AMDHD1 (amidohydrolase domain containing 1) - Rat Genome Database

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Gene: AMDHD1 (amidohydrolase domain containing 1) Canis lupus familiaris
Analyze
Symbol: AMDHD1
Name: amidohydrolase domain containing 1
RGD ID: 12257358
Description: ENCODES a protein that exhibits hydrolase activity (inferred); hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides (inferred); metal ion binding (inferred); INVOLVED IN L-histidine catabolic process to glutamate and formamide (inferred); L-histidine catabolic process to glutamate and formate (inferred); L-histidine metabolic process (inferred); PARTICIPATES IN histidine metabolic pathway; histidinemia pathway; FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: probable imidazolonepropionase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11535,741,190 - 35,761,848 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1535,692,161 - 35,760,978 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1536,132,469 - 36,148,396 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01536,411,148 - 36,426,868 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1536,410,952 - 36,427,134 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11535,684,044 - 35,699,752 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01535,778,577 - 35,794,280 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01536,041,752 - 36,057,471 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
AMDHD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11535,741,190 - 35,761,848 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1535,692,161 - 35,760,978 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1536,132,469 - 36,148,396 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01536,411,148 - 36,426,868 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1536,410,952 - 36,427,134 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11535,684,044 - 35,699,752 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01535,778,577 - 35,794,280 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01536,041,752 - 36,057,471 (+)NCBIUU_Cfam_GSD_1.0
AMDHD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381295,943,331 - 95,968,720 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1295,943,331 - 95,968,720 (+)EnsemblGRCh38hg38GRCh38
GRCh371296,337,109 - 96,362,498 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361294,861,202 - 94,886,500 (+)NCBINCBI36Build 36hg18NCBI36
Celera1296,005,967 - 96,028,689 (+)NCBICelera
Cytogenetic Map12q23.1NCBI
HuRef1293,401,507 - 93,424,233 (+)NCBIHuRef
CHM1_11296,302,439 - 96,327,344 (+)NCBICHM1_1
T2T-CHM13v2.01295,919,901 - 95,942,718 (+)NCBIT2T-CHM13v2.0
Amdhd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391093,359,200 - 93,375,973 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1093,359,200 - 93,375,895 (-)EnsemblGRCm39 Ensembl
GRCm381093,523,338 - 93,540,111 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1093,523,338 - 93,540,033 (-)EnsemblGRCm38mm10GRCm38
MGSCv371092,986,083 - 93,002,778 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361092,953,137 - 92,969,832 (-)NCBIMGSCv36mm8
Celera1095,509,267 - 95,526,553 (-)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1048.54NCBI
Amdhd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8729,930,966 - 29,946,199 (-)NCBIGRCr8
mRatBN7.2728,043,923 - 28,059,156 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl728,043,716 - 28,059,156 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx730,034,284 - 30,049,520 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0732,196,501 - 32,211,738 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0731,971,373 - 31,986,628 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0734,362,635 - 34,406,282 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl734,361,633 - 34,406,318 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0734,427,627 - 34,471,274 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4730,557,367 - 30,572,599 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1730,577,176 - 30,592,879 (-)NCBI
Celera725,143,208 - 25,186,848 (-)NCBICelera
Cytogenetic Map7q13NCBI
Amdhd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540532,283,413 - 32,308,230 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540532,281,726 - 32,308,230 (+)NCBIChiLan1.0ChiLan1.0
AMDHD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210104,016,375 - 104,039,599 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112104,012,765 - 104,035,989 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01293,534,881 - 93,557,762 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11296,923,879 - 96,946,507 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1296,923,879 - 96,946,507 (+)Ensemblpanpan1.1panPan2
Amdhd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494524,185,003 - 24,201,632 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650712,033,797 - 12,050,118 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650712,033,804 - 12,049,210 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMDHD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl587,551,913 - 87,569,305 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1587,551,887 - 87,569,271 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2591,755,963 - 91,765,895 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AMDHD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11191,319,330 - 91,341,466 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1191,319,409 - 91,341,559 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037153,787,157 - 153,810,144 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Amdhd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475011,352,368 - 11,377,694 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475011,352,368 - 11,377,329 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in AMDHD1
314 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000010335   ⟹   ENSCAFP00000009582
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1535,692,210 - 35,698,835 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000010343   ⟹   ENSCAFP00000009589
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1535,692,161 - 35,760,978 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000084249   ⟹   ENSCAFP00000057085
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1535,692,161 - 35,712,720 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845042650   ⟹   ENSCAFP00845033443
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1536,410,952 - 36,427,134 (+)Ensembl
RefSeq Acc Id: XM_038451787   ⟹   XP_038307715
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1536,132,469 - 36,148,396 (+)NCBI
RefSeq Acc Id: XM_038496315   ⟹   XP_038352243
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11535,684,044 - 35,699,752 (+)NCBI
RefSeq Acc Id: XM_038558699   ⟹   XP_038414627
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01536,041,752 - 36,057,471 (+)NCBI
RefSeq Acc Id: XM_038622614   ⟹   XP_038478542
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01535,778,577 - 35,794,280 (+)NCBI
RefSeq Acc Id: XM_038688286   ⟹   XP_038544214
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01536,411,148 - 36,426,868 (+)NCBI
Ensembl Acc Id: ENSCAFP00000057085   ⟸   ENSCAFT00000084249
Ensembl Acc Id: ENSCAFP00000009582   ⟸   ENSCAFT00000010335
Ensembl Acc Id: ENSCAFP00000009589   ⟸   ENSCAFT00000010343
RefSeq Acc Id: XP_038352243   ⟸   XM_038496315
RefSeq Acc Id: XP_038478542   ⟸   XM_038622614
RefSeq Acc Id: XP_038544214   ⟸   XM_038688286
- UniProtKB: A0A8C0LC58 (UniProtKB/TrEMBL),   A0A8C0P933 (UniProtKB/TrEMBL),   A0A8I3PQT9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038307715   ⟸   XM_038451787
- UniProtKB: A0A8C0LC58 (UniProtKB/TrEMBL),   A0A8C0P933 (UniProtKB/TrEMBL),   A0A8I3PQT9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038414627   ⟸   XM_038558699
- UniProtKB: A0A8C0LC58 (UniProtKB/TrEMBL),   A0A8C0P933 (UniProtKB/TrEMBL),   A0A8I3PQT9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845033443   ⟸   ENSCAFT00845042650
Protein Domains
Amidohydrolase-related


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000006406 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030022502 UniProtKB/TrEMBL
  ENSCAFG00845024156 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000010343.5 UniProtKB/TrEMBL
  ENSCAFT00030041342.1 UniProtKB/TrEMBL
  ENSCAFT00845042650 ENTREZGENE
  ENSCAFT00845042650.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.40.10 UniProtKB/TrEMBL
  Metal-dependent hydrolases UniProtKB/TrEMBL
InterPro Amidohydro-rel UniProtKB/TrEMBL
  HutI UniProtKB/TrEMBL
  Metal-dep_hydrolase_composite UniProtKB/TrEMBL
  Metal_Hydrolase UniProtKB/TrEMBL
NCBI Gene AMDHD1 ENTREZGENE
PANTHER IMIDAZOLONEPROPIONASE-RELATED UniProtKB/TrEMBL
  PTHR42752 UniProtKB/TrEMBL
Pfam Amidohydro_1 UniProtKB/TrEMBL
Superfamily-SCOP SSF51338 UniProtKB/TrEMBL
  SSF51556 UniProtKB/TrEMBL
UniProt A0A8C0LC58 ENTREZGENE
  A0A8C0P933 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PQT9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:54193 ENTREZGENE