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Gene: Mettl27 (methyltransferase like 27) Ictidomys tridecemlineatus

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Symbol:

Mettl27

Name:

methyltransferase like 27

RGD ID:

12693317

Description:

ENCODES a protein that exhibits S-adenosylmethionine-dependent methyltransferase activity (inferred); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); intestinal volvulus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

methyltransferase-like protein 27; Wbscr27; Williams Beuren syndrome chromosome region 27

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	131,043,461 - 131,047,540 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936543	2,989,013 - 2,993,117 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936543	2,989,027 - 2,993,087 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mettl27	Squirrel	autism spectrum disorder		ISO	METTL27 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Autism spectrum disorder	ClinVar	PMID:21658581 more ...
Mettl27	Squirrel	autistic disorder		ISO	METTL27 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Autism	ClinVar	PMID:21681106 and PMID:30208311
Mettl27	Squirrel	intestinal volvulus		ISO	METTL27 (Homo sapiens)	8554872	ClinVar Annotator: match by term: INTESTINAL MALROTATION and FAMILIAL	ClinVar	PMID:25741868
Mettl27	Squirrel	Neurodevelopmental Disorders		ISO	METTL27 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Neurodevelopmental disorder	ClinVar	PMID:25741868
Mettl27	Squirrel	pleomorphic xanthoastrocytoma		ISO	METTL27 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Pleomorphic xanthoastrocytoma	ClinVar	PMID:28299358
Mettl27	Squirrel	schizophrenia		ISO	METTL27 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Schizophrenia	ClinVar	PMID:21681106 and PMID:30208311
Mettl27	Squirrel	supravalvular aortic stenosis		ISO	METTL27 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Supravalvar aortic stenosis	ClinVar	PMID:10627943 more ...
Mettl27	Squirrel	Volvulus Of Midgut		ISO	METTL27 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Volvulus of midgut	ClinVar	PMID:25741868
Mettl27	Squirrel	Williams-Beuren syndrome		ISO	METTL27 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Williams syndrome	ClinVar	PMID:25741868

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mettl27	Squirrel	protein binding	enables	ISO	UniProtKB:Q92569	9068941	PMID:25814554	IntAct	PMID:25814554
Mettl27	Squirrel	protein binding	enables	ISO	UniProtKB:A5D8V6 more ...	9068941	PMID:32296183	IntAct	PMID:32296183
Mettl27	Squirrel	protein binding	enables	ISO	UniProtKB:O14645 more ...	9068941	PMID:32814053	IntAct	PMID:32814053
Mettl27	Squirrel	S-adenosylmethionine-dependent methyltransferase activity	enables	IEA	InterPro:IPR013216	150520179		InterPro	GO_REF:0000002

PMID:22301074

Mettl27
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	131,043,461 - 131,047,540 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936543	2,989,013 - 2,993,117 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936543	2,989,027 - 2,993,087 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

METTL27
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	73,834,590 - 73,842,516 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	73,834,590 - 73,842,516 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	73,248,920 - 73,256,846 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	72,886,856 - 72,894,791 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	72,693,574 - 72,701,506	NCBI
Celera	7	68,727,572 - 68,735,487 (-)	NCBI		Celera
Cytogenetic Map	7	q11.23	NCBI
HuRef	7	69,132,202 - 69,139,989 (-)	NCBI		HuRef
CHM1_1	7	73,394,299 - 73,402,246 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	75,035,482 - 75,043,363 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	72,581,992 - 72,589,927 (-)	NCBI

Mettl27
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	134,961,158 - 134,971,491 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	134,961,222 - 134,971,491 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	134,932,304 - 134,942,637 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	134,932,368 - 134,942,637 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	135,408,243 - 135,418,507 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	135,217,000 - 135,227,264 (+)	NCBI		MGSCv36	mm8
Celera	5	131,943,197 - 131,953,461 (+)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	74.89	NCBI

Mettl27
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	27,394,067 - 27,403,220 (-)	NCBI		GRCr8
mRatBN7.2	12	21,757,545 - 21,766,698 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	21,757,329 - 21,766,685 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	22,898,419 - 22,907,667 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	23,510,743 - 23,519,991 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	22,578,958 - 22,587,866 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	24,767,351 - 24,775,891 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	24,767,351 - 24,775,891 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	26,767,253 - 26,776,539 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	22,821,037 - 22,831,092 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	12	23,518,792 - 23,527,332 (-)	NCBI		Celera
Cytogenetic Map	12	q12	NCBI

Mettl27
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955456	13,956,294 - 13,960,213 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955456	13,955,257 - 13,959,758 (+)	NCBI	ChiLan1.0	ChiLan1.0

METTL27
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	91,059,631 - 91,068,296 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	139,324,263 - 139,331,414 (+)	NCBI		NHGRI_mPanPan1
PanPan1.1	7	80,987,124 - 80,992,344 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	80,987,370 - 80,992,344 (-)	Ensembl	panpan1.1		panPan2

