KCNK10 (potassium two pore domain channel subfamily K member 10) - Rat Genome Database

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Gene: KCNK10 (potassium two pore domain channel subfamily K member 10) Canis lupus familiaris
Analyze
Symbol: KCNK10
Name: potassium two pore domain channel subfamily K member 10
RGD ID: 12345252
Description: ENCODES a protein that exhibits potassium channel activity (ortholog); INVOLVED IN memory (ortholog); ASSOCIATED WITH brain ischemia (ortholog); Deafness (ortholog); Leber congenital amaurosis 3 (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: potassium channel subfamily K member 10; potassium channel, subfamily K, member 10
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1859,484,385 - 59,612,891 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl859,484,328 - 59,612,750 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha859,058,106 - 59,190,884 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0859,748,550 - 59,882,007 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl859,753,288 - 59,882,355 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1859,426,150 - 59,559,090 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0859,472,627 - 59,606,367 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0859,806,721 - 59,940,310 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KCNK10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1859,484,385 - 59,612,891 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl859,484,328 - 59,612,750 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha859,058,106 - 59,190,884 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0859,748,550 - 59,882,007 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl859,753,288 - 59,882,355 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1859,426,150 - 59,559,090 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0859,472,627 - 59,606,367 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0859,806,721 - 59,940,310 (-)NCBIUU_Cfam_GSD_1.0
KCNK10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381488,180,108 - 88,326,912 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1488,180,103 - 88,326,907 (-)EnsemblGRCh38hg38GRCh38
GRCh371488,646,452 - 88,793,256 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361487,720,993 - 87,863,004 (-)NCBINCBI36Build 36hg18NCBI36
Build 341487,720,999 - 87,863,004NCBI
Celera1468,692,135 - 68,838,993 (-)NCBICelera
Cytogenetic Map14q31.3NCBI
HuRef1468,816,576 - 68,963,621 (-)NCBIHuRef
CHM1_11488,584,550 - 88,731,289 (-)NCBICHM1_1
T2T-CHM13v2.01482,400,736 - 82,547,879 (-)NCBIT2T-CHM13v2.0
Kcnk10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391298,395,691 - 98,544,472 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1298,395,696 - 98,544,569 (-)EnsemblGRCm39 Ensembl
GRCm381298,429,432 - 98,578,213 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1298,429,437 - 98,578,310 (-)EnsemblGRCm38mm10GRCm38
MGSCv371299,672,204 - 99,816,150 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361298,835,044 - 98,978,990 (-)NCBIMGSCv36mm8
Celera1299,659,474 - 99,802,888 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1249.86NCBI
Kcnk10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86123,419,778 - 123,555,820 (-)NCBIGRCr8
mRatBN7.26117,690,052 - 117,826,120 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6117,694,222 - 117,825,695 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6117,844,163 - 117,973,353 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06118,140,969 - 118,270,161 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06117,475,841 - 117,605,022 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06122,417,079 - 122,549,532 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6122,419,046 - 122,545,899 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06131,631,562 - 131,760,720 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46122,600,156 - 122,729,583 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16122,603,902 - 122,733,330 (-)NCBI
Celera6115,256,086 - 115,384,773 (-)NCBICelera
Cytogenetic Map6q32NCBI
Kcnk10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543810,873,131 - 10,999,441 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543810,867,695 - 10,996,005 (-)NCBIChiLan1.0ChiLan1.0
KCNK10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21589,318,727 - 89,465,402 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11488,535,233 - 88,681,901 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01468,792,290 - 68,938,947 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11488,152,288 - 88,298,811 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1488,157,714 - 88,235,878 (-)Ensemblpanpan1.1panPan2
Kcnk10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864016,240,409 - 16,371,438 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648815,698,143 - 15,827,661 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648815,698,137 - 15,773,582 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNK10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7110,121,263 - 110,271,481 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17110,117,087 - 110,271,877 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27116,613,778 - 116,770,316 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNK10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12465,835,010 - 65,989,030 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2465,835,650 - 65,987,964 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605353,194,967 - 53,339,806 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnk10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473413,990,495 - 14,156,674 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473414,062,218 - 14,161,869 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KCNK10
