Alx4 (ALX homeobox 4) - Rat Genome Database

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Gene: Alx4 (ALX homeobox 4) Ictidomys tridecemlineatus
Analyze
Symbol: Alx4
Name: ALX homeobox 4
RGD ID: 12456859
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Adenomatous Polyps (ortholog); bronchiolo-alveolar adenocarcinoma (ortholog); colorectal cancer (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); transcription regulator complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: homeobox protein aristaless-like 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494722,204,908 - 22,218,129 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365624,314,870 - 4,326,000 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365624,316,550 - 4,326,022 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 9 of 9 rows

  
1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Alx4SquirrelCraniosynostosis 5  ISOALX4 (Homo sapiens)8554872ClinVar Annotator: match by term: Craniosynostosis 5 and susceptibility toClinVarPMID:22829454 more ...
Alx4Squirrelfrontonasal dysplasia 2  ISOALX4 (Homo sapiens)8554872ClinVar Annotator: match by term: Frontonasal dysplasia 2ClinVarPMID:19692347 more ...
Alx4Squirrelgenetic disease  ISOALX4 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:19692347 more ...
Alx4Squirrelintellectual disability  ISOALX4 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
Alx4Squirreloptic nerve glioma  ISOALX4 (Homo sapiens)8554872ClinVar Annotator: match by term: Optic nerve gliomaClinVarPMID:25741868
Alx4Squirrelparietal foramina  ISOALX4 (Homo sapiens)8554872ClinVar Annotator: match by term: Cranium bifidum occultumClinVar 
Alx4SquirrelParietal Foramina 2  ISOALX4 (Homo sapiens)8554872ClinVar Annotator: match by term: Parietal foramina 2ClinVarPMID:11106354 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Alx4SquirrelCraniofacial Abnormalities  ISOALX4 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:9847249
Alx4Squirrelcraniosynostosis  ISOALX4 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTD 
Alx4Squirrelfrontonasal dysplasia  ISOALX4 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTD 
Alx4SquirrelLung Neoplasms  ISOALX4 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:24037716
Alx4Squirrelpolydactyly  ISOALX4 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:9847249
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Alx4SquirrelCraniosynostosis 5  ISOALX4 (Homo sapiens)7240710 OMIM 
Alx4Squirrelfrontonasal dysplasia 2  ISOALX4 (Homo sapiens)7240710 OMIM 
Alx4SquirrelParietal Foramina 2  ISOALX4 (Homo sapiens)7240710 OMIM 