METTL27
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	6,488,020 - 6,491,915 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	6,487,606 - 6,540,294 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	8,185,635 - 8,189,554 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	6,303,033 - 6,306,952 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	6,303,385 - 6,306,790 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	6,292,751 - 6,296,678 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	6,240,624 - 6,244,543 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	6,404,400 - 6,408,319 (+)	NCBI		UU_Cfam_GSD_1.0

METTL27
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	11,054,960 - 11,057,704 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	11,054,822 - 11,057,734 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	10,773,098 - 10,776,001 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

METTL27
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	9,234,974 - 9,240,296 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666070	7,267,227 - 7,272,871 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mettl27
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624740	14,027,930 - 14,032,058 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_021728589	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040277874	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010004404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000026351 ⟹ ENSSTOP00000017253

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936543	2,989,013 - 2,993,117 (-)	Ensembl

RefSeq Acc Id:

XM_021728589 ⟹ XP_021584264

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409344	131,043,461 - 131,047,540 (+)	NCBI
SpeTri2.0	NW_004936543	2,989,027 - 2,993,087 (-)	NCBI

Sequence:

show sequence

GCTGCCGGGCCCGCCCCGAGTTCCGGAGCCCTCTTACCCCTGACAGGTCAGTTTAGCGGAGGATGGCTCAGGAGAAGGGTGGGAACCTGTCCGAGGTACAAGCCCGGATTGGGGCCTCCCACAACATC
AAAGACCTGGACCGCAAGCTCCAATTCTATGGTCGCTGGGCTCCAGATTACGACCAGGATGTGGCTGCCCTGCAGTACCGAGCCCCCAGGCTTGCTGTGGACTGTCTCACTCAAGCCCTTCCAGGCCC
ACCCCATGATGCCCTGATCCTGGACGTTGCCTGTGGCACCGGCCTTGTAGCTGCGGAGCTGCAGGCTCGGGGCTTCCTCCAGCTGCATGGAGTGGATGGGAGCCCAGAGATGCTGGAACAGGCCCAGG
CCTGCGGCCTCTACCAGCACCTCAGCCTCTGTATCCTGGGTCAGGAGCCTCTGCCCAGCCCCGAAGGGACCTTTGACGCAGTGCTGATAGTGGGTGCCCTCAGTGATGGCCAGGTGCCCTGCAGTGCC
ATACCTGAGCTCCTGCGTGTCGCCAAGCCAGGTGGGCTGGTGTGCCTGACCACCAGGACCAACCCATCCAACCTGCAGTACAAGGAGGCACTGGAGGCCACCCTGGACAAGCTAGAGCAGGCTGGGGC
CTGGAAACGCCTGGTGGCCCAGACTGTTGACCAATGGGAGCTGGCCACCTCTCCACTTGAGGTGGCACCTGGAGCCAAGGATGGCTTCATCTCGGGCATCATCTACTTGTACCAAAAGCAGAGGTCTC
CCTGATGGAGGGAGTGAGGCCCAGTCACAGCTCTTAGCTGGCCTCTGAGCTTCCAAGTGACCTTAGCCAGGCCCGTCTTCTGGCCCTCTTTGCTCCATCTGTAAAATGGGACCATTGTATCAAACCTG
CCCCTTAAGAATGTTCTGCCTATTAAATGAACTCCCAGAAGTAA

hide sequence

RefSeq Acc Id:

XM_040277874 ⟹ XP_040133808

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409344	131,043,461 - 131,047,540 (+)	NCBI


Protein RefSeqs	XP_021584264	(Get FASTA)	NCBI Sequence Viewer
	XP_040133808	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000017253.2
GenBank Protein	KAG3259792	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_021584264 ⟸ XM_021728589
- Peptide Label:	isoform X1
- UniProtKB:	I3MYQ7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAQEKGGNLSEVQARIGASHNIKDLDRKLQFYGRWAPDYDQDVAALQYRAPRLAVDCLTQALPGPPHDALILDVACGTGLVAAELQARGFLQLHGVDGSPEMLEQAQACGLYQHLSLCILGQEPLPSP EGTFDAVLIVGALSDGQVPCSAIPELLRVAKPGGLVCLTTRTNPSNLQYKEALEATLDKLEQAGAWKRLVAQTVDQWELATSPLEVAPGAKDGFISGIIYLYQKQRSP hide sequence

RefSeq Acc Id:	XP_040133808 ⟸ XM_040277874
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSSTOP00000017253 ⟸ ENSSTOT00000026351

Protein Domains

Methyltransferase type

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000021502	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000026351.2	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.150	UniProtKB/TrEMBL
InterPro	Methyltransf_11	UniProtKB/TrEMBL
	SAM-dependent_MTases	UniProtKB/TrEMBL
NCBI Gene	Wbscr27	ENTREZGENE
PANTHER	METHYLTRANSFERASE	UniProtKB/TrEMBL
	METHYLTRANSFERASE-LIKE PROTEIN 27	UniProtKB/TrEMBL
Pfam	Methyltransf_11	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53335	UniProtKB/TrEMBL
UniProt	I3MYQ7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-03-28	Mettl27	methyltransferase like 27	Wbscr27	Williams Beuren syndrome chromosome region 27	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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Imported Disease Annotations - ClinVar