DMRT3 (doublesex and mab-3 related transcription factor 3)

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Gene: DMRT3 (doublesex and mab-3 related transcription factor 3) Canis lupus familiaris

Analyze

Symbol:

DMRT3

Name:

doublesex and mab-3 related transcription factor 3

RGD ID:

12280577

Description:

ENCODES a protein that exhibits sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN adult walking behavior (ortholog); male sex differentiation (ortholog); regulation of odontogenesis of dentin-containing tooth (ortholog); ASSOCIATED WITH primary ovarian insufficiency (ortholog); FOUND IN nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Also known as:

doublesex- and mab-3-related transcription factor 3; duplex and mab-3 related transcription factor 3-like; LOC609208; LOW QUALITY PROTEIN: doublesex and mab-3 related transcription factor 3; LOW QUALITY PROTEIN: doublesex- and mab-3-related transcription factor 3

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	1	89,798,100 - 89,812,328 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	1	89,798,215 - 89,813,140 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

primary ovarian insufficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adult walking behavior (IEA,ISO)

male sex differentiation (IBA,ISO)

regulation of odontogenesis of dentin-containing tooth (IEA,ISO)

regulation of transcription by RNA polymerase II (IBA)

sex differentiation (IBA)

transmission of nerve impulse (IEA,ISO)

ventral spinal cord interneuron specification (IEA,ISO)

Cellular Component

nucleus (IBA,ISO)

Molecular Function

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

metal ion binding (IEA)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA)

sequence-specific DNA binding (ISO)

sequence-specific double-stranded DNA binding (ISO)

References

Genomics

Comparative Map Data

DMRT3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	1	89,798,100 - 89,812,328 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	1	89,798,215 - 89,813,140 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

DMRT3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	9	976,655 - 991,732 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	9	976,655 - 991,732 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	9	976,655 - 991,732 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
GRCh37	9	976,968 - 991,732 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	966,964 - 981,732 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	9	966,963 - 981,732	NCBI
Celera	9	894,871 - 909,644 (+)	NCBI
Cytogenetic Map	9	p24.3	NCBI
HuRef	9	929,719 - 944,508 (+)	NCBI		HuRef
CHM1_1	9	977,145 - 991,912 (+)	NCBI		CHM1_1

Dmrt3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	25,587,609 - 25,601,285 (+)	NCBI	GRCm39		mm39
GRCm38	19	25,610,246 - 25,623,921 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	25,610,301 - 25,623,921 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	25,685,027 - 25,698,411 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	19	25,677,634 - 25,691,016 (+)	NCBI			mm8
Celera	19	26,405,156 - 26,418,520 (+)	NCBI		Celera
Cytogenetic Map	19	B	NCBI

Dmrt3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	223,244,340 - 223,264,254 (+)	NCBI
Rnor_6.0 Ensembl	1	243,589,607 - 243,602,926 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	1	243,589,607 - 243,602,926 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	1	250,848,350 - 250,861,669 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	229,044,302 - 229,058,689 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	1	229,206,114 - 229,222,715 (+)	NCBI
Celera	1	220,451,183 - 220,464,645 (+)	NCBI		Celera
Cytogenetic Map	1	q51	NCBI

Dmrt3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955434	5,455,449 - 5,470,343 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955434	5,455,449 - 5,470,343 (+)	NCBI	ChiLan1.0	ChiLan1.0

DMRT3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	9	980,586 - 994,885 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
Mhudiblu_PPA_v0	9	786,402 - 801,114 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

Dmrt3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936503	3,922,417 - 3,936,493 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DMRT3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	220,820,556 - 220,833,835 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	220,819,525 - 220,834,080 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

DMRT3
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	78,528,709 - 78,543,509 (-)	NCBI
ChlSab1.1 Ensembl	12	78,529,443 - 78,543,419 (-)	Ensembl

Dmrt3
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624736	5,648,318 - 5,662,301 (+)	NCBI

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	integumental system	nervous system	reproductive system	adipose tissue
High
Medium
Low			4		4	1
Below cutoff	1	1	2	6	6	7	1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_038465030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038525618	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038589821	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038653748	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_846422	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000354	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSCAFT00000003148 ⟹ ENSCAFP00000002924

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	1	89,798,100 - 89,812,328 (+)	Ensembl

RefSeq Acc Id:

