UBE2B (ubiquitin conjugating enzyme E2 B) - Rat Genome Database

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Gene: UBE2B (ubiquitin conjugating enzyme E2 B) Canis lupus familiaris
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Symbol: UBE2B
Name: ubiquitin conjugating enzyme E2 B
RGD ID: 12342010
Description: ENCODES a protein that exhibits ATP binding (inferred); transferase activity (inferred); ubiquitin conjugating enzyme activity (inferred); INVOLVED IN apoptotic process (ortholog); cellular response to insulin stimulus (ortholog); chiasma assembly (ortholog); ASSOCIATED WITH familial adenomatous polyposis 1 (ortholog); Hereditary Neoplastic Syndromes (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN chromatin (inferred); cytoplasm (inferred); HULC complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ubiquitin-conjugating enzyme E2 B; ubiquitin-conjugating enzyme E2B (RAD6 homolog)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11122,523,671 - 22,541,473 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1122,525,051 - 22,540,388 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1121,269,251 - 21,287,230 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01123,325,044 - 23,343,019 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1123,326,331 - 23,345,713 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11122,024,744 - 22,042,221 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01121,890,257 - 21,907,725 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01122,532,474 - 22,550,185 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IEA)
cytoplasm  (IEA)
HULC complex  (IBA,IEA)
nucleus  (IEA)
replication fork  (IEA)
XY body  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
UBE2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11122,523,671 - 22,541,473 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1122,525,051 - 22,540,388 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1121,269,251 - 21,287,230 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01123,325,044 - 23,343,019 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1123,326,331 - 23,345,713 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11122,024,744 - 22,042,221 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01121,890,257 - 21,907,725 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01122,532,474 - 22,550,185 (+)NCBIUU_Cfam_GSD_1.0
UBE2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385134,371,569 - 134,392,108 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5134,371,184 - 134,392,108 (+)EnsemblGRCh38hg38GRCh38
GRCh375133,707,260 - 133,727,799 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365133,734,769 - 133,755,698 (+)NCBINCBI36Build 36hg18NCBI36
Build 345133,734,768 - 133,755,698NCBI
Celera5129,830,646 - 129,851,595 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5128,891,659 - 128,912,617 (+)NCBIHuRef
CHM1_15133,139,494 - 133,160,408 (+)NCBICHM1_1
T2T-CHM13v2.05134,895,355 - 134,915,908 (+)NCBIT2T-CHM13v2.0
Ube2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391151,875,965 - 51,894,972 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1151,876,324 - 51,891,589 (-)EnsemblGRCm39 Ensembl
GRCm381151,985,138 - 52,004,145 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1151,985,497 - 52,000,762 (-)EnsemblGRCm38mm10GRCm38
MGSCv371151,798,648 - 51,813,968 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361151,828,985 - 51,843,810 (-)NCBIMGSCv36mm8
Celera1156,553,448 - 56,568,767 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.82NCBI
Ube2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81036,749,365 - 36,764,335 (-)NCBIGRCr8
mRatBN7.21036,248,434 - 36,263,379 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1036,248,438 - 36,264,665 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1040,942,877 - 40,957,457 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01040,432,847 - 40,447,427 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01035,936,569 - 35,951,149 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01037,439,947 - 37,454,867 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1037,441,284 - 37,455,022 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01037,213,057 - 37,229,080 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41037,509,322 - 37,523,900 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11037,516,863 - 37,530,245 (-)NCBI
Celera1035,603,474 - 35,618,052 (-)NCBICelera
Cytogenetic Map10q22NCBI
Ube2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554085,552,619 - 5,572,145 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554085,552,619 - 5,572,145 (+)NCBIChiLan1.0ChiLan1.0
