Msh6<sup>m1Hubr</sup> (mutS homolog 6; ENU induced mutant 1, Hubr) - Rat Genome Database

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Gene: Msh6m1Hubr (mutS homolog 6; ENU induced mutant 1, Hubr) Rattus norvegicus
Symbol: Msh6m1Hubr
Name: mutS homolog 6; ENU induced mutant 1, Hubr
RGD ID: 126848738
Description: The Msh6 knockout allele was generated by ENU-driven mutagenesis on Crl:WI rats. The allele carried an ENU-induced premature stop codon in exon 4 of the Msh6 gene.
ASSOCIATED WITH increased tumor incidence; premature death; ASSOCIATED WITH hereditary nonpolyposis colorectal cancer type 5; Microsatellite Instability
Type: allele  of Msh6  
Previously known as: Msh6^[m1Hubr]
Is Marker For: Strains:   WI- Msh6m1Hubr  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. Lack of DNA mismatch repair protein MSH6 in the rat results in hereditary non-polyposis colorectal cancer-like tumorigenesis. van Boxtel R, etal., Carcinogenesis. 2008 Apr 15;.


Related Rat Strains
The following Strains have been annotated to Msh6m1Hubr



Nucleotide Sequences

Additional Information