DLA-DRA (MHC class II DR alpha chain) - Rat Genome Database

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Gene: DLA-DRA (MHC class II DR alpha chain) Canis lupus familiaris
Analyze
Symbol: DLA-DRA
Name: MHC class II DR alpha chain
RGD ID: 12152913
Description: ENCODES a protein that exhibits peptide antigen binding (inferred); polysaccharide binding (inferred); T cell receptor binding (inferred); INVOLVED IN antigen processing and presentation of exogenous peptide antigen via MHC class II (ortholog); immunoglobulin mediated immune response (ortholog); positive regulation of immune response (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; ASSOCIATED WITH allergic disease (ortholog); asthma (ortholog); Asthma and Nasal Polyps (ortholog); FOUND IN external side of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DLA-DRA1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,133,026 - 2,137,825 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,132,499 - 2,168,975 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,282,352 - 2,285,906 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0122,409,388 - 2,414,180 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl122,409,425 - 2,449,778 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1122,132,677 - 2,136,225 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0122,213,826 - 2,217,378 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0122,287,866 - 2,291,417 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:7638867   PMID:15607421   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DLA-DRA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,133,026 - 2,137,825 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,132,499 - 2,168,975 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,282,352 - 2,285,906 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0122,409,388 - 2,414,180 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl122,409,425 - 2,449,778 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1122,132,677 - 2,136,225 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0122,213,826 - 2,217,378 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0122,287,866 - 2,291,417 (+)NCBIUU_Cfam_GSD_1.0
HLA-DRA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38632,439,887 - 32,445,046 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl632,439,878 - 32,445,046 (+)EnsemblGRCh38hg38GRCh38
GRCh37632,407,664 - 32,412,823 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,515,625 - 32,520,801 (+)NCBINCBI36Build 36hg18NCBI36
Build 34632,515,624 - 32,520,799NCBI
Celera633,973,612 - 33,978,821 (+)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef632,160,529 - 32,165,737 (+)NCBIHuRef
CHM1_1632,410,098 - 32,415,302 (+)NCBICHM1_1
T2T-CHM13v2.0632,292,811 - 32,297,976 (+)NCBIT2T-CHM13v2.0
H2-Ea
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,560,926 - 34,563,619 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,560,926 - 34,563,618 (-)EnsemblGRCm39 Ensembl
GRCm381734,341,952 - 34,344,645 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,341,959 - 34,344,645 (-)EnsemblGRCm38mm10GRCm38
MGSCv371734,478,902 - 34,484,492 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,479,157 - 34,481,590 (-)NCBIMGSCv36mm8
Celera1737,104,259 - 37,109,038 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
RT1-Da
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,515,393 - 4,520,387 (+)NCBIGRCr8
mRatBN7.2204,513,464 - 4,518,457 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,512,911 - 4,518,455 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx205,276,067 - 5,281,031 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,637,807 - 4,642,772 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,110,863 - 5,115,835 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,127,644 - 4,132,616 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,127,644 - 4,132,616 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,207,782 - 6,212,754 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,636,310 - 4,641,282 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera206,115,646 - 6,120,618 (+)NCBICelera
Cytogenetic Map20p12NCBI
LOC102019320
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554371,109,713 - 1,114,802 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554371,109,735 - 1,114,742 (+)NCBIChiLan1.0ChiLan1.0
LOC100987081
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,921,122 - 46,926,280 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,882,622 - 42,887,781 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0632,105,421 - 32,110,579 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,982,228 - 32,987,417 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,982,228 - 32,987,417 (+)Ensemblpanpan1.1panPan2
LOC101969065
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494637,016,438 - 37,021,225 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936727540,217 - 545,036 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936727540,225 - 544,968 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLA-DRA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl724,825,052 - 24,835,158 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1724,825,037 - 24,830,650 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2729,036,552 - 29,042,147 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7q1.1NCBI
