Dennd4c (DENN domain containing 4C) - Rat Genome Database

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Gene: Dennd4c (DENN domain containing 4C) Ictidomys tridecemlineatus
Analyze
Symbol: Dennd4c
Name: DENN domain containing 4C
RGD ID: 12554833
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN cellular response to insulin stimulus (inferred); protein localization to plasma membrane (inferred); regulation of Rab protein signal transduction (inferred); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; FOUND IN cytoplasm (inferred); cytoplasmic vesicle (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DENN domain-containing protein 4C
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947153,479,598 - 153,581,391 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366521,149,099 - 1,250,921 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366521,149,106 - 1,250,571 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Dennd4c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947153,479,598 - 153,581,391 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366521,149,099 - 1,250,921 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366521,149,106 - 1,250,571 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DENND4C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38919,230,513 - 19,374,281 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl919,230,435 - 19,374,281 (+)EnsemblGRCh38hg38GRCh38
GRCh37919,230,511 - 19,374,279 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36919,280,749 - 19,364,139 (+)NCBINCBI36Build 36hg18NCBI36
Build 34919,288,065 - 19,362,856NCBI
Celera919,216,854 - 19,300,236 (+)NCBICelera
Cytogenetic Map9p22.1NCBI
HuRef919,192,829 - 19,335,696 (+)NCBIHuRef
CHM1_1919,230,600 - 19,373,937 (+)NCBICHM1_1
T2T-CHM13v2.0919,243,303 - 19,387,084 (+)NCBIT2T-CHM13v2.0
Dennd4c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39486,666,761 - 86,768,841 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl486,666,792 - 86,768,840 (+)EnsemblGRCm39 Ensembl
GRCm38486,748,518 - 86,850,603 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl486,748,555 - 86,850,603 (+)EnsemblGRCm38mm10GRCm38
MGSCv37486,394,459 - 86,476,071 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36486,219,786 - 86,321,834 (+)NCBIMGSCv36mm8
Celera485,265,548 - 85,350,171 (+)NCBICelera
Cytogenetic Map4C4NCBI
cM Map440.69NCBI
Dennd4c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85106,316,942 - 106,421,484 (+)NCBIGRCr8
mRatBN7.25101,272,298 - 101,369,529 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5101,272,005 - 101,368,118 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.05105,100,081 - 105,195,634 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5105,114,433 - 105,193,988 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05109,085,833 - 109,182,502 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45106,090,415 - 106,162,420 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15106,090,717 - 106,167,026 (+)NCBI
Celera5101,714,237 - 101,809,916 (-)NCBICelera
Cytogenetic Map5q32NCBI
Dennd4c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543421,639,986 - 21,740,842 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543421,640,068 - 21,740,842 (+)NCBIChiLan1.0ChiLan1.0
DENND4C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211105,172,746 - 105,309,405 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19105,178,690 - 105,315,282 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0919,046,857 - 19,183,364 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1919,537,938 - 19,672,299 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl919,537,997 - 19,672,299 (+)Ensemblpanpan1.1panPan2
DENND4C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11139,035,241 - 39,161,135 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1139,072,944 - 39,159,611 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1137,693,992 - 37,818,852 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01139,968,568 - 40,094,556 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1139,968,663 - 40,093,014 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11138,661,590 - 38,786,923 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01138,456,479 - 38,584,445 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01139,093,527 - 39,218,421 (+)NCBIUU_Cfam_GSD_1.0