1585 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 32 21 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005623724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022422301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022422302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038484000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038484001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038545495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038545496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038593505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038609587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038609588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038674404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038674405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000027482   ⟹   ENSCAFP00000025558
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl859,484,328 - 59,612,750 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000043710   ⟹   ENSCAFP00000038091
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl859,484,328 - 59,609,470 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845017588   ⟹   ENSCAFP00845013692
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl859,753,288 - 59,882,355 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845017629   ⟹   ENSCAFP00845013726
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl859,753,288 - 59,878,574 (-)Ensembl
RefSeq Acc Id: XM_005623724   ⟹   XP_005623781
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1859,484,385 - 59,609,636 (-)NCBI
Dog10K_Boxer_Tasha859,058,106 - 59,187,604 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038484000   ⟹   XP_038339928
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1859,426,150 - 59,559,090 (-)NCBI
RefSeq Acc Id: XM_038484001   ⟹   XP_038339929
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1859,426,150 - 59,555,827 (-)NCBI
RefSeq Acc Id: XM_038545495   ⟹   XP_038401423
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0859,806,721 - 59,936,907 (-)NCBI
RefSeq Acc Id: XM_038545496   ⟹   XP_038401424
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0859,806,721 - 59,940,310 (-)NCBI
RefSeq Acc Id: XM_038593505   ⟹   XP_038449433
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha859,058,106 - 59,190,884 (-)NCBI
RefSeq Acc Id: XM_038609587   ⟹   XP_038465515
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0859,472,627 - 59,603,054 (-)NCBI
RefSeq Acc Id: XM_038609588   ⟹   XP_038465516
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0859,472,627 - 59,606,367 (-)NCBI
RefSeq Acc Id: XM_038674404   ⟹   XP_038530332
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0859,748,550 - 59,878,640 (-)NCBI
RefSeq Acc Id: XM_038674405   ⟹   XP_038530333
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0859,748,550 - 59,882,007 (-)NCBI
RefSeq Acc Id: XP_005623781   ⟸   XM_005623724
- Peptide Label: isoform X1
- UniProtKB: A0A8C0M8T0 (UniProtKB/TrEMBL),   A0A8I3N317 (UniProtKB/TrEMBL),   A0A8C0R2B4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000038091   ⟸   ENSCAFT00000043710
Ensembl Acc Id: ENSCAFP00000025558   ⟸   ENSCAFT00000027482
RefSeq Acc Id: XP_038339928   ⟸   XM_038484000
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038339929   ⟸   XM_038484001
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038465516   ⟸   XM_038609588
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038465515   ⟸   XM_038609587
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038530333   ⟸   XM_038674405
- Peptide Label: isoform X2
- UniProtKB: A0A8C0RBI8 (UniProtKB/TrEMBL),   A0A8I3N9B1 (UniProtKB/TrEMBL),   A0A8C0R2B4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038530332   ⟸   XM_038674404
- Peptide Label: isoform X1
- UniProtKB: A0A8C0M8T0 (UniProtKB/TrEMBL),   A0A8I3N317 (UniProtKB/TrEMBL),   A0A8C0R2B4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038449433   ⟸   XM_038593505
- Peptide Label: isoform X2
- UniProtKB: A0A8P0NII3 (UniProtKB/TrEMBL),   A0A8C0R2B4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038401424   ⟸   XM_038545496
- Peptide Label: isoform X2
- UniProtKB: A0A8C0R2B4 (UniProtKB/TrEMBL),   A0A8C0RBI8 (UniProtKB/TrEMBL),   A0A8I3N9B1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038401423   ⟸   XM_038545495
- Peptide Label: isoform X1
- UniProtKB: A0A8C0M8T0 (UniProtKB/TrEMBL),   A0A8C0R2B4 (UniProtKB/TrEMBL),   A0A8I3N317 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845013726   ⟸   ENSCAFT00845017629
Ensembl Acc Id: ENSCAFP00845013692   ⟸   ENSCAFT00845017588
Protein Domains
Potassium channel


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000017343 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030002992 UniProtKB/TrEMBL
  ENSCAFG00040001240 UniProtKB/TrEMBL
  ENSCAFG00845009995 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000027482.7 UniProtKB/TrEMBL
  ENSCAFT00000043710.4 UniProtKB/TrEMBL
  ENSCAFT00030005604.1 UniProtKB/TrEMBL
  ENSCAFT00030005623.1 UniProtKB/TrEMBL
  ENSCAFT00040002334.1 UniProtKB/TrEMBL
  ENSCAFT00040002347.1 UniProtKB/TrEMBL
  ENSCAFT00845017588 ENTREZGENE
  ENSCAFT00845017588.1 UniProtKB/TrEMBL
  ENSCAFT00845017629 ENTREZGENE
  ENSCAFT00845017629.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
InterPro 2pore_dom_K_chnl UniProtKB/TrEMBL
  2pore_dom_K_chnl_TREK UniProtKB/TrEMBL
  K_chnl_dom UniProtKB/TrEMBL
KEGG Report cfa:490822 UniProtKB/TrEMBL
NCBI Gene KCNK10 ENTREZGENE
PANTHER POTASSIUM CHANNEL SUBFAMILY K MEMBER 10 UniProtKB/TrEMBL
  PTHR11003 UniProtKB/TrEMBL
Pfam Ion_trans_2 UniProtKB/TrEMBL
PRINTS 2POREKCHANEL UniProtKB/TrEMBL
  TREKCHANNEL UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A8C0M8T0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PP28_CANLF UniProtKB/TrEMBL
  A0A8C0R2B4 ENTREZGENE
  A0A8C0RBI8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N317 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N9B1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NII3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:42270 ENTREZGENE