Hmga1 (high mobility group AT-hook 1) - Rat Genome Database

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Gene: Hmga1 (high mobility group AT-hook 1) Ictidomys tridecemlineatus
Analyze
Symbol: Hmga1
Name: high mobility group AT-hook 1
RGD ID: 12640174
Description: ENCODES a protein that exhibits 5'-deoxyribose-5-phosphate lyase activity (ortholog); DNA binding, bending (ortholog); DNA-(apurinic or apyrimidinic site) endonuclease activity (ortholog); INVOLVED IN autophagy (ortholog); B cell differentiation (ortholog); base-excision repair (ortholog); PARTICIPATES IN interleukin-4 signaling pathway; ASSOCIATED WITH hyperglycemia (ortholog); Insulin Resistance (ortholog); leiomyosarcoma (ortholog); FOUND IN cytoplasm (ortholog); mitochondrion (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: high mobility group protein HMG-I/HMG-Y
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494639,156,880 - 39,164,376 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647624,795,877 - 24,801,567 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647624,795,854 - 24,803,138 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagy  (IEA,ISO)
B cell differentiation  (IEA,ISO)
base-excision repair  (ISO)
cell population proliferation  (IEA,ISO)
chromatin organization  (IEA,ISO)
erythrocyte differentiation  (IEA,ISO)
gene expression  (IEA,ISO)
glucose homeostasis  (IEA,ISO)
heart development  (IEA,ISO)
inflammatory cell apoptotic process  (IEA,ISO)
inflammatory response  (IEA,ISO)
insulin receptor signaling pathway  (IEA,ISO)
insulin secretion  (IEA,ISO)
lung morphogenesis  (IEA,ISO)
lymphoid progenitor cell differentiation  (IEA,ISO)
multicellular organism growth  (IEA,ISO)
negative regulation of cell population proliferation  (IEA)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
neurogenesis  (IEA,ISO)
oncogene-induced cell senescence  (IEA)
peroxisome proliferator activated receptor signaling pathway  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of macromolecule biosynthetic process  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
regulation of DNA-templated transcription  (IEA)
regulation of gene expression  (IEA)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
respiratory system process  (IEA,ISO)
response to cAMP  (IEA,ISO)
response to glucagon  (IEA,ISO)
response to glucose  (IEA,ISO)
response to insulin  (IEA,ISO)
response to wounding  (IEA,ISO)
spermatogenesis  (IEA,ISO)
T cell differentiation  (IEA,ISO)
thyroid gland development  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Hmga1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494639,156,880 - 39,164,376 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647624,795,877 - 24,801,567 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647624,795,854 - 24,803,138 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HMGA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38634,236,873 - 34,246,231 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl634,236,873 - 34,246,231 (+)EnsemblGRCh38hg38GRCh38
GRCh37634,204,650 - 34,214,008 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36634,312,628 - 34,321,986 (+)NCBINCBI36Build 36hg18NCBI36
Build 34634,314,545 - 34,321,986NCBI
Celera635,758,945 - 35,768,381 (+)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef633,927,318 - 33,936,673 (+)NCBIHuRef
CHM1_1634,207,231 - 34,216,597 (+)NCBICHM1_1
T2T-CHM13v2.0634,060,576 - 34,069,936 (+)NCBIT2T-CHM13v2.0
Hmga1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391727,774,798 - 27,782,649 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1727,775,471 - 27,782,648 (+)EnsemblGRCm39 Ensembl
GRCm381727,556,574 - 27,563,672 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1727,556,497 - 27,563,674 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,762,794 - 120,764,419 (+)EnsemblGRCm38mm10GRCm38
MGSCv371727,693,519 - 27,700,617 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361727,284,171 - 27,291,260 (+)NCBIMGSCv36mm8
Celera1728,108,639 - 28,115,776 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1714.5NCBI
Hmga1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8205,612,902 - 5,620,596 (+)NCBIGRCr8
mRatBN7.2205,611,088 - 5,618,755 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl205,611,694 - 5,618,752 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx206,327,117 - 6,330,067 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0205,688,869 - 5,691,819 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0206,169,005 - 6,171,956 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0207,132,501 - 7,140,155 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl207,136,007 - 7,138,980 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0209,334,866 - 9,342,510 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,769,052 - 5,772,269 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1205,769,278 - 5,772,496 (+)NCBI
Celera207,177,471 - 7,180,533 (+)NCBICelera
Cytogenetic Map20p12NCBI
Hmga1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554372,478,414 - 2,486,809 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554372,478,414 - 2,486,809 (+)NCBIChiLan1.0ChiLan1.0
HMGA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2548,712,783 - 48,722,294 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1644,580,061 - 44,589,567 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0633,807,171 - 33,816,603 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1634,914,923 - 34,920,482 (+)NCBIpanpan1.1PanPan1.1panPan2
HMGA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1123,528,818 - 3,538,533 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl123,533,102 - 3,538,533 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha123,544,725 - 3,554,094 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0123,865,251 - 3,874,712 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl123,865,303 - 3,888,352 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1123,527,697 - 3,537,024 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0123,609,068 - 3,618,412 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0123,707,513 - 3,716,880 (+)NCBIUU_Cfam_GSD_1.0
HMGA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl730,320,410 - 30,329,408 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1730,320,090 - 30,329,413 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2734,981,570 - 34,990,089 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7q11NCBI
HMGA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11737,848,110 - 37,857,835 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1737,849,412 - 37,853,880 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604434,150,889 - 34,160,977 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hmga1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475422,892,226 - 22,898,807 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475422,888,052 - 22,900,685 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000016562   ⟹   ENSSTOP00000014822
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647624,795,877 - 24,801,567 (-)Ensembl
RefSeq Acc Id: XM_005318796   ⟹   XP_005318853
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494639,157,095 - 39,164,376 (+)NCBI
SpeTri2.0NW_00493647624,795,854 - 24,803,136 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005318798   ⟹   XP_005318855
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494639,156,880 - 39,164,376 (+)NCBI
SpeTri2.0NW_00493647624,795,854 - 24,803,138 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005318853 (Get FASTA)   NCBI Sequence Viewer  
  XP_005318855 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000014822.2
RefSeq Acc Id: XP_005318855   ⟸   XM_005318798
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005318853   ⟸   XM_005318796
- Peptide Label: isoform X1
- UniProtKB: I3MRS7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000014822   ⟸   ENSSTOT00000016562


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000016559 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000016562.3 UniProtKB/TrEMBL
InterPro AT_hook_DNA-bd_motif UniProtKB/TrEMBL
  HMGA UniProtKB/TrEMBL
  HMGI/Y_DNA-bd_CS UniProtKB/TrEMBL
NCBI Gene Hmga1 ENTREZGENE
PANTHER HIGH MOBILITY GROUP PROTEIN HMG-I/HMG-Y UniProtKB/TrEMBL
  HIGH MOBILITY GROUP PROTEINS HMG-A AND C UniProtKB/TrEMBL
PRINTS ATHOOK UniProtKB/TrEMBL
  HIGHMOBLTYIY UniProtKB/TrEMBL
PROSITE HMGI_Y UniProtKB/TrEMBL
SMART AT_hook UniProtKB/TrEMBL
UniProt I3MRS7 ENTREZGENE, UniProtKB/TrEMBL