XM_846422 ⟹ XP_851515

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	1	89,798,215 - 89,813,140 (+)	NCBI

Sequence:

show sequence

ATGAACGGCTACGGCTCCCCCTACCTGTACATGGGCGGCCCGGTGTCGCAGCCGCCGCGGGCGC
CCTTGCAGCGCACGCCCAAGTGCGCGCGCTGCCGCAACCACGGCGTGCTGTCCTGGCTCAAGGG
CCACAAGCGCTACTGCCGCTTCAAGGACTGCACCTGCGAGAAGTGCATCCTCATCATCGAGCGG
CAGCGGGTCATGGCCGCGCAGGTGGCGCTGCGCCGGCAGCAGGCCAACGAGAGCCTCGAGAGCC
TCATCCCGGACTCGCTGCGCGCCCTGCCGGGACCCCCGCCGCCGGGGGACGCCGCCGCCGCCCC
GCCGCCGCCGCAGACCTCGCAGCCGTCCCAGCCGCCGCCGCCCCGGCCCGCCGCGGACTTGGCC
GCCGCCGCCGCGCTGCGCTGGGCCTCGGAGCCGCAGCCCGGGGCGTTGCAGGCGCCCCTCGCCA
AGCCAGATCTCGCCTAGGAGCGGCTGGGGGACGGCGGCGGCTCGGCCGACAACGCCGAGAGCTT
CAGCGACAAGGAGGCGGACCAGAGGAGCTCCCCGGACGTGGCCCCAAGCAAGGGCTGCTTCGGC
CCGGAGAGCCCCGAGGTGGTGTCGGTGGACGAAGGCGGCTACGCGCTCGCGAAGAGCGGGGGCC
CCCCCGGGAGCCGGCCCGGCAGCCCCAGGTGCGCCGCGGAGCAGAGCCACCTGCTGATCGAGGG
CCCCTCGGGGACCGTGTCCCTGCCCTTCAGCCTCAAGGCCAACCGGCCGCCCCTGGAGGTGCTG
AAGAAGATCTTCCCGGGCCAGAAGCCGGCGGTGCTGGAGCTCATCCTCAAGGGCTGCGGGGGGG
ACCTGGTGGGCGCCGTGGAGGTCCTGCTGTCCAGCCGCTCGTCGGCGGCGGCGGCCTCCGAGCG
GACCGCGGCCGAGCCCGAGGCGCTGGTGCTGCCCCCCAACGGGCACCTCTTCGAACACGGCCTG
GGCTCCTACCCGCTCTCGTCCTCCAAGTGGTCCGTGGGCTCGGCCTTCAGGGTCCCGGACACGC
TGCGCTTCTCGGCCGACTCGGCCAACGTGGTCCCCAGCCCGCTGGCCGTGCCCCTGCAGCACCC
CTTCCCCCAGCCGCCCCGGTACCCGCTGATGCTGAGGAATACCTTGGCCAGGAACCAGTCGAGC
CCCTTCCTGCCCAACGACGTGACCCTGTGGAACACCATGACCTTGCAGCAGCAGTACCAGCTGA
GGTCCCAGTACGTGGGCCCCTTCCCCGCCAACTCCGCCGGCGTCTTCCGGGGCTCCCCGGTCCT
GCCCGCGCGCGCCCCCGAGGACCCCCGCATCTCGCTCCCCGACGACGGCTGTCCCATCGTGGCC
AAGCAGCCGCTCTACGCCGAGGAGGACTATGACGAGAGGTCCGACTCCTCAGACTCTAGAATAC
TCAACACTTCCTCCTAAAGCGCACTGCTGGGGGGGTGTGACCAGGTGACCTTTTTTTTTTTTTT
TCTGTGCATTTGAAACCCCCCTCCTCCCCCTCCCCCCCTGCCCTCCCCCTGTGCGGGGAGAGAG
GCCACCTCCTGTGCATACCCTCTCTCCTTCTGTTTGACAAAGTGACTGTGCTCGATGCTATATA
CCTTAGCAATAAAAACATAACTTATTTAATTTCTTGCACTTCATTGGGAAATGCCAAATAGCTC
TGCTCTGTGGCTTTAGTGCTGAATGTGTATTGTTAAAAGAGGGTCTGATGCTAAGAATAGTCTT
GGGAAAGCCGGGGCCACCGAAGATTGATGTGGGAGGTGGGGGGTGGGGGGAGATCTCTAAAGCT
GAAGGTCAGCTTTTGCTCCTGCCTCAACTCAACCCGGAATGTCCGAGAAAATAGTATACTTGAA
TGCGGTTTTTGTAAAAGAGGATGCCTCAGGATTTGTAAAACCTAAATAAAGCAAGTGGTTCGGT
TGCAAATGGACGATACACAGGGACCTTATATTCTTACGCTAAAAATCCTTCCTGCGTTTTAGAG
AGAGACTGCACTTAAGAATAGAGTGAACCGCTCACATGCTTATTTAAGCTTGGACAGTTTTCGG
AGACAAACTCCCATTAAGAATTATTCTTTTCACATGGCTGAATTGAAACATGCATAATGTCAAT
GTAAAGCCAATCACAGCTGTGAACTGCATGAAATGTATTGTGAAATGAACACAAGATTAAGCTT
TGTCAGGTTAATGTAGCATGCTGAGGACTCTAGAAAAAAAAAATAAACTAAGGAGACGATC

