PFDN6 (prefoldin subunit 6) - Rat Genome Database

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Gene: PFDN6 (prefoldin subunit 6) Canis lupus familiaris
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Symbol: PFDN6
Name: prefoldin subunit 6
RGD ID: 12132212
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); INVOLVED IN negative regulation of amyloid fibril formation (ortholog); ASSOCIATED WITH autosomal dominant intellectual developmental disorder 5 (ortholog); MHC class I deficiency (ortholog); proteasome-associated autoinflammatory syndrome 1 (ortholog); FOUND IN RPAP3/R2TP/prefoldin-like complex (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: protein Ke2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: LOC609675  
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,729,562 - 2,730,858 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,729,562 - 2,737,163 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,810,481 - 2,811,777 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0123,060,976 - 3,062,272 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl123,060,976 - 3,068,578 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1122,728,205 - 2,729,498 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0122,809,691 - 2,810,986 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0122,884,403 - 2,885,699 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PFDN6Dogautosomal dominant intellectual developmental disorder 5  ISORGD:13513148554872ClinVar Annotator: match by term: Intellectual disability, autosomal dominant 5ClinVarPMID:28492532
PFDN6DogMHC class I deficiency  ISORGD:13513148554872ClinVar Annotator: match by term: MHC class I deficiencyClinVarPMID:28492532
PFDN6Dogproteasome-associated autoinflammatory syndrome 1  ISORGD:13513148554872ClinVar Annotator: match by term: Proteasome-associated autoinflammatory syndrome 1ClinVarPMID:28492532


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PFDN6Dogchaperone-mediated protein complex assembly involved_inIBAPANTHER:PTN000484524|UniProtKB:O15212150520179 GO_CentralGO_REF:0000033
PFDN6Dognegative regulation of amyloid fibril formation involved_inISORGD:13513149068941 PMID:23614719FlyBasePMID:23614719
PFDN6Dogprotein folding involved_inIEAInterPro:IPR002777150520179 InterProGO_REF:0000002
PFDN6Dogprotein folding involved_inIBAPANTHER:PTN000484524|SGD:S000004190|TAIR:locus:2198289|UniProtKB:O15212150520179 GO_CentralGO_REF:0000033

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PFDN6Dogcytoplasm located_inIEAARBA:ARBA00026971150520179 UniProtGO_REF:0000117
PFDN6Dogcytoplasm is_active_inIBAPANTHER:PTN000484524|SGD:S000004190|TAIR:locus:2198289|WB:WBGene00009004150520179 GO_CentralGO_REF:0000033
PFDN6Dogprefoldin complex part_ofIBAPANTHER:PTN000484524|SGD:S000004190|TAIR:locus:2198289|UniProtKB:O15212150520179 GO_CentralGO_REF:0000033
PFDN6Dogprefoldin complex part_ofIEAInterPro:IPR002777150520179 InterProGO_REF:0000002
PFDN6DogRPAP3/R2TP/prefoldin-like complex part_ofISORGD:13513149068941 PMID:31738558ComplexPortalPMID:31738558

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PFDN6Dogamyloid-beta binding enablesISORGD:13513149068941 PMID:23614719FlyBasePMID:23614719
PFDN6Dogprotein binding enablesISOUniProtKB:P226079068941 PMID:32814053IntActPMID:32814053
PFDN6Dogprotein binding enablesISOUniProtKB:O15481|UniProtKB:O95983-2|UniProtKB:P53567|UniProtKB:Q13155|UniProtKB:Q63ZY3|UniProtKB:Q8TD31-3|UniProtKB:Q9BVG8-5|UniProtKB:Q9NQG5|UniProtKB:Q9UK229068941 PMID:32296183IntActPMID:32296183
PFDN6Dogprotein-folding chaperone binding enablesIBAPANTHER:PTN000484524|UniProtKB:O15212150520179 GO_CentralGO_REF:0000033
PFDN6Dogunfolded protein binding enablesIEAInterPro:IPR002777150520179 InterProGO_REF:0000002

