EIF3A (eukaryotic translation initiation factor 3 subunit A) - Rat Genome Database

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Gene: EIF3A (eukaryotic translation initiation factor 3 subunit A) Canis lupus familiaris
Analyze
Symbol: EIF3A
Name: eukaryotic translation initiation factor 3 subunit A
RGD ID: 12086958
Description: ENCODES a protein that exhibits receptor tyrosine kinase binding (ortholog); translation initiation factor activity (ortholog); INVOLVED IN negative regulation of ERK1 and ERK2 cascade (ortholog); PARTICIPATES IN translation initiation pathway; ASSOCIATED WITH Prostatic Neoplasms (ortholog); FOUND IN microtubule (ortholog); postsynaptic density (ortholog); INTERACTS WITH masitinib
Type: protein-coding
RefSeq Status: MODEL
Previously known as: EIF3S10; eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12829,290,668 - 29,326,851 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2829,291,422 - 29,326,701 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2829,432,879 - 29,469,314 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02829,821,606 - 29,857,976 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2829,821,622 - 29,857,939 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12829,375,678 - 29,411,864 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02829,395,449 - 29,431,740 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02829,589,681 - 29,626,027 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
masitinib  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
EIF3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12829,290,668 - 29,326,851 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2829,291,422 - 29,326,701 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2829,432,879 - 29,469,314 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02829,821,606 - 29,857,976 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2829,821,622 - 29,857,939 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12829,375,678 - 29,411,864 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02829,395,449 - 29,431,740 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02829,589,681 - 29,626,027 (-)NCBIUU_Cfam_GSD_1.0
EIF3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810119,033,670 - 119,080,817 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10119,033,670 - 119,080,817 (-)EnsemblGRCh38hg38GRCh38
GRCh3710120,793,182 - 120,840,329 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610120,784,531 - 120,830,324 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410120,784,546 - 120,830,291NCBI
Celera10114,525,146 - 114,570,792 (-)NCBICelera
Cytogenetic Map10q26.11NCBI
HuRef10114,423,579 - 114,469,868 (-)NCBIHuRef
CHM1_110121,078,880 - 121,124,758 (-)NCBICHM1_1
T2T-CHM13v2.010119,929,080 - 119,976,262 (-)NCBIT2T-CHM13v2.0
Eif3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391960,749,554 - 60,779,131 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1960,749,555 - 60,779,096 (-)EnsemblGRCm39 Ensembl
GRCm381960,761,116 - 60,790,693 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1960,761,117 - 60,790,658 (-)EnsemblGRCm38mm10GRCm38
MGSCv371960,837,019 - 60,866,596 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361960,815,785 - 60,845,306 (-)NCBIMGSCv36mm8
Celera1962,970,389 - 62,999,944 (-)NCBICelera
Cytogenetic Map19D3NCBI
cM Map1956.52NCBI
Eif3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81269,888,730 - 269,925,785 (-)NCBIGRCr8
mRatBN7.21259,902,767 - 259,932,976 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1259,902,680 - 259,932,976 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1268,109,376 - 268,139,913 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01274,815,401 - 274,845,939 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01267,469,710 - 267,500,251 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01282,139,809 - 282,170,017 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1282,139,823 - 282,170,017 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01289,478,360 - 289,508,568 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41267,369,497 - 267,399,705 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11267,580,496 - 267,610,974 (-)NCBI
Celera1255,543,560 - 255,573,769 (-)NCBICelera
Cytogenetic Map1q55NCBI
Eif3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543123,543,838 - 23,578,757 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543123,542,842 - 23,578,892 (-)NCBIChiLan1.0ChiLan1.0
EIF3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28130,896,493 - 130,943,480 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110130,901,834 - 130,948,616 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010115,608,394 - 115,654,586 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110119,030,884 - 119,077,603 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10119,033,253 - 119,072,889 (-)Ensemblpanpan1.1panPan2
