AMDHD1 (amidohydrolase domain containing 1)

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Gene: AMDHD1 (amidohydrolase domain containing 1) Canis lupus familiaris

Analyze

Symbol:

AMDHD1

Name:

amidohydrolase domain containing 1

RGD ID:

12257358

Description:

INVOLVED IN histidine catabolic process to glutamate and formamide (inferred); histidine catabolic process to glutamate and formate (inferred); mRNA splicing, via spliceosome (inferred); PARTICIPATES IN histidine metabolic pathway; histidinemia pathway; FOUND IN cytoplasm (inferred); integral component of membrane (inferred); sno(s)RNA-containing ribonucleoprotein complex (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Also known as:

probable imidazolonepropionase

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	15	35,692,161 - 35,760,978 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	15	35,741,190 - 35,761,848 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

histidine catabolic process (IBA)

histidine catabolic process to glutamate and formamide (IEA)

histidine catabolic process to glutamate and formate (IEA)

mRNA splicing, via spliceosome (IBA,IEA)

spliceosomal snRNP assembly (IEA)

Cellular Component

catalytic step 2 spliceosome (IBA)

cytoplasm (IEA)

integral component of membrane (IEA)

sno(s)RNA-containing ribonucleoprotein complex (IEA)

spliceosomal complex (IEA)

U1 snRNP (IBA)

Molecular Function

imidazolonepropionase activity (IBA)

RNA binding (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

histidine metabolic pathway (ISO)

histidinemia pathway (ISO)

References

Genomics

Comparative Map Data

AMDHD1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	15	35,692,161 - 35,760,978 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	15	35,741,190 - 35,761,848 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

AMDHD1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	12	95,943,331 - 95,968,720 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	12	95,943,331 - 95,968,720 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	12	96,337,071 - 96,362,370 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	94,861,202 - 94,886,500 (+)	NCBI	NCBI36		hg18	NCBI36
Celera	12	96,005,967 - 96,028,689 (+)	NCBI
Cytogenetic Map	12	q23.1	NCBI
HuRef	12	93,401,507 - 93,424,233 (+)	NCBI		HuRef
CHM1_1	12	96,302,439 - 96,327,344 (+)	NCBI		CHM1_1

Amdhd1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	93,359,200 - 93,375,973 (-)	NCBI	GRCm39		mm39
GRCm38	10	93,523,338 - 93,540,111 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	93,523,338 - 93,540,033 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	92,986,083 - 93,002,778 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	10	92,953,137 - 92,969,832 (-)	NCBI			mm8
Celera	10	95,509,267 - 95,526,553 (-)	NCBI		Celera
Cytogenetic Map	10	C2	NCBI

Amdhd1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	7	34,362,635 - 34,406,282 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	34,361,633 - 34,406,318 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	34,427,627 - 34,471,274 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	30,557,367 - 30,572,599 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	7	30,577,176 - 30,592,879 (-)	NCBI
Celera	7	25,143,208 - 25,186,848 (-)	NCBI		Celera
Cytogenetic Map	7	q13	NCBI

Amdhd1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955405	32,283,413 - 32,308,230 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955405	32,281,726 - 32,308,230 (+)	NCBI	ChiLan1.0	ChiLan1.0

AMDHD1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	12	96,923,879 - 96,946,507 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	96,923,879 - 96,946,507 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	12	93,534,881 - 93,557,762 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

Amdhd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936507	12,033,804 - 12,049,210 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AMDHD1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	87,553,022 - 87,569,305 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	87,551,887 - 87,569,271 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	91,755,963 - 91,765,895 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AMDHD1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	91,319,330 - 91,341,466 (+)	NCBI
ChlSab1.1 Ensembl	11	91,319,409 - 91,341,559 (+)	Ensembl

Amdhd1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624750	11,352,368 - 11,377,329 (-)	NCBI

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium	3		13	6		6	6		6		6	6
Low	2	5	9		6			2	6	8	4
Below cutoff								4

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_038451787	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038496315	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038558699	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038622614	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038688286	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000165	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000372	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSCAFT00000010335 ⟹ ENSCAFP00000009582

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	15	35,692,210 - 35,698,835 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000010343 ⟹ ENSCAFP00000009589

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	15	35,692,161 - 35,760,978 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000084249 ⟹ ENSCAFP00000057085

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	15	35,692,161 - 35,712,720 (+)	Ensembl

RefSeq Acc Id:

XM_022427686 ⟹ XP_022283394

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	15	35,741,190 - 35,761,848 (+)	NCBI

Sequence:

show sequence

ATGAGGCGCACCATGAGCCACAGCAGCGTAAGCCCATGGAGAAAGCATTTGGAAGAGGAAGGAT
ACCCGGTGTGTTTGAGGAACCGCCAGGAGAAGTTTGGGTCCGGGAGCCGGTCCGACCTATCCTT
CGGGAAGGCGTTAGGGGACGGGGGGCAGAGGCGCCAGGGGGTTCTCTCGTCCCGGTCTAGCCTC
CCCCGCCCGGATCTCCCTTCATCTCGGGGACCTTCTGGGAGGGGATCCCGGAGCGGAGCTGGCC
AACCGAAAATTGTGCGCGGCACCCGCCCCCCCCGCGGCCGCGCGGACCCAGGAGCCCCCCCCGC
AGGGGTTCGTCCGCGCAGCCCGCCCTTCTCCCCGGTAAGCCAGCTTCGGGGCCCGATCTGCAGA
GTAGGGGCAGTGGTCCCCGGCACACGCGCCCAGAGCCGGACGGGGCGGAACCAGGACTGTCCCG
GTCAAGGGGATGGGTTTATAAAAGCCATCGGTCCTGCTGACGCTATCCAAAAACTGTTTTCTGA
AGAAACGTTCGAAGAAAGAATCGACTGTTCTGGGAAATGCATCTTGCCAGGTTTGGTGGATGCA
CACACACATCCAGTATGGGCTGGTGAAAGAGTTCACGAGTTTGCAATGAAGCTGGCAGGTGCCA
CGTACATGGATATCCACCAGGCTGGAGGAGGGATCAACTTCACGGTGGAGCACACGCGCCAAGC
CTCGGAGGAGGAGCTGTTCGGCTCCCTCCGGGGGCGGCTGCAGAGCATGGTGCGCGCGGGGACC
ACGCTGGCGGAGTGCAAGAGCGGATACGGCCTCGACCTGCAGACGGAGCTCAAGATGCTGCGCG
TGATCGAGCGCGCCCGCCGGCAGCTGCCCATCGGCATCTCGGCCACGTACTGCGGGGCTCACTC
GGTGCCAAAAGGAAAGACTGCTGTGGAAGCTGCTGATGAAATCATCAATAGCCACCTCCCAAAG
CTGATGGAGCTGGGTGCAAGTGGGGAAATCCACGTGGACAACATAGATGTGTTCTGTGAGAAGG
GCGTCTTCGATCTCAATTCCACCAGAAGGATTCTTCAAAGTGGAAAAGAGATGGGATTACAGAT
TAACTTCCACGGGGATGAACTCCACCCAATGAAGGCTGCTGAGCTCGGGGCTGAGCTGGGAGCC
CTGGCGGTCAGTCACCTGGAAGAAGCTAGCGACGAAGGCATCGCTGCCATGGCAACGGCCAGGT
GCTCGGCCATCCTCCTGCCCACCACGGCCTACATGCTGAGACTGAAGCAACCTCGCGCTAGGAA
GATGTTAGATGAAGGAGTCATAGTTGCTCTGGGCAGCGATTTCAACCCTAACGCATATTGCTTT
TCAATGCCAGTGGTCATGCACCTGGCCTGTGTGAACATGAGAATGTCCATGCCTGAAGCCTTGG
CGGCTGCCACCATCAATGCAGCTTATGCTCTGGGAAAATCTCACACACACGGATCCCTGGAAGT
GGGCAAACAGGGAGATCTCATTGTCATCAATGCGGCCAGATGGGAGCATTTGATTTACCAGTTT
GGAGGCCATCATGAATTAATTGAATATGTTGTAGCTAAAGGAAAAGTCATCTATAAAAATGAAA
GATCTGAAAGAAAATAGAAGACTCTGCGACAGTATAAGTCAACGCAGTTGCAGTAAAAGTTAAA
ACACTCTAGTGATTTACCAATGTGATGTCACTTAAATATATTTCAGTACTTTGTTAATCCACTT
GAAAAAAAATCAAGTCATTAATTTCTTTTAACATGTGCACCTGGACATATTAACAGGTAAATCA
AATGGATCATGATCTTAGAACATTACATCACTTCACAGAGATTTGTTACAAATATTTTGGAGAT
TAATATGATAGAGTATCATCGAAATGCCTTCATTGGGGAAAAGCAGATTGGCAGTTAGGTAGAC
ATGGCTTGAAATTGCCATTTTGTTTCTGCTTTTCAAATTTCAGTCTTTAAACTACATTTTGTGA
AAATTAGGGGATGGTGAGAAATCCAAGTGATATGTCCCAAACTAAGCAAATGTAGCCTTCTATG
ATAAGCAGCTAGATTGTCCTTTCCCCACACATTGTTTCTCTAAAAGCTCTTTGAATGCATGAGT
GTCCCCTGAGAGAGGATGTCCTTCTATTCCTAATCTCTTCTCTGCTCTAACAATAGAGCTTCAC
AGCACAGTTCAAGACTCATCATTTTACATGTAGGTATAGGGGCCTTCCTAGAATGGATGCATTT
GGACCAAATCCAATAATGTAATTTTCAAAAATCATTTTTAATTTTTTGATTATTCACATTACAA
ATAAAAACAAAATTTTTATAGTTCTTAATAAATATTTGTTGTCACTATTATTGTTTCTAGCCCT
GTAAGTAGATCGGTAGCATTACCTATTATAGTTTTTTAGGAAATGAACAATATAAATAGGTGTT
TCTAAAACCATATGAGTTTACTTGAAATCTTTTTAAATGTTTAGACATCCTTATAATCACAACT
GCATTATTAAACTTTATCCTATTTATGAATAATTTGAGAAGTAAATATTAATCAAATTATCAAA
TTATCACCCATTACACATTAATAAAGGCTGAATCAATGAGG

hide sequence

Protein Sequences


Protein RefSeqs	XP_038307715	(Get FASTA)	NCBI Sequence Viewer
	XP_038352243	(Get FASTA)	NCBI Sequence Viewer
	XP_038414627	(Get FASTA)	NCBI Sequence Viewer
	XP_038478542	(Get FASTA)	NCBI Sequence Viewer
	XP_038544214	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_022283394 ⟸ XM_022427686

- Sequence:

show sequence

MRRTMSHSSVSPWRKHLEEEGYPVCLRNRQEKFGSGSRSDLSFGKALGDGGQRRQGVLSSRSSL
PRPDLPSSRGPSGRGSRSGAGQPKIVRGTRPPRGRADPGAPPAGVRPRSPPFSPVSQLRGPICR
VGAVVPGTRAQSRTGRNQDCPGQGDGFIKAIGPADAIQKLFSEETFEERIDCSGKCILPGLVDA
HTHPVWAGERVHEFAMKLAGATYMDIHQAGGGINFTVEHTRQASEEELFGSLRGRLQSMVRAGT
TLAECKSGYGLDLQTELKMLRVIERARRQLPIGISATYCGAHSVPKGKTAVEAADEIINSHLPK
LMELGASGEIHVDNIDVFCEKGVFDLNSTRRILQSGKEMGLQINFHGDELHPMKAAELGAELGA
LAVSHLEEASDEGIAAMATARCSAILLPTTAYMLRLKQPRARKMLDEGVIVALGSDFNPNAYCF
SMPVVMHLACVNMRMSMPEALAAATINAAYALGKSHTHGSLEVGKQGDLIVINAARWEHLIYQF
GGHHELIEYVVAKGKVIYKNERSERK

hide sequence

RefSeq Acc Id:

ENSCAFP00000057085 ⟸ ENSCAFT00000084249

RefSeq Acc Id:

ENSCAFP00000009582 ⟸ ENSCAFT00000010335

RefSeq Acc Id:

ENSCAFP00000009589 ⟸ ENSCAFT00000010343

Protein Domains

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000006406	Ensembl, UniProtKB/TrEMBL
Ensembl Protein	ENSCAFP00000009582	UniProtKB/TrEMBL
	ENSCAFP00000009589	UniProtKB/TrEMBL
	ENSCAFP00000057085	UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000010335	UniProtKB/TrEMBL
	ENSCAFT00000010343	UniProtKB/TrEMBL
	ENSCAFT00000084249	UniProtKB/TrEMBL
InterPro	Amidohydro-rel	UniProtKB/TrEMBL
	HutI	UniProtKB/TrEMBL
	Lsm6/sSmF	UniProtKB/TrEMBL
	LSM_dom_euk/arc	UniProtKB/TrEMBL
	LSM_dom_sf	UniProtKB/TrEMBL
	Metal-dep_hydrolase_composite	UniProtKB/TrEMBL
	Metal_Hydrolase	UniProtKB/TrEMBL
	Sm_F	UniProtKB/TrEMBL
NCBI Gene	AMDHD1	ENTREZGENE
PANTHER	PTHR11021	UniProtKB/TrEMBL
	PTHR42752	UniProtKB/TrEMBL
Pfam	Amidohydro_1	UniProtKB/TrEMBL
	LSM	UniProtKB/TrEMBL
PIRSF	snRNP_SmF	UniProtKB/TrEMBL
SMART	SM00651	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50182	UniProtKB/TrEMBL
	SSF51338	UniProtKB/TrEMBL
	SSF51556	UniProtKB/TrEMBL
TIGRFAMs	hutI	UniProtKB/TrEMBL
UniProt	A0A5F4CUF4_CANLF	UniProtKB/TrEMBL
	F1Q0L2_CANLF	UniProtKB/TrEMBL
	F1Q0L5_CANLF	UniProtKB/TrEMBL
VGNC ID	VGNC:54193	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Annotations - SMPDB