CASKIN1 (CASK interacting protein 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: CASKIN1 (CASK interacting protein 1) Canis lupus familiaris
Analyze
Symbol: CASKIN1
Name: CASK interacting protein 1
RGD ID: 12166812
Description: ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN signal transduction (ortholog); ASSOCIATED WITH autosomal dominant polycystic kidney disease (ortholog); developmental and epileptic encephalopathy 1 (ortholog); endometrial carcinoma (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding (Ensembl: pseudogene)
RefSeq Status: MODEL
Previously known as: caskin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,776,710 - 38,788,253 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,776,710 - 38,786,727 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha640,010,760 - 40,027,402 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0639,079,958 - 39,096,763 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1638,764,968 - 38,781,377 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,737,294 - 38,753,692 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,216,016 - 39,232,351 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
CASKIN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,776,710 - 38,788,253 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,776,710 - 38,786,727 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha640,010,760 - 40,027,402 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0639,079,958 - 39,096,763 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1638,764,968 - 38,781,377 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,737,294 - 38,753,692 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,216,016 - 39,232,351 (+)NCBIUU_Cfam_GSD_1.0
CASKIN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,177,180 - 2,196,605 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,177,180 - 2,196,605 (-)EnsemblGRCh38hg38GRCh38
GRCh37162,227,181 - 2,246,606 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,167,185 - 2,186,466 (-)NCBINCBI36Build 36hg18NCBI36
Build 34162,167,184 - 2,186,466NCBI
Celera162,441,604 - 2,476,669 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef162,153,438 - 2,188,429 (-)NCBIHuRef
CHM1_1162,227,157 - 2,246,403 (-)NCBICHM1_1
T2T-CHM13v2.0162,199,649 - 2,219,075 (-)NCBIT2T-CHM13v2.0
Caskin1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,706,871 - 24,727,883 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,707,575 - 24,727,645 (+)EnsemblGRCm39 Ensembl
GRCm381724,487,897 - 24,508,909 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,488,601 - 24,508,671 (+)EnsemblGRCm38mm10GRCm38
MGSCv371724,625,728 - 24,645,854 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361724,216,383 - 24,236,509 (+)NCBIMGSCv36mm8
Celera1725,004,604 - 25,024,884 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.4NCBI
Caskin1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,016,780 - 14,037,927 (+)NCBIGRCr8
mRatBN7.21013,512,684 - 13,533,380 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,513,465 - 13,533,377 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,259,991 - 18,279,926 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,748,836 - 17,768,771 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,248,023 - 13,267,958 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,853,107 - 13,874,254 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,854,339 - 13,874,254 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,670,657 - 13,691,239 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,740,593 - 13,760,485 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11013,740,569 - 13,760,484 (+)NCBI
Celera1013,193,740 - 13,213,647 (+)NCBICelera
Cytogenetic Map10q12NCBI
Caskin1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544215,030,219 - 15,092,786 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544215,075,427 - 15,092,786 (+)NCBIChiLan1.0ChiLan1.0
CASKIN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2182,680,201 - 2,699,622 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,461,014 - 6,480,427 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0161,035,826 - 1,055,005 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1162,278,390 - 2,293,059 (-)NCBIpanpan1.1PanPan1.1panPan2
Caskin1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344104,841,356 - 104,853,537 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366941,856,603 - 1,866,617 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366941,856,529 - 1,868,107 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASKIN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,794,293 - 39,811,009 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1339,794,400 - 39,811,381 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2342,369,985 - 42,381,726 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CASKIN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.152,071,884 - 2,091,539 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl52,073,253 - 2,091,346 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606828,970,627 - 28,990,165 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Caskin1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462491362,332 - 77,819 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462491362,217 - 79,228 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CASKIN1
87 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 8
Low 4 3 15 1 1 6 4 6 2
Below cutoff 1 2 5 5 6 5 6 8 4 4

Sequence


RefSeq Acc Id: ENSCAFT00000030864
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl638,776,710 - 38,786,727 (+)Ensembl
RefSeq Acc Id: XM_038479472   ⟹   XP_038335400
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1638,764,968 - 38,781,377 (+)NCBI
RefSeq Acc Id: XM_038479473   ⟹   XP_038335401
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1638,764,968 - 38,781,377 (+)NCBI
RefSeq Acc Id: XM_038540731   ⟹   XP_038396659
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0639,216,016 - 39,232,351 (+)NCBI
RefSeq Acc Id: XM_038549741   ⟹   XP_038405669
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha640,010,760 - 40,027,402 (+)NCBI
RefSeq Acc Id: XM_038604852   ⟹   XP_038460780
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0638,737,294 - 38,753,692 (+)NCBI
RefSeq Acc Id: XM_038669550   ⟹   XP_038525478
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0639,079,958 - 39,096,763 (+)NCBI
RefSeq Acc Id: XP_038335400   ⟸   XM_038479472
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038335401   ⟸   XM_038479473
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038460780   ⟸   XM_038604852
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038525478   ⟸   XM_038669550
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LQK0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038405669   ⟸   XM_038549741
- Peptide Label: isoform X6
- UniProtKB: A0A8C0LX61 (UniProtKB/TrEMBL),   A0A8P0PKS5 (UniProtKB/TrEMBL),   A0A8C0LQK0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038396659   ⟸   XM_038540731
- Peptide Label: isoform X5
- UniProtKB: A0A8C0LQK0 (UniProtKB/TrEMBL),   A0A8C0LX61 (UniProtKB/TrEMBL),   A0A8P0PKS5 (UniProtKB/TrEMBL)
Protein Domains
SAM   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000019412 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030000544 UniProtKB/TrEMBL
  ENSCAFG00845004670 ENTREZGENE
Ensembl Transcript ENSCAFT00000030864.5 UniProtKB/TrEMBL
  ENSCAFT00000100194.1 UniProtKB/TrEMBL
  ENSCAFT00000110056.1 UniProtKB/TrEMBL
  ENSCAFT00030000948.1 UniProtKB/TrEMBL
  ENSCAFT00030000979.1 UniProtKB/TrEMBL
  ENSCAFT00845008353 ENTREZGENE
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  Caskin1-CID UniProtKB/TrEMBL
  Caskin1/2_SAM_1 UniProtKB/TrEMBL
  Caskin1/2_SAM_2 UniProtKB/TrEMBL
  Caskin_C UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
NCBI Gene CASKIN1 ENTREZGENE
PANTHER ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
  PTHR24174:SF11 UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  Ank_4 UniProtKB/TrEMBL
  Caskin-Pro-rich UniProtKB/TrEMBL
  Caskin-tail UniProtKB/TrEMBL
  Caskin1-CID UniProtKB/TrEMBL
  SAM_1 UniProtKB/TrEMBL
  SH3_2 UniProtKB/TrEMBL
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  SAM_DOMAIN UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF47769 UniProtKB/TrEMBL
  SSF48403 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
UniProt A0A8C0LQK0 ENTREZGENE
  A0A8C0LX61 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0LX82_CANLF UniProtKB/TrEMBL
  A0A8P0PKS5 ENTREZGENE
  A0A8P0TP55_CANLF UniProtKB/TrEMBL
UniProt Secondary A0A8P0PKS5 UniProtKB/TrEMBL
  A0A8P0PL48 UniProtKB/TrEMBL
VGNC ID VGNC:38730 ENTREZGENE