Eif3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721317,026,204 - 17,060,008 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364868,499,893 - 8,534,938 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364868,501,290 - 8,536,321 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14128,967,653 - 129,007,173 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114128,967,645 - 129,007,168 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214140,498,415 - 140,537,898 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EIF3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19111,828,858 - 111,887,546 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9111,830,988 - 111,887,518 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604873,092,189 - 73,142,011 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eif3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473727,691,762 - 27,733,638 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in EIF3A
463 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000019160   ⟹   ENSCAFP00000017766
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2829,291,422 - 29,326,701 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845027964   ⟹   ENSCAFP00845022013
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2829,821,622 - 29,857,939 (-)Ensembl
RefSeq Acc Id: XM_005637775   ⟹   XP_005637832
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12829,290,668 - 29,326,851 (-)NCBI
Dog10K_Boxer_Tasha2829,432,879 - 29,469,314 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038440725   ⟹   XP_038296653
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02829,821,606 - 29,857,976 (-)NCBI
RefSeq Acc Id: XM_038440726   ⟹   XP_038296654
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02829,821,606 - 29,857,976 (-)NCBI
RefSeq Acc Id: XM_038515325   ⟹   XP_038371253
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12829,375,678 - 29,411,864 (-)NCBI
RefSeq Acc Id: XM_038515326   ⟹   XP_038371254
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12829,375,678 - 29,411,864 (-)NCBI
RefSeq Acc Id: XM_038578935   ⟹   XP_038434863
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02829,589,681 - 29,626,027 (-)NCBI
RefSeq Acc Id: XM_038578936   ⟹   XP_038434864
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02829,589,681 - 29,626,027 (-)NCBI
RefSeq Acc Id: XM_038643145   ⟹   XP_038499073
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02829,395,449 - 29,431,740 (-)NCBI
RefSeq Acc Id: XM_038643146   ⟹   XP_038499074
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02829,395,449 - 29,431,740 (-)NCBI
RefSeq Acc Id: XM_847038   ⟹   XP_852131
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12829,290,668 - 29,326,851 (-)NCBI
Dog10K_Boxer_Tasha2829,432,879 - 29,469,314 (-)NCBI
Sequence:
RefSeq Acc Id: XP_005637832   ⟸   XM_005637775
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_852131   ⟸   XM_847038
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KMV2 (UniProtKB/TrEMBL),   A0A8C0Z702 (UniProtKB/TrEMBL),   A0A8P0SGW8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000017766   ⟸   ENSCAFT00000019160
RefSeq Acc Id: XP_038371254   ⟸   XM_038515326
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038371253   ⟸   XM_038515325
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038499074   ⟸   XM_038643146
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038499073   ⟸   XM_038643145
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038296654   ⟸   XM_038440726
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038296653   ⟸   XM_038440725
- Peptide Label: isoform X1
- UniProtKB: A0A8C0RSM9 (UniProtKB/TrEMBL),   A0A8I3NXD1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038434864   ⟸   XM_038578936
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038434863   ⟸   XM_038578935
- Peptide Label: isoform X1
- UniProtKB: A0A8C0RSM9 (UniProtKB/TrEMBL),   A0A8I3NXD1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845022013   ⟸   ENSCAFT00845027964
Protein Domains
PCI


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012057 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030024419 UniProtKB/TrEMBL
  ENSCAFG00040025356 UniProtKB/TrEMBL
  ENSCAFG00845015674 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000019160.6 UniProtKB/TrEMBL
  ENSCAFT00030045012.1 UniProtKB/TrEMBL
  ENSCAFT00040047300.1 UniProtKB/TrEMBL
  ENSCAFT00845027964 ENTREZGENE
  ENSCAFT00845027964.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.860 UniProtKB/TrEMBL
  UVR domain UniProtKB/TrEMBL
InterPro EIF3A UniProtKB/TrEMBL
  PCI_dom UniProtKB/TrEMBL
NCBI Gene EIF3A ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A UniProtKB/TrEMBL
  PTHR14005 UniProtKB/TrEMBL
Pfam eIF3a_PCI_TPR-like UniProtKB/TrEMBL
  PCI UniProtKB/TrEMBL
PROSITE PCI UniProtKB/TrEMBL
SMART PINT UniProtKB/TrEMBL
UniProt A0A8C0KMV2 ENTREZGENE
  A0A8C0RSM9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Z702 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NXD1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SGW8 ENTREZGENE
UniProt Secondary A0A8P0SGW8 UniProtKB/TrEMBL
VGNC ID VGNC:40268 ENTREZGENE