Plvap (plasmalemma vesicle associated protein)

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Gene: Plvap (plasmalemma vesicle associated protein) Ictidomys tridecemlineatus

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Symbol:

Plvap

Name:

plasmalemma vesicle associated protein

RGD ID:

12489009

Description:

ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN developmental process (ortholog); ASSOCIATED WITH DIARRHEA 10, PROTEIN-LOSING ENTEROPATHY TYPE (ortholog); genetic disease (ortholog); hepatocellular carcinoma (ortholog); FOUND IN caveola (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC101967593

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	203,962,082 - 203,974,049 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936596	3,511,185 - 3,523,252 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936596	3,511,235 - 3,523,164 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

DIARRHEA 10, PROTEIN-LOSING ENTEROPATHY TYPE (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

developmental process (ISO)

MAPK cascade (IEA)

positive regulation of cellular extravasation (IEA)

regulation of vascular permeability (IEA)

tumor necrosis factor-mediated signaling pathway (IEA)

Cellular Component

caveola (IEA,ISO)

cell surface (IEA)

membrane (IEA)

Molecular Function

identical protein binding (ISO)

protein binding (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Plvap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	203,962,082 - 203,974,049 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936596	3,511,185 - 3,523,252 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936596	3,511,235 - 3,523,164 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PLVAP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	17,351,455 - 17,377,342 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	17,351,450 - 17,377,342 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	17,462,264 - 17,488,151 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	17,323,264 - 17,349,137 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	17,323,263 - 17,349,137	NCBI
Celera	19	17,364,020 - 17,389,889 (-)	NCBI		Celera
Cytogenetic Map	19	p13.11	NCBI
HuRef	19	17,028,734 - 17,054,390 (-)	NCBI		HuRef
CHM1_1	19	17,461,538 - 17,487,419 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	17,486,174 - 17,512,068 (-)	NCBI		T2T-CHM13v2.0

Plvap
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	71,950,397 - 71,964,446 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	71,950,409 - 71,964,396 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	71,497,753 - 71,511,806 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	71,497,765 - 71,511,752 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	74,021,652 - 74,035,668 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	74,426,754 - 74,440,720 (-)	NCBI		MGSCv36	mm8
Celera	8	74,008,038 - 74,022,136 (-)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI
cM Map	8	34.43	NCBI

Plvap
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	18,218,966 - 18,231,279 (-)	NCBI		GRCr8
mRatBN7.2	16	18,184,985 - 18,197,301 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	18,184,975 - 18,197,301 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	18,236,033 - 18,248,378 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	493,274 - 505,606 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	18,288,971 - 18,301,316 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	19,906,354 - 19,918,668 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	19,906,318 - 19,918,689 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	19,767,918 - 19,780,232 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	18,668,569 - 18,678,431 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	18,668,567 - 18,678,429 (-)	NCBI
Celera	16	18,389,929 - 18,402,243 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

Plvap
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955524	885,276 - 893,044 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955524	885,245 - 895,552 (+)	NCBI	ChiLan1.0	ChiLan1.0

PLVAP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	22,223,244 - 22,247,509 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	21,229,863 - 21,254,093 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	16,840,151 - 16,864,334 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	17,813,665 - 17,838,331 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	17,814,574 - 17,838,271 (-)	Ensembl	panpan1.1		panPan2

PLVAP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	45,405,295 - 45,417,093 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	45,351,091 - 45,416,477 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	45,318,243 - 45,330,053 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	45,891,523 - 45,903,334 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	45,891,427 - 45,903,330 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	45,128,088 - 45,139,885 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	45,538,005 - 45,549,803 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	45,813,549 - 45,825,406 (+)	NCBI		UU_Cfam_GSD_1.0

PLVAP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	60,324,560 - 60,344,443 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	60,324,565 - 60,344,450 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

PLVAP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	15,857,945 - 15,879,022 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	15,857,947 - 15,879,058 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666074	3,561,081 - 3,583,720 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Plvap
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624908	601,687 - 614,975 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624908	602,388 - 613,445 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005333013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000012252 ⟹ ENSSTOP00000010982

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936596	3,511,185 - 3,523,252 (+)	Ensembl

RefSeq Acc Id:

XM_005333013 ⟹ XP_005333070

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405118	203,962,082 - 203,974,049 (+)	NCBI
SpeTri2.0	NW_004936596	3,511,235 - 3,523,164 (+)	NCBI

Sequence:

