ABRA (actin binding Rho activating protein)

Gene: ABRA (actin binding Rho activating protein) Sus scrofa

Analyze

Symbol:

ABRA

Name:

actin binding Rho activating protein

RGD ID:

14202081

Description:

ENCODES a protein that exhibits actin binding (inferred); INVOLVED IN positive regulation of DNA-templated transcription (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); protein import into nucleus (ortholog); ASSOCIATED WITH dilated cardiomyopathy (ortholog); genetic disease (ortholog); FOUND IN actin cytoskeleton (inferred); cytoplasm (inferred); cytoskeleton (inferred)

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

actin-binding Rho-activating protein; STARS; striated muscle activator of Rho-dependent signaling

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	30,712,238 - 30,721,193 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	30,712,238 - 30,719,495 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	33,354,419 - 33,361,711 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

dilated cardiomyopathy (ISO)

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of DNA-templated transcription (IEA,ISO)

positive regulation of Rho protein signal transduction (IBA,IEA)

positive regulation of transcription by RNA polymerase II (IBA,IEA,ISO)

protein import into nucleus (IEA,ISO)

protein transport (IEA)

transcription by RNA polymerase II (IEA,ISO)

Cellular Component

actin cytoskeleton (IEA)

cytoplasm (IEA)

cytoskeleton (IEA)

myofibril (IEA)

plasma membrane (IEA)

sarcomere (IBA,IEA)

Molecular Function

actin binding (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:15679890	PMID:18726684	PMID:30032202

Genomics

Comparative Map Data

ABRA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	30,712,238 - 30,721,193 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	30,712,238 - 30,719,495 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	33,354,419 - 33,361,711 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ABRA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	106,759,483 - 106,770,244 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	106,759,483 - 106,770,244 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	107,771,711 - 107,782,472 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	107,842,321 - 107,851,649 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	8	103,958,692 - 103,969,453 (-)	NCBI		Celera
Cytogenetic Map	8	q23.1	NCBI
HuRef	8	103,092,762 - 103,103,523 (-)	NCBI		HuRef
CHM1_1	8	107,812,158 - 107,822,919 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	107,887,295 - 107,936,923 (-)	NCBI		T2T-CHM13v2.0

Abra
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	41,728,689 - 41,733,116 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	41,727,472 - 41,733,116 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	41,865,293 - 41,869,720 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	41,864,076 - 41,869,720 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	41,696,839 - 41,701,266 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	41,695,367 - 41,699,794 (-)	NCBI		MGSCv36	mm8
Celera	15	42,363,406 - 42,367,822 (-)	NCBI		Celera
Cytogenetic Map	15	B3.1	NCBI
cM Map	15	16.42	NCBI

Abra
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	74,855,008 - 74,859,076 (-)	NCBI		GRCr8
mRatBN7.2	7	72,970,187 - 72,974,255 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	72,970,186 - 72,974,255 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	74,848,003 - 74,852,070 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	77,050,507 - 77,054,574 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	76,918,628 - 76,922,695 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	80,792,615 - 80,796,683 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	80,792,600 - 80,796,670 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	80,816,575 - 80,820,643 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	77,506,885 - 77,510,953 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	77,527,614 - 77,531,683 (-)	NCBI
Celera	7	69,986,321 - 69,990,389 (-)	NCBI		Celera
Cytogenetic Map	7	q31	NCBI

Abra
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955417	29,875,928 - 29,883,584 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955417	29,874,234 - 29,883,648 (-)	NCBI	ChiLan1.0	ChiLan1.0

ABRA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	124,115,621 - 124,134,259 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	99,642,580 - 99,656,364 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	103,399,433 - 103,410,184 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	105,546,026 - 105,556,777 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	105,546,026 - 105,556,777 (-)	Ensembl	panpan1.1		panPan2

ABRA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	7,589,840 - 7,599,573 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	7,589,665 - 7,599,529 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	7,595,649 - 7,605,524 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	7,850,252 - 7,860,117 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	7,848,785 - 7,860,241 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	7,604,638 - 7,614,480 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	7,725,256 - 7,735,119 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	7,801,727 - 7,811,618 (-)	NCBI		UU_Cfam_GSD_1.0

