TMX1 (thioredoxin related transmembrane protein 1) - Rat Genome Database

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Gene: TMX1 (thioredoxin related transmembrane protein 1) Canis lupus familiaris
Analyze
Symbol: TMX1
Name: thioredoxin related transmembrane protein 1
RGD ID: 12110397
Description: ENCODES a protein that exhibits disulfide oxidoreductase activity (inferred); enzyme inhibitor activity (inferred); protein disulfide isomerase activity (inferred); INVOLVED IN negative regulation of platelet aggregation (inferred); negative regulation of triglyceride biosynthetic process (inferred); positive regulation of ERAD pathway (inferred); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); mitochondria-associated endoplasmic reticulum membrane contact site (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: thioredoxin domain containing 1; thioredoxin-related transmembrane protein 1; TXNDC1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1827,541,407 - 27,556,058 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl827,541,460 - 27,554,681 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha827,294,348 - 27,309,006 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0827,720,393 - 27,735,066 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl827,720,419 - 27,735,066 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1827,375,197 - 27,389,859 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0827,449,389 - 27,464,067 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0827,796,517 - 27,811,194 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

References

Genomics

Comparative Map Data
TMX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1827,541,407 - 27,556,058 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl827,541,460 - 27,554,681 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha827,294,348 - 27,309,006 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0827,720,393 - 27,735,066 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl827,720,419 - 27,735,066 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1827,375,197 - 27,389,859 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0827,449,389 - 27,464,067 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0827,796,517 - 27,811,194 (+)NCBIUU_Cfam_GSD_1.0
TMX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381451,240,247 - 51,257,655 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1451,240,162 - 51,257,655 (+)EnsemblGRCh38hg38GRCh38
GRCh371451,706,965 - 51,724,373 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361450,776,636 - 50,794,123 (+)NCBINCBI36Build 36hg18NCBI36
Build 341450,776,685 - 50,792,512NCBI
Celera1431,573,863 - 31,591,352 (+)NCBICelera
Cytogenetic Map14q22.1NCBI
HuRef1431,866,596 - 31,884,390 (+)NCBIHuRef
CHM1_11451,645,399 - 51,662,884 (+)NCBICHM1_1
T2T-CHM13v2.01445,446,717 - 45,464,426 (+)NCBIT2T-CHM13v2.0
Tmx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391270,499,928 - 70,514,398 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1270,499,869 - 70,514,814 (+)EnsemblGRCm39 Ensembl
GRCm381270,453,154 - 70,467,624 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1270,453,095 - 70,468,040 (+)EnsemblGRCm38mm10GRCm38
MGSCv371271,554,141 - 71,568,611 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361271,371,759 - 71,386,229 (+)NCBIMGSCv36mm8
Celera1271,558,987 - 71,573,471 (+)NCBICelera
Cytogenetic Map12C2NCBI
cM Map1229.13NCBI
Tmx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8694,696,699 - 94,707,751 (+)NCBIGRCr8
mRatBN7.2688,960,691 - 88,971,744 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl688,960,695 - 88,971,301 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx689,352,744 - 89,363,806 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0689,652,189 - 89,663,251 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0689,091,717 - 89,102,779 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0692,864,123 - 92,875,141 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl692,864,123 - 92,874,204 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06102,311,253 - 102,322,281 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4692,562,592 - 92,572,638 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1692,566,047 - 92,576,094 (+)NCBI
Celera687,447,253 - 87,457,339 (+)NCBICelera
Cytogenetic Map6q24NCBI
Tmx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540911,710,646 - 11,722,342 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540911,708,867 - 11,722,205 (-)NCBIChiLan1.0ChiLan1.0
TMX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21552,378,563 - 52,394,539 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11451,595,079 - 51,612,555 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01431,844,418 - 31,861,911 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11450,129,565 - 50,146,148 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1450,129,568 - 50,147,057 (+)Ensemblpanpan1.1panPan2
Tmx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864059,744,345 - 59,759,804 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649514,431,137 - 14,447,476 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649514,432,971 - 14,447,380 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1180,933,859 - 180,951,341 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11180,933,678 - 180,950,826 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21201,220,189 - 201,235,370 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12428,334,017 - 28,350,571 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2428,333,357 - 28,352,457 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605316,656,245 - 16,672,417 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473117,718,868 - 17,730,586 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473117,713,812 - 17,730,521 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TMX1
92 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000023221   ⟹   ENSCAFP00000021563
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl827,541,460 - 27,554,681 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845006146   ⟹   ENSCAFP00845004890
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl827,720,419 - 27,735,066 (+)Ensembl
RefSeq Acc Id: XM_038483256   ⟹   XP_038339184
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1827,375,197 - 27,389,859 (+)NCBI
RefSeq Acc Id: XM_038544703   ⟹   XP_038400631
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0827,796,517 - 27,811,194 (+)NCBI
RefSeq Acc Id: XM_038608827   ⟹   XP_038464755
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0827,449,389 - 27,464,067 (+)NCBI
RefSeq Acc Id: XM_038673629   ⟹   XP_038529557
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0827,720,393 - 27,735,066 (+)NCBI
RefSeq Acc Id: XM_848339   ⟹   XP_853432
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1827,541,407 - 27,556,058 (+)NCBI
Dog10K_Boxer_Tasha827,294,348 - 27,309,006 (+)NCBI
Sequence:
RefSeq Acc Id: XP_853432   ⟸   XM_848339
- UniProtKB: A0A8C0KYH5 (UniProtKB/TrEMBL),   A0A8C0Q257 (UniProtKB/TrEMBL),   A0A8I3MQG4 (UniProtKB/TrEMBL),   A0A8C0M778 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000021563   ⟸   ENSCAFT00000023221
RefSeq Acc Id: XP_038339184   ⟸   XM_038483256
RefSeq Acc Id: XP_038464755   ⟸   XM_038608827
RefSeq Acc Id: XP_038529557   ⟸   XM_038673629
- UniProtKB: A0A8C0KYH5 (UniProtKB/TrEMBL),   A0A8C0Q257 (UniProtKB/TrEMBL),   A0A8I3MQG4 (UniProtKB/TrEMBL),   A0A8C0M778 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038400631   ⟸   XM_038544703
- UniProtKB: A0A8C0M778 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845004890   ⟸   ENSCAFT00845006146
Protein Domains
Thioredoxin

