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Gene: Wnt8b (Wnt family member 8B) Ictidomys tridecemlineatus

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Symbol:

Wnt8b

Name:

Wnt family member 8B

RGD ID:

12533274

Description:

ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); receptor ligand activity (inferred); INVOLVED IN gene expression (ortholog); negative regulation of gene expression (ortholog); positive regulation of gene expression (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Hirschsprung's disease (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	33,560,758 - 33,584,103 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936600	5,163,972 - 5,187,224 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936600	5,163,940 - 5,187,098 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Hirschsprung's disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

canonical Wnt signaling pathway (IEA)

cell fate commitment (IEA)

gene expression (ISO)

negative regulation of gene expression (ISO)

neuron differentiation (IEA)

positive regulation of gene expression (ISO)

Wnt signaling pathway (IEA)

Cellular Component

extracellular region (IEA)

extracellular space (IEA)

Molecular Function

cytokine activity (IEA)

frizzled binding (IEA)

receptor ligand activity (IEA)

signaling receptor binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

Wnt signaling pathway (ISO)

Wnt signaling, canonical pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Wnt8b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	33,560,758 - 33,584,103 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936600	5,163,972 - 5,187,224 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936600	5,163,940 - 5,187,098 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

WNT8B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	100,463,009 - 100,483,744 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	100,463,009 - 100,483,744 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	102,222,766 - 102,243,501 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	102,212,802 - 102,233,389 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	102,212,787 - 102,233,491	NCBI
Celera	10	95,960,656 - 95,981,247 (+)	NCBI		Celera
Cytogenetic Map	10	q24.31	NCBI
HuRef	10	95,851,649 - 95,872,259 (+)	NCBI		HuRef
CHM1_1	10	102,507,449 - 102,528,036 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	101,346,091 - 101,366,850 (+)	NCBI		T2T-CHM13v2.0

Wnt8b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	44,481,912 - 44,502,712 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	44,481,911 - 44,502,712 (+)	Ensembl		GRCm39 Ensembl
GRCm38	19	44,493,472 - 44,514,273 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	44,493,472 - 44,514,273 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	44,567,962 - 44,588,763 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	44,546,784 - 44,565,828 (+)	NCBI		MGSCv36	mm8
Celera	19	45,276,759 - 45,282,000 (+)	NCBI		Celera
Cytogenetic Map	19	C3	NCBI
cM Map	19	37.98	NCBI

Wnt8b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	253,303,369 - 253,325,224 (+)	NCBI		GRCr8
mRatBN7.2	1	243,354,145 - 243,376,000 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	243,354,086 - 243,374,286 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	251,515,855 - 251,519,653 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	258,216,947 - 258,220,745 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	250,866,030 - 250,869,828 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	264,244,150 - 264,266,136 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	264,260,505 - 264,264,302 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	271,686,942 - 271,707,512 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	249,559,236 - 249,563,033 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	249,743,064 - 249,822,688 (+)	NCBI
Celera	1	239,184,707 - 239,188,504 (+)	NCBI		Celera
Cytogenetic Map	1	q54	NCBI

Wnt8b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955485	9,658,432 - 9,679,385 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955485	9,658,432 - 9,679,371 (-)	NCBI	ChiLan1.0	ChiLan1.0

WNT8B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	112,347,018 - 112,367,626 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	112,352,338 - 112,372,946 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	97,079,996 - 97,083,933 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	100,550,158 - 100,565,369 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	100,544,531 - 100,565,369 (+)	Ensembl	panpan1.1		panPan2

WNT8B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	13,187,927 - 13,210,398 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	13,188,142 - 13,210,398 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	13,358,682 - 13,383,539 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	13,656,897 - 13,681,768 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	13,657,358 - 13,679,572 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	13,203,326 - 13,228,261 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	13,241,826 - 13,266,719 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	13,375,944 - 13,400,875 (+)	NCBI		UU_Cfam_GSD_1.0

WNT8B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	111,562,489 - 111,589,893 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	111,562,278 - 111,589,897 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	63,953,354 - 63,981,516 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

WNT8B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	93,478,569 - 93,504,279 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	93,479,392 - 93,501,835 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	54,535,855 - 54,544,499 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Wnt8b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624831	129,252 - 148,553 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624831	139,884 - 149,135 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005333684	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010002273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000025448 ⟹ ENSSTOP00000018208

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936600	5,163,972 - 5,187,224 (-)	Ensembl

RefSeq Acc Id:

XM_005333684 ⟹ XP_005333741

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	33,560,758 - 33,584,103 (-)	NCBI
SpeTri2.0	NW_004936600	5,163,940 - 5,187,098 (-)	NCBI