UBE2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24129,669,779 - 129,689,993 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15127,809,653 - 127,829,555 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05129,775,011 - 129,794,853 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15135,925,217 - 135,944,609 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5135,925,217 - 135,944,609 (+)Ensemblpanpan1.1panPan2
Ube2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213113,888,593 - 113,911,224 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936647891,996 - 911,033 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936647891,357 - 913,963 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UBE2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2136,652,785 - 136,667,949 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12136,652,764 - 136,667,213 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22142,228,179 - 142,237,960 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UBE2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12337,180,011 - 37,199,250 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2337,180,424 - 37,198,064 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603440,733,276 - 40,753,205 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ube2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473337,891,280 - 37,906,066 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473337,890,350 - 37,907,846 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in UBE2B
208 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000001566   ⟹   ENSCAFP00000001440
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1122,525,051 - 22,540,388 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845022937   ⟹   ENSCAFP00845017980
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1123,326,331 - 23,345,713 (+)Ensembl
RefSeq Acc Id: XM_022425310   ⟹   XP_022281018
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11122,523,671 - 22,541,473 (+)NCBI
Dog10K_Boxer_Tasha1121,269,251 - 21,287,230 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038490105   ⟹   XP_038346033
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11122,024,744 - 22,042,221 (+)NCBI
RefSeq Acc Id: XM_038552182   ⟹   XP_038408110
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01122,532,474 - 22,550,185 (+)NCBI
RefSeq Acc Id: XM_038616048   ⟹   XP_038471976
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01121,890,257 - 21,907,725 (+)NCBI
RefSeq Acc Id: XM_038681540   ⟹   XP_038537468
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01123,325,044 - 23,343,019 (+)NCBI
RefSeq Acc Id: XP_022281018   ⟸   XM_022425310
- UniProtKB: A0A8C0QP58 (UniProtKB/TrEMBL),   A0A8C0QTG1 (UniProtKB/TrEMBL),   A0A8I3NQN0 (UniProtKB/TrEMBL),   A0A8C0JVD4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000001440   ⟸   ENSCAFT00000001566
RefSeq Acc Id: XP_038346033   ⟸   XM_038490105
RefSeq Acc Id: XP_038471976   ⟸   XM_038616048
RefSeq Acc Id: XP_038537468   ⟸   XM_038681540
- UniProtKB: A0A8C0QP58 (UniProtKB/TrEMBL),   A0A8C0QTG1 (UniProtKB/TrEMBL),   A0A8I3NQN0 (UniProtKB/TrEMBL),   A0A8C0JVD4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038408110   ⟸   XM_038552182
- UniProtKB: A0A8C0JVD4 (UniProtKB/TrEMBL),   A0A8C0QP58 (UniProtKB/TrEMBL),   A0A8C0QTG1 (UniProtKB/TrEMBL),   A0A8I3NQN0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845017980   ⟸   ENSCAFT00845022937
Protein Domains
UBC core


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001019 Ensembl
  ENSCAFG00000055704 UniProtKB/TrEMBL
  ENSCAFG00030009295 UniProtKB/TrEMBL
  ENSCAFG00040007884 UniProtKB/TrEMBL
  ENSCAFG00845012898 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000095323.1 UniProtKB/TrEMBL
  ENSCAFT00030017208.1 UniProtKB/TrEMBL
  ENSCAFT00040014673.1 UniProtKB/TrEMBL
  ENSCAFT00845022937 ENTREZGENE
  ENSCAFT00845022937.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.110.10 UniProtKB/TrEMBL
InterPro Ub_conjugating_enzyme UniProtKB/TrEMBL
  UBQ-conjugat_E2 UniProtKB/TrEMBL
  UBQ-conjugating_AS UniProtKB/TrEMBL
  UBQ-conjugating_enzyme/RWD UniProtKB/TrEMBL
NCBI Gene UBE2B ENTREZGENE
PANTHER UBIQUITIN-CONJUGATING ENZYME E2 UniProtKB/TrEMBL
Pfam UQ_con UniProtKB/TrEMBL
PROSITE UBC_1 UniProtKB/TrEMBL
  UBC_2 UniProtKB/TrEMBL
SMART UBCc UniProtKB/TrEMBL
Superfamily-SCOP SSF54495 UniProtKB/TrEMBL
UniProt A0A8C0JVD4 ENTREZGENE
  A0A8C0QP58 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QTG1 ENTREZGENE
  A0A8I3NQN0 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:56072 ENTREZGENE