Biological Process
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Alx4Squirrelanterior/posterior pattern specification acts_upstream_of_or_withinIEAUniProtKB:O35137 and ensembl:ENSMUSP00000047962150520179 EnsemblGO_REF:0000107
Alx4Squirreldigestive tract development acts_upstream_of_or_withinIEAUniProtKB:O35137 and ensembl:ENSMUSP00000047962150520179 EnsemblGO_REF:0000107
Alx4Squirrelembryonic digit morphogenesis acts_upstream_of_or_withinIEAUniProtKB:O35137 and ensembl:ENSMUSP00000047962150520179 EnsemblGO_REF:0000107
Alx4Squirrelembryonic forelimb morphogenesis acts_upstream_of_or_withinIEAUniProtKB:O35137 and ensembl:ENSMUSP00000047962150520179 EnsemblGO_REF:0000107
Alx4Squirrelembryonic hindlimb morphogenesis acts_upstream_of_or_withinIEAUniProtKB:O35137 and ensembl:ENSMUSP00000047962150520179 EnsemblGO_REF:0000107
Alx4Squirrelembryonic skeletal system morphogenesis acts_upstream_of_or_withinIEAUniProtKB:O35137 and ensembl:ENSMUSP00000047962150520179 EnsemblGO_REF:0000107
Alx4Squirrelhair follicle development involved_inIEAUniProtKB:Q9H161 and ensembl:ENSP00000498217150520179 EnsemblGO_REF:0000107
Alx4Squirrellimb morphogenesis acts_upstream_of_or_withinIEAUniProtKB:O35137 and ensembl:ENSMUSP00000047962150520179 EnsemblGO_REF:0000107
Alx4Squirrelmuscle organ development acts_upstream_of_or_withinIEAUniProtKB:O35137 and ensembl:ENSMUSP00000047962150520179 EnsemblGO_REF:0000107
Alx4Squirrelpattern specification process acts_upstream_of_or_withinIEAUniProtKB:O35137 and ensembl:ENSMUSP00000047962150520179 EnsemblGO_REF:0000107
Alx4Squirrelpositive regulation of transcription by RNA polymerase II acts_upstream_of_or_withinIEAUniProtKB:O35137 and ensembl:ENSMUSP00000047962150520179 EnsemblGO_REF:0000107
Alx4Squirrelpositive regulation of transcription by RNA polymerase II involved_inISOAlx4 (Mus musculus)9068941 PMID:9847249NTNU_SBPMID:9847249
Alx4Squirrelpost-embryonic development acts_upstream_of_or_withinIEAUniProtKB:O35137 and ensembl:ENSMUSP00000047962150520179 EnsemblGO_REF:0000107
Alx4Squirrelregulation of apoptotic process acts_upstream_of_or_withinIEAUniProtKB:O35137 and ensembl:ENSMUSP00000047962150520179 EnsemblGO_REF:0000107
Alx4Squirrelregulation of DNA-templated transcription involved_inIEAInterPro:IPR017970150520179 InterProGO_REF:0000002
Alx4Squirrelregulation of transcription by RNA polymerase II involved_inIEAPANTHER:PTN001965393150520179 TreeGrafterGO_REF:0000118
Alx4Squirrelregulation of transcription by RNA polymerase II acts_upstream_of_or_withinIEAUniProtKB:O35137 and ensembl:ENSMUSP00000047962150520179 EnsemblGO_REF:0000107
Alx4Squirrelroof of mouth development acts_upstream_of_or_withinIEAUniProtKB:O35137 and ensembl:ENSMUSP00000047962150520179 EnsemblGO_REF:0000107
Alx4Squirrelskeletal system morphogenesis acts_upstream_of_or_withinIEAUniProtKB:O35137 and ensembl:ENSMUSP00000047962150520179 EnsemblGO_REF:0000107
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Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Alx4Squirrelnucleoplasm located_inIEAUniProtKB:Q9H161 and ensembl:ENSP00000498217150520179 EnsemblGO_REF:0000107
Alx4Squirrelnucleus located_inIEAUniRule:UR000401037150520179 UniProtGO_REF:0000104
Alx4Squirrelnucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
Alx4Squirrelnucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044
Alx4Squirrelnucleus located_inIEAUniProtKB:O35137 more ...150520179 EnsemblGO_REF:0000107
Alx4Squirreltranscription regulator complex part_ofIEAUniProtKB:O35137 and ensembl:ENSMUSP00000047962150520179 EnsemblGO_REF:0000107

Molecular Function
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Alx4SquirrelDNA binding enablesIEAUniRule:UR000401037150520179 UniProtGO_REF:0000104
Alx4SquirrelDNA binding enablesIEAInterPro:IPR001356150520179 InterProGO_REF:0000002
Alx4SquirrelDNA binding enablesIEAUniProtKB-KW:KW-0238 and UniProtKB-KW:KW-0371150520179 UniProtGO_REF:0000043
Alx4SquirrelDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAPANTHER:PTN001965393150520179 TreeGrafterGO_REF:0000118
Alx4SquirrelDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:O35137 and ensembl:ENSMUSP00000047962150520179 EnsemblGO_REF:0000107
Alx4SquirrelDNA-binding transcription factor activity enablesIEAUniProtKB:O35137 and ensembl:ENSMUSP00000047962150520179 EnsemblGO_REF:0000107
Alx4SquirrelDNA-binding transcription factor activity, RNA polymerase II-specific enablesIEAPANTHER:PTN001965393150520179 TreeGrafterGO_REF:0000118
Alx4SquirrelDNA-binding transcription factor activity, RNA polymerase II-specific enablesIEAInterPro:IPR017970150520179 InterProGO_REF:0000002
Alx4SquirrelHMG box domain binding enablesIEAUniProtKB:O35137 and ensembl:ENSMUSP00000047962150520179 EnsemblGO_REF:0000107
Alx4Squirrelprotein binding enablesISOUniProtKB:Q089999068941 PMID:9786416MGIPMID:9786416
Alx4Squirrelprotein binding enablesISOPR:Q8C8B09068941 PMID:9847249MGIPMID:9847249
Alx4Squirrelprotein binding enablesISOPR:P277829068941 PMID:11696550MGIPMID:11696550
Alx4Squirrelprotein binding enablesISOUniProtKB:Q8NA54 and UniProtKB:Q9HBI09068941 PMID:32296183IntActPMID:32296183
Alx4SquirrelRNA polymerase II transcription regulatory region sequence-specific DNA binding enablesIEAPANTHER:PTN001965393150520179 TreeGrafterGO_REF:0000118
Alx4SquirrelRNA polymerase II transcription regulatory region sequence-specific DNA binding enablesIEAUniProtKB:O35137 and ensembl:ENSMUSP00000047962150520179 EnsemblGO_REF:0000107
Alx4Squirrelsequence-specific DNA binding enablesIEAUniProtKB:O35137 and ensembl:ENSMUSP00000047962150520179 EnsemblGO_REF:0000107
Alx4Squirrelsequence-specific double-stranded DNA binding enablesIEAUniProtKB:Q9H161 and ensembl:ENSP00000498217150520179 EnsemblGO_REF:0000107
1 to 17 of 17 rows

