ABRA (actin binding Rho activating protein) - Rat Genome Database

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Gene: ABRA (actin binding Rho activating protein) Canis lupus familiaris
Analyze
Symbol: ABRA
Name: actin binding Rho activating protein
RGD ID: 12355263
Description: ENCODES a protein that exhibits actin binding (inferred); INVOLVED IN positive regulation of DNA-templated transcription (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); protein import into nucleus (ortholog); ASSOCIATED WITH dilated cardiomyopathy (ortholog); genetic disease (ortholog); FOUND IN actin cytoskeleton (inferred); myofibril (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1137,589,840 - 7,599,573 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl137,589,665 - 7,599,529 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha137,595,649 - 7,605,524 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0137,850,252 - 7,860,117 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl137,848,785 - 7,860,241 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1137,604,638 - 7,614,480 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0137,725,256 - 7,735,119 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0137,801,727 - 7,811,618 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
ABRA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1137,589,840 - 7,599,573 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl137,589,665 - 7,599,529 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha137,595,649 - 7,605,524 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0137,850,252 - 7,860,117 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl137,848,785 - 7,860,241 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1137,604,638 - 7,614,480 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0137,725,256 - 7,735,119 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0137,801,727 - 7,811,618 (-)NCBIUU_Cfam_GSD_1.0
ABRA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388106,759,483 - 106,770,244 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8106,759,483 - 106,770,244 (-)EnsemblGRCh38hg38GRCh38
GRCh378107,771,711 - 107,782,472 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368107,842,321 - 107,851,649 (-)NCBINCBI36Build 36hg18NCBI36
Celera8103,958,692 - 103,969,453 (-)NCBICelera
Cytogenetic Map8q23.1NCBI
HuRef8103,092,762 - 103,103,523 (-)NCBIHuRef
CHM1_18107,812,158 - 107,822,919 (-)NCBICHM1_1
T2T-CHM13v2.08107,887,295 - 107,936,923 (-)NCBIT2T-CHM13v2.0
Abra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391541,728,689 - 41,733,116 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1541,727,472 - 41,733,116 (-)EnsemblGRCm39 Ensembl
GRCm381541,865,293 - 41,869,720 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1541,864,076 - 41,869,720 (-)EnsemblGRCm38mm10GRCm38
MGSCv371541,696,839 - 41,701,266 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361541,695,367 - 41,699,794 (-)NCBIMGSCv36mm8
Celera1542,363,406 - 42,367,822 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1516.42NCBI
Abra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8774,855,008 - 74,859,076 (-)NCBIGRCr8
mRatBN7.2772,970,187 - 72,974,255 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl772,970,186 - 72,974,255 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx774,848,003 - 74,852,070 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0777,050,507 - 77,054,574 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0776,918,628 - 76,922,695 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0780,792,615 - 80,796,683 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl780,792,600 - 80,796,670 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0780,816,575 - 80,820,643 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4777,506,885 - 77,510,953 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1777,527,614 - 77,531,683 (-)NCBI
Celera769,986,321 - 69,990,389 (-)NCBICelera
Cytogenetic Map7q31NCBI
Abra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541729,875,928 - 29,883,584 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541729,874,234 - 29,883,648 (-)NCBIChiLan1.0ChiLan1.0
ABRA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27124,115,621 - 124,134,259 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1899,642,580 - 99,656,364 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08103,399,433 - 103,410,184 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18105,546,026 - 105,556,777 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8105,546,026 - 105,556,777 (-)Ensemblpanpan1.1panPan2
Abra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530330,293,845 - 30,300,974 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647037,719,933 - 37,727,102 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647037,719,469 - 37,727,066 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABRA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl430,712,238 - 30,721,193 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1430,712,238 - 30,719,495 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2433,354,419 - 33,361,711 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABRA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18101,541,780 - 101,552,423 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8101,538,492 - 101,551,440 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603939,032,752 - 39,042,375 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abra
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476322,348,043 - 22,353,351 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476322,346,911 - 22,353,213 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ABRA
91 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 6 8
Low 1
Below cutoff 4 22 6 6 6 6 12 10 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000001063   ⟹   ENSCAFP00000000975
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl137,589,665 - 7,599,529 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845019151   ⟹   ENSCAFP00845014961
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl137,848,785 - 7,860,241 (-)Ensembl
RefSeq Acc Id: XM_003639444   ⟹   XP_003639492
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1137,589,840 - 7,599,573 (-)NCBI
Dog10K_Boxer_Tasha137,595,649 - 7,605,524 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038493072   ⟹   XP_038349000
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1137,604,638 - 7,614,480 (-)NCBI
RefSeq Acc Id: XM_038555331   ⟹   XP_038411259
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0137,801,727 - 7,811,618 (-)NCBI
RefSeq Acc Id: XM_038619231   ⟹   XP_038475159
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0137,725,256 - 7,735,119 (-)NCBI
RefSeq Acc Id: XM_038684847   ⟹   XP_038540775
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0137,850,252 - 7,860,117 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003639492   ⟸   XM_003639444
- UniProtKB: A0A8P0S6N5 (UniProtKB/TrEMBL),   A0A8I3NBF4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000000975   ⟸   ENSCAFT00000001063
RefSeq Acc Id: XP_038349000   ⟸   XM_038493072
RefSeq Acc Id: XP_038475159   ⟸   XM_038619231
RefSeq Acc Id: XP_038540775   ⟸   XM_038684847
- UniProtKB: A0A8P0S6N5 (UniProtKB/TrEMBL),   A0A8I3NBF4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038411259   ⟸   XM_038555331
- UniProtKB: A0A8I3NBF4 (UniProtKB/TrEMBL),   A0A8P0S6N5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845014961   ⟸   ENSCAFT00845019151
Protein Domains
Costars

Promoters
RGD ID:13685573
Promoter ID:EPDNEW_C3640
Type:single initiation site
Name:ABRA_1
Description:actin binding Rho activating protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1137,599,547 - 7,599,607EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000682 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030024125 UniProtKB/TrEMBL
  ENSCAFG00845010850 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000001063.5 UniProtKB/TrEMBL
  ENSCAFT00030044377.1 UniProtKB/TrEMBL
  ENSCAFT00845019151 ENTREZGENE
  ENSCAFT00845019151.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.1540 UniProtKB/TrEMBL
InterPro Abra UniProtKB/TrEMBL
  Costars_dom UniProtKB/TrEMBL
  Costars_sf UniProtKB/TrEMBL
KEGG Report cfa:100856177 UniProtKB/TrEMBL
NCBI Gene ABRA ENTREZGENE
PANTHER ACTIN-BINDING RHO-ACTIVATING PROTEIN UniProtKB/TrEMBL
  PTHR22739 UniProtKB/TrEMBL
Pfam Costars UniProtKB/TrEMBL
SMART Costars UniProtKB/TrEMBL
UniProt A0A8C0PDL0_CANLF UniProtKB/TrEMBL
  A0A8I3NBF4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0S6N5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:37482 ENTREZGENE