Abra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	30,293,845 - 30,300,974 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936470	37,719,933 - 37,727,102 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936470	37,719,469 - 37,727,066 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ABRA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	101,541,780 - 101,552,423 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	101,538,492 - 101,551,440 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	39,032,752 - 39,042,375 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Abra
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624763	22,348,043 - 22,353,351 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624763	22,346,911 - 22,353,213 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in ABRA
203 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
High
Medium		2			2
Low	1		3	3		19	2	2	2
Below cutoff	9	2		2		4		1	1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001135960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK347188	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY609571	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU462955	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ536197	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSSCT00000041495 ⟹ ENSSSCP00000034829

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	4	30,712,238 - 30,721,193 (+)	Ensembl

RefSeq Acc Id:

NM_001135960 ⟹ NP_001129432

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	4	30,712,238 - 30,719,495 (+)	NCBI

Sequence:

show sequence

ATTCATTTCAGCCCGTGCCCAGATTACCAGCAGAGAAGAGAAGGGCAGCATGGCCCGGGGAGAA
AAGGGAAGAGGGGAGGGACCTGCCAAGAGTGCCCTCCGGAAGGTACGCACAGCCACCCTGGTTA
TCAACTTGGCCCGGGGCTGGCAGCAGTGGGCAAATGAGAATAGCACCAGGCAGGCCCAGGAGCC
TACAGGCTGGATGCCAGGAGGGGCCAGGGAGTCAGACCAACCTTCTGGACCAGTGATACACCCT
ACAACCCACCAGAAAGTCCAGAGTGCCCCAAAATCTCCCTCCCCAAAGCCAGGGGGATATGGAG
CTGGACAAAGCTCAGAGGGAGCCACCGAAGTCTCTCCTATCAAAAGGAAAGAGGTGACCAAGAC
CATTGTCAGCAAAGCTTACGAGAGAGGAGGTGATGTAAGCCACCTCAGCCATAGATACGAGAAG
GATGGTGATGAGCCTGAACCCGAGCAGCCAGAGAGTGACATTGACAGACTCCTCCGCAGCCATG
GCTCCCCAACGCGGAGAAGAAAATGTGCCAACCTGGTATCTGAGCTGACCAAGGGCTGGAAGGA
GATGGAACAGGAGGAACAGGAGGAGCTCAAATGCAGGAGTGATAGCATAGACACAGAAGACAGC
GGCTACGGAGGGGAGACAGAGGAGAGGCCGGAGCAGGATGGAGAGCAGGTGGCCATCGCCAGAA
TCAAACGCCCCTTGCCCTCCCAGGCAAATAGATTTACCGAGAAACTCAATTGCAAAGCCCAGCG
GAAATACAGCCAAGTGGGCCACCTGAAAGGGAGGTGGCAGCAGTGGGCTGATGAACACATACAA
TCCCAGAAGCTCAACCCTTTCAGTGACGAGTTTGATTATGAATTGGCCATGTCCACCCGCCTGC
ACAAAGGAGATGAAGGCTACGGCCGTCCCAAGGAAGGAACCAGAACTGCGGAAAGGGCTAAGAG
AGCTGAGGAGCACATCTACAGAGAAATCATGGACATGTGCTTCATCATCCGCACGATGGCGCAC
CCCAGGCGGGACGGCAAGATCCAGGTTACTTTCGGAGATCTCTTTGACAGATACGTTCGTATTT
CAGATAAAGTAGTGGGCATTCTCATGCGCGCCAGGAAACACGGACTGGTTGACTTTGAGGGAGA
GATGCTATGGCAAGGCCGAGATGACCACGTTGTGATCACTCTGCTAAAGTGAACTTGCAACAAC
ACAAACCAGACTTGACCCACTCCTGTCTTAATGCTAAACGCGAAAGCAGTGAAATTTAAAAGGC
AAACTGCTCTGTACCGAGTTAGTAAACATTAAACAATTTTTACAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001129432	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ABG00262	(Get FASTA)	NCBI Sequence Viewer
	B5SNZ6	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000034829
	ENSSSCP00000034829.1
	ENSSSCP00005012715.1
	ENSSSCP00015019244.1
	ENSSSCP00025039006.1
	ENSSSCP00030008252.1
	ENSSSCP00035035006.1
	ENSSSCP00040003978.1
	ENSSSCP00045028372.1
	ENSSSCP00050017661.1
	ENSSSCP00055039488.1
	ENSSSCP00060018809.1
	ENSSSCP00065025561.1
	ENSSSCP00070014531.1

