DMRT3 (doublesex and mab-3 related transcription factor 3) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: DMRT3 (doublesex and mab-3 related transcription factor 3) Canis lupus familiaris
Analyze
Symbol: DMRT3
Name: doublesex and mab-3 related transcription factor 3
RGD ID: 12280577
Description: ENCODES a protein that exhibits DNA binding (inferred); metal ion binding (inferred); sequence-specific DNA binding (inferred); INVOLVED IN adult walking behavior (ortholog); male sex differentiation (ortholog); regulation of odontogenesis of dentin-containing tooth (ortholog); ASSOCIATED WITH chromosome 9p deletion syndrome (ortholog); primary ovarian insufficiency (ortholog); FOUND IN nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: doublesex- and mab-3-related transcription factor 3; duplex and mab-3 related transcription factor 3-like; LOC609208
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1189,798,215 - 89,813,140 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl189,798,100 - 89,812,328 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha190,265,734 - 90,280,606 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0190,346,567 - 90,361,456 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl190,346,567 - 90,360,657 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1189,994,340 - 90,009,257 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0189,704,994 - 89,719,915 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0190,474,207 - 90,489,149 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DMRT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1189,798,215 - 89,813,140 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl189,798,100 - 89,812,328 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha190,265,734 - 90,280,606 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0190,346,567 - 90,361,456 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl190,346,567 - 90,360,657 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1189,994,340 - 90,009,257 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0189,704,994 - 89,719,915 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0190,474,207 - 90,489,149 (+)NCBIUU_Cfam_GSD_1.0
DMRT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389976,655 - 991,732 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9976,655 - 991,732 (+)EnsemblGRCh38hg38GRCh38
GRCh379976,655 - 991,732 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369966,964 - 981,732 (+)NCBINCBI36Build 36hg18NCBI36
Build 349966,963 - 981,732NCBI
Celera9894,871 - 909,644 (+)NCBICelera
Cytogenetic Map9p24.3NCBI
HuRef9929,719 - 944,508 (+)NCBIHuRef
CHM1_19977,145 - 991,912 (+)NCBICHM1_1
T2T-CHM13v2.09977,925 - 992,996 (+)NCBIT2T-CHM13v2.0
Dmrt3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391925,587,609 - 25,601,285 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1925,587,665 - 25,601,285 (+)EnsemblGRCm39 Ensembl
GRCm381925,610,246 - 25,623,921 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1925,610,301 - 25,623,921 (+)EnsemblGRCm38mm10GRCm38
MGSCv371925,685,027 - 25,698,411 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361925,677,634 - 25,691,016 (+)NCBIMGSCv36mm8
Celera1926,405,156 - 26,418,520 (+)NCBICelera
Cytogenetic Map19BNCBI
cM Map1920.5NCBI
Dmrt3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81232,670,642 - 232,690,557 (+)NCBIGRCr8
mRatBN7.21223,244,340 - 223,264,254 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1223,248,747 - 223,262,530 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1231,696,334 - 231,710,133 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01238,626,427 - 238,640,213 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01231,447,200 - 231,460,981 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01243,589,607 - 243,602,926 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1243,589,607 - 243,602,926 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01250,848,350 - 250,861,669 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41229,044,302 - 229,058,689 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11229,206,114 - 229,222,715 (+)NCBI
Celera1220,451,183 - 220,464,645 (+)NCBICelera
Cytogenetic Map1q51NCBI
Dmrt3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554345,455,449 - 5,470,343 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554345,455,449 - 5,470,343 (+)NCBIChiLan1.0ChiLan1.0
DMRT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211123,588,955 - 123,607,298 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19123,594,898 - 123,613,241 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09786,402 - 801,114 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19980,586 - 994,885 (+)NCBIpanpan1.1PanPan1.1panPan2
Dmrt3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947137,236,171 - 137,250,587 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365033,922,417 - 3,936,493 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365033,922,417 - 3,936,493 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DMRT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,820,556 - 220,834,034 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,819,525 - 220,834,080 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DMRT3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11278,528,709 - 78,543,509 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1278,529,443 - 78,543,419 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603866,909,248 - 66,924,674 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dmrt3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247365,648,318 - 5,661,584 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247365,648,318 - 5,662,301 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DMRT3
270 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
1 1 1 16 6 6 2 1 10 14

