TSPAN8 (tetraspanin 8) - Rat Genome Database

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Gene: TSPAN8 (tetraspanin 8) Canis lupus familiaris
Analyze
Symbol: TSPAN8
Name: tetraspanin 8
RGD ID: 12338477
Description: ENCODES a protein that exhibits integrin binding (ortholog); INVOLVED IN negative regulation of blood coagulation (ortholog); regulation of gene expression (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH adult respiratory distress syndrome (ortholog); Arterial Occlusive Diseases (ortholog); breast ductal carcinoma (ortholog); FOUND IN cell surface (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tetraspanin-8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11012,786,824 - 12,818,257 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1012,786,867 - 12,818,088 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1012,725,247 - 12,756,661 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01012,919,135 - 12,950,691 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1012,919,178 - 12,950,562 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11012,784,319 - 12,816,660 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01013,031,549 - 13,062,936 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01013,155,666 - 13,187,030 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell surface  (IEA)
membrane  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TSPAN8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11012,786,824 - 12,818,257 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1012,786,867 - 12,818,088 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1012,725,247 - 12,756,661 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01012,919,135 - 12,950,691 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1012,919,178 - 12,950,562 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11012,784,319 - 12,816,660 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01013,031,549 - 13,062,936 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01013,155,666 - 13,187,030 (-)NCBIUU_Cfam_GSD_1.0
TSPAN8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381271,125,096 - 71,157,999 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1271,125,085 - 71,441,898 (-)EnsemblGRCh38hg38GRCh38
GRCh371271,518,876 - 71,551,779 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361269,805,144 - 69,838,046 (-)NCBINCBI36Build 36hg18NCBI36
Build 341269,805,143 - 69,838,046NCBI
Celera1271,182,199 - 71,215,102 (-)NCBICelera
Cytogenetic Map12q21.1NCBI
HuRef1268,568,317 - 68,601,483 (-)NCBIHuRef
CHM1_11271,488,354 - 71,521,249 (-)NCBICHM1_1
T2T-CHM13v2.01271,104,602 - 71,137,962 (-)NCBIT2T-CHM13v2.0
Tspan8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910115,652,722 - 115,685,798 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10115,652,737 - 115,685,798 (+)EnsemblGRCm39 Ensembl
GRCm3810115,816,817 - 115,849,893 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10115,816,832 - 115,849,893 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710115,254,340 - 115,286,949 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610115,221,394 - 115,253,726 (+)NCBIMGSCv36mm8
Celera10117,748,806 - 117,782,287 (+)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1063.51NCBI
Tspan8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8753,331,019 - 53,365,402 (+)NCBIGRCr8
mRatBN7.2751,444,946 - 51,479,360 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl751,445,074 - 51,479,356 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx753,351,868 - 53,386,094 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0755,554,937 - 55,589,176 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0755,332,961 - 55,367,187 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0758,814,805 - 58,847,564 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl758,814,805 - 58,847,563 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0758,821,787 - 58,854,525 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4755,104,257 - 55,136,906 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1755,124,986 - 55,157,635 (+)NCBI
Celera748,232,246 - 48,265,180 (+)NCBICelera
Cytogenetic Map7q22NCBI
Tspan8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540511,199,280 - 11,232,955 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540511,200,290 - 11,233,094 (-)NCBIChiLan1.0ChiLan1.0
TSPAN8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21079,158,701 - 79,407,526 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11279,155,101 - 79,403,926 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01268,653,209 - 68,686,565 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11271,417,577 - 71,450,873 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1271,417,577 - 71,450,873 (-)Ensemblpanpan1.1panPan2
