Tln2 (talin 2) - Rat Genome Database

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Gene: Tln2 (talin 2) Ictidomys tridecemlineatus
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Symbol: Tln2
Name: talin 2
RGD ID: 12493796
Description: ENCODES a protein that exhibits actin filament binding (inferred); integrin binding (inferred); structural constituent of cytoskeleton (inferred); INVOLVED IN actin cytoskeleton organization (inferred); cell adhesion (inferred); cell-cell adhesion (inferred); PARTICIPATES IN integrin mediated signaling pathway; ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); hypertrophic cardiomyopathy (ortholog); FOUND IN fascia adherens (ortholog); presynapse (ortholog); synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: talin 2, transcript variant X1; talin 2, transcript variant X2; talin 2, transcript variant X3; talin 2, transcript variant X4; talin 2, transcript variant X5; talin-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640105,225,660 - 105,631,223 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647123,135,006 - 23,479,288 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647123,073,267 - 23,479,286 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tln2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640105,225,660 - 105,631,223 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647123,135,006 - 23,479,288 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647123,073,267 - 23,479,286 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381562,390,550 - 62,844,631 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1562,390,526 - 62,844,631 (+)EnsemblGRCh38hg38GRCh38
GRCh371562,682,749 - 63,136,830 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361560,726,802 - 60,923,883 (+)NCBINCBI36Build 36hg18NCBI36
Build 341560,726,801 - 60,920,733NCBI
Celera1539,819,286 - 40,016,441 (+)NCBICelera
Cytogenetic Map15q22.2NCBI
HuRef1539,762,354 - 39,959,569 (+)NCBIHuRef
CHM1_11563,058,568 - 63,256,014 (+)NCBICHM1_1
T2T-CHM13v2.01560,194,145 - 60,648,431 (+)NCBIT2T-CHM13v2.0
Tln2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39967,124,371 - 67,541,357 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl967,124,369 - 67,466,985 (-)EnsemblGRCm39 Ensembl
GRCm38967,217,085 - 67,634,045 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl967,217,087 - 67,559,703 (-)EnsemblGRCm38mm10GRCm38
MGSCv37967,064,892 - 67,407,510 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36967,017,280 - 67,338,759 (-)NCBIMGSCv36mm8
MGSCv36967,820,018 - 68,028,925 (-)NCBIMGSCv36mm8
Celera964,440,386 - 64,782,550 (-)NCBICelera
Cytogenetic Map9CNCBI
cM Map936.39NCBI
Tln2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8876,712,112 - 77,133,361 (-)NCBIGRCr8
mRatBN7.2867,830,920 - 68,252,240 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl867,834,326 - 68,252,219 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0873,009,980 - 73,441,536 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl873,014,137 - 73,194,837 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0877,342,736 - 77,771,053 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4871,532,270 - 71,964,142 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera873,455,547 - 73,874,934 (+)NCBICelera
Cytogenetic Map8q24NCBI
Tln2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545012,394,377 - 12,728,925 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545012,391,049 - 12,740,232 (-)NCBIChiLan1.0ChiLan1.0
TLN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21651,638,537 - 52,092,397 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11555,814,626 - 56,268,524 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01541,337,084 - 41,790,949 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11559,635,488 - 60,088,662 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1559,892,920 - 60,088,414 (+)Ensemblpanpan1.1panPan2
TLN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13027,023,731 - 27,452,575 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3027,257,948 - 27,449,267 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3026,939,212 - 27,366,590 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03027,192,437 - 27,619,533 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3027,192,442 - 27,616,357 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13027,129,804 - 27,556,957 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03027,191,240 - 27,619,171 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03027,434,199 - 27,862,607 (+)NCBIUU_Cfam_GSD_1.0