Sequence:

show sequence

CCACTGAGGAGAATACTTCCTCAACTTACTACCCTGTCTCCCAATTTTTCCGAATTTCCTTTCT
CTTTACTCAGAGGATTATGTTTCTCATGAAGCCTTCTGTGTGCATCTTCCTTTTCACCTGTGTC
TTCCAACTCAGCCACACCTGGTCAGTAAACAATTTCCTGATGACTGGTCCAAAAGCTTACCTGA
TCTACTCCAGCAGTGTGGCAGCAGGTGCTCAGAGTGGTATTGAAGAATGCAAATACCAGTTTGC
CTGGGACCGCTGGAACTGCCCTGAGAGAGCCTTGCAACTTTCCAGCCATGGTGGACTTCGAAGT
GCTAATCGGGAGACAGCATTTGTACATGCCATCAGTTCTGCTGGAGTCATGTACACTCTGACCA
GAAACTGCAGCCTTGGAGATTTTGACAACTGTGGATGTGATGACTCCCGCAATGGGCAACTGGG
GGGTCAAGGTTGGCTGTGGGGAGGCTGCAGCGACAACGTGGGCTTCGGAGAGGCAATCTCCAAG
CAGTTTGTGGATGCCCTGGAAACAGGACAGGATGCCCGGGCAGCCATGAATCTTCATAATAACG
AGGCCGGCCGTAAGGCGGTGAAGGGCACCATGAAACGCACGTGTAAGTGCCACGGCGTGTCTGG
CAGCTGCACCACACAGACCTGCTGGCTGCAGCTGCCTGAGTTCCGCGAGGTGGGCGCGCACCTG
AAGGAGAAATACCACGCCGCTCTCAAGGTGGACCTACTGCAGGGTGCTGGCAACAGCGCTGCCG
GCCGCGGCGCCATCGCCGACACCTTCCGCTCCATCTCCACCAGGGAGCTGGTGCACCTGGAGGA
CTCCCCAGACTACTGCTTGGAGAACAAGACGCTAGGGCTGCTGGGCACTGAAGGCCGGGAATGC
CTGCGGCGCGGGCGGGCTCTGGGCCGCTGGGAGCGCCGCAGCTGCCGCCGTCTGTGCGGGGATT
GTGGGCTGGCGGTGGAGGAGCGCCGCGCGGAAACCGTGTCCAGCTGTAACTGCAAGTTCCACTG
GTGCTGTGCTGTCCGCTGTGAGCAGTGCCGCCGGCGGGTCACCAAGTACTTCTGTAGCCGCGCA
GAGCGGCCGCGGGGAGGCGCTGCGCACAAACCCGGGAGAAAATCCTAAGGGTCTCCTCTCCTGC
CTCCTTTCCCAATTTGTCCTTGGCTTCGTTTAGCGACCCCAGTAATAGAGGAACCTAGGAATTG
GGGACCCCGCACTCCCAAGTCCAGAGATCCTGAGAAGGAGAGGATGCAATCTTTCTGGAGCTTG
CCACTTCCCTAACGTTTCCCCAATTTCTCTGTGCTCTCCTAGAATTGGTTCTGCGTCTCCTCAC
AGCCCACACTTTGGTGTGAGACTGCGCTATTGGTCTTCCTTGGACTAGGGTGAAAAATAGGCGC
TCCTCCCCGACCCCACCTCCCAACTGGCCTAAGCCTGACTAAGACTTGGGAACTAGAAGGACCC
TTCTCAGACATGGAGGGCTCAGGTAAAGCCATGTCTTTTTCTCTTGCCCATTGTCTGCTACCAA
GCCTGATGGCAGGGGCATTCCCTTCCTGCAGAGCCCATCCCGATCTTGCAACTTCCTGCTATTG
ACCCAGATACTCCCAGGAATCTCTAACACTTTCTCTTTCCTTCCCCTTTTCCCCTTCCTCTGAA
AACAAAACAAAACAAAAAAACTGACCTGGGAATAAATGTACCTTAGGGACTGGTCCCTAGAGGA
AGAAGTAGAATATGGTGTAAAAGGGAACTTGACTTGCTAAACACCAGGGTGGTACTTCTTGTGA
CACCATGTCACCAATGGACTTTACCAGTGAGGTAACTGTCTTCCTAGATGATCACCCAAGGTAC
TCCAGAATTATACCCAAGAGGTCAAGAAACTATGTAAACACAGATTACTGTTATTTCCTTCCCT
TCAAAGTTATCTTCTCCCTGCTCCTAACCTATTTCTTCCCTGAAAACTTCACCTTTTTTCCTTT
CCAAAGCTTTGTTCCTCTGAGCCAAAACTGAGGTAAATAAAGGCAATTTCCCATTCGGACCCTG
TCTGCACCTCTAAAGGCAGGCCATAGGAAGAAGCAGAGCCCCTTCCTTTCACTCACCTGGTTCT
CCAACAGGCAGAGTTCAGGGCATTGGATACTTTCCTTCAATAAGTAAACTTCCTGCAATGAAAC
TGTTGCTAATAGGAAGTTCAGCACCTTGAACTTTAATTTATTTCAATCATTATGATATGTGCCT
CATTTCCTGAGTACTGAGCTTCTTCTTGGGGATACTGGGGTAGGGTGGGGTAGAAGATATAACT
TTAAGACTCTTATTTTCTTCCCACCATGGCAGGATACTGTTTTCCCTAGAAACTTGCTTCCTTG
ATAGCCTAGTAGCTAGCCTAACTTGATTGAGGCTAATCTTTTGAGGATTAGTAAATCATCCACA
TAAACCTTCCACTAATACAGTCACTCCATAGCCAAAAGCTTGCTGCTTGTGGTACTTGAGTCTT
TTTGGTTCCATTTTCAGAGAGAAGCATTCCGCATGAACTTGTTTATGAAACAGAGCTCTTGGGA
ATGAAGAGCCAATTCCTTACAGTCCTTCTGTAGCCCCAAGAGCTTCCCAGCCTGCTTTCTTGCC
CTGGGCCAGTCCGGGTCTAGACACCAGGCAGCTCTTCCAGAGTAGAACTGGTCATATGCTAGAC
TTATCCCTTTTCTTCCAAAGCAGGAAAAAGTGCAGAGGTCACAAAATCCAAGGCTCTGGAAAAA
TAGAAGGGCTCTTATACTCCAAACTGAGACAGTGGCCAAATCAGACCCAGGCCCTAGTCTCACC
CCTACATCTTCTGGTCTGACTAATACTTACTGGAAGAGAAGTTCCCTTTCCTCCTTACCAGGGG
GATACACTTCCCTTCAGGGTTTCTTAATGCTTAATTTCCAGCTTTATCAGCAAAAGGCCCTTTG
CTTGTTTTCTCAGCTCTTGGGCCTCCTGGGTCTCCCAAGCCACTCTTCTTTTCTAATCAAGCAG
CAGCATATACTAACCTAGTTGTCTCATTTGGCAGAGTTACTTGTGATAGGAAGAAAATCTGGCA
AGGCGACTAGAAAATTTAAAAGTAAATGTTGTAAAGTAAAGCTGTACTCTCCCAGAGGTCTTCC
AACATAAGAGAACTATTGTGCTTCAAATTGGTGACAACAGGTCAGCACTCCAAACATGTTATGC
TGCCAGGAAGTTCTTTCATAGATTATTGTTTTGTATCCCCAGATAGATATGATTGATACCAGAA
TGATTTGAGTTTTATAAAGAAAACATTGTTGAGCTATCTTAGATCTGCATTGCTTTTTTTAACC
CCTTTTTCATTATTC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005333741	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000018208.2
GenBank Protein	KAG3264280	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005333741 ⟸ XM_005333684

