Sorcs1 (sortilin related VPS10 domain containing receptor 1) - Rat Genome Database

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Gene: Sorcs1 (sortilin related VPS10 domain containing receptor 1) Ictidomys tridecemlineatus
Analyze
Symbol: Sorcs1
Name: sortilin related VPS10 domain containing receptor 1
RGD ID: 12442293
Description: INVOLVED IN post-Golgi vesicle-mediated transport (inferred); ASSOCIATED WITH Alzheimer's disease 6 (ortholog); prostate cancer (ortholog); proteinuria (ortholog); FOUND IN Golgi apparatus (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC101978640; sortilin-related VPS10 domain containing receptor 1; VPS10 domain-containing receptor SorCS1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721327,085,308 - 27,300,512 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493677628,537 - 241,135 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493677627,519 - 240,225 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Sorcs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721327,085,308 - 27,300,512 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493677628,537 - 241,135 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493677627,519 - 240,225 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SORCS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810106,573,663 - 107,181,138 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10106,573,663 - 107,164,706 (-)EnsemblGRCh38hg38GRCh38
GRCh3710108,333,421 - 108,924,464 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610108,323,411 - 108,914,282 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410108,323,410 - 108,914,282NCBI
Celera10102,072,553 - 102,663,374 (-)NCBICelera
Cytogenetic Map10q25.1NCBI
HuRef10101,965,988 - 102,556,901 (-)NCBIHuRef
CHM1_110108,615,122 - 109,206,295 (-)NCBICHM1_1
T2T-CHM13v2.010107,460,647 - 108,068,078 (-)NCBIT2T-CHM13v2.0
Sorcs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391950,131,733 - 50,668,030 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1950,131,737 - 50,667,084 (-)EnsemblGRCm39 Ensembl
GRCm381950,143,295 - 50,679,129 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1950,143,299 - 50,678,646 (-)EnsemblGRCm38mm10GRCm38
MGSCv371950,222,150 - 50,753,102 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361950,204,284 - 50,731,796 (-)NCBIMGSCv36mm8
Celera1950,907,555 - 51,438,064 (-)NCBICelera
Cytogenetic Map19D1NCBI
cM Map1945.05NCBI
Sorcs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81259,022,007 - 259,535,731 (-)NCBIGRCr8
mRatBN7.21249,080,662 - 249,594,520 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1249,081,355 - 249,594,507 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1257,225,370 - 257,730,896 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01263,918,158 - 264,423,716 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01256,561,905 - 257,073,670 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01269,965,824 - 270,473,097 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1269,973,351 - 270,472,866 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01277,404,996 - 277,912,261 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41255,767,411 - 256,279,565 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11256,033,640 - 256,545,663 (-)NCBI
Celera1244,828,397 - 245,333,325 (-)NCBICelera
Cytogenetic Map1q55NCBI
Sorcs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554853,719,008 - 4,218,699 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554853,719,006 - 4,222,143 (+)NCBIChiLan1.0ChiLan1.0
SORCS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28118,454,472 - 119,044,048 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110118,459,805 - 119,049,387 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010103,164,581 - 103,753,754 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110106,623,481 - 107,211,230 (-)NCBIpanpan1.1PanPan1.1panPan2
SORCS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12818,619,015 - 18,933,785 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2818,622,234 - 18,797,249 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2818,745,291 - 19,221,898 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02819,098,613 - 19,608,198 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2819,067,554 - 19,609,122 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12818,630,873 - 19,139,229 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02818,678,797 - 19,178,427 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02818,811,161 - 19,310,390 (-)NCBIUU_Cfam_GSD_1.0
SORCS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14117,479,787 - 118,009,583 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114117,479,817 - 118,009,485 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214127,817,702 - 128,359,641 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SORCS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1999,581,375 - 100,171,637 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604860,747,868 - 61,334,611 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sorcs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248315,435,192 - 5,736,481 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248315,433,671 - 5,901,911 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000015661   ⟹   ENSSTOP00000014018
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493677628,537 - 241,135 (-)Ensembl
RefSeq Acc Id: XM_040272538   ⟹   XP_040128472
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721327,085,308 - 27,300,512 (+)NCBI
Protein Sequences
Protein RefSeqs XP_040128472 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000014018.3
RefSeq Acc Id: XP_040128472   ⟸   XM_040272538
- UniProtKB: I3MQ45 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000014018   ⟸   ENSSTOT00000015661
Protein Domains
PKD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000015654 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000015661.3 UniProtKB/TrEMBL
Gene3D-CATH 2.10.70.80 UniProtKB/TrEMBL
  2.120.10.10 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  3.30.60.270 UniProtKB/TrEMBL
InterPro Ig-like_fold UniProtKB/TrEMBL
  PKD_dom UniProtKB/TrEMBL
  PKD_dom_sf UniProtKB/TrEMBL
  Sortilin_C UniProtKB/TrEMBL
  Sortilin_N UniProtKB/TrEMBL
  VPS10 UniProtKB/TrEMBL
  VPS10-sortilin UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
NCBI Gene LOC101978640 ENTREZGENE
PANTHER SORTILIN RELATED UniProtKB/TrEMBL
  VPS10 DOMAIN-CONTAINING RECEPTOR SORCS1 UniProtKB/TrEMBL
Pfam PKD UniProtKB/TrEMBL
  Sortilin-Vps10 UniProtKB/TrEMBL
  Sortilin_C UniProtKB/TrEMBL
PROSITE PKD UniProtKB/TrEMBL
SMART VPS10 UniProtKB/TrEMBL
Superfamily-SCOP Oligoxyloglucan reducing end-specific cellobiohydrolase UniProtKB/TrEMBL
  SSF49299 UniProtKB/TrEMBL
UniProt I3MQ45 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-07-13 Sorcs1  sortilin related VPS10 domain containing receptor 1  LOC101978640  VPS10 domain-containing receptor SorCS1  Symbol and/or name change 5135510 APPROVED