TLN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1109,208,672 - 109,584,727 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11109,208,663 - 109,680,663 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21120,431,291 - 120,698,794 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12620,688,048 - 21,140,585 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2620,691,779 - 20,940,450 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048120,250,091 - 120,703,945 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tln2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247819,623,413 - 9,965,960 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247819,626,031 - 10,030,427 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000014850   ⟹   ENSSTOP00000013301
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647123,135,006 - 23,475,521 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000031102   ⟹   ENSSTOP00000030396
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647123,296,776 - 23,479,288 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000042156   ⟹   ENSSTOP00000031258
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647123,296,776 - 23,470,588 (+)Ensembl
RefSeq Acc Id: XM_005316644   ⟹   XP_005316701
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640105,225,660 - 105,631,223 (+)NCBI
SpeTri2.0NW_00493647123,073,784 - 23,479,286 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021727180   ⟹   XP_021582855
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640105,225,660 - 105,631,223 (+)NCBI
SpeTri2.0NW_00493647123,073,784 - 23,479,286 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040275958   ⟹   XP_040131892
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640105,225,660 - 105,631,223 (+)NCBI
RefSeq Acc Id: XM_040275959   ⟹   XP_040131893
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640105,225,660 - 105,631,223 (+)NCBI
RefSeq Acc Id: XP_005316701   ⟸   XM_005316644
- Peptide Label: isoform X2
- UniProtKB: I3MNP2 (UniProtKB/TrEMBL),   A0A287DCJ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021582855   ⟸   XM_021727180
- Peptide Label: isoform X1
- UniProtKB: A0A287DCJ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040131893   ⟸   XM_040275959
- Peptide Label: isoform X3
- UniProtKB: A0A287DCJ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040131892   ⟸   XM_040275958
- Peptide Label: isoform X1
- UniProtKB: A0A287DCJ1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000030396   ⟸   ENSSTOT00000031102
Ensembl Acc Id: ENSSTOP00000031258   ⟸   ENSSTOT00000042156
Ensembl Acc Id: ENSSTOP00000013301   ⟸   ENSSTOT00000014850
Protein Domains
FERM   I/LWEQ


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000014824 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000014850.3 UniProtKB/TrEMBL
  ENSSTOT00000031102.1 UniProtKB/TrEMBL
  ENSSTOT00000042156.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.80.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  Alpha-catenin/vinculin-like UniProtKB/TrEMBL
  I/LWEQ domain UniProtKB/TrEMBL
  Talin, central domain UniProtKB/TrEMBL
InterPro Alpha-catenin/vinculin-like_sf UniProtKB/TrEMBL
  Band_41_domain UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_sf UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  FERM_CS UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  FERM_f0 UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
  I/LWEQ_dom_sf UniProtKB/TrEMBL
  ILWEQ_dom UniProtKB/TrEMBL
  IRS_PTB UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  Talin1/2-RS UniProtKB/TrEMBL
  Talin_cent UniProtKB/TrEMBL
  Talin_cent_sf UniProtKB/TrEMBL
  Talin_IBS2B UniProtKB/TrEMBL
  Talin_R4 UniProtKB/TrEMBL
  TLN1-like_RS UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
  Vinculin-bd_dom UniProtKB/TrEMBL
NCBI Gene Tln2 ENTREZGENE
PANTHER TALIN UniProtKB/TrEMBL
  TALIN-2 UniProtKB/TrEMBL
Pfam FERM_f0 UniProtKB/TrEMBL
  FERM_M UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
  I_LWEQ UniProtKB/TrEMBL
  IRS UniProtKB/TrEMBL
  Talin_IBS2B UniProtKB/TrEMBL
  Talin_middle UniProtKB/TrEMBL
  Talin_R4 UniProtKB/TrEMBL
  TLN1-like_RS UniProtKB/TrEMBL
  VBS UniProtKB/TrEMBL
PROSITE FERM_2 UniProtKB/TrEMBL
  FERM_3 UniProtKB/TrEMBL
  I_LWEQ UniProtKB/TrEMBL
SMART B41 UniProtKB/TrEMBL
  ILWEQ UniProtKB/TrEMBL
  IRS UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF109880 UniProtKB/TrEMBL
  SSF109885 UniProtKB/TrEMBL
  SSF47031 UniProtKB/TrEMBL
  SSF47220 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A287DCJ1 ENTREZGENE, UniProtKB/TrEMBL
  I3MNP2 ENTREZGENE, UniProtKB/TrEMBL