HAL (histidine ammonia-lyase) - Rat Genome Database
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Gene: HAL (histidine ammonia-lyase) Canis lupus familiaris
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Symbol: HAL
Name: histidine ammonia-lyase
RGD ID: 12306364
Description: ENCODES a protein that exhibits histidine ammonia-lyase activity (inferred); INVOLVED IN histidine catabolic process to glutamate and formamide (inferred); histidine catabolic process to glutamate and formate (inferred); PARTICIPATES IN histidine metabolic pathway; histidinemia pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); histidinemia (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1535,759,672 - 35,791,003 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11535,767,314 - 35,791,086 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
HAL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1535,759,672 - 35,791,003 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11535,767,314 - 35,791,086 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
HAL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1295,972,662 - 95,996,365 (-)EnsemblGRCh38hg38GRCh38
GRCh381295,972,662 - 95,996,344 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371296,366,440 - 96,390,143 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361294,891,273 - 94,914,202 (-)NCBINCBI36hg18NCBI36
Build 341294,869,609 - 94,892,539NCBI
Celera1296,033,432 - 96,056,362 (-)NCBI
Cytogenetic Map12q23.1NCBI
HuRef1293,428,306 - 93,452,016 (-)NCBIHuRef
CHM1_11296,331,432 - 96,355,134 (-)NCBICHM1_1
Hal
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391093,324,630 - 93,352,623 (+)NCBIGRCm39mm39
GRCm381093,488,768 - 93,516,761 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1093,488,768 - 93,519,304 (+)EnsemblGRCm38mm10GRCm38
MGSCv371092,951,513 - 92,979,488 (+)NCBIGRCm37mm9NCBIm37
MGSCv361093,707,053 - 93,735,128 (+)NCBImm8
MGSCv361092,918,567 - 92,946,542 (+)NCBImm8
Celera1095,474,543 - 95,502,727 (+)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1048.49NCBI
Hal
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0734,326,087 - 34,356,413 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl734,326,087 - 34,356,413 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0734,391,142 - 34,421,405 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4730,520,913 - 30,551,145 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1730,541,183 - 30,571,416 (+)NCBI
Celera725,107,998 - 25,136,986 (+)NCBICelera
Cytogenetic Map7q13NCBI
RH 3.4 Map7191.8RGD
Hal
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540532,316,326 - 32,341,485 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540532,317,345 - 32,341,409 (-)NCBIChiLan1.0ChiLan1.0
HAL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11296,950,020 - 96,973,662 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1296,950,020 - 96,973,662 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01293,561,401 - 93,585,215 (-)NCBIMhudiblu_PPA_v0panPan3
Hal
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493650712,058,583 - 12,078,159 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl587,522,522 - 87,547,491 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1587,522,483 - 87,547,489 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2591,725,402 - 91,751,694 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HAL
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11191,343,715 - 91,367,384 (-)NCBI
Hal
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475011,318,572 - 11,344,326 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6 6 6 6
Low 5
Below cutoff 5 5 16 6 6 12 8 5 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000010385   ⟹   ENSCAFP00000009628
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1535,767,785 - 35,791,003 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000062542   ⟹   ENSCAFP00000059133
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1535,767,931 - 35,791,003 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000091795   ⟹   ENSCAFP00000052372
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1535,759,672 - 35,791,003 (-)Ensembl
RefSeq Acc Id: XM_532657   ⟹   XP_532657
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11535,767,314 - 35,791,086 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_532657 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_532657   ⟸   XM_532657
- UniProtKB: E2QW26 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000009628   ⟸   ENSCAFT00000010385
RefSeq Acc Id: ENSCAFP00000052372   ⟸   ENSCAFT00000091795
RefSeq Acc Id: ENSCAFP00000059133   ⟸   ENSCAFT00000062542

Promoters
RGD ID:13685961
Promoter ID:EPDNEW_C4030
Type:single initiation site
Name:HAL_1
Description:histidine ammonia-lyase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11535,791,010 - 35,791,070EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000006412 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000009628 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000052372 UniProtKB/TrEMBL
  ENSCAFP00000059133 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000010385 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFT00000062542 UniProtKB/TrEMBL
  ENSCAFT00000091795 UniProtKB/TrEMBL
Gene3D-CATH 1.10.275.10 UniProtKB/TrEMBL
InterPro Aromatic_Lyase UniProtKB/TrEMBL
  Fumarase/histidase_N UniProtKB/TrEMBL
  HutH UniProtKB/TrEMBL
  L-Aspartase-like UniProtKB/TrEMBL
  Phe/His_NH3-lyase_AS UniProtKB/TrEMBL
KEGG Report cfa:475433 UniProtKB/TrEMBL
NCBI Gene HAL ENTREZGENE
PANTHER PTHR10362 UniProtKB/TrEMBL
Pfam Lyase_aromatic UniProtKB/TrEMBL
PROSITE PAL_HISTIDASE UniProtKB/TrEMBL
Superfamily-SCOP SSF48557 UniProtKB/TrEMBL
TIGRFAMs hutH UniProtKB/TrEMBL
UniProt A0A5F4CDN4_CANLF UniProtKB/TrEMBL
  A0A5F4D2Q0_CANLF UniProtKB/TrEMBL
  E2QW26 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:41587 ENTREZGENE