L3MBTL2 (L3MBTL histone methyl-lysine binding protein 2) - Rat Genome Database

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Gene: L3MBTL2 (L3MBTL histone methyl-lysine binding protein 2) Canis lupus familiaris
Analyze
Symbol: L3MBTL2
Name: L3MBTL histone methyl-lysine binding protein 2
RGD ID: 12217290
Description: ENCODES a protein that exhibits promoter-specific chromatin binding (ortholog); INVOLVED IN chromatin organization (ortholog); ectoderm development (ortholog); negative regulation of gene expression (ortholog); ASSOCIATED WITH adenylosuccinase lyase deficiency (ortholog); common variable immunodeficiency 4 (ortholog); medulloblastoma (ortholog); FOUND IN nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: L3MBTL2 polycomb repressive complex 1 subunit; L3MBTL2, polycomb repressive complex 1 subunit; lethal(3)malignant brain tumor-like protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11024,000,008 - 24,021,883 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1024,002,183 - 24,021,753 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1023,932,676 - 23,953,922 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01024,744,975 - 24,766,229 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1024,744,957 - 24,766,173 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11024,461,399 - 24,482,648 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01024,782,259 - 24,803,509 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01024,956,795 - 24,978,045 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
L3MBTL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11024,000,008 - 24,021,883 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1024,002,183 - 24,021,753 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1023,932,676 - 23,953,922 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01024,744,975 - 24,766,229 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1024,744,957 - 24,766,173 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11024,461,399 - 24,482,648 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01024,782,259 - 24,803,509 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01024,956,795 - 24,978,045 (-)NCBIUU_Cfam_GSD_1.0
L3MBTL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382241,205,312 - 41,231,271 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2241,205,282 - 41,231,271 (+)EnsemblGRCh38hg38GRCh38
GRCh372241,601,316 - 41,627,275 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362239,931,259 - 39,957,221 (+)NCBINCBI36Build 36hg18NCBI36
Build 342239,925,812 - 39,951,774NCBI
Celera2225,407,662 - 25,433,655 (+)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2224,565,907 - 24,591,739 (+)NCBIHuRef
CHM1_12241,560,987 - 41,586,967 (+)NCBICHM1_1
T2T-CHM13v2.02241,680,250 - 41,706,208 (+)NCBIT2T-CHM13v2.0
L3mbtl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391581,548,090 - 81,572,516 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1581,548,090 - 81,572,516 (+)EnsemblGRCm39 Ensembl
GRCm381581,663,889 - 81,688,315 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1581,663,889 - 81,688,315 (+)EnsemblGRCm38mm10GRCm38
MGSCv371581,494,366 - 81,518,735 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361581,491,191 - 81,515,560 (+)NCBIMGSCv36mm8
Celera1583,782,718 - 83,807,411 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1538.19NCBI
L3mbtl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87115,066,427 - 115,087,625 (+)NCBIGRCr8
mRatBN7.27113,186,303 - 113,209,706 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7113,186,370 - 113,207,489 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7114,949,034 - 114,970,119 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07117,172,532 - 117,193,617 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07117,141,956 - 117,163,045 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07122,896,860 - 122,918,025 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7122,896,871 - 122,918,036 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07122,871,375 - 122,892,521 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47120,016,773 - 120,037,852 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17120,050,975 - 120,071,944 (+)NCBI
Celera7109,505,411 - 109,526,484 (+)NCBICelera
Cytogenetic Map7q34NCBI
L3mbtl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541326,831,066 - 26,851,859 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541326,831,065 - 26,847,638 (+)NCBIChiLan1.0ChiLan1.0
L3MBTL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22351,038,016 - 51,064,031 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12253,737,939 - 53,763,951 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02222,102,348 - 22,128,351 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12240,193,492 - 40,218,925 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2240,193,492 - 40,218,925 (+)Ensemblpanpan1.1panPan2
L3mbtl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049457,632,020 - 7,656,038 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936492637,835 - 666,435 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936492642,434 - 666,402 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
L3MBTL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl57,253,644 - 7,277,576 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.157,257,806 - 7,277,633 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.254,509,562 - 4,530,093 (+)NCBISscrofa10.2Sscrofa10.2susScr3
L3MBTL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11923,749,894 - 23,774,749 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1923,750,212 - 23,776,947 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045101,649,621 - 101,674,624 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
L3mbtl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247527,292,852 - 7,309,856 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247527,291,888 - 7,309,379 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in L3MBTL2
157 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_014117329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038488516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038550445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038614411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038679752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_538356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005331854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005365553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005399993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005433349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_293337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000001714   ⟹   ENSCAFP00000001579
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1024,002,183 - 24,021,753 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000082738   ⟹   ENSCAFP00000052675
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1024,003,608 - 24,021,753 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845031834   ⟹   ENSCAFP00845024908
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1024,744,957 - 24,766,155 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845031954   ⟹   ENSCAFP00845024988
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1024,746,541 - 24,766,173 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845032095   ⟹   ENSCAFP00845025095
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1024,747,948 - 24,766,173 (-)Ensembl
RefSeq Acc Id: XM_038488516   ⟹   XP_038344444
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11024,461,399 - 24,482,648 (-)NCBI
RefSeq Acc Id: XM_038550445   ⟹   XP_038406373
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01024,956,795 - 24,978,045 (-)NCBI
RefSeq Acc Id: XM_038614411   ⟹   XP_038470339
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01024,782,259 - 24,803,509 (-)NCBI
RefSeq Acc Id: XM_038679752   ⟹   XP_038535680
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01024,744,975 - 24,766,229 (-)NCBI
RefSeq Acc Id: XM_538356   ⟹   XP_538356
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11024,000,008 - 24,021,883 (-)NCBI
Dog10K_Boxer_Tasha1023,932,676 - 23,953,922 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005331854
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11024,463,825 - 24,482,648 (-)NCBI
RefSeq Acc Id: XR_005365553
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01024,959,221 - 24,978,045 (-)NCBI
RefSeq Acc Id: XR_005399993
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01024,784,685 - 24,803,509 (-)NCBI
RefSeq Acc Id: XR_005433349
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01024,747,401 - 24,766,229 (-)NCBI
RefSeq Acc Id: XR_293337
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11024,003,060 - 24,021,883 (-)NCBI
Dog10K_Boxer_Tasha1023,935,102 - 23,953,922 (-)NCBI
Sequence:
RefSeq Acc Id: XP_538356   ⟸   XM_538356
- UniProtKB: A0A8C0T329 (UniProtKB/TrEMBL),   A0A8C0P5D6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000001579   ⟸   ENSCAFT00000001714
Ensembl Acc Id: ENSCAFP00000052675   ⟸   ENSCAFT00000082738
RefSeq Acc Id: XP_038344444   ⟸   XM_038488516
RefSeq Acc Id: XP_038470339   ⟸   XM_038614411
RefSeq Acc Id: XP_038535680   ⟸   XM_038679752
- UniProtKB: A0A8C0P5D6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038406373   ⟸   XM_038550445
- UniProtKB: A0A8C0P5D6 (UniProtKB/TrEMBL),   A0A8C0T329 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845024908   ⟸   ENSCAFT00845031834
Ensembl Acc Id: ENSCAFP00845025095   ⟸   ENSCAFT00845032095
Ensembl Acc Id: ENSCAFP00845024988   ⟸   ENSCAFT00845031954
Protein Domains
FCS-type

Promoters
RGD ID:13684954
Promoter ID:EPDNEW_C3022
Type:multiple initiation site
Name:L3MBTL2_1
Description:L3MBTL2, polycomb repressive complex 1 subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11024,021,808 - 24,021,868EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001120 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030022443 UniProtKB/TrEMBL
  ENSCAFG00040017931 UniProtKB/TrEMBL
  ENSCAFG00845017974 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000001714.5 UniProtKB/TrEMBL
  ENSCAFT00000082738.2 UniProtKB/TrEMBL
  ENSCAFT00000094539.1 UniProtKB/TrEMBL
  ENSCAFT00030041346.1 UniProtKB/TrEMBL
  ENSCAFT00030041569.1 UniProtKB/TrEMBL
  ENSCAFT00040033283.1 UniProtKB/TrEMBL
  ENSCAFT00040033383.1 UniProtKB/TrEMBL
  ENSCAFT00845031834 ENTREZGENE
  ENSCAFT00845031834.1 UniProtKB/TrEMBL
  ENSCAFT00845031954 ENTREZGENE
  ENSCAFT00845031954.1 UniProtKB/TrEMBL
  ENSCAFT00845032095.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.30.140 UniProtKB/TrEMBL
  3.30.60.160 UniProtKB/TrEMBL
InterPro Mbt UniProtKB/TrEMBL
  MBT_L3MBTL2_rpt1 UniProtKB/TrEMBL
  MBT_L3MBTL2_rpt2 UniProtKB/TrEMBL
  PcG_chromatin_remod_factors UniProtKB/TrEMBL
  Znf_FCS UniProtKB/TrEMBL
  Znf_FCS_sf UniProtKB/TrEMBL
KEGG Report cfa:481235 UniProtKB/TrEMBL
NCBI Gene L3MBTL2 ENTREZGENE
PANTHER POLYCOMB GROUP PROTEIN UniProtKB/TrEMBL
  PTHR12247:SF64 UniProtKB/TrEMBL
Pfam MBT UniProtKB/TrEMBL
  zf-FCS_1 UniProtKB/TrEMBL
PROSITE MBT UniProtKB/TrEMBL
  ZF_FCS UniProtKB/TrEMBL
SMART MBT UniProtKB/TrEMBL
Superfamily-SCOP Tudor/PWWP/MBT UniProtKB/TrEMBL
UniProt A0A8C0P5D6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PFV0_CANLF UniProtKB/TrEMBL
  A0A8C0T329 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Z133_CANLF UniProtKB/TrEMBL
  A0A8I3P1Y1_CANLF UniProtKB/TrEMBL
  A0A8I3P4W2_CANLF UniProtKB/TrEMBL
  A0A8I3P6B9_CANLF UniProtKB/TrEMBL
  A0A8P0S7C2_CANLF UniProtKB/TrEMBL
UniProt Secondary A0A8P0PH67 UniProtKB/TrEMBL
VGNC ID VGNC:42558 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-16 L3MBTL2  L3MBTL histone methyl-lysine binding protein 2    L3MBTL2, polycomb repressive complex 1 subunit  Symbol and/or name change 5135510 APPROVED
2017-05-30 L3MBTL2  L3MBTL2, polycomb repressive complex 1 subunit    L3MBTL2 polycomb repressive complex 1 subunit  Symbol and/or name change 5135510 APPROVED