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Gene: Hoxc13 (homeobox C13) Ictidomys tridecemlineatus

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Symbol:

Hoxc13

Name:

homeobox C13

RGD ID:

12445697

Description:

ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN anatomical structure morphogenesis (ortholog); anterior/posterior pattern specification (ortholog); hair follicle development (ortholog); ASSOCIATED WITH BILATERAL CLEFT LIP (ortholog); ectodermal dysplasia 9 (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

homeobox protein Hox-C13

RGD Orthologs

Alliance Orthologs

More Info

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HOXC13 (homeobox C13)	NCBI	Ortholog
Mus musculus (house mouse):	Hoxc13 (homeobox C13)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Hoxc13 (homeobox C13)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Hoxc13 (homeobox C13)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	HOXC13 (homeobox C13)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	HOXC13 (homeobox C13)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	HOXC13 (homeobox C13)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	HOXC13 (homeobox C13)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Hoxc13 (homeobox C13)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	61,997,436 - 62,004,487 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936512	11,160,343 - 11,166,616 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

BILATERAL CLEFT LIP (ISO)

ectodermal dysplasia 9 (ISO)

Neurodevelopmental Disorders (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anatomical structure morphogenesis (ISO)

anterior/posterior pattern specification (ISO)

hair follicle development (ISO)

nail development (ISO)

positive regulation of DNA-templated transcription (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

tongue morphogenesis (ISO)

Cellular Component

nucleus (ISO)

Molecular Function

chromatin binding (ISO)

DNA-binding transcription activator activity, RNA polymerase II-specific (ISO)

DNA-binding transcription factor activity (ISO)

DNA-binding transcription factor binding (ISO)

protein binding (ISO)

sequence-specific double-stranded DNA binding (ISO)

transcription cis-regulatory region binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Hoxc13
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	61,997,436 - 62,004,487 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936512	11,160,343 - 11,166,616 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HOXC13
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	53,938,831 - 53,946,544 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	53,938,831 - 53,946,544 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	54,332,615 - 54,340,328 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	52,618,843 - 52,626,595 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	52,618,842 - 52,626,594	NCBI
Celera	12	53,982,194 - 53,989,933 (+)	NCBI		Celera
Cytogenetic Map	12	q13.13	NCBI
HuRef	12	51,370,279 - 51,377,685 (+)	NCBI		HuRef
CHM1_1	12	54,299,300 - 54,307,033 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	53,904,353 - 53,912,048 (+)	NCBI		T2T-CHM13v2.0

Hoxc13
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	102,829,566 - 102,837,249 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	102,829,538 - 102,837,249 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	102,921,131 - 102,928,814 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	102,921,103 - 102,928,814 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	102,751,562 - 102,759,245 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	102,749,165 - 102,756,848 (+)	NCBI		MGSCv36	mm8
Celera	15	105,078,954 - 105,086,637 (+)	NCBI		Celera
Cytogenetic Map	15	F3	NCBI
cM Map	15	57.99	NCBI

Hoxc13
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	135,937,126 - 135,943,962 (+)	NCBI		GRCr8
mRatBN7.2	7	134,058,640 - 134,065,479 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	134,058,640 - 134,064,800 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	7	144,531,814 - 144,538,298 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	144,531,814 - 144,537,966 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	142,323,171 - 142,329,323 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	141,685,004 - 141,691,159 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	130,489,719 - 130,491,373 (+)	NCBI		Celera
Cytogenetic Map	7	q36	NCBI

Hoxc13
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	1,197,295 - 1,205,127 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	1,197,295 - 1,205,098 (+)	NCBI	ChiLan1.0	ChiLan1.0

HOXC13
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	40,239,252 - 40,246,959 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	40,236,020 - 40,243,727 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	34,808,575 - 34,816,324 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	35,596,821 - 35,604,560 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	35,596,821 - 35,604,560 (-)	Ensembl	panpan1.1		panPan2

HOXC13
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	1,315,532 - 1,323,470 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	1,273,131 - 1,323,370 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	44,926,178 - 44,934,051 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	1,319,256 - 1,327,126 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	1,319,221 - 1,327,051 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	1,336,900 - 1,344,764 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	1,318,461 - 1,326,337 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	45,329,789 - 45,337,670 (+)	NCBI		UU_Cfam_GSD_1.0

HOXC13
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	19,151,084 - 19,158,646 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	19,151,096 - 19,159,008 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	19,624,272 - 19,632,185 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HOXC13
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	50,039,034 - 50,057,178 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	50,049,509 - 50,055,895 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	195,985,021 - 195,992,836 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hoxc13
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624904	1,993,854 - 2,000,500 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624904	1,993,854 - 2,001,623 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005325128	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_005325128 ⟹ XP_005325185

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404945	61,997,436 - 62,004,487 (-)	NCBI
SpeTri2.0	NW_004936512	11,160,343 - 11,166,616 (+)	NCBI

Sequence:

show sequence

ATGACGACTTCGCTGCTCCTGCATCCACGCTGGCCGGAGAGCCTTATGTACGTCTATGAGGACA
GCGCGGCGGAGAGCGGCAGCAGCGGCGGCGGCGGGGGAGGCGGTGGTGCGGGAGGAACGGGGGG
CGGCTGCAGCGGAGCCAGCCCCGGCAAAGCCCCAAGCATGGACGGTCTGGGCAGCAGCTGCCCG
GCCAGCCACTGCAGCGGCCCCTCCTCACCCGAACATCAGGGCCCTCCAGACCCAGGCGCCCCAA
CAGTATCCTTTTCACCTTCCTGCCGGCCTTTCGGCTCTTGTTGCCGCAGCCCGGGGGGACCCCG
CAGTCCGGGGGGACCCTCTTGCCCGCCGCCACCCTTCAGCCAGGAAAGGGACTGCCGCTCAAGC
CCCAGGCACCGGGCTTGGCCAGAGCTTTTGGGGTTCCCCGGCAGCAGCACTGCGGGGCGCACTG
GGACCCTCCGCAGTACGCAAAGGTGCAAAGGATTACTTAGGCAGAGCAATCCGCGGGCCCTCTT
TGAGTCCCTGCCCAAACCCCGTGCTTCAGCAGTGTCACAGCCTTGCTTGCGGCCTCTAGCCAGA
TCCAGCCGCTTGCCTCACTTCCTCCCGCCCGCCTTCTCTTTCCCCTCAGATGTGGTTCCCCTAC
AGCCCGAAGTGAGCAGCTACCGGCGCGGGCGCAAGAAACGTGTGCCCTATACTAAGGTGCAGCT
AAAGGAGCTAGAGAAGGAGTATGCGGCTAGCAAGTTCATCACCAAAGAGAAGCGCCGGCGCATC
TCTGCTACCACGAACCTCTCCGAGCGCCAGGTCACCATCTGGTTCCAGAACCGCCGGGTGAAAG
AGAAGAAGGTGGTCAGCAAATCGAAAGCACCTCATCTCCACTCCACCTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005325185	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	KAG3291807	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005325185 ⟸ XM_005325128

- Sequence:

show sequence

MTTSLLLHPRWPESLMYVYEDSAAESGSSGGGGGGGGAGGTGGGCSGASPGKAPSMDGLGSSCP
ASHCSGPSSPEHQGPPDPGAPTVSFSPSCRPFGSCCRSPGGPRSPGGPSCPPPPFSQERDCRSS
PRHRAWPELLGFPGSSTAGRTGTLRSTQRCKGLLRQSNPRALFESLPKPRASAVSQPCLRPLAR
SSRLPHFLPPAFSFPSDVVPLQPEVSSYRRGRKKRVPYTKVQLKELEKEYAASKFITKEKRRRI
SATTNLSERQVTIWFQNRRVKEKKVVSKSKAPHLHST

hide sequence

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	Hoxc13	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIA

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIA

Imported Disease Annotations - OMIM