MIR590 (microRNA mir-590) - Rat Genome Database

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Gene: MIR590 (microRNA mir-590) Canis lupus familiaris
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Symbol: MIR590 (Ensembl: cfa-mir-590)
Name: microRNA mir-590 (Ensembl:cfa-mir-590)
RGD ID: 12322241
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: cfa-mir-590; microRNA 590
RGD Orthologs
Human
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.166,186,538 - 6,186,598 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl66,186,538 - 6,186,598 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha67,884,630 - 7,884,690 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.066,000,974 - 6,001,034 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.165,991,916 - 5,991,976 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.065,939,653 - 5,939,713 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.066,103,177 - 6,103,237 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR590Dogautism spectrum disorder  ISOMIR590 (Homo sapiens)8554872ClinVar Annotator: match by term: Autism spectrum disorderClinVarPMID:21658581 more ...
MIR590Dogautistic disorder  ISOMIR590 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
MIR590Dogintestinal volvulus  ISOMIR590 (Homo sapiens)8554872ClinVar Annotator: match by term: INTESTINAL MALROTATION and FAMILIALClinVarPMID:25741868
MIR590DogNeurodevelopmental Disorders  ISOMIR590 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
MIR590Dogpleomorphic xanthoastrocytoma  ISOMIR590 (Homo sapiens)8554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358
MIR590Dogschizophrenia  ISOMIR590 (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106 and PMID:30208311
MIR590DogVolvulus Of Midgut  ISOMIR590 (Homo sapiens)8554872ClinVar Annotator: match by term: Volvulus of midgutClinVarPMID:25741868
MIR590DogWilliams-Beuren syndrome  ISOMIR590 (Homo sapiens)8554872ClinVar Annotator: match by term: Williams syndromeClinVarPMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR590Dogcongestive heart failure  ISOMIR590 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:36071497


Biological Process
1 to 13 of 13 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR590Dogcholesterol homeostasis involved_inISOMIR590 (Homo sapiens)9068941 PMID:25149060BHF-UCLPMID:25149060
MIR590DogmiRNA-mediated gene silencing by inhibition of translation involved_inISOMIR590 (Homo sapiens)9068941 PMID:19398468 and PMID:24952353BHF-UCLPMID:19398468 and PMID:24952353
MIR590DogmiRNA-mediated post-transcriptional gene silencing involved_inISOMIR590 (Homo sapiens)9068941 PMID:23598417 more ...BHF-UCLPMID:23598417 more ...
MIR590Dognegative regulation of cardiac muscle cell differentiation involved_inISOMIR590 (Homo sapiens)9068941 PMID:25163461BHF-UCLPMID:25163461
MIR590Dognegative regulation of cellular senescence involved_inISOMIR590 (Homo sapiens)9068941 PMID:25465621BHF-UCLPMID:25465621
MIR590Dognegative regulation of chemokine production acts_upstream_ofISOMIR590 (Homo sapiens)9068941 PMID:25149060BHF-UCLPMID:25149060
MIR590Dognegative regulation of endothelial cell apoptotic process involved_inISOMIR590 (Homo sapiens)9068941 PMID:26648441BHF-UCLPMID:26648441
MIR590Dognegative regulation of epithelial to mesenchymal transition involved_inISOMIR590 (Homo sapiens)9068941 PMID:26459119BHF-UCLPMID:26459119
MIR590Dognegative regulation of inflammatory response involved_inISOMIR590 (Homo sapiens)9068941 PMID:25149060BHF-UCLPMID:25149060
MIR590Dognegative regulation of reactive oxygen species biosynthetic process involved_inISOMIR590 (Homo sapiens)9068941 PMID:26648441BHF-UCLPMID:26648441
MIR590Dogpositive regulation of cell cycle involved_inISOMIR590 (Homo sapiens)9068941 PMID:24288179BHF-UCLPMID:24288179
MIR590Dogpositive regulation of cell migration involved_inISOMIR590 (Homo sapiens)9068941 PMID:24288179BHF-UCLPMID:24288179
MIR590Dogpositive regulation of cell population proliferation involved_inISOMIR590 (Homo sapiens)9068941 PMID:24288179BHF-UCLPMID:24288179
1 to 13 of 13 rows

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR590DogmRNA base-pairing translational repressor activity enablesISOMIR590 (Homo sapiens)9068941 PMID:19398468 more ...BHF-UCLPMID:19398468 more ...

PMID:16381832   PMID:18392026   PMID:19398468  



MIR590
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.166,186,538 - 6,186,598 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl66,186,538 - 6,186,598 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha67,884,630 - 7,884,690 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.066,000,974 - 6,001,034 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.165,991,916 - 5,991,976 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.065,939,653 - 5,939,713 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.066,103,177 - 6,103,237 (-)NCBIUU_Cfam_GSD_1.0
MIR590
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38774,191,198 - 74,191,294 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl774,191,198 - 74,191,294 (+)EnsemblGRCh38hg38GRCh38
GRCh37773,605,528 - 73,605,624 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36773,243,463 - 73,243,559 (+)NCBINCBI36Build 36hg18NCBI36
Celera769,084,962 - 69,085,058 (+)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef769,486,996 - 69,487,092 (+)NCBIHuRef
CHM1_1773,750,612 - 73,750,708 (+)NCBICHM1_1
T2T-CHM13v2.0775,393,197 - 75,393,293 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2772,938,600 - 72,938,696 (+)NCBI

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Variants in MIR590
2 total Variants






Ensembl Acc Id: ENSCAFT00000063951
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl66,186,538 - 6,186,598 (-)Ensembl
RefSeq Acc Id: NR_049341
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.166,186,538 - 6,186,598 (-)NCBI
Dog10K_Boxer_Tasha67,884,630 - 7,884,690 (-)NCBI
ROS_Cfam_1.066,000,974 - 6,001,034 (-)NCBI
UMICH_Zoey_3.165,991,916 - 5,991,976 (-)NCBI
UNSW_CanFamBas_1.065,939,653 - 5,939,713 (-)NCBI
UU_Cfam_GSD_1.066,103,177 - 6,103,237 (-)NCBI
Sequence:


Database
Acc Id
Source(s)
Ensembl Genes ENSCAFG00000042120 Ensembl
miRBase MI0008114 ENTREZGENE
NCBI Gene MIR590 ENTREZGENE
RNAcentral URS0000272039 RNACentral
  URS00007E365D RNACentral
  URS00021ED9D9 RNACentral


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 MIR590  microRNA mir-590    microRNA 590  Symbol and/or name change 5135510 APPROVED