LOC479668 (haptoglobin-like) - Rat Genome Database

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Gene: LOC479668 (haptoglobin-like) Canis lupus familiaris
Analyze
Symbol: LOC479668 (Ensembl: DHODH)
Name: haptoglobin-like
RGD ID: 12273002
Description: ENCODES a protein that exhibits antioxidant activity (inferred); dihydroorotate dehydrogenase activity (inferred); hemoglobin binding (inferred); INVOLVED IN 'de novo' pyrimidine nucleobase biosynthetic process (inferred); 'de novo' UMP biosynthetic process (inferred); acute-phase response (inferred); ASSOCIATED WITH Anhaptoglobinemia (ortholog); autosomal dominant dyskeratosis congenita 6 (ortholog); COVID-19 (ortholog); FOUND IN spherical high-density lipoprotein particle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: haptoglobin; haptoglobin-related protein; HP; HPR
RGD Orthologs
Human
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1577,795,183 - 77,800,034 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha577,756,965 - 77,761,766 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0578,234,618 - 78,239,419 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl578,195,854 - 78,239,419 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1578,054,623 - 78,059,418 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0577,877,528 - 77,882,329 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0578,376,676 - 78,381,473 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:22937913   PMID:30032202   PMID:33730638   PMID:36748822  


Genomics

Comparative Map Data
LOC479668
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1577,795,183 - 77,800,034 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha577,756,965 - 77,761,766 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0578,234,618 - 78,239,419 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl578,195,854 - 78,239,419 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1578,054,623 - 78,059,418 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0577,877,528 - 77,882,329 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0578,376,676 - 78,381,473 (+)NCBIUU_Cfam_GSD_1.0
HPR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381672,063,226 - 72,077,246 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1672,063,148 - 72,077,246 (+)EnsemblGRCh38hg38GRCh38
GRCh371672,097,125 - 72,111,145 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361670,654,626 - 70,668,646 (+)NCBINCBI36Build 36hg18NCBI36
Build 341670,654,625 - 70,668,645NCBI
Celera1656,411,244 - 56,425,264 (+)NCBICelera
Cytogenetic Map16q22.2NCBI
HuRef1657,863,957 - 57,877,977 (+)NCBIHuRef
CHM1_11673,510,473 - 73,524,493 (+)NCBICHM1_1
T2T-CHM13v2.01677,879,540 - 77,893,560 (+)NCBIT2T-CHM13v2.0
HPR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1555,223,995 - 55,227,908 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604718,013,015 - 18,015,908 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in LOC479668
39 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 22 21 16 6 6 6 6 33 22 11 13 10

Sequence


Ensembl Acc Id: ENSCAFT00845014047   ⟹   ENSCAFP00845010887
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl578,195,854 - 78,239,419 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845014141   ⟹   ENSCAFP00845010959
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl578,195,854 - 78,239,419 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845014228   ⟹   ENSCAFP00845011029
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl578,195,854 - 78,211,683 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845014294   ⟹   ENSCAFP00845011077
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl578,234,613 - 78,239,289 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845014315   ⟹   ENSCAFP00845011090
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl578,234,672 - 78,239,419 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845014335   ⟹   ENSCAFP00845011105
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl578,234,672 - 78,239,419 (+)Ensembl
RefSeq Acc Id: XM_038477252   ⟹   XP_038333180
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1578,054,623 - 78,059,418 (+)NCBI
RefSeq Acc Id: XM_038538455   ⟹   XP_038394383
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0578,376,676 - 78,381,473 (+)NCBI
RefSeq Acc Id: XM_038602573   ⟹   XP_038458501
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0577,877,528 - 77,882,329 (+)NCBI
RefSeq Acc Id: XM_038667180   ⟹   XP_038523108
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0578,234,618 - 78,239,419 (+)NCBI
RefSeq Acc Id: XM_845903   ⟹   XP_850996
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1577,795,183 - 77,800,034 (+)NCBI
Dog10K_Boxer_Tasha577,756,965 - 77,761,766 (+)NCBI
Sequence:
RefSeq Acc Id: XP_850996   ⟸   XM_845903
- UniProtKB: Q9TRH7 (UniProtKB/Swiss-Prot),   Q9TRH6 (UniProtKB/Swiss-Prot),   P19006 (UniProtKB/Swiss-Prot),   A0A8C0T540 (UniProtKB/TrEMBL),   A0A8I3N4M8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038333180   ⟸   XM_038477252
RefSeq Acc Id: XP_038458501   ⟸   XM_038602573
RefSeq Acc Id: XP_038523108   ⟸   XM_038667180
- UniProtKB: Q9TRH7 (UniProtKB/Swiss-Prot),   Q9TRH6 (UniProtKB/Swiss-Prot),   P19006 (UniProtKB/Swiss-Prot),   A0A8C0T540 (UniProtKB/TrEMBL),   A0A8I3N4M8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038394383   ⟸   XM_038538455
- UniProtKB: Q9TRH7 (UniProtKB/Swiss-Prot),   Q9TRH6 (UniProtKB/Swiss-Prot),   P19006 (UniProtKB/Swiss-Prot),   A0A8C0T540 (UniProtKB/TrEMBL),   A0A8I3N4M8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845011090   ⟸   ENSCAFT00845014315
Ensembl Acc Id: ENSCAFP00845011029   ⟸   ENSCAFT00845014228
Ensembl Acc Id: ENSCAFP00845011105   ⟸   ENSCAFT00845014335
Ensembl Acc Id: ENSCAFP00845011077   ⟸   ENSCAFT00845014294
Ensembl Acc Id: ENSCAFP00845010887   ⟸   ENSCAFT00845014047
Ensembl Acc Id: ENSCAFP00845010959   ⟸   ENSCAFT00845014141
Protein Domains
Peptidase S1   Sushi