PMID:15607421   PMID:22301074   PMID:30032202  



PFDN6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,729,562 - 2,730,858 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,729,562 - 2,737,163 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,810,481 - 2,811,777 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0123,060,976 - 3,062,272 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl123,060,976 - 3,068,578 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1122,728,205 - 2,729,498 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0122,809,691 - 2,810,986 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0122,884,403 - 2,885,699 (+)NCBIUU_Cfam_GSD_1.0
PFDN6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38633,289,197 - 33,290,934 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl633,289,302 - 33,298,401 (+)EnsemblGRCh38hg38GRCh38
GRCh37633,257,374 - 33,258,711 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,365,356 - 33,366,689 (+)NCBINCBI36Build 36hg18NCBI36
Build 34633,365,355 - 33,366,689NCBI
Celera634,811,736 - 34,813,069 (+)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef632,999,008 - 33,000,345 (+)NCBIHuRef
CHM1_1633,259,314 - 33,260,651 (+)NCBICHM1_1
T2T-CHM13v2.0633,110,554 - 33,112,296 (+)NCBIT2T-CHM13v2.0
Pfdn6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,157,883 - 34,159,317 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,157,795 - 34,159,317 (-)EnsemblGRCm39 Ensembl
GRCm381733,938,909 - 33,940,343 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1733,938,821 - 33,940,343 (-)EnsemblGRCm38mm10GRCm38
MGSCv371734,075,854 - 34,077,288 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361733,549,377 - 33,550,759 (-)NCBIMGSCv36mm8
Celera1736,691,821 - 36,693,255 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
Pfdn6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,947,844 - 4,949,318 (+)NCBIGRCr8
mRatBN7.2204,945,959 - 4,947,433 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,945,959 - 4,947,433 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx205,669,442 - 5,670,913 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0205,031,187 - 5,032,658 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,511,980 - 5,513,454 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,455,974 - 5,457,448 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,455,974 - 5,457,444 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,514,586 - 7,516,060 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,097,725 - 5,099,199 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1205,097,988 - 5,099,417 (+)NCBI
Celera206,530,176 - 6,531,651 (+)NCBICelera
Cytogenetic Map20p12NCBI
Pfdn6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554371,848,571 - 1,849,824 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554371,848,571 - 1,849,824 (+)NCBIChiLan1.0ChiLan1.0
PFDN6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2547,767,049 - 47,768,838 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1643,638,721 - 43,640,506 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0632,861,793 - 32,863,234 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1633,975,889 - 33,977,304 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl633,975,992 - 33,983,245 (+)Ensemblpanpan1.1panPan2
Pfdn6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,383,438 - 38,384,733 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647625,575,534 - 25,576,818 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647625,575,534 - 25,576,827 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PFDN6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl729,653,679 - 29,654,945 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1729,653,569 - 29,654,957 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2734,157,268 - 34,158,709 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PFDN6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11738,786,556 - 38,787,913 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1738,786,045 - 38,787,613 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604433,124,206 - 33,125,566 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pfdn6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,531,016 - 23,532,388 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475423,531,016 - 23,532,350 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in PFDN6
13 total Variants



adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10



Ensembl Acc Id: ENSCAFT00845037384   ⟹   ENSCAFP00845029285
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl123,060,976 - 3,068,578 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845037435   ⟹   ENSCAFP00845029325
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl123,060,976 - 3,062,272 (+)Ensembl
RefSeq Acc Id: NM_001048089   ⟹   NP_001041554
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1122,729,562 - 2,730,858 (+)NCBI
Dog10K_Boxer_Tasha122,810,481 - 2,811,777 (+)NCBI
ROS_Cfam_1.0123,060,976 - 3,062,272 (+)NCBI
UMICH_Zoey_3.1122,728,205 - 2,729,498 (+)NCBI
UNSW_CanFamBas_1.0122,809,691 - 2,810,986 (+)NCBI
UU_Cfam_GSD_1.0122,884,403 - 2,885,699 (+)NCBI
Sequence:
Protein RefSeqs NP_001041554 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAI11442 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000001363.3
  ENSCAFP00030021099.1
  ENSCAFP00040034080.1
  ENSCAFP00845029325
  ENSCAFP00845029325.1
GenBank Protein Q5TJE6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001041554   ⟸   NM_001048089
- UniProtKB: Q5TJE6 (UniProtKB/Swiss-Prot),   A0A8C0QUM0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00845029285   ⟸   ENSCAFT00845037384
Ensembl Acc Id: ENSCAFP00845029325   ⟸   ENSCAFT00845037435

RGD ID:13685379
Promoter ID:EPDNEW_C3448
Type:multiple initiation site
Name:PFDN6_1
Description:prefoldin subunit 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1122,729,584 - 2,729,644EPDNEW


1 to 24 of 24 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCAFG00000000956 Ensembl, UniProtKB/Swiss-Prot
  ENSCAFG00030013071 UniProtKB/Swiss-Prot
  ENSCAFG00040021078 UniProtKB/Swiss-Prot
  ENSCAFG00845021180 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSCAFT00000001479.4 UniProtKB/Swiss-Prot
  ENSCAFT00030024194.1 UniProtKB/Swiss-Prot
  ENSCAFT00040039083.1 UniProtKB/Swiss-Prot
  ENSCAFT00845037435 ENTREZGENE
  ENSCAFT00845037435.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.370 UniProtKB/Swiss-Prot
InterPro PFD_beta-like UniProtKB/Swiss-Prot
  Prefoldin UniProtKB/Swiss-Prot
KEGG Report cfa:474872 UniProtKB/Swiss-Prot
  cfa:610181 UniProtKB/Swiss-Prot
NCBI Gene PFDN6 ENTREZGENE
PANTHER PREFOLDIN SUBUNIT 6 UniProtKB/Swiss-Prot
  PREFOLDIN SUBUNIT 6 UniProtKB/Swiss-Prot
Pfam Prefoldin_2 UniProtKB/Swiss-Prot
Superfamily-SCOP Prefoldin UniProtKB/Swiss-Prot
UniProt A0A8C0NDL4_CANLF UniProtKB/TrEMBL
  A0A8C0QUM0 ENTREZGENE
  A0A8I3PCA3_CANLF UniProtKB/TrEMBL
  PFD6_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:44441 ENTREZGENE
1 to 24 of 24 rows