- UniProtKB:

I3N1G2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MFLMKPSVCIFLFTCVFQLSHTWSVNNFLMTGPKAYLIYSSSVAAGAQSGIEECKYQFAWDRWN
CPERALQLSSHGGLRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNGQLGGQGWL
WGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQ
TCWLQLPEFREVGAHLKEKYHAALKVDLLQGAGNSAAGRGAIADTFRSISTRELVHLEDSPDYC
LENKTLGLLGTEGRECLRRGRALGRWERRSCRRLCGDCGLAVEERRAETVSSCNCKFHWCCAVR
CEQCRRRVTKYFCSRAERPRGGAAHKPGRKS

hide sequence

Ensembl Acc Id:

ENSSTOP00000018208 ⟸ ENSSTOT00000025448

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000022425	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000025448.2	UniProtKB/TrEMBL
Gene3D-CATH	3.30.2460.20	UniProtKB/TrEMBL
InterPro	Wnt	UniProtKB/TrEMBL
	Wnt8	UniProtKB/TrEMBL
	Wnt_C	UniProtKB/TrEMBL
	Wnt_CS	UniProtKB/TrEMBL
NCBI Gene	Wnt8b	ENTREZGENE
PANTHER	PTHR12027	UniProtKB/TrEMBL
	PTHR12027:SF94	UniProtKB/TrEMBL
Pfam	wnt	UniProtKB/TrEMBL
PRINTS	WNT8PROTEIN	UniProtKB/TrEMBL
	WNTPROTEIN	UniProtKB/TrEMBL
PROSITE	WNT1	UniProtKB/TrEMBL
SMART	WNT1	UniProtKB/TrEMBL
UniProt	I3N1G2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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RGD Manual Annotations