PMID:30032202  



Alx4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494722,204,908 - 22,218,129 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365624,314,870 - 4,326,000 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365624,316,550 - 4,326,022 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALX4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381144,260,440 - 44,310,139 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1144,260,440 - 44,310,139 (-)EnsemblGRCh38hg38GRCh38
GRCh371144,281,990 - 44,331,689 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361144,242,734 - 44,288,292 (-)NCBINCBI36Build 36hg18NCBI36
Build 341144,242,733 - 44,288,292NCBI
Celera1144,429,565 - 44,479,005 (-)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1143,991,253 - 44,040,694 (-)NCBIHuRef
CHM1_11144,281,300 - 44,330,733 (-)NCBICHM1_1
T2T-CHM13v2.01144,415,783 - 44,465,465 (-)NCBIT2T-CHM13v2.0
Alx4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39293,472,779 - 93,511,686 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl293,472,729 - 93,511,684 (+)EnsemblGRCm39 Ensembl
GRCm38293,642,434 - 93,681,341 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl293,642,384 - 93,681,339 (+)EnsemblGRCm38mm10GRCm38
MGSCv37293,482,591 - 93,521,496 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36293,443,273 - 93,478,775 (+)NCBIMGSCv36mm8
Celera295,046,101 - 95,085,009 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map251.62NCBI
Alx4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83100,067,052 - 100,103,624 (+)NCBIGRCr8
mRatBN7.2379,611,682 - 79,648,260 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl379,611,719 - 79,648,260 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx383,085,796 - 83,122,265 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0391,684,866 - 91,721,334 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0389,536,444 - 89,573,057 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0382,548,959 - 82,585,531 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl382,548,959 - 82,585,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0389,249,541 - 89,286,113 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4378,057,714 - 78,094,285 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1377,954,190 - 77,990,612 (+)NCBI
Celera378,814,063 - 78,850,575 (+)NCBICelera
Cytogenetic Map3q31NCBI
Alx4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554223,278,615 - 3,291,714 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554223,278,615 - 3,290,799 (+)NCBIChiLan1.0ChiLan1.0
ALX4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2946,474,416 - 46,524,451 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11146,464,895 - 46,530,312 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01144,219,865 - 44,269,597 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11144,714,503 - 44,729,758 (-)NCBIpanpan1.1PanPan1.1panPan2
ALX4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11844,922,042 - 44,967,557 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1844,922,150 - 44,967,550 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1843,590,411 - 43,635,910 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01845,583,479 - 45,629,082 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1845,583,532 - 45,629,081 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11845,066,662 - 45,112,191 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01844,620,210 - 44,665,671 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01845,356,336 - 45,401,930 (+)NCBIUU_Cfam_GSD_1.0
ALX4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl218,037,401 - 18,085,683 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1218,070,726 - 18,085,685 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2219,626,044 - 19,627,294 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALX4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,051,413 - 21,099,159 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,051,580 - 21,097,605 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038118,279,875 - 118,329,166 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alx4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247673,770,762 - 3,805,323 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247673,770,755 - 3,808,511 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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RefSeq Transcripts XM_005330087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSTOT00000021489   ⟹   ENSSTOP00000022296
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365624,314,870 - 4,326,000 (+)Ensembl
RefSeq Acc Id: XM_005330087   ⟹   XP_005330144
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494722,204,908 - 22,218,129 (+)NCBI
SpeTri2.0NW_0049365624,316,550 - 4,326,022 (+)NCBI
Sequence:
Protein RefSeqs XP_005330144 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000022296.2
GenBank Protein KAG3285432 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005330144   ⟸   XM_005330087
- Sequence:
Ensembl Acc Id: ENSSTOP00000022296   ⟸   ENSSTOT00000021489
Homeobox   OAR



1 to 19 of 19 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSSTOG00000029078 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000021489.2 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  OAR_dom UniProtKB/TrEMBL
  Paired_Homeobox_TFs UniProtKB/TrEMBL
NCBI Gene Alx4 ENTREZGENE
PANTHER HOMEOBOX PROTEIN ARISTALESS UniProtKB/TrEMBL
  PTHR24329:SF322 UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/TrEMBL
  OAR UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
  OAR UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt I3ND49_ICTTR UniProtKB/TrEMBL
1 to 19 of 19 rows