hide sequence

Protein Sequences


Protein RefSeqs	XP_038320958	(Get FASTA)	NCBI Sequence Viewer
	XP_038381546	(Get FASTA)	NCBI Sequence Viewer
	XP_038445749	(Get FASTA)	NCBI Sequence Viewer
	XP_038509676	(Get FASTA)	NCBI Sequence Viewer
	XP_851515	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_851515 ⟸ XM_846422

- Sequence:

show sequence

MNGYGSPYLYMGGPVSQPPRAPLQRTPKCARCRNHGVLSWLKGHKRYCRFKDCTCEKCILIIER
QRVMAAQVALRRQQANESLESLIPDSLRALPGPPPPGDAAAAPPPPQTSQPSQPPPPRPAADLA
AAAALRWASEPQPGALQAPLAKPDLAXERLGDGGGSADNAESFSDKEADQRSSPDVAPSKGCFG
PESPEVVSVDEGGYALAKSGGPPGSRPGSPRCAAEQSHLLIEGPSGTVSLPFSLKANRPPLEVL
KKIFPGQKPAVLELILKGCGGDLVGAVEVLLSSRSSAAAASERTAAEPEALVLPPNGHLFEHGL
GSYPLSSSKWSVGSAFRVPDTLRFSADSANVVPSPLAVPLQHPFPQPPRYPLMLRNTLARNQSS
PFLPNDVTLWNTMTLQQQYQLRSQYVGPFPANSAGVFRGSPVLPARAPEDPRISLPDDGCPIVA
KQPLYAEEDYDERSDSSDSRILNTSS

hide sequence

RefSeq Acc Id:

ENSCAFP00000002924 ⟸ ENSCAFT00000003148

Promoters

RGD ID:

13682101

Promoter ID:

EPDNEW_C168

Type:

multiple initiation site

Name:

DMRT3_1

Description:

doublesex and mab-3 related transcription factor 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	1	89,798,178 - 89,798,238	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000023150	Ensembl, UniProtKB/TrEMBL
Ensembl Protein	ENSCAFP00000002924	UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000003148	UniProtKB/TrEMBL
Gene3D-CATH	4.10.1040.10	UniProtKB/TrEMBL
InterPro	DM_DNA-bd	UniProtKB/TrEMBL
	DM_DNA-bd_sf	UniProtKB/TrEMBL
	DMA	UniProtKB/TrEMBL
	DMRT/dsx/mab-3	UniProtKB/TrEMBL
	UBA-like_sf	UniProtKB/TrEMBL
NCBI Gene	LOC609208	ENTREZGENE
PANTHER	PTHR12322	UniProtKB/TrEMBL
Pfam	DMA	UniProtKB/TrEMBL
	PF00751	UniProtKB/TrEMBL
PROSITE	DM_1	UniProtKB/TrEMBL
	DM_2	UniProtKB/TrEMBL
SMART	SM00301	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46934	UniProtKB/TrEMBL
	SSF82927	UniProtKB/TrEMBL
UniProt	E2RLR2_CANLF	UniProtKB/TrEMBL
VGNC ID	VGNC:49682	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-09-12	DMRT3	doublesex and mab-3 related transcription factor 3	LOC609208		Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar