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Gene: LOC100683045 (interferon alpha-1/2) Canis lupus familiaris

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No known orthologs.

Symbol:

LOC100683045

Name:

interferon alpha-1/2

RGD ID:

12405798

Description:

ENCODES a protein that exhibits cytokine activity (inferred); cytokine receptor binding (inferred); INVOLVED IN defense response (inferred); defense response to virus (inferred); signal transduction (inferred); FOUND IN extracellular region (inferred); extracellular space (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

interferon alpha-1/2-like

RGD Orthologs

Alliance Orthologs

More Info

homologs ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Dog10K_Boxer_Tasha	11	39,401,133 - 39,401,681 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	41,680,722 - 41,681,524 (-)	NCBI		ROS_Cfam_1.0
UNSW_CanFamBas_1.0	11	40,161,681 - 40,162,244 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	40,796,811 - 40,797,440 (-)	NCBI		UU_Cfam_GSD_1.0

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
LOC100683045	Dog	adaptive immune response	involved_in	IBA	MGI:107657\|PANTHER:PTN002618644	150520179		GO_Central	GO_REF:0000033
LOC100683045	Dog	B cell activation involved in immune response	involved_in	IBA	PANTHER:PTN002618644\|UniProtKB:P01574	150520179		GO_Central	GO_REF:0000033
LOC100683045	Dog	defense response	involved_in	IEA	InterPro:IPR000471	150520179		InterPro	GO_REF:0000002
LOC100683045	Dog	defense response to virus	involved_in	IEA	UniProtKB-KW:KW-0051	150520179		UniProt	GO_REF:0000043
LOC100683045	Dog	humoral immune response	involved_in	IBA	MGI:107657\|PANTHER:PTN002618644	150520179		GO_Central	GO_REF:0000033
LOC100683045	Dog	natural killer cell activation involved in immune response	involved_in	IBA	MGI:107659\|MGI:107664\|MGI:107668\|PANTHER:PTN002618644	150520179		GO_Central	GO_REF:0000033
LOC100683045	Dog	response to exogenous dsRNA	involved_in	IBA	PANTHER:PTN002618644\|RGD:2865\|UniProtKB:P01574\|ZFIN:ZDB-GENE-030721-3	150520179		GO_Central	GO_REF:0000033
LOC100683045	Dog	signal transduction	involved_in	IEA	GO:0005125	150520179		GOC	GO_REF:0000108
LOC100683045	Dog	T cell activation involved in immune response	involved_in	IBA	MGI:107668\|PANTHER:PTN002618644	150520179		GO_Central	GO_REF:0000033
LOC100683045	Dog	type I interferon-mediated signaling pathway	involved_in	IBA	MGI:107657\|MGI:107668\|PANTHER:PTN002618644\|UniProtKB:P01563\|UniProtKB:P01574	150520179		GO_Central	GO_REF:0000033

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
LOC100683045	Dog	extracellular region	located_in	IEA	UniProtKB-KW:KW-0964	150520179		UniProt	GO_REF:0000043
LOC100683045	Dog	extracellular region	located_in	IEA	InterPro:IPR000471	150520179		InterPro	GO_REF:0000002
LOC100683045	Dog	extracellular region	located_in	IEA	UniProtKB-SubCell:SL-0243	150520179		UniProt	GO_REF:0000044
LOC100683045	Dog	extracellular space	located_in	IEA	UniProtKB-KW:KW-0202	150520179		UniProt	GO_REF:0000043
LOC100683045	Dog	extracellular space	is_active_in	IBA	MGI:107657\|MGI:107659\|MGI:107662\|MGI:107664\|MGI:107668\|PANTHER:PTN000190054\|UniProtKB:P01563\|UniProtKB:P01574	150520179		GO_Central	GO_REF:0000033

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
LOC100683045	Dog	cytokine activity	enables	IEA	UniProtKB-KW:KW-0202	150520179		UniProt	GO_REF:0000043
LOC100683045	Dog	cytokine activity	enables	IBA	MGI:107657\|MGI:107668\|PANTHER:PTN000190054\|UniProtKB:P01563\|UniProtKB:P01574	150520179		GO_Central	GO_REF:0000033
LOC100683045	Dog	cytokine receptor binding	enables	IEA	InterPro:IPR000471	150520179		InterPro	GO_REF:0000002
LOC100683045	Dog	type I interferon receptor binding	enables	IBA	MGI:107657\|MGI:2448469\|PANTHER:PTN000190054\|UniProtKB:Q9P0W0	150520179		GO_Central	GO_REF:0000033

PMID:22301074	PMID:30032202

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_003435427	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038525313	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038552524	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038616383	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038681859	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000356	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000479	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_003435427 ⟹ XP_003435475

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	11	39,401,133 - 39,401,681 (-)	NCBI