MHC-DRA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11739,623,324 - 39,628,464 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1739,622,402 - 39,629,261 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604432,311,484 - 32,316,629 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101706353
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475424,079,366 - 24,084,512 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475424,079,459 - 24,086,342 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DLA-DRA
74 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000001254   ⟹   ENSCAFP00000001147
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl122,133,091 - 2,137,499 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000067174   ⟹   ENSCAFP00000058766
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl122,133,685 - 2,168,975 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000083428   ⟹   ENSCAFP00000045482
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl122,132,499 - 2,137,748 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845030935   ⟹   ENSCAFP00845024244
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl122,409,425 - 2,414,477 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845030976   ⟹   ENSCAFP00845024273
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl122,409,449 - 2,414,172 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845031161   ⟹   ENSCAFP00845024400
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl122,410,045 - 2,449,778 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845031265   ⟹   ENSCAFP00845024472
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl122,410,045 - 2,444,814 (+)Ensembl
RefSeq Acc Id: NM_001011723   ⟹   NP_001011723
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1122,133,124 - 2,136,678 (+)NCBI
Dog10K_Boxer_Tasha122,282,352 - 2,285,906 (+)NCBI
ROS_Cfam_1.0122,409,489 - 2,413,034 (+)NCBI
UMICH_Zoey_3.1122,132,677 - 2,136,225 (+)NCBI
UNSW_CanFamBas_1.0122,213,826 - 2,217,378 (+)NCBI
UU_Cfam_GSD_1.0122,287,866 - 2,291,417 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038682741   ⟹   XP_038538669
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0122,409,389 - 2,414,180 (+)NCBI
RefSeq Acc Id: XM_038682742   ⟹   XP_038538670
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0122,409,388 - 2,414,180 (+)NCBI
RefSeq Acc Id: NP_001011723   ⟸   NM_001011723
- Peptide Label: precursor
- UniProtKB: Q30437 (UniProtKB/TrEMBL),   F1PLW1 (UniProtKB/TrEMBL),   A0A8C0JK13 (UniProtKB/TrEMBL),   A0A8C0RKX0 (UniProtKB/TrEMBL),   A0A8C0T6C8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000001147   ⟸   ENSCAFT00000001254
Ensembl Acc Id: ENSCAFP00000045482   ⟸   ENSCAFT00000083428
Ensembl Acc Id: ENSCAFP00000058766   ⟸   ENSCAFT00000067174
RefSeq Acc Id: XP_038538670   ⟸   XM_038682742
- Peptide Label: isoform X1
- UniProtKB: F1PLW1 (UniProtKB/TrEMBL),   A0A8C0JK13 (UniProtKB/TrEMBL),   A0A8C0RKX0 (UniProtKB/TrEMBL),   Q30437 (UniProtKB/TrEMBL),   A0A8C0T6C8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038538669   ⟸   XM_038682741
- Peptide Label: isoform X1
- UniProtKB: F1PLW1 (UniProtKB/TrEMBL),   A0A8C0JK13 (UniProtKB/TrEMBL),   A0A8C0RKX0 (UniProtKB/TrEMBL),   Q30437 (UniProtKB/TrEMBL),   A0A8C0T6C8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845024400   ⟸   ENSCAFT00845031161
Ensembl Acc Id: ENSCAFP00845024472   ⟸   ENSCAFT00845031265
Ensembl Acc Id: ENSCAFP00845024273   ⟸   ENSCAFT00845030976
Ensembl Acc Id: ENSCAFP00845024244   ⟸   ENSCAFT00845030935
Protein Domains
Ig-like

Promoters
RGD ID:13685361
Promoter ID:EPDNEW_C3431
Type:initiation region
Name:DLA-DRA_1
Description:major histocompatibility complex, class II, DR alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1122,133,060 - 2,133,120EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000803 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030015343 UniProtKB/TrEMBL
  ENSCAFG00040019499 UniProtKB/TrEMBL
  ENSCAFG00845017467 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000001254.5 UniProtKB/TrEMBL
  ENSCAFT00000067174.2 UniProtKB/TrEMBL
  ENSCAFT00000083428.2 UniProtKB/TrEMBL
  ENSCAFT00030028398.1 UniProtKB/TrEMBL
  ENSCAFT00030028481.1 UniProtKB/TrEMBL
  ENSCAFT00030028538.1 UniProtKB/TrEMBL
  ENSCAFT00040036064.1 UniProtKB/TrEMBL
  ENSCAFT00845030935 ENTREZGENE
  ENSCAFT00845030935.1 UniProtKB/TrEMBL
  ENSCAFT00845030976 ENTREZGENE
  ENSCAFT00845030976.1 UniProtKB/TrEMBL
  ENSCAFT00845031161.1 UniProtKB/TrEMBL
  ENSCAFT00845031265.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/TrEMBL
  Ig_C1-set UniProtKB/TrEMBL
  MHC/Immunoglobulin UniProtKB/TrEMBL
  MHC_I/II-like_Ag-recog UniProtKB/TrEMBL
  MHC_II_a/b_N UniProtKB/TrEMBL
  MHC_II_a_N UniProtKB/TrEMBL
KEGG Report cfa:481731 UniProtKB/TrEMBL
NCBI Gene DLA-DRA ENTREZGENE
PANTHER HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN-RELATED UniProtKB/TrEMBL
  MHC CLASS II-RELATED UniProtKB/TrEMBL
Pfam C1-set UniProtKB/TrEMBL
  MHC_II_alpha UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  IG_MHC UniProtKB/TrEMBL
SMART IGc1 UniProtKB/TrEMBL
  MHC_II_alpha UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  SSF54452 UniProtKB/TrEMBL
UniProt A0A8C0JK13 ENTREZGENE
  A0A8C0RKV0_CANLF UniProtKB/TrEMBL
  A0A8C0RKW1_CANLF UniProtKB/TrEMBL
  A0A8C0RKX0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0T6C8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NY30_CANLF UniProtKB/TrEMBL
  A0A8I3NY87_CANLF UniProtKB/TrEMBL
  A0A8I3S2N1_CANLF UniProtKB/TrEMBL
  A0A8P0TAQ6_CANLF UniProtKB/TrEMBL
  F1PLW1 ENTREZGENE
  Q30437 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A8P0SYI2 UniProtKB/TrEMBL
  F1PLW1 UniProtKB/TrEMBL