RefSeq Acc Id:

NP_001129432 ⟸ NM_001135960

- UniProtKB:

B5SNZ6 (UniProtKB/Swiss-Prot), A0A286ZTQ0 (UniProtKB/TrEMBL), A0A8D1DAB9 (UniProtKB/TrEMBL), A0A8D1Z1C8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MARGEKGRGEGPAKSALRKVRTATLVINLARGWQQWANENSTRQAQEPTGWMPGGARESDQPSG
PVIHPTTHQKVQSAPKSPSPKPGGYGAGQSSEGATEVSPIKRKEVTKTIVSKAYERGGDVSHLS
HRYEKDGDEPEPEQPESDIDRLLRSHGSPTRRRKCANLVSELTKGWKEMEQEEQEELKCRSDSI
DTEDSGYGGETEERPEQDGEQVAIARIKRPLPSQANRFTEKLNCKAQRKYSQVGHLKGRWQQWA
DEHIQSQKLNPFSDEFDYELAMSTRLHKGDEGYGRPKEGTRTAERAKRAEEHIYREIMDMCFII
RTMAHPRRDGKIQVTFGDLFDRYVRISDKVVGILMRARKHGLVDFEGEMLWQGRDDHVVITLLK

hide sequence

RefSeq Acc Id:

ENSSSCP00000034829 ⟸ ENSSSCT00000041495

Protein Domains

Costars

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000031728	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00005013617	UniProtKB/Swiss-Prot
	ENSSSCG00015036376	UniProtKB/Swiss-Prot
	ENSSSCG00025064982	UniProtKB/Swiss-Prot
	ENSSSCG00030013589	UniProtKB/Swiss-Prot
	ENSSSCG00035062655	UniProtKB/Swiss-Prot
	ENSSSCG00040007785	UniProtKB/TrEMBL
	ENSSSCG00045023911	UniProtKB/Swiss-Prot
	ENSSSCG00050031771	UniProtKB/TrEMBL
	ENSSSCG00055025019	UniProtKB/TrEMBL
	ENSSSCG00060032554	UniProtKB/Swiss-Prot
	ENSSSCG00065043114	UniProtKB/TrEMBL
	ENSSSCG00070009047	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSSSCT00000041495	ENTREZGENE
	ENSSSCT00000041495.2	UniProtKB/TrEMBL
	ENSSSCT00005021245.1	UniProtKB/Swiss-Prot
	ENSSSCT00015048398.1	UniProtKB/Swiss-Prot
	ENSSSCT00025089178.1	UniProtKB/Swiss-Prot
	ENSSSCT00030018633.1	UniProtKB/Swiss-Prot
	ENSSSCT00035084200.1	UniProtKB/Swiss-Prot
	ENSSSCT00040010211.1	UniProtKB/TrEMBL
	ENSSSCT00045040820.1	UniProtKB/Swiss-Prot
	ENSSSCT00050042699.1	UniProtKB/TrEMBL
	ENSSSCT00055049418.1	UniProtKB/TrEMBL
	ENSSSCT00060044091.1	UniProtKB/Swiss-Prot
	ENSSSCT00065058954.1	UniProtKB/TrEMBL
	ENSSSCT00070017535.1	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.10.1540	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Abra	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Costars_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Costars_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	ssc:100154546	UniProtKB/Swiss-Prot
NCBI Gene	ABRA	ENTREZGENE
PANTHER	ACTIN-BINDING RHO-ACTIVATING PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR22739	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Costars	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	Costars	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A286ZTQ0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D1DAB9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D1Z1C8	ENTREZGENE, UniProtKB/TrEMBL
	ABRA_PIG	UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID	VGNC:84990	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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