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000020220 UniProtKB/TrEMBL
  ENSCAFG00030011071 UniProtKB/TrEMBL
  ENSCAFG00040019305 UniProtKB/TrEMBL
  ENSCAFG00845007968 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000032207.5 UniProtKB/TrEMBL
  ENSCAFT00000073958.2 UniProtKB/TrEMBL
  ENSCAFT00000079808.2 UniProtKB/TrEMBL
  ENSCAFT00030020508.1 UniProtKB/TrEMBL
  ENSCAFT00030020547.1 UniProtKB/TrEMBL
  ENSCAFT00030020578.1 UniProtKB/TrEMBL
  ENSCAFT00040035727.1 UniProtKB/TrEMBL
  ENSCAFT00040035744.1 UniProtKB/TrEMBL
  ENSCAFT00040035773.1 UniProtKB/TrEMBL
  ENSCAFT00845014047.1 UniProtKB/TrEMBL
  ENSCAFT00845014141.1 UniProtKB/TrEMBL
  ENSCAFT00845014294.1 UniProtKB/TrEMBL
  ENSCAFT00845014315 ENTREZGENE
  ENSCAFT00845014315.1 UniProtKB/TrEMBL
  ENSCAFT00845014335.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
  3.20.20.70 UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin-like serine proteases UniProtKB/Swiss-Prot
InterPro Aldolase_TIM UniProtKB/TrEMBL
  DHO_dehydrogenase UniProtKB/TrEMBL
  Dihydroorotate_DH UniProtKB/TrEMBL
  Dihydroorotate_DH_2 UniProtKB/TrEMBL
  Dihydroorotate_DH_CS UniProtKB/TrEMBL
  Haptoglobin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:479668 UniProtKB/TrEMBL
NCBI Gene LOC479668 ENTREZGENE
PANTHER COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL UniProtKB/TrEMBL
  DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED UniProtKB/TrEMBL
  HAPTOGLOBIN-RELATED PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DHO_dh UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Haptoglobin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DHODEHASE_1 UniProtKB/TrEMBL
  DHODEHASE_2 UniProtKB/TrEMBL
  SUSHI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Complement control module/SCR domain UniProtKB/Swiss-Prot
  FMN-linked oxidoreductases UniProtKB/TrEMBL
  SSF50494 UniProtKB/TrEMBL
  SSF57535 UniProtKB/TrEMBL
  Trypsin-like serine proteases UniProtKB/Swiss-Prot
UniProt A0A8C0MZL1_CANLF UniProtKB/TrEMBL
  A0A8C0T540 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0T6N2_CANLF UniProtKB/TrEMBL
  A0A8I3MX03_CANLF UniProtKB/TrEMBL
  A0A8I3N262_CANLF UniProtKB/TrEMBL
  A0A8I3N2C8_CANLF UniProtKB/TrEMBL
  A0A8I3N4M8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N5Q6_CANLF UniProtKB/TrEMBL
  HPT_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
  Q9TRH6 ENTREZGENE
  Q9TRH7 ENTREZGENE
UniProt Secondary Q9TRH6 UniProtKB/Swiss-Prot
  Q9TRH7 UniProtKB/Swiss-Prot