CRNKL1 (crooked neck pre-mRNA splicing factor 1) - Rat Genome Database

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Gene: CRNKL1 (crooked neck pre-mRNA splicing factor 1) Canis lupus familiaris
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Symbol: CRNKL1
Name: crooked neck pre-mRNA splicing factor 1
RGD ID: 12269138
Description: ENCODES a protein that exhibits RNA binding (inferred); INVOLVED IN cellular response to brain-derived neurotrophic factor stimulus (ortholog); cellular response to leukemia inhibitory factor (ortholog); cerebral cortex development (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH basal cell carcinoma (ortholog); familial hyperinsulinemic hypoglycemia 1 (ortholog); melanoma (ortholog); FOUND IN catalytic step 2 spliceosome (inferred); nucleus (inferred); spliceosomal complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: crooked neck pre-mRNA splicing factor-like 1; crooked neck-like protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1243,294,607 - 3,310,846 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl243,294,616 - 3,310,702 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha243,322,820 - 3,338,912 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0243,703,030 - 3,719,137 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl243,702,577 - 3,720,541 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1243,298,774 - 3,314,853 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0243,401,816 - 3,417,906 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0243,679,794 - 3,695,883 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CRNKL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1243,294,607 - 3,310,846 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl243,294,616 - 3,310,702 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha243,322,820 - 3,338,912 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0243,703,030 - 3,719,137 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl243,702,577 - 3,720,541 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1243,298,774 - 3,314,853 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0243,401,816 - 3,417,906 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0243,679,794 - 3,695,883 (+)NCBIUU_Cfam_GSD_1.0
CRNKL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382020,034,368 - 20,056,046 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2020,034,368 - 20,056,046 (-)EnsemblGRCh38hg38GRCh38
GRCh372020,015,012 - 20,036,690 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362019,963,012 - 19,984,690 (-)NCBINCBI36Build 36hg18NCBI36
Build 342019,963,011 - 19,984,690NCBI
Celera2020,089,029 - 20,110,711 (-)NCBICelera
Cytogenetic Map20p11.23NCBI
HuRef2019,976,670 - 19,998,362 (-)NCBIHuRef
CHM1_12020,015,382 - 20,037,072 (-)NCBICHM1_1
T2T-CHM13v2.02020,088,648 - 20,110,326 (-)NCBIT2T-CHM13v2.0
Crnkl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392145,759,402 - 145,776,620 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2145,759,399 - 145,776,934 (-)EnsemblGRCm39 Ensembl
GRCm382145,917,482 - 145,934,700 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2145,917,479 - 145,935,014 (-)EnsemblGRCm38mm10GRCm38
MGSCv372145,743,218 - 145,760,436 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362145,608,923 - 145,626,141 (-)NCBIMGSCv36mm8
Celera2147,153,324 - 147,170,535 (-)NCBICelera
Cytogenetic Map2G1NCBI
cM Map271.28NCBI
Crnkl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83153,764,718 - 153,807,973 (-)NCBIGRCr8
mRatBN7.23133,338,593 - 133,354,329 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl61,140,615 - 1,142,918 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl3133,337,039 - 133,354,302 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx61,362,744 - 1,365,058 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.061,672,026 - 1,674,340 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.061,196,426 - 1,198,740 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0618,349,226 - 18,351,540 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl618,349,167 - 18,351,536 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0628,249,112 - 28,251,426 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43134,538,940 - 134,554,660 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6957,687 - 960,001 (+)NCBICelera
Cytogenetic Map3q41NCBI
Crnkl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541528,158,351 - 28,172,055 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541528,158,351 - 28,171,335 (-)NCBIChiLan1.0ChiLan1.0
CRNKL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22120,924,252 - 20,940,546 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12020,919,773 - 20,937,382 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02019,992,092 - 20,010,809 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12019,957,545 - 19,975,809 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2019,959,356 - 19,979,094 (-)Ensemblpanpan1.1panPan2
Crnkl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640151,896,734 - 151,919,612 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936485327,835 - 350,132 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936485328,077 - 351,323 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRNKL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1728,077,707 - 28,111,558 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11728,079,541 - 28,111,871 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21731,810,243 - 31,816,810 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CRNKL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1249,052,304 - 49,070,600 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl249,054,125 - 49,070,576 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660783,838,825 - 3,857,376 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crnkl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474120,564,474 - 20,581,716 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474120,565,686 - 20,581,708 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CRNKL1
107 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000008599   ⟹   ENSCAFP00000007969
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl243,294,616 - 3,310,702 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845051207   ⟹   ENSCAFP00845040161
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl243,702,577 - 3,720,541 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845051259   ⟹   ENSCAFP00845040204
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl243,702,577 - 3,720,541 (+)Ensembl
RefSeq Acc Id: XM_005634714   ⟹   XP_005634771
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1243,294,607 - 3,310,846 (+)NCBI
Dog10K_Boxer_Tasha243,322,820 - 3,338,912 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038432975   ⟹   XP_038288903
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0243,703,030 - 3,719,137 (+)NCBI
RefSeq Acc Id: XM_038508190   ⟹   XP_038364118
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1243,298,774 - 3,314,853 (+)NCBI
RefSeq Acc Id: XM_038571445   ⟹   XP_038427373
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0243,679,794 - 3,695,883 (+)NCBI
RefSeq Acc Id: XM_038635682   ⟹   XP_038491610
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0243,401,816 - 3,417,906 (+)NCBI
RefSeq Acc Id: XP_005634771   ⟸   XM_005634714
- UniProtKB: A0A8C0Z5N9 (UniProtKB/TrEMBL),   A0A8I3Q040 (UniProtKB/TrEMBL),   A0A8I3QI81 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000007969   ⟸   ENSCAFT00000008599
RefSeq Acc Id: XP_038364118   ⟸   XM_038508190
RefSeq Acc Id: XP_038491610   ⟸   XM_038635682
RefSeq Acc Id: XP_038288903   ⟸   XM_038432975
- UniProtKB: A0A8C0Z5N9 (UniProtKB/TrEMBL),   A0A8I3Q040 (UniProtKB/TrEMBL),   A0A8I3QI81 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038427373   ⟸   XM_038571445
- UniProtKB: A0A8C0Z5N9 (UniProtKB/TrEMBL),   A0A8I3Q040 (UniProtKB/TrEMBL),   A0A8I3QI81 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845040161   ⟸   ENSCAFT00845051207
Ensembl Acc Id: ENSCAFP00845040204   ⟸   ENSCAFT00845051259


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000005333 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030023812 UniProtKB/TrEMBL
  ENSCAFG00040023847 UniProtKB/TrEMBL
  ENSCAFG00845028961 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000008599.5 UniProtKB/TrEMBL
  ENSCAFT00030043806.1 UniProtKB/TrEMBL
  ENSCAFT00040044405.1 UniProtKB/TrEMBL
  ENSCAFT00845051207 ENTREZGENE
  ENSCAFT00845051207.1 UniProtKB/TrEMBL
  ENSCAFT00845051259.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
InterPro HAT UniProtKB/TrEMBL
  Syf1-like UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/TrEMBL
KEGG Report cfa:477137 UniProtKB/TrEMBL
NCBI Gene CRNKL1 ENTREZGENE
PANTHER CROOKED NECK-LIKE PROTEIN 1 UniProtKB/TrEMBL
  PTHR11246 UniProtKB/TrEMBL
Pfam HAT UniProtKB/TrEMBL
SMART HAT UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/TrEMBL
UniProt A0A8C0Z5N9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q040 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3QI81 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:39625 ENTREZGENE