Dock5 (dedicator of cytokinesis 5) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Dock5 (dedicator of cytokinesis 5) Ictidomys tridecemlineatus
Analyze
Symbol: Dock5
Name: dedicator of cytokinesis 5
RGD ID: 12668699
Description: ENCODES a protein that exhibits GTPase activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); small GTPase binding (inferred); INVOLVED IN bone remodeling (ortholog); podosome assembly (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease type 2E (ortholog); prostate cancer (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dedicator of cytokinesis protein 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494310,038,136 - 10,219,086 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367571,289,954 - 1,576,984 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367571,289,941 - 1,419,257 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Dock5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494310,038,136 - 10,219,086 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367571,289,954 - 1,576,984 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367571,289,941 - 1,419,257 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DOCK5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38825,184,689 - 25,415,711 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl825,184,689 - 25,418,082 (+)EnsemblGRCh38hg38GRCh38
GRCh37825,042,204 - 25,273,227 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36825,098,204 - 25,326,536 (+)NCBINCBI36Build 36hg18NCBI36
Build 34825,098,203 - 25,326,535NCBI
Celera824,006,779 - 24,231,488 (+)NCBICelera
Cytogenetic Map8p21.2NCBI
HuRef823,646,114 - 23,815,584 (+)NCBIHuRef
CHM1_1825,243,660 - 25,472,059 (+)NCBICHM1_1
T2T-CHM13v2.0825,463,647 - 25,690,937 (+)NCBIT2T-CHM13v2.0
Dock5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391467,989,377 - 68,171,021 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1467,989,584 - 68,170,891 (-)EnsemblGRCm39 Ensembl
GRCm381467,751,928 - 67,933,572 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1467,752,135 - 67,933,442 (-)EnsemblGRCm38mm10GRCm38
MGSCv371468,369,985 - 68,551,629 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361466,705,258 - 66,886,902 (-)NCBIMGSCv36mm8
Celera1465,509,536 - 65,693,300 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.66NCBI
Dock5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81546,155,124 - 46,334,127 (-)NCBIGRCr8
mRatBN7.21541,979,728 - 42,158,733 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1541,979,729 - 42,158,649 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1543,844,391 - 44,023,294 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01544,994,614 - 45,173,520 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01543,439,945 - 43,618,862 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01544,449,108 - 44,627,774 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1544,453,308 - 44,627,765 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01546,969,497 - 47,148,088 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41547,313,859 - 47,491,774 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11547,330,683 - 47,462,329 (-)NCBI
Celera1541,643,960 - 41,822,851 (-)NCBICelera
Cytogenetic Map15p12NCBI
Dock5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540348,146,084 - 48,338,218 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540348,146,616 - 48,338,218 (+)NCBIChiLan1.0ChiLan1.0
DOCK5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2743,723,728 - 43,956,881 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1819,438,094 - 19,671,268 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0824,463,582 - 24,696,736 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1821,372,756 - 21,605,877 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl821,372,756 - 21,605,877 (+)Ensemblpanpan1.1panPan2
DOCK5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12532,046,165 - 32,257,011 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2532,046,527 - 32,283,658 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2532,630,797 - 32,841,994 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02532,245,463 - 32,457,029 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2532,248,523 - 32,457,282 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12532,201,136 - 32,412,574 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02532,050,626 - 32,261,933 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02532,216,436 - 32,428,154 (-)NCBIUU_Cfam_GSD_1.0
DOCK5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl149,197,293 - 9,436,249 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1149,197,280 - 9,438,715 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21410,412,335 - 10,593,481 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DOCK5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1823,310,524 - 23,540,174 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl823,310,673 - 23,540,478 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605218,627,353 - 18,861,082 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dock5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475820,255,062 - 20,440,370 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475820,255,036 - 20,444,194 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_013365008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSTOT00000008770   ⟹   ENSSTOP00000007861
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049367571,293,571 - 1,576,984 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000034953   ⟹   ENSSTOP00000025406
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049367571,289,954 - 1,419,307 (-)Ensembl
RefSeq Acc Id: XM_013365008   ⟹   XP_013220462
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494310,038,136 - 10,219,086 (-)NCBI
SpeTri2.0NW_0049367571,289,941 - 1,419,257 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013220462 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000007861.3
  ENSSTOP00000025406.1
GenBank Protein KAG3294351 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_013220462   ⟸   XM_013365008
- UniProtKB: A0A287CVV4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000007861   ⟸   ENSSTOT00000008770
Ensembl Acc Id: ENSSTOP00000025406   ⟸   ENSSTOT00000034953
Protein Domains
C2 DOCK-type   DOCKER   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000008718 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000008770.3 UniProtKB/TrEMBL
  ENSSTOT00000034953.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.350 UniProtKB/TrEMBL
  1.20.58.740 UniProtKB/TrEMBL
  1.25.40.410 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  C2_DOCK-type_domain UniProtKB/TrEMBL
  C2_DOCKER_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  DOCK UniProtKB/TrEMBL
  DOCK5 UniProtKB/TrEMBL
  DOCK_C_lobe_A UniProtKB/TrEMBL
  DOCK_C_lobe_C UniProtKB/TrEMBL
  DOCK_N UniProtKB/TrEMBL
  DOCK_N_sub1 UniProtKB/TrEMBL
  DOCKER_Lobe_A UniProtKB/TrEMBL
  DOCKER_Lobe_B UniProtKB/TrEMBL
  DOCKER_Lobe_C UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
NCBI Gene Dock5 ENTREZGENE
PANTHER PTHR45653 UniProtKB/TrEMBL
  PTHR45653:SF3 UniProtKB/TrEMBL
Pfam DHR-2 UniProtKB/TrEMBL
  DHR-2_Lobe_B UniProtKB/TrEMBL
  DHR-2_Lobe_C UniProtKB/TrEMBL
  DOCK-C2 UniProtKB/TrEMBL
  DOCK_N UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PROSITE C2_DOCK UniProtKB/TrEMBL
  DOCKER UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
UniProt A0A287CVV4 ENTREZGENE, UniProtKB/TrEMBL
  I3MC94_ICTTR UniProtKB/TrEMBL