HAL (histidine ammonia-lyase) - Rat Genome Database

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Gene: HAL (histidine ammonia-lyase) Canis lupus familiaris
Analyze
Symbol: HAL
Name: histidine ammonia-lyase
RGD ID: 12306364
Description: ENCODES a protein that exhibits histidine ammonia-lyase activity (ortholog); INVOLVED IN L-histidine catabolic process (ortholog); PARTICIPATES IN histidine metabolic pathway; histidinemia pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); histidinemia (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11535,767,314 - 35,791,086 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1535,759,672 - 35,791,003 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1536,153,957 - 36,177,503 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01536,432,429 - 36,455,977 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1536,433,070 - 36,455,953 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11535,705,313 - 35,728,861 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01535,799,841 - 35,823,389 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01536,063,032 - 36,086,577 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HAL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11535,767,314 - 35,791,086 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1535,759,672 - 35,791,003 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1536,153,957 - 36,177,503 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01536,432,429 - 36,455,977 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1536,433,070 - 36,455,953 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11535,705,313 - 35,728,861 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01535,799,841 - 35,823,389 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01536,063,032 - 36,086,577 (-)NCBIUU_Cfam_GSD_1.0
HAL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381295,972,662 - 95,996,344 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1295,972,662 - 95,996,365 (-)EnsemblGRCh38hg38GRCh38
GRCh371296,366,440 - 96,390,122 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361294,891,273 - 94,914,202 (-)NCBINCBI36Build 36hg18NCBI36
Build 341294,869,609 - 94,892,539NCBI
Celera1296,033,432 - 96,056,362 (-)NCBICelera
Cytogenetic Map12q23.1NCBI
HuRef1293,428,306 - 93,452,016 (-)NCBIHuRef
CHM1_11296,331,432 - 96,355,134 (-)NCBICHM1_1
T2T-CHM13v2.01295,946,669 - 95,970,341 (-)NCBIT2T-CHM13v2.0
Hal
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391093,324,630 - 93,352,623 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1093,324,630 - 93,355,166 (+)EnsemblGRCm39 Ensembl
GRCm381093,488,768 - 93,516,761 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1093,488,768 - 93,519,304 (+)EnsemblGRCm38mm10GRCm38
MGSCv371092,951,513 - 92,979,488 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361093,707,053 - 93,735,128 (+)NCBIMGSCv36mm8
MGSCv361092,918,567 - 92,946,542 (+)NCBIMGSCv36mm8
Celera1095,474,543 - 95,502,727 (+)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1048.49NCBI
Hal
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8729,894,495 - 29,924,744 (+)NCBIGRCr8
mRatBN7.2728,007,449 - 28,037,701 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl728,006,972 - 28,037,701 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx729,997,815 - 30,028,068 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0732,160,030 - 32,190,285 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0731,934,946 - 31,965,140 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0734,326,087 - 34,356,413 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl734,326,087 - 34,356,413 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0734,391,142 - 34,421,405 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4730,520,913 - 30,551,145 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1730,541,183 - 30,571,416 (+)NCBI
Celera725,107,998 - 25,136,986 (+)NCBICelera
RH 3.4 Map7191.8RGD
Cytogenetic Map7q13NCBI
Hal
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540532,316,326 - 32,341,485 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540532,317,345 - 32,341,409 (-)NCBIChiLan1.0ChiLan1.0
HAL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210104,043,373 - 104,067,070 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112104,039,763 - 104,063,460 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01293,561,401 - 93,585,215 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11296,950,020 - 96,973,662 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1296,950,020 - 96,973,662 (-)Ensemblpanpan1.1panPan2
Hal