Tspan8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494545,408,788 - 45,442,759 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936568285,696 - 311,864 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936568285,130 - 304,479 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSPAN8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl535,240,715 - 35,321,845 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1535,210,744 - 35,482,788 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2537,839,246 - 37,889,811 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TSPAN8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11166,726,714 - 66,882,234 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1166,725,231 - 66,758,091 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037178,902,512 - 178,937,777 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tspan8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475026,633,793 - 26,669,980 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475026,634,019 - 26,668,779 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TSPAN8
342 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000000723   ⟹   ENSCAFP00000000667
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1012,786,867 - 12,818,088 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845039243   ⟹   ENSCAFP00845030736
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1012,919,178 - 12,950,562 (-)Ensembl
RefSeq Acc Id: XM_038488125   ⟹   XP_038344053
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11012,784,319 - 12,816,660 (-)NCBI
RefSeq Acc Id: XM_038550015   ⟹   XP_038405943
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01013,155,666 - 13,187,030 (-)NCBI
RefSeq Acc Id: XM_038614011   ⟹   XP_038469939
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01013,031,549 - 13,062,936 (-)NCBI
RefSeq Acc Id: XM_038679355   ⟹   XP_038535283
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01012,919,135 - 12,950,691 (-)NCBI
RefSeq Acc Id: XM_531678   ⟹   XP_531678
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11012,786,824 - 12,818,257 (-)NCBI
Dog10K_Boxer_Tasha1012,725,247 - 12,756,661 (-)NCBI
Sequence:
RefSeq Acc Id: XP_531678   ⟸   XM_531678
- UniProtKB: A0A8C0S7T2 (UniProtKB/TrEMBL),   A0A8C0KW39 (UniProtKB/TrEMBL),   A0A8I3PI03 (UniProtKB/TrEMBL),   A0A8C0MIJ6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000000667   ⟸   ENSCAFT00000000723
RefSeq Acc Id: XP_038344053   ⟸   XM_038488125
RefSeq Acc Id: XP_038469939   ⟸   XM_038614011
RefSeq Acc Id: XP_038535283   ⟸   XM_038679355
- UniProtKB: A0A8C0S7T2 (UniProtKB/TrEMBL),   A0A8C0KW39 (UniProtKB/TrEMBL),   A0A8I3PI03 (UniProtKB/TrEMBL),   A0A8C0MIJ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038405943   ⟸   XM_038550015
- UniProtKB: A0A8C0KW39 (UniProtKB/TrEMBL),   A0A8C0MIJ6 (UniProtKB/TrEMBL),   A0A8C0S7T2 (UniProtKB/TrEMBL),   A0A8I3PI03 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845030736   ⟸   ENSCAFT00845039243

Promoters
RGD ID:13684905
Promoter ID:EPDNEW_C2973
Type:initiation region
Name:TSPAN8_1
Description:tetraspanin 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11012,817,988 - 12,818,048EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000450 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030005594 UniProtKB/TrEMBL
  ENSCAFG00040010819 UniProtKB/TrEMBL
  ENSCAFG00845022247 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000000723.5 UniProtKB/TrEMBL
  ENSCAFT00030010235.1 UniProtKB/TrEMBL
  ENSCAFT00030010288.1 UniProtKB/TrEMBL
  ENSCAFT00040020017.1 UniProtKB/TrEMBL
  ENSCAFT00845039243 ENTREZGENE
  ENSCAFT00845039243.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1450.10 UniProtKB/TrEMBL
InterPro Tetraspanin/Peripherin UniProtKB/TrEMBL
  Tetraspanin_animals UniProtKB/TrEMBL
  Tetraspanin_CS UniProtKB/TrEMBL
  Tetraspanin_EC2_sf UniProtKB/TrEMBL
KEGG Report cfa:474448 UniProtKB/TrEMBL
NCBI Gene TSPAN8 ENTREZGENE
PANTHER PTHR19282 UniProtKB/TrEMBL
  TETRASPANIN-8 UniProtKB/TrEMBL
Pfam Tetraspanin UniProtKB/TrEMBL
PIRSF Tetraspanin UniProtKB/TrEMBL
PRINTS TMFOUR UniProtKB/TrEMBL
PROSITE TM4_1 UniProtKB/TrEMBL
Superfamily-SCOP SSF48652 UniProtKB/TrEMBL
UniProt A0A8C0KW39 ENTREZGENE
  A0A8C0MIJ6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0S7T2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PI03 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:47925 ENTREZGENE