LOC101969737 (procathepsin L) - Rat Genome Database

Name: LOC101969737
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: LOC101969737 (procathepsin L) Ictidomys tridecemlineatus

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Symbol:

LOC101969737 (Ensembl: CTSV)

Name:

procathepsin L (Ensembl:cathepsin V)

RGD ID:

12461198

Description:

ENCODES a protein that exhibits cysteine-type peptidase activity (inferred); INVOLVED IN proteolysis (inferred); ASSOCIATED WITH intellectual disability (ortholog); FOUND IN lysosome (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cathepsin L2; cathepsin V; Ctsv

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	6,474,523 - 6,479,682 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936487	688,893 - 696,180 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936487	690,826 - 696,099 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

intellectual disability (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

proteolysis (IEA)

Cellular Component

lysosome (IEA)

Molecular Function

cysteine-type peptidase activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

LOC101969737
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	6,474,523 - 6,479,682 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936487	688,893 - 696,180 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936487	690,826 - 696,099 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CTSV
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	97,029,677 - 97,039,643 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	97,029,677 - 97,156,556 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	99,791,959 - 99,801,925 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	98,834,758 - 98,841,360 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	96,874,491 - 96,881,094	NCBI
Celera	9	70,309,232 - 70,315,833 (-)	NCBI		Celera
Cytogenetic Map	9	q22.33	NCBI
HuRef	9	69,392,607 - 69,402,573 (-)	NCBI		HuRef
CHM1_1	9	99,938,916 - 99,948,882 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	109,201,457 - 109,211,423 (-)	NCBI		T2T-CHM13v2.0

Ctsv
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	23,722,034 - 23,728,134 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	23,722,899 - 23,728,426 (+)	NCBI	ChiLan1.0	ChiLan1.0

CTSV
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	42,419,131 - 42,426,254 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	42,421,507 - 42,434,520 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	68,119,453 - 68,129,522 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	96,240,690 - 96,249,708 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	96,240,690 - 96,249,708 (-)	Ensembl	panpan1.1		panPan2

CTSV
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	69,937,550 - 69,943,316 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	70,700,498 - 70,706,262 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	70,236,635 - 70,242,398 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	70,237,060 - 70,245,613 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
ROS_Cfam_1.0 Ensembl	X	40,978,098 - 40,979,498 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	70,050,639 - 70,056,394 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	69,816,647 - 69,822,414 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	70,524,416 - 70,530,174 (+)	NCBI		UU_Cfam_GSD_1.0

CTSV
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	25,202,389 - 25,209,210 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	25,202,360 - 25,208,058 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	76,997,800 - 77,003,497 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CTSV
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	106,282,990 - 106,289,486 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	106,283,147 - 106,291,033 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	94,670,039 - 94,676,543 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005320857	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000007833 ⟹ ENSSTOP00000007010

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936487	688,893 - 696,180 (-)	Ensembl

RefSeq Acc Id:

XM_005320857 ⟹ XP_005320914

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404944	6,474,523 - 6,479,682 (-)	NCBI
SpeTri2.0	NW_004936487	690,826 - 696,099 (-)	NCBI

Sequence:

show sequence

TTAAAGTCCGAGACAGGCCCGCTGGGCCAGATGCTCGGACCTCGGCGACCTCTGGGGAGCTGCG
TGTGCGGAGTGCGCCTGCGCAGCTGCGGCCGCCCAGGTTTCTGAACCATGAATCTCCCACTCTT
CCTGGCTGCCCTTTGCTTGGGAATAGCCTCAGCTATTCCAAAATTTGATCAAAACTTAGATACA
CAGTGGTACCAGTGGAAGGCCACACACAAGAGACTATATGGCATGAATGAAGAAGGATGGAGGC
GAGCGGTGTGGGAGAAGAACATGAGGATGATCGAGCAGCACAATGGGGAGTACAGCCAGGGGAA
GCATGGTTTCACCATGGCCATGAATGCCTTCGGGGACATGACCAATGAAGAATTCAAACAGCTG
AAGAATGGCTTTAAAATCCAGAAGTACCGGCGCCAGGGGAAAGTGTTTCGGGAACCTCTGCTGT
TTGGGAGCCCCAAATCTGTGGATTGGAGAGAAAAGGGCTACGTGACTCCCGTGAAGAACCAGGG
TCAGTGTGGTTCCTGTTGGGCATTTAGCGCAACTGGATCCCTGGAAGGACAGATGTTCCGGAAA
ACTGGCAAACTTATCTCGCTGAGTGAGCAGAACCTTGTTGACTGCTCTCGGCCTCAAGGCAATT
TGGGCTGTGATGGCGGGCTGATGGATAATGCCTTCCAGTACATCAAGGACAACGGAGGCCTGGA
CTCAGAGGATTCCTATCCTTACGAAGCACAGGATGAAACCTGTAAGTACAAGCCTGAGTTTGCA
GTTGCTAATGACACTGGATTTGTGGACATCCCTCCGCGGGAGAAAGCCCTCATGAGCGCAGTGG
CCACGGTGGGGCCCATCTCTGTGGCTATTGACGCCGGACACGCATCCTTCCAGTTCTACAAATC
AGGAGTTTATTATGATCCAGAATGCAGCAGCAAAGACCTAGATCATGGTGTTCTGGTGGTTGGC
TACGGTGTTGAAGCAAATTCAAATAAGAAATTTTGGCTTGTCAAGAACAGCTGGGGTTCAGAAT
GGGGTGCAGATGGCTATGTCAAAATGGCCAAAGACAAGAACAACCACTGTGGAATTGCCACCGC
AGCCAGCTATCCCACTGTGTGAGCCGACGACGGACGGACGGGGACAGTGGAGGACTTGCGGACA
GCATGTCCAAAGGCACTCTCTCTCAAAACTGACCAAACCTTTAATGTATAAAACAATACTTGAA
TCATTGAGGATCCAAGTTGTGATTTGAATTCTGTGACATTTTCACAAGGGTAAAATGTTACCAC
TACTTTCACTACTGTTATAAACTGCTTCATGATATTGAAGACTCATTGTTTAATTCTAAGACTT
TTGAATTTTCATTTTTTAAAATGTGTAAAGCTTTCTTTACAGAATAAATTTTAGTTCAGTATAT
AGAGGCGGAACTTCTGTTTGTAATGCATTGACATTTTATTTAGTTGGAAAATGTAATTGGGCTC
CAAGGACATAAGTCAAAATGTGTCAGCGGTACGTTAGGGAAGAGATGAAGGAGGGTGAGTGGAC
CTCTGGTGTCTCACTAAAAAATACAGATTTTATGTCAGCTG

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Protein Sequences


Protein RefSeqs	XP_005320914	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000007010.3
GenBank Protein	KAG3293566	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005320914 ⟸ XM_005320857

- UniProtKB:

I3MAI4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNLPLFLAALCLGIASAIPKFDQNLDTQWYQWKATHKRLYGMNEEGWRRAVWEKNMRMIEQHNG
EYSQGKHGFTMAMNAFGDMTNEEFKQLKNGFKIQKYRRQGKVFREPLLFGSPKSVDWREKGYVT
PVKNQGQCGSCWAFSATGSLEGQMFRKTGKLISLSEQNLVDCSRPQGNLGCDGGLMDNAFQYIK
DNGGLDSEDSYPYEAQDETCKYKPEFAVANDTGFVDIPPREKALMSAVATVGPISVAIDAGHAS
FQFYKSGVYYDPECSSKDLDHGVLVVGYGVEANSNKKFWLVKNSWGSEWGADGYVKMAKDKNNH
CGIATAASYPTV

hide sequence

Ensembl Acc Id:

ENSSTOP00000007010 ⟸ ENSSTOT00000007833

Protein Domains

Cathepsin propeptide inhibitor Peptidase C1A papain C-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000007841	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000007833.3	UniProtKB/TrEMBL
Gene3D-CATH	Cysteine proteinases	UniProtKB/TrEMBL
InterPro	Papain-like_cys_pep_sf	UniProtKB/TrEMBL
	Pept_asp_AS	UniProtKB/TrEMBL
	Pept_cys_AS	UniProtKB/TrEMBL
	Pept_his_AS	UniProtKB/TrEMBL
	Peptidase_C1A	UniProtKB/TrEMBL
	Peptidase_C1A_C	UniProtKB/TrEMBL
	Peptidase_C1A_papain-like	UniProtKB/TrEMBL
	Prot_inhib_I29	UniProtKB/TrEMBL
NCBI Gene	Ctsv	ENTREZGENE
PANTHER	CATHEPSIN L2	UniProtKB/TrEMBL
	CYSTEINE PROTEASE FAMILY C1-RELATED	UniProtKB/TrEMBL
Pfam	Inhibitor_I29	UniProtKB/TrEMBL
	Peptidase_C1	UniProtKB/TrEMBL
PRINTS	PAPAIN	UniProtKB/TrEMBL
PROSITE	THIOL_PROTEASE_ASN	UniProtKB/TrEMBL
	THIOL_PROTEASE_CYS	UniProtKB/TrEMBL
	THIOL_PROTEASE_HIS	UniProtKB/TrEMBL
SMART	Inhibitor_I29	UniProtKB/TrEMBL
	Pept_C1	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54001	UniProtKB/TrEMBL
UniProt	I3MAI4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-26	LOC101969737	procathepsin L	Ctsv	cathepsin V	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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