Sequence:

show sequence

CCGAACTTTTCTGGATGATGCGTGAAAAGCCAATCCAGAAGACTCTGGAGGCAAGGGCAGTCATGACAAGCACGCCCATGTAGTTGGGAAACAGTGCTCTAGAGCCAGTCGAAAGTGCATCATAAAGG
AAAGCAAAAAGAGAAGTAGAAAGTGAGGGAGACGTTCAGAAATGGAAAACGCGTCTGTTGCCTACTTAAGCCCCACACACGAGGGAAGATGCTCAGAGAAGCTGAAGCCGCGGTTCCCACACTTGCCC
AGCGCAGCCAGGCCCACAGCCCCTGCAGGATCCCCGATGGCCCTGCCCTGCTCCTTCTCGGTGGCCCTGGTGCTGCTCAGCTGCCACTCCCTGTGCTGTCTGGCTTGCCACCTGCCCGACACCCACGG
CCTGCGCAACTGGAGGGTCCTGACGCTCCTGGGACAGATGAGGAGACTCTCCGCCGGCTCTTGTGACCACTACACCAATGACTTTGCCTTCCCCAAGGAGCTGTTTGATGGCCAGCGGCTCCAGGAGG
CGCAGGCCCTCTCTGTGGTCCACGTGATGACCCAGAAGGTCTTCCACCTCTTCTGCCCGGACACGTCCTCTGCTCCTTGGAACATGACTCTCCTGGAGGAACTGTGCTCGGGGCTCTCTGAGCAGCTG
GATGACCTGGAGGCCTGTCCCCTGCAGGAGGCGGGGCTGGCCGAGACCCCCCTCATGCATGAGGACTCCACCCTGAGGACCTACTTCCAAAGGATCTCCCTCTACCTGCAAGACAGGAACCACAGCCC
GTGTGCCTGGGAGATGGTCCGAGCAGAAATCGGGAGATCCTTCTTCTCCTCGACAATCTTGCAAGAAAGAATCAGGAGGAGGAAATGAGACCCGCCCGGGTCCGCACGGAAATGACATTCCCTGACTG
ATCAGAGCACACTTGCACGTGTCCTGCCGCCTCAGAGAAGCTCACGCCTGCCGTCACGGTGACACGAAGGCAATCGGGTGTCCAACGTGTTCAGGACGGGGCAGCACCATCAAGTCAAGTCGACAAAC
ACCGCTTACTTTCACATAACCTTGCCCATCTCTCTACTTACTACTCATTCG

hide sequence

RefSeq Acc Id:

XM_038552524 ⟹ XP_038408452

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	11	40,796,811 - 40,797,440 (-)	NCBI

RefSeq Acc Id:

XM_038616383 ⟹ XP_038472311

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	11	40,161,681 - 40,162,244 (-)	NCBI

RefSeq Acc Id:

XM_038681859 ⟹ XP_038537787

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	11	41,680,722 - 41,681,524 (-)	NCBI


Protein RefSeqs	XP_003435475	(Get FASTA)	NCBI Sequence Viewer
	XP_038381241	(Get FASTA)	NCBI Sequence Viewer
	XP_038408452	(Get FASTA)	NCBI Sequence Viewer
	XP_038472311	(Get FASTA)	NCBI Sequence Viewer
	XP_038537787	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00030006318.1
	ENSCAFP00845023038.1

RefSeq Acc Id:	XP_038472311 ⟸ XM_038616383
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038537787 ⟸ XM_038681859
- Peptide Label:	isoform X1
- UniProtKB:	A0A7R8C3V6 (UniProtKB/TrEMBL)

RefSeq Acc Id:

XP_003435475 ⟸ XM_003435427

- Peptide Label:

isoform X5

- Sequence:

show sequence

MENASVAYLSPTHEGRCSEKLKPRFPHLPSAARPTAPAGSPMALPCSFSVALVLLSCHSLCCLACHLPDTHGLRNWRVLTLLGQMRRLSAGSCDHYTNDFAFPKELFDGQRLQEAQALSVVHVMTQKV
FHLFCPDTSSAPWNMTLLEELCSGLSEQLDDLEACPLQEAGLAETPLMHEDSTLRTYFQRISLYLQDRNHSPCAWEMVRAEIGRSFFSSTILQERIRRRK

hide sequence

RefSeq Acc Id:	XP_038408452 ⟸ XM_038552524
- Peptide Label:	isoform X4
- UniProtKB:	P81255 (UniProtKB/Swiss-Prot), A0A8C0LCC4 (UniProtKB/TrEMBL), A0A8C0RC53 (UniProtKB/TrEMBL)

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00030003911	UniProtKB/TrEMBL
	ENSCAFG00845016397	UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00030007210.1	UniProtKB/TrEMBL
	ENSCAFT00845029299.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1250.10	UniProtKB/TrEMBL
InterPro	4_helix_cytokine-like_core	UniProtKB/TrEMBL
	Interferon_alpha/beta/delta	UniProtKB/TrEMBL
NCBI Gene	LOC100683045	ENTREZGENE
PANTHER	INTERFERON ALPHA-5	UniProtKB/TrEMBL
	PTHR11691	UniProtKB/TrEMBL
Pfam	Interferon	UniProtKB/TrEMBL
PRINTS	INTERFERONAB	UniProtKB/TrEMBL
PROSITE	INTERFERON_A_B_D	UniProtKB/TrEMBL
SMART	IFabd	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47266	UniProtKB/TrEMBL
UniProt	A0A7R8C3V6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0LCC4	ENTREZGENE
	A0A8C0RC53	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3P2H1_CANLF	UniProtKB/TrEMBL
	P81255	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-01-12	LOC100683045	interferon alpha-1/2	LOC100683045	interferon alpha-1/2-like	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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