Npffr2 (neuropeptide FF receptor 2)

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Gene: Npffr2 (neuropeptide FF receptor 2) Ictidomys tridecemlineatus

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Symbol:

Npffr2

Name:

neuropeptide FF receptor 2

RGD ID:

12554909

Description:

ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); neuropeptide receptor activity (inferred); opioid receptor binding (inferred); INVOLVED IN cellular response to hormone stimulus (inferred); G protein-coupled receptor signaling pathway (inferred); neuropeptide signaling pathway (inferred); FOUND IN plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

neuropeptide FF receptor 2, transcript variant X1; neuropeptide FF receptor 2, transcript variant X2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	14,540,862 - 14,612,269 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936598	2,992,780 - 3,003,355 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936598	2,993,845 - 3,063,891 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to hormone stimulus (IEA)

G protein-coupled receptor signaling pathway (IEA)

neuropeptide signaling pathway (IEA)

regulation of MAPK cascade (IEA)

Cellular Component

actin cytoskeleton (IEA)

membrane (IEA)

plasma membrane (IEA,ISO)

Molecular Function

G protein-coupled receptor activity (IEA)

neuropeptide receptor activity (IEA)

opioid receptor binding (IEA)

peptide binding (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Npffr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	14,540,862 - 14,612,269 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936598	2,992,780 - 3,003,355 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936598	2,993,845 - 3,063,891 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NPFFR2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	72,032,000 - 72,148,305 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	72,031,902 - 72,148,305 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	72,897,717 - 73,014,022 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	73,116,385 - 73,232,642 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	73,270,125 - 73,378,813	NCBI
Celera	4	70,253,879 - 70,369,821 (+)	NCBI		Celera
Cytogenetic Map	4	q13.3	NCBI
HuRef	4	68,702,459 - 68,818,720 (+)	NCBI		HuRef
CHM1_1	4	72,933,070 - 73,049,409 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	75,374,029 - 75,490,284 (+)	NCBI		T2T-CHM13v2.0

Npffr2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	89,674,805 - 89,731,473 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	89,675,288 - 89,731,599 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	89,526,840 - 89,583,914 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	89,527,429 - 89,583,740 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	89,956,454 - 90,012,765 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	90,602,628 - 90,658,939 (+)	NCBI		MGSCv36	mm8
Celera	5	87,701,454 - 87,717,464 (+)	NCBI		Celera
Cytogenetic Map	5	E1	NCBI
cM Map	5	44.32	NCBI

Npffr2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	18,794,868 - 18,842,186 (-)	NCBI		GRCr8
mRatBN7.2	14	18,513,120 - 18,558,074 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	18,513,277 - 18,521,919 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	18,503,730 - 18,512,373 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	19,822,615 - 19,831,258 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	18,537,009 - 18,545,776 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	20,148,485 - 20,193,577 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	20,148,913 - 20,193,083 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	20,054,945 - 20,099,540 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	20,041,856 - 20,050,499 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	20,041,855 - 20,050,499 (-)	NCBI
Celera	14	17,879,584 - 17,888,229 (-)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

Npffr2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955447	1,112,854 - 1,205,322 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955447	1,112,856 - 1,205,051 (-)	NCBI	ChiLan1.0	ChiLan1.0

NPFFR2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	57,930,645 - 58,049,684 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	58,128,207 - 58,246,527 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	52,073,462 - 52,189,443 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	58,393,065 - 58,412,577 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	58,393,065 - 58,508,526 (-)	Ensembl	panpan1.1		panPan2

NPFFR2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	61,140,285 - 61,164,966 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	61,148,828 - 61,164,811 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	60,874,074 - 60,899,431 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	61,950,541 - 61,973,894 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	61,958,652 - 61,973,971 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	61,558,985 - 61,584,534 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	61,050,028 - 61,073,505 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	62,198,644 - 62,224,209 (+)	NCBI		UU_Cfam_GSD_1.0

NPFFR2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	68,572,578 - 68,643,756 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	68,572,164 - 68,643,394 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	72,528,102 - 72,559,432 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NPFFR2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	20,552,443 - 20,664,818 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	20,646,369 - 20,664,578 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666084	2,149,982 - 2,168,443 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Npffr2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624890	3,562,775 - 3,581,448 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005333258	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021731649	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040292320	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040292321	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040292322	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000344	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000026464 ⟹ ENSSTOP00000014924

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936598	2,992,780 - 3,003,355 (-)	Ensembl

RefSeq Acc Id:

XM_005333258 ⟹ XP_005333315

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405285	14,540,862 - 14,612,268 (-)	NCBI
SpeTri2.0	NW_004936598	2,993,845 - 3,063,891 (-)	NCBI

Sequence:

show sequence

GTCTGGCGCCGGCGGCTGCGGCTGAGCAGCCCAAAGACAAGAAGTACCGGCACCAGACTGGGGA
CATAACCTGTTGCTGAAGGCGGGTTTGGTGGTTTCTGTTTCCAGAGGCTGCCAGGGGTCTGTTC
TGCCCTTCGCGATGAGCATGTCCATCATGAGTGAGAAATGGGACTCAAACTCTTCAGAAAACTG
GTATCACATCTGGAGTGTCAATGACACACAGCATCACCTGTATTCAAACAGTAGTATTACCTAT
GTGAACTACTATCTTCACCATCCTCAAGTGGCAGCAATCTTCATTATTTCCTACTTTCTGATCT
TCTTCCTGTGCATGGTGGGAAATTCCGTGGTTTGCTTTATTGTTATGAGGAATAAACACATGCA
TACTGTCACTAATCTCTTCATCTTAAACCTGGCAATAAGCGATTTACTGGTTGGCATATTCTGT
ATGCCCATAACACTGCTGGACAATATTATAGCAGGATGGCCATTTGGAAATACAATGTGCAAGA
TCAGTGGATTGGTCCAGGGAATATCAGTTGCAGCTTCAGTCTTTACTTTAGTAGCTATAGCAGT
GGATAGATTCCGGTGTGTTGTCCACCCTTTTAAACCAAAGCTCACTATCAAGACAGCATTTGTC
ATTATTGTGATCATCTGGGTCCTGGCCATCGCCATTATGTCTCCATCTGCAGTAATGTTACACG
TACAAGAAGAGAAATATTACCAAGTGAGAATCAACTCTCAGAATAAAACCAGTCCAGTCTACTG
GTGCCGGGAGGACTGGCCACATCAGGAAATGAGGAAGATCTACACCACTGTGCTCTTCACTACC
ATCTATCTGGCTCCCCTATCCCTCATTGTCATCATGTACGGAAGGATTGGGATTTCGCTCTTTA
AGTCTGCAGTGCCTCATACAGGCAAGCAGAGCCAGGAGCAATGGCATGTGGTATCCAAAAAAAA
GCAGAAGGTCATCAAGATGCTCCTGACCGTGGCTCTGCTTTTCATTCTCTCCTGGCTACCCCTA
TGGACTTTGATGATGCTCTCAGACTATGTTGACCTCTCTCCAAATGTACTGCGGATCATCAACA
TCTACATCTACCCTTTTGCACACTGGCTGGCCTTCTGCAACAGCAGTGTCAACCCCATTATATA
TGGTTTCTTCAATGAGAATTTCCGCCGTGGTTTCCAAGATGCTTTCCAGCTCCAGGTCTGCTGG
AAAAGAGGAAAGCCCCAGGAAGCCTATGTCCTAAGAGCTAGAAACAATGTGCTCATAAACACAA
CTGCTCAGCTCGCCCGGGAACCTGAATTTCAAAACCCACACGGGGAAAATTTGCTTTATGGAAA
AAGTGCTGAAAACCCCCAAAAGGAATTAGCAATGGAAGAATTGGGAAAAGCTCCCAAGAGTAAT
GAGATGTAAGACTCGGTGTGATAATACAAACTTTAACGTGTGTTATATATGTAAACACTGTTGC
TTTTTGTGGCTTTGTACTGTAATTCTAAGGCACTAAAGAAAATATTTACTGAAAGCCCTCTCTG
GCAAAAAATAAAAAATGTAAACAAAATAATCAAGTGGTATATAAAATATGTACAGTGACTCACA
GATTTGCCTGAATAAATCTGATTCTAAGAAACAGTT

hide sequence

RefSeq Acc Id:

XM_040292320 ⟹ XP_040148254

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405285	14,540,862 - 14,612,268 (-)	NCBI

RefSeq Acc Id:

XM_040292321 ⟹ XP_040148255

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405285	14,540,862 - 14,612,268 (-)	NCBI

RefSeq Acc Id:

XM_040292322 ⟹ XP_040148256

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405285	14,540,862 - 14,612,269 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_005333315	(Get FASTA)	NCBI Sequence Viewer
	XP_040148254	(Get FASTA)	NCBI Sequence Viewer
	XP_040148255	(Get FASTA)	NCBI Sequence Viewer
	XP_040148256	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000014924.1
GenBank Protein	KAG3276452	(Get FASTA)	NCBI Sequence Viewer
	KAG3276453	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005333315 ⟸ XM_005333258

- Peptide Label:

isoform X2

- Sequence:

show sequence

MSMSIMSEKWDSNSSENWYHIWSVNDTQHHLYSNSSITYVNYYLHHPQVAAIFIISYFLIFFLC
MVGNSVVCFIVMRNKHMHTVTNLFILNLAISDLLVGIFCMPITLLDNIIAGWPFGNTMCKISGL
VQGISVAASVFTLVAIAVDRFRCVVHPFKPKLTIKTAFVIIVIIWVLAIAIMSPSAVMLHVQEE
KYYQVRINSQNKTSPVYWCREDWPHQEMRKIYTTVLFTTIYLAPLSLIVIMYGRIGISLFKSAV
PHTGKQSQEQWHVVSKKKQKVIKMLLTVALLFILSWLPLWTLMMLSDYVDLSPNVLRIINIYIY
PFAHWLAFCNSSVNPIIYGFFNENFRRGFQDAFQLQVCWKRGKPQEAYVLRARNNVLINTTAQL
AREPEFQNPHGENLLYGKSAENPQKELAMEELGKAPKSNEM

hide sequence

RefSeq Acc Id:	XP_040148256 ⟸ XM_040292322
- Peptide Label:	isoform X3
- UniProtKB:	I3MS29 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_040148255 ⟸ XM_040292321
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_040148254 ⟸ XM_040292320
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSSTOP00000014924 ⟸ ENSSTOT00000026464

Protein Domains

G-protein coupled receptors family 1 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000025504	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000026464.2	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
	NPFF_rcpt	UniProtKB/TrEMBL
	NPFF_rcpt_2	UniProtKB/TrEMBL
NCBI Gene	Npffr2	ENTREZGENE
PANTHER	NEUROPEPTIDE FF RECEPTOR 2	UniProtKB/TrEMBL
	NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PRINTS	GPCRRHODOPSN	UniProtKB/TrEMBL
	NPFFRECEPTOR	UniProtKB/TrEMBL
	NPFFRECEPTR2	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
SMART	7TM_GPCR_Srsx	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	I3MS29	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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