Sequence


Ensembl Acc Id: ENSCAFT00000003148   ⟹   ENSCAFP00000002924
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl189,798,100 - 89,812,328 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845003494   ⟹   ENSCAFP00845002770
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl190,346,567 - 90,360,657 (+)Ensembl
RefSeq Acc Id: XM_038465030   ⟹   XP_038320958
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1189,994,340 - 90,009,257 (+)NCBI
RefSeq Acc Id: XM_038525618   ⟹   XP_038381546
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0190,474,207 - 90,489,149 (+)NCBI
RefSeq Acc Id: XM_038589821   ⟹   XP_038445749
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0189,704,994 - 89,719,915 (+)NCBI
RefSeq Acc Id: XM_038653748   ⟹   XP_038509676
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0190,346,567 - 90,361,456 (+)NCBI
RefSeq Acc Id: XM_846422   ⟹   XP_851515
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1189,798,215 - 89,813,140 (+)NCBI
Dog10K_Boxer_Tasha190,265,734 - 90,280,606 (+)NCBI
Sequence:
RefSeq Acc Id: XP_851515   ⟸   XM_846422
- UniProtKB: A0A8P0S7U3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000002924   ⟸   ENSCAFT00000003148
RefSeq Acc Id: XP_038320958   ⟸   XM_038465030
RefSeq Acc Id: XP_038445749   ⟸   XM_038589821
RefSeq Acc Id: XP_038509676   ⟸   XM_038653748
- UniProtKB: A0A8I3MLU1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038381546   ⟸   XM_038525618
- UniProtKB: A0A8C0LR96 (UniProtKB/TrEMBL),   A0A8C0NCF3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845002770   ⟸   ENSCAFT00845003494
Protein Domains
DM

Promoters
RGD ID:13682101
Promoter ID:EPDNEW_C168
Type:multiple initiation site
Name:DMRT3_1
Description:doublesex and mab-3 related transcription factor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1189,798,178 - 89,798,238EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000023150 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030013316 UniProtKB/TrEMBL
  ENSCAFG00845002003 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000003148.5 UniProtKB/TrEMBL
  ENSCAFT00030024634.1 UniProtKB/TrEMBL
  ENSCAFT00845003494 ENTREZGENE
  ENSCAFT00845003494.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.1040.10 UniProtKB/TrEMBL
InterPro DM_DNA-bd UniProtKB/TrEMBL
  DM_DNA-bd_sf UniProtKB/TrEMBL
  DMA UniProtKB/TrEMBL
  DMRT UniProtKB/TrEMBL
  UBA-like_sf UniProtKB/TrEMBL
NCBI Gene LOC609208 ENTREZGENE
PANTHER DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR 3 UniProtKB/TrEMBL
  PTHR12322 UniProtKB/TrEMBL
Pfam DMA UniProtKB/TrEMBL
  PF00751 UniProtKB/TrEMBL
PROSITE DM_1 UniProtKB/TrEMBL
  DM_2 UniProtKB/TrEMBL
SMART SM00301 UniProtKB/TrEMBL
Superfamily-SCOP SSF46934 UniProtKB/TrEMBL
  SSF82927 UniProtKB/TrEMBL
UniProt A0A8C0LR96 ENTREZGENE
  A0A8C0NCF3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MLU1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0S7U3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:49682 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-12 DMRT3  doublesex and mab-3 related transcription factor 3  LOC609208    Symbol and/or name change 5135510 APPROVED