show sequence

CGGGCGGCAGCGGGCGGGAGCGGGCAGTGCAGGGCAGGAGCATGGGTCTGGCCATGGAGCACCG
CGGGGCCTACTCCCGGGCGGGGGACAGTCCCCGGGGCTGCTGGTATTACCTGCGCTACTTTTTC
CTCTTCGTCTCGCTCATCCAGTTCCTCATCATCCTGGGCCTGGTCCTCTTCATGGTCTACGGCA
ACGTGCACTTGAGCACCGAGTCCAACCTGCAGGCCACCGAGCGCCGCGCCGAGAGCCTGTACAG
CCAGGTCGTGGGGCTGTCGGCCGCCCAGGTCAACCTGTCCAAGGAGCTCAACATCACGGCGCGC
ACCAAGGACAACATCATGCAGATGCTGCTCAGCGCCCGCCGCGAGCTGGAGCGCATCAATGCCA
GCTTCCGCCAGTGCCAGAGTGAGCGGGCCGTCTACATCAGCAGGGAGAAATACATAGTGGCCAT
CATCCTGAGCGAGCAGGAGTGCCAGGAGCAGCTGAAACAGGCCAACAAGTCCTGCAACGCCTTG
CTCTACGTGTGGGACCAGAAGGCCAAGGCCCTGGAGATGGAGCTGGCCAAGGAGAAGGTGGTGT
GTGCCCAGGACAAGGAGGGCCTGCTGGCCAGCAAGCGAGCGGCGGAGCAGCAGCTGGTGGCCTG
CAACCAGGTGCGCGAGCAGCAGCAGCAGGAGCGGCAGCTGGCCCAGGACCGGCTGCAGAAGGTG
CAGGCCCTCTGCCTCCCGCTGGACAAGGACAAGTTCGAGATGGACCTGCGCAACCTGTGGAAGG
ACTCCATCGTCTCCCGCAGCCTGGAGACCTTGGGCTACAACATGGGCTACCCCATGATCTCACA
TTCGGATGTGATCTCCATCCGGAGAACCTGCGACCAGATGCCCAGCATCATGAGCACCAAGGTG
GAGGAGCTGGCCCGGAGCCTGCGGGCCGGCATCGAGCGCGTGGCCCGCGAGAACTCGGACCTCC
AGCGCCAGAAGCTGGAGGCCGAGCAGAGCCTGCGAGCCAGTCAGGAGGCCAAGGAGCAGGCGGA
GAAGGAGGCCCGGGCCCGCGAGGCCAAGATCCAAGCCGGATGCACCCAGCAGGTGCAGCTGGCC
CTGGAGGAGAAGGCGGTGCTGCGGAGGGAGAGGGACAACCTGGCCAAGGAGCTGGCAGAGAAGA
AGCGAGAGGTGGAGCAGCTGAAGATGCAGATGGACGTCAGAATCTCGGCCCTGGACACCTGTCT
CAAGGCCAAGTCACAGTCGATCCCCCTTCCAAGACCGGTGGGCCCTGTCCCCCAGCCCCAGCCC
CAGCCCATCGACCCAGCGAGCCTAGAGGAGTTCAAGAAGAGGATCCTGGAATCCCAGCGGTCCC
CTGCAGGCAACCCTGCAGTCCTGTCCAGTGGCTGAGGACGGTGGCCCGAGGAGTGAGGGGCGGG
CGCCCAGCTTGCCCGCCCGCCTGCCGACAGCGCAGAAGGACACTCGCATCCAGGGCCCAGGCCC
AGCAGCCAGGAGGCCCCCCTCACCTGCTCCAATCGCCTCTCCCAGCCCCACACCGCACCCCACA
ACCCCTCACCCCTAGACACGGTGATGAGGTCACCCACAGCTGCAGCCACGATGTCAGAAAGCCA
GGGACAATGTTCCCCTGGAAGTCCATGGCAACATCATACACAGAAGCAGCCATGTCACACAGAC
ACATGGAGGGAGGGTGTCACAGAGAGCAATCACTGCACACAGTGACAAAGCCACACACCTATGC
AGCACCCACATTACACTCACTTTATACTCACTTTCTGCCCTACTCCAGGGGCCAAGGCACCACA
GTGTCACCCTGCGTTCTGCACAGCCCTGTGTCCCACCATCCCCTCCTCCAACTTCCTTATCTCC
CAGCGCCTGGACCAGGAGGTGAGAACAGGAAGCCATTCACCTCCAACCCTTTGAGAGTTTCCAG
GCTCCCTTGAGAGTTTCTAGGCGCACCTCCTGGAGAGTTTCCAGGCTCCCCTTGTGAGGGAGAG
CCTGGTCCAGGGGTGGGGGTCCAGTGCGGAGAGCATCCCCTTCCCTCCCACCCCCTCCCCACCC
AGCCCTGCCTGTG

hide sequence

Protein Sequences


Protein RefSeqs	XP_005333070	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000010982.3
GenBank Protein	KAG3279964	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005333070 ⟸ XM_005333013

- UniProtKB:

I3MIT7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGLAMEHRGAYSRAGDSPRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHLSTESNLQATE
RRAESLYSQVVGLSAAQVNLSKELNITARTKDNIMQMLLSARRELERINASFRQCQSERAVYIS
REKYIVAIILSEQECQEQLKQANKSCNALLYVWDQKAKALEMELAKEKVVCAQDKEGLLASKRA
AEQQLVACNQVREQQQQERQLAQDRLQKVQALCLPLDKDKFEMDLRNLWKDSIVSRSLETLGYN
MGYPMISHSDVISIRRTCDQMPSIMSTKVEELARSLRAGIERVARENSDLQRQKLEAEQSLRAS
QEAKEQAEKEARAREAKIQAGCTQQVQLALEEKAVLRRERDNLAKELAEKKREVEQLKMQMDVR
ISALDTCLKAKSQSIPLPRPVGPVPQPQPQPIDPASLEEFKKRILESQRSPAGNPAVLSSG

hide sequence

Ensembl Acc Id:

ENSSTOP00000010982 ⟸ ENSSTOT00000012252

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000012250	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000012252.3	UniProtKB/TrEMBL
InterPro	PV-1	UniProtKB/TrEMBL
NCBI Gene	Plvap	ENTREZGENE
PANTHER	PLASMALEMMA VESICLE-ASSOCIATED PROTEIN	UniProtKB/TrEMBL
	PTHR21687	UniProtKB/TrEMBL
Pfam	PV-1	UniProtKB/TrEMBL
UniProt	I3MIT7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-08-09	Plvap	plasmalemma vesicle associated protein	LOC101967593	plasmalemma vesicle associated protein	Symbol and/or name change	5135510	APPROVED
2021-03-26	LOC101967593	plasmalemma vesicle associated protein	Plvap	plasmalemma vesicle associated protein	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM