,ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
post-anal tail morphogenesis  (IEA,ISO)
regulation of apoptotic process  (IEA,ISO)
regulation of cell population proliferation  (IEA,ISO)
regulation of establishment of planar polarity  (IEA,ISO)
regulation of midbrain dopaminergic neuron differentiation  (IEA)
regulation of neuron projection development  (IEA)
regulation of stem cell division  (IEA)
regulation of Wnt signaling pathway  (IEA)
response to nutrient  (ISO)
response to xenobiotic stimulus  (IEA)
sclerotome development  (IEA)
somitogenesis  (IEA,ISO)
stem cell fate specification  (IEA,ISO)
Wnt signaling pathway  (IEA)
Wnt signaling pathway involved in somitogenesis  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Sfrp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530138,934,030 - 38,942,739 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936576604,069 - 613,021 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936576604,174 - 612,440 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SFRP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384153,780,591 - 153,789,083 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4153,780,591 - 153,789,083 (-)EnsemblGRCh38hg38GRCh38
GRCh374154,701,743 - 154,710,235 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364154,921,192 - 154,929,678 (-)NCBINCBI36Build 36hg18NCBI36
Build 344155,059,346 - 155,067,833NCBI
Celera4152,026,238 - 152,034,728 (-)NCBICelera
Cytogenetic Map4q31.3NCBI
HuRef4150,432,908 - 150,441,398 (-)NCBIHuRef
CHM1_14154,680,045 - 154,688,529 (-)NCBICHM1_1
T2T-CHM13v2.04157,105,099 - 157,113,596 (-)NCBIT2T-CHM13v2.0
Sfrp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39383,673,628 - 83,681,621 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl383,673,628 - 83,681,623 (+)EnsemblGRCm39 Ensembl
GRCm38383,765,750 - 83,774,314 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl383,766,321 - 83,774,316 (+)EnsemblGRCm38mm10GRCm38
MGSCv37383,570,243 - 83,578,236 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36383,852,248 - 83,860,242 (+)NCBIMGSCv36mm8
Celera383,778,926 - 83,786,923 (+)NCBICelera
Cytogenetic Map3E3NCBI
cM Map337.37NCBI
Sfrp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82171,387,536 - 171,395,081 (+)NCBIGRCr8
mRatBN7.22169,089,517 - 169,097,064 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2169,089,517 - 169,097,063 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2176,277,331 - 176,284,893 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02174,297,265 - 174,304,827 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02168,898,730 - 168,906,293 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02182,723,732 - 182,731,277 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2182,723,854 - 182,731,764 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02202,136,233 - 202,143,778 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42175,479,320 - 175,486,865 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12175,435,856 - 175,436,574 (+)NCBI
Celera2163,105,875 - 163,113,424 (+)NCBICelera
Cytogenetic Map2q34NCBI
Sfrp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554718,103,783 - 8,112,321 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554718,103,937 - 8,112,596 (-)NCBIChiLan1.0ChiLan1.0
SFRP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23151,668,957 - 151,682,045 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14152,024,677 - 152,032,604 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04146,123,075 - 146,131,543 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14157,944,733 - 157,953,258 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4157,944,733 - 157,953,258 (-)Ensemblpanpan1.1panPan2
SFRP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11551,541,197 - 51,548,765 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1551,540,500 - 51,548,765 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1551,886,301 - 51,894,431 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01552,226,638 - 52,234,922 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1552,226,643 - 52,235,106 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11551,482,317 - 51,490,435 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01551,588,474 - 51,596,595 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01551,900,564 - 51,908,708 (-)NCBIUU_Cfam_GSD_1.0
SFRP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl875,337,144 - 75,345,921 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1875,337,311 - 75,345,926 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2879,743,347 - 79,751,962 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SFRP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17100,336,442 - 100,345,093 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7100,336,119 - 100,345,086 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603779,988,717 - 79,997,279 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sfrp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248585,052,518 - 5,061,591 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248585,052,736 - 5,061,495 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005330904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSTOT00000002338   ⟹   ENSSTOP00000002090
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936576604,069 - 613,021 (-)Ensembl
RefSeq Acc Id: XM_005330904   ⟹   XP_005330961
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530138,934,030 - 38,942,739 (+)NCBI
SpeTri2.0NW_004936576604,174 - 612,440 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005330961 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000002090.2
GenBank Protein KAG3276051 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005330961   ⟸   XM_005330904
- UniProtKB: I3M081 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000002090   ⟸   ENSSTOT00000002338
Protein Domains
FZ   NTR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000002344 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000002338.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.2000.10 UniProtKB/TrEMBL
  2.40.50.120 UniProtKB/TrEMBL
InterPro Frizzled/SFRP UniProtKB/TrEMBL
  Frizzled_dom UniProtKB/TrEMBL
  Frizzled_dom_sf UniProtKB/TrEMBL
  Netrin_domain UniProtKB/TrEMBL
  Netrin_module_non-TIMP UniProtKB/TrEMBL
  SFRP2_CRD UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/TrEMBL
NCBI Gene Sfrp2 ENTREZGENE
PANTHER PTHR11309 UniProtKB/TrEMBL
  SECRETED FRIZZLED-RELATED PROTEIN 1 UniProtKB/TrEMBL
Pfam NTR UniProtKB/TrEMBL
  PF01392 UniProtKB/TrEMBL
PROSITE NTR UniProtKB/TrEMBL
  PS50038 UniProtKB/TrEMBL
SMART C345C UniProtKB/TrEMBL
  FRI UniProtKB/TrEMBL
Superfamily-SCOP SSF50242 UniProtKB/TrEMBL
  SSF63501 UniProtKB/TrEMBL
UniProt I3M081 ENTREZGENE, UniProtKB/TrEMBL