DENND4C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1203,449,835 - 203,601,292 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11203,449,832 - 203,601,298 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21227,100,329 - 227,251,158 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DENND4C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11260,359,979 - 60,499,631 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1260,361,914 - 60,499,713 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603848,473,266 - 48,616,996 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dennd4c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473623,233,444 - 23,326,780 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473623,206,686 - 23,328,391 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000025867   ⟹   ENSSTOP00000019519
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366521,149,099 - 1,250,921 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000028664   ⟹   ENSSTOP00000016845
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366521,164,404 - 1,249,420 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000038260   ⟹   ENSSTOP00000027024
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366521,216,217 - 1,250,921 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000042816   ⟹   ENSSTOP00000026415
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366521,149,099 - 1,250,921 (+)Ensembl
RefSeq Acc Id: XM_013363189   ⟹   XP_013218643
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947153,479,598 - 153,581,391 (+)NCBI
SpeTri2.0NW_0049366521,149,111 - 1,250,571 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021733685   ⟹   XP_021589360
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947153,504,812 - 153,581,391 (+)NCBI
SpeTri2.0NW_0049366521,173,764 - 1,249,808 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021733686   ⟹   XP_021589361
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947153,479,598 - 153,566,687 (+)NCBI
SpeTri2.0NW_0049366521,149,106 - 1,236,083 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040285841   ⟹   XP_040141775
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947153,479,598 - 153,581,391 (+)NCBI
RefSeq Acc Id: XM_040285842   ⟹   XP_040141776
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947153,479,598 - 153,581,391 (+)NCBI
RefSeq Acc Id: XM_040285843   ⟹   XP_040141777
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947153,479,598 - 153,581,391 (+)NCBI
RefSeq Acc Id: XP_013218643   ⟸   XM_013363189
- Peptide Label: isoform X1
- UniProtKB: I3N573 (UniProtKB/TrEMBL),   A0A287CYK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021589361   ⟸   XM_021733686
- Peptide Label: isoform X4
- UniProtKB: A0A287CYK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021589360   ⟸   XM_021733685
- Peptide Label: isoform X3
- UniProtKB: A0A287CYK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040141775   ⟸   XM_040285841
- Peptide Label: isoform X1
- UniProtKB: I3N573 (UniProtKB/TrEMBL),   A0A287CYK0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040141776   ⟸   XM_040285842
- Peptide Label: isoform X2
- UniProtKB: I3MXK0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040141777   ⟸   XM_040285843
- Peptide Label: isoform X5
Ensembl Acc Id: ENSSTOP00000016845   ⟸   ENSSTOT00000028664
Ensembl Acc Id: ENSSTOP00000019519   ⟸   ENSSTOT00000025867
Ensembl Acc Id: ENSSTOP00000026415   ⟸   ENSSTOT00000042816
Ensembl Acc Id: ENSSTOP00000027024   ⟸   ENSSTOT00000038260
Protein Domains
MABP   uDENN


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000025059 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000025867.2 UniProtKB/TrEMBL
  ENSSTOT00000028664.2 UniProtKB/TrEMBL
  ENSSTOT00000038260.1 UniProtKB/TrEMBL
  ENSSTOT00000042816.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
  2.100.10.50 UniProtKB/TrEMBL
  3.40.50.11500 UniProtKB/TrEMBL
InterPro cDENN_dom UniProtKB/TrEMBL
  dDENN_dom UniProtKB/TrEMBL
  DENN_C UniProtKB/TrEMBL
  DENN_Domain_GEFs UniProtKB/TrEMBL
  MABP UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/TrEMBL
  Tripartite_DENN UniProtKB/TrEMBL
  uDENN_dom UniProtKB/TrEMBL
NCBI Gene Dennd4c ENTREZGENE
PANTHER DENN DOMAIN-CONTAINING PROTEIN 4 UniProtKB/TrEMBL
  DENN DOMAIN-CONTAINING PROTEIN 4C UniProtKB/TrEMBL
Pfam dDENN UniProtKB/TrEMBL
  DENN UniProtKB/TrEMBL
  uDENN UniProtKB/TrEMBL
PROSITE DENN UniProtKB/TrEMBL
  MABP UniProtKB/TrEMBL
SMART dDENN UniProtKB/TrEMBL
  DENN UniProtKB/TrEMBL
  uDENN UniProtKB/TrEMBL
UniProt A0A287CYK0 ENTREZGENE, UniProtKB/TrEMBL
  A0A287D0G6_ICTTR UniProtKB/TrEMBL
  I3MXK0 ENTREZGENE, UniProtKB/TrEMBL
  I3N573 ENTREZGENE, UniProtKB/TrEMBL