RGD Reference Report - Enhanced expressions of arachidonic acid-sensitive tandem-pore domain potassium channels in rat experimental acute cerebral ischemia. - Rat Genome Database

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Enhanced expressions of arachidonic acid-sensitive tandem-pore domain potassium channels in rat experimental acute cerebral ischemia.

Authors: Li, ZB  Zhang, HX  Li, LL  Wang, XL 
Citation: Li ZB, etal., Biochem Biophys Res Commun. 2005 Feb 25;327(4):1163-9.
RGD ID: 9831167
Pubmed: PMID:15652517   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2004.12.124   (Journal Full-text)

To further explore the pathophysiological significance of arachidonic acid-sensitive potassium channels, RT-PCR and Western blot analysis were used to investigate the expression changes of TREK channels in cortex and hippocampus in rat experimental acute cerebral ischemia in this study. Results showed that TREK-1 and TRAAK mRNA in cortex, TREK-1 and TREK-2 mRNA in hippocampus showed significant increases 2 h after middle cerebral artery occlusion (MCAO). While the mRNA expression levels of the all three channel subtypes increased significantly 24 h after MCAO in cortex and hippocampus. At the same time, the protein expressions of all the three channel proteins showed significant increase 24 h after MCAO in cortex and hippocampus, but only TREK-1 showed increased expression 2 h after MCAO in cortex and hippocampus. Immunohistochemical experiments verified that all the three channel proteins had higher expression levels in cortical and hippocampal neurons 24 h after MCAO. These results suggested a strong correlation between TREK channels and acute cerebral ischemia. TREK channels might provide a neuroprotective mechanism in the pathological process.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
brain ischemia  ISOKcnk10 (Rattus norvegicus)9831167; 9831167mRNA more ...RGD 
brain ischemia  IEP 9831167mRNA more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Kcnk10  (potassium two pore domain channel subfamily K member 10)

Genes (Mus musculus)
Kcnk10  (potassium channel, subfamily K, member 10)

Genes (Homo sapiens)
KCNK10  (potassium two pore domain channel subfamily K member 10)


Additional Information