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Gene: Areg (amphiregulin) Ictidomys tridecemlineatus

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Symbol:

Areg

Name:

amphiregulin

RGD ID:

12444552

Description:

ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); growth factor activity (ortholog); INVOLVED IN dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis (ortholog); epidermal growth factor receptor signaling pathway (ortholog); epithelial cell proliferation involved in mammary gland duct elongation (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); asthma (ortholog); breast cancer (ortholog); FOUND IN extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AREG (amphiregulin)	NCBI	Ortholog
Mus musculus (house mouse):	Areg (amphiregulin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Areg (amphiregulin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Areg (amphiregulin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	AREG (amphiregulin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	AREG (amphiregulin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	AREG (amphiregulin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	AREG (amphiregulin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Areg (amphiregulin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	12,822,538 - 12,834,155 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936598	1,274,565 - 1,283,746 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936598	1,276,599 - 1,283,612 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Animal Mammary Neoplasms (ISO)

asthma (ISO)

breast cancer (ISO)

Breast Neoplasms (ISO)

COVID-19 (ISO)

ductal carcinoma in situ (ISO)

Endometrioid Carcinomas (ISO)

endometriosis (ISO)

erythropoietic protoporphyria (ISO)

Experimental Mammary Neoplasms (ISO)

Head and Neck Neoplasms (ISO)

high grade glioma (ISO)

invasive ductal carcinoma (ISO)

juvenile rheumatoid arthritis (ISO)

lung non-small cell carcinoma (ISO)

Myocardial Ischemia (ISO)

Ovarian Neoplasms (ISO)

prostate carcinoma in situ (ISO)

Prostatic Neoplasms (ISO)

pulmonary fibrosis (ISO)

squamous cell carcinoma (ISO)

Stomach Neoplasms (ISO)

transitional cell carcinoma (ISO)

urinary bladder cancer (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis (IEA,ISO)

epidermal growth factor receptor signaling pathway (IEA,ISO)

epithelial cell proliferation involved in mammary gland duct elongation (IEA,ISO)

ERBB2-EGFR signaling pathway (IEA)

G protein-coupled receptor signaling pathway (IEA)

glial cell proliferation (ISO)

mammary gland alveolus development (IEA,ISO)

mammary gland branching involved in thelarche (IEA,ISO)

negative regulation of osteoblast differentiation (ISO)

neuron projection development (ISO)

positive regulation of cell population proliferation (IEA,ISO)

positive regulation of peptidyl-tyrosine phosphorylation (ISO)

positive regulation of phosphorylation (ISO)

response to cAMP (ISO)

response to estradiol (IEA,ISO)

response to glucocorticoid (ISO)

response to hydrogen peroxide (ISO)

response to peptide hormone (ISO)

Cellular Component

cell surface (IEA)

cytoplasm (IEA)

extracellular space (IEA,ISO)

membrane (IEA)

nucleus (IEA)

Molecular Function

epidermal growth factor receptor binding (IEA,ISO)

growth factor activity (IEA,ISO)

protein binding (ISO)

receptor ligand activity (IEA)

signaling receptor binding (IEA)

transmembrane receptor protein tyrosine kinase activator activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

epidermal growth factor/neuregulin signaling pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Areg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	12,822,538 - 12,834,155 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936598	1,274,565 - 1,283,746 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936598	1,276,599 - 1,283,612 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AREG
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	74,445,136 - 74,455,005 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	74,445,136 - 74,455,005 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	75,310,853 - 75,320,722 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	75,529,717 - 75,539,590 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	75,675,887 - 75,685,760	NCBI
Celera	4	72,671,109 - 72,680,980 (+)	NCBI		Celera
Cytogenetic Map	4	q13.3	NCBI
HuRef	4	71,121,847 - 71,131,718 (+)	NCBI		HuRef
CHM1_1	4	75,346,752 - 75,356,715 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	77,788,795 - 77,798,664 (+)	NCBI		T2T-CHM13v2.0

Areg
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	91,287,458 - 91,296,291 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	91,287,458 - 91,296,291 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	91,139,599 - 91,148,432 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	91,139,599 - 91,148,432 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	91,568,641 - 91,577,458 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	92,214,815 - 92,223,632 (+)	NCBI		MGSCv36	mm8
Celera	5	89,277,608 - 89,286,422 (+)	NCBI		Celera
Cytogenetic Map	5	E2	NCBI
cM Map	5	44.78	NCBI

Areg
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	17,256,384 - 17,265,641 (-)	NCBI		GRCr8
mRatBN7.2	14	16,972,185 - 16,981,443 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	16,972,187 - 16,981,535 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	16,971,509 - 16,980,539 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	18,290,441 - 18,299,471 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	16,982,558 - 16,991,588 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	18,521,921 - 18,531,179 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	18,521,930 - 18,531,179 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	18,431,477 - 18,440,735 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	18,466,313 - 18,475,571 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	18,466,313 - 18,475,571 (-)	NCBI
Celera	14	16,350,045 - 16,359,315 (-)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

Areg
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955474	680,204 - 689,088 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955474	680,212 - 689,021 (+)	NCBI	ChiLan1.0	ChiLan1.0

AREG
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	55,604,814 - 55,617,056 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	55,794,221 - 55,806,459 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	49,737,191 - 49,747,013 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	55,570,299 - 55,580,142 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	55,570,299 - 55,580,142 (-)	Ensembl	panpan1.1		panPan2

AREG
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	62,925,761 - 62,936,753 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	62,926,301 - 62,936,738 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	62,614,442 - 62,625,448 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	63,756,606 - 63,767,617 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	63,757,757 - 63,767,594 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	63,371,389 - 63,382,383 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	62,853,171 - 62,864,176 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	63,996,005 - 64,007,006 (+)	NCBI		UU_Cfam_GSD_1.0

AREG
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	70,417,923 - 70,428,102 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	70,417,935 - 70,428,106 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	74,568,826 - 74,579,003 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AREG
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	22,979,574 - 22,990,179 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	22,980,249 - 22,990,162 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	1,272,704 - 1,282,711 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Areg
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	1,290,655 - 1,299,410 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	1,290,692 - 1,299,365 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005333237	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040292303	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000344	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000008653 ⟹ ENSSTOP00000007757

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936598	1,274,565 - 1,283,746 (-)	Ensembl

RefSeq Acc Id:

XM_005333237 ⟹ XP_005333294

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405285	12,822,538 - 12,834,155 (-)	NCBI
SpeTri2.0	NW_004936598	1,276,599 - 1,283,612 (-)	NCBI

Sequence:

show sequence

CACAGCCGCTCTTGTGCCCTTTTTTCCTACCACTTCTTCCTTCTGCCAGTAGCTGCCGTCTGAG
TTGCCCCAGAGACCCAGACGCCGACGTCCCGAGGGACCAATGAGAACTCCGCTGCTGCCTCAGG
CGCCGGTGGTGCTGTGGCTCTTGATCCTCGGCTCAGGCCATCATGCTGTTGGATTGGATCTCAA
TGACACTGACTCTGGGAAAGGGGAACCATTGTCCAAGAACCACAGTACTAGTGGACCTGAGGTT
GCTTCAAGAAATGAGACGACCCCAGGAATTGAGATTTCCCCTGTGACTGAAACGCCTTCTAGTA
CTGAAGTGTCCTCAGGAACTGACTATGACTATTTAGAATATGATGCTGAACTACAAATATCTGG
CTACATCGTGGATGATTCAGTCAGAGTTGAACAGGTAATTAAGCCCAAGAAAAACAAAACAGAA
AGTGAAAAGACTTCAGATAAACCCAAAAGAAAGAAAAAGGGAGGGAAAGGTGGAAAAAATAGAA
GAAACAAAAAGAAGAAAAATCCATGTGATGCAGAATTTCAAAATTTCTGCATTCATGGAGAATG
CAAATATATAGAGAATCTGGAGGCAGTAACATGCAAATGTCATCATGATTATTTTGGTGAACGA
TGTGGAGAAAAATCCATGAAGACTCACAGCATGGGTGACAGAGATTTCTCAAAAGTTGCATTAG
CAGCTATAGCTGCCTTTGTCTCTGCTACAAGCTTCACTGCTGTTGCTGTTGTTATTACAGTCCA
GCTTCGAAAAAGATACTTCAGAGAATTTGAAGAAGAAGCAGAAGAACAAAAGAAACTTCAACAA
GAAAATGGACATGCACATTCTATAGCATAA

hide sequence

RefSeq Acc Id:

XM_040292303 ⟹ XP_040148237

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405285	12,822,538 - 12,834,155 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_005333294	(Get FASTA)	NCBI Sequence Viewer
	XP_040148237	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000007757.2
GenBank Protein	KAG3276421	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005333294 ⟸ XM_005333237

- UniProtKB:

I3MC15 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRTPLLPQAPVVLWLLILGSGHHAVGLDLNDTDSGKGEPLSKNHSTSGPEVASRNETTPGIEIS
PVTETPSSTEVSSGTDYDYLEYDAELQISGYIVDDSVRVEQVIKPKKNKTESEKTSDKPKRKKK
GGKGGKNRRNKKKKNPCDAEFQNFCIHGECKYIENLEAVTCKCHHDYFGERCGEKSMKTHSMGD
RDFSKVALAAIAAFVSATSFTAVAVVITVQLRKRYFREFEEEAEEQKKLQQENGHAHSIA

hide sequence

RefSeq Acc Id:	XP_040148237 ⟸ XM_040292303
- UniProtKB:	I3MC15 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSSTOP00000007757 ⟸ ENSSTOT00000008653

Protein Domains

EGF-like

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000008661	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000008653.3	UniProtKB/TrEMBL
Gene3D-CATH	Laminin	UniProtKB/TrEMBL
InterPro	EGF-like_dom	UniProtKB/TrEMBL
NCBI Gene	Areg	ENTREZGENE
PANTHER	AMPHIREGULIN	UniProtKB/TrEMBL
	PTHR10740	UniProtKB/TrEMBL
PROSITE	EGF_1	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
Superfamily-SCOP	EGF/Laminin	UniProtKB/TrEMBL
UniProt	I3MC15	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)