Promoters
RGD ID:13684200
Promoter ID:EPDNEW_C2268
Type:initiation region
Name:TMX1_1
Description:thioredoxin related transmembrane protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1827,541,429 - 27,541,489EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014626 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030004563 UniProtKB/TrEMBL
  ENSCAFG00040004310 UniProtKB/TrEMBL
  ENSCAFG00845003463 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000023221.5 UniProtKB/TrEMBL
  ENSCAFT00030008388.1 UniProtKB/TrEMBL
  ENSCAFT00040008224.1 UniProtKB/TrEMBL
  ENSCAFT00845006146 ENTREZGENE
  ENSCAFT00845006146.1 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/TrEMBL
InterPro Thioredoxin-like_sf UniProtKB/TrEMBL
  Thioredoxin_CS UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/TrEMBL
  TMX_domain-containing UniProtKB/TrEMBL
KEGG Report cfa:610791 UniProtKB/TrEMBL
NCBI Gene TMX1 ENTREZGENE
PANTHER DUMPY: SHORTER THAN WILD-TYPE UniProtKB/TrEMBL
  THIOREDOXIN-RELATED TRANSMEMBRANE PROTEIN 1 UniProtKB/TrEMBL
Pfam Thioredoxin UniProtKB/TrEMBL
PROSITE THIOREDOXIN_1 UniProtKB/TrEMBL
  THIOREDOXIN_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/TrEMBL
UniProt A0A8C0KYH5 ENTREZGENE
  A0A8C0M778 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Q257 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MQG4 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:47643 ENTREZGENE