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494524,156,940 - 24,178,046 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650712,058,698 - 12,078,214 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650712,058,583 - 12,078,159 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl587,522,542 - 87,547,455 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1587,522,483 - 87,547,489 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2591,725,402 - 91,751,694 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HAL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11191,343,715 - 91,367,384 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037153,758,865 - 153,784,917 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hal
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475011,318,511 - 11,343,459 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475011,318,572 - 11,344,326 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HAL
256 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000010385   ⟹   ENSCAFP00000009628
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1535,767,785 - 35,791,003 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000062542   ⟹   ENSCAFP00000059133
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1535,767,931 - 35,791,003 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000091795   ⟹   ENSCAFP00000052372
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1535,759,672 - 35,791,003 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845042950   ⟹   ENSCAFP00845033667
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1536,433,070 - 36,455,953 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845043190   ⟹   ENSCAFP00845033863
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1536,433,216 - 36,455,953 (-)Ensembl
RefSeq Acc Id: XM_038496316   ⟹   XP_038352244
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11535,705,313 - 35,728,861 (-)NCBI
RefSeq Acc Id: XM_038558700   ⟹   XP_038414628
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01536,063,032 - 36,086,577 (-)NCBI
RefSeq Acc Id: XM_038622615   ⟹   XP_038478543
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01535,799,841 - 35,823,389 (-)NCBI
RefSeq Acc Id: XM_038688287   ⟹   XP_038544215
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01536,432,429 - 36,455,977 (-)NCBI
RefSeq Acc Id: XM_532657   ⟹   XP_532657
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11535,767,314 - 35,791,086 (-)NCBI
Dog10K_Boxer_Tasha1536,153,957 - 36,177,503 (-)NCBI
Sequence:
RefSeq Acc Id: XP_532657   ⟸   XM_532657
- UniProtKB: A0A8C0P4P3 (UniProtKB/TrEMBL),   A0A8I3Q1B2 (UniProtKB/TrEMBL),   A0A8C0LHA0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000009628   ⟸   ENSCAFT00000010385
Ensembl Acc Id: ENSCAFP00000052372   ⟸   ENSCAFT00000091795
Ensembl Acc Id: ENSCAFP00000059133   ⟸   ENSCAFT00000062542
RefSeq Acc Id: XP_038352244   ⟸   XM_038496316
RefSeq Acc Id: XP_038478543   ⟸   XM_038622615
RefSeq Acc Id: XP_038544215   ⟸   XM_038688287
- UniProtKB: A0A8C0P4P3 (UniProtKB/TrEMBL),   A0A8I3Q1B2 (UniProtKB/TrEMBL),   A0A8C0LHA0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038414628   ⟸   XM_038558700
- UniProtKB: A0A8C0LHA0 (UniProtKB/TrEMBL),   A0A8C0P4P3 (UniProtKB/TrEMBL),   A0A8I3Q1B2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845033667   ⟸   ENSCAFT00845042950
Ensembl Acc Id: ENSCAFP00845033863   ⟸   ENSCAFT00845043190

Promoters
RGD ID:13685961
Promoter ID:EPDNEW_C4030
Type:single initiation site
Name:HAL_1
Description:histidine ammonia-lyase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11535,791,010 - 35,791,070EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000006412 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030022252 UniProtKB/TrEMBL
  ENSCAFG00040005628 UniProtKB/TrEMBL
  ENSCAFG00845024266 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000010385.5 UniProtKB/TrEMBL
  ENSCAFT00000062542.2 UniProtKB/TrEMBL
  ENSCAFT00030041206.1 UniProtKB/TrEMBL
  ENSCAFT00030041260.1 UniProtKB/TrEMBL
  ENSCAFT00040010688.1 UniProtKB/TrEMBL
  ENSCAFT00040010750.1 UniProtKB/TrEMBL
  ENSCAFT00845042950 ENTREZGENE
  ENSCAFT00845042950.1 UniProtKB/TrEMBL
  ENSCAFT00845043190.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.275.10 UniProtKB/TrEMBL
  Fumarase/aspartase (Central domain) UniProtKB/TrEMBL
InterPro Aromatic_Lyase UniProtKB/TrEMBL
  Fumarase/histidase_N UniProtKB/TrEMBL
  HutH UniProtKB/TrEMBL
  L-Aspartase-like UniProtKB/TrEMBL
  Phe/His_NH3-lyase_AS UniProtKB/TrEMBL
KEGG Report cfa:475433 UniProtKB/TrEMBL
NCBI Gene HAL ENTREZGENE
PANTHER HISTIDINE AMMONIA-LYASE UniProtKB/TrEMBL
  PTHR10362 UniProtKB/TrEMBL
Pfam Lyase_aromatic UniProtKB/TrEMBL
PROSITE PAL_HISTIDASE UniProtKB/TrEMBL
Superfamily-SCOP SSF48557 UniProtKB/TrEMBL
UniProt A0A8C0LHA0 ENTREZGENE
  A0A8C0P4P3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QLP6_CANLF UniProtKB/TrEMBL
  A0A8I3Q1B2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3S8N8_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:41587 ENTREZGENE