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Gene: NWD1 (NACHT and WD repeat domain containing 1) Canis lupus familiaris

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Symbol:

NWD1

Name:

NACHT and WD repeat domain containing 1

RGD ID:

12072473

Description:

INVOLVED IN negative regulation of NF-kappaB transcription factor activity (ortholog); ASSOCIATED WITH prostate cancer (ortholog); FOUND IN cytosol (inferred); nucleolus (inferred); INTERACTS WITH bisphenol A

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

NACHT and WD repeat domain-containing protein 1; NACHT domain- and WD repeat-containing protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	45,792,745 - 45,854,889 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	45,794,306 - 45,852,100 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	45,706,235 - 45,772,311 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	46,279,282 - 46,345,502 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	46,279,297 - 46,345,510 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	45,514,886 - 45,581,005 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	45,925,619 - 45,991,612 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	46,201,195 - 46,266,989 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
NWD1	Dog	prostate cancer		ISO	NWD1 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Malignant tumor of prostate	ClinVar	PMID:23265383

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
NWD1	Dog	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of NWD1 mRNA	CTD	PMID:38866337

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
NWD1	Dog	negative regulation of NF-kappaB transcription factor activity	involved_in	ISO	NWD1 (Homo sapiens)	9068941	PMID:24681825	UniProt	PMID:24681825
NWD1	Dog	positive regulation of gene expression	involved_in	IEA	UniProtKB:Q149M9 and ensembl:ENSP00000428579	150520179		Ensembl	GO_REF:0000107

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
NWD1	Dog	cytosol	located_in	IEA	UniProtKB:Q149M9 and ensembl:ENSP00000428579	150520179		Ensembl	GO_REF:0000107
NWD1	Dog	nucleolus	located_in	IEA	UniProtKB:Q149M9 and ensembl:ENSP00000428579	150520179		Ensembl	GO_REF:0000107

PMID:22301074	PMID:30032202

NWD1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	45,792,745 - 45,854,889 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	45,794,306 - 45,852,100 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	45,706,235 - 45,772,311 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	46,279,282 - 46,345,502 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	46,279,297 - 46,345,510 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	45,514,886 - 45,581,005 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	45,925,619 - 45,991,612 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	46,201,195 - 46,266,989 (-)	NCBI		UU_Cfam_GSD_1.0

NWD1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	16,719,847 - 16,817,963 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	16,719,847 - 16,817,963 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	16,830,658 - 16,928,774 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	16,691,787 - 16,789,764 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	19	16,732,646 - 16,830,313 (+)	NCBI		Celera
Cytogenetic Map	19	p13.11	NCBI
HuRef	19	16,399,721 - 16,497,684 (+)	NCBI		HuRef
CHM1_1	19	16,830,805 - 16,928,529 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	16,854,654 - 16,952,783 (+)	NCBI		T2T-CHM13v2.0

Nwd1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	73,372,865 - 73,443,508 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	73,373,339 - 73,444,504 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	72,646,225 - 72,716,880 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	72,646,711 - 72,717,876 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	75,170,610 - 75,238,645 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	75,540,415 - 75,604,144 (+)	NCBI		MGSCv36	mm8
Celera	8	76,962,656 - 77,030,120 (+)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI
cM Map	8	35.08	NCBI

Nwd1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	17,204,731 - 17,278,184 (-)	NCBI		GRCr8
mRatBN7.2	16	17,166,479 - 17,242,055 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	17,170,659 - 17,252,705 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	16	18,875,768 - 18,944,775 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	18,877,257 - 18,937,562 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	18,740,763 - 18,803,402 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	16	17,396,593 - 17,464,531 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

Nwd1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955524	1,084,750 - 1,121,689 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955524	1,083,237 - 1,122,615 (-)	NCBI	ChiLan1.0	ChiLan1.0

NWD1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	21,591,857 - 21,688,508 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	20,598,431 - 20,695,014 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	16,209,324 - 16,305,897 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	17,189,728 - 17,283,045 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	17,202,805 - 17,281,335 (+)	Ensembl	panpan1.1		panPan2

Nwd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	204,330,959 - 204,399,516 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936596	3,884,269 - 3,942,406 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936596	3,882,259 - 3,948,664 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NWD1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	60,800,438 - 60,906,046 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	60,800,064 - 60,906,536 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	60,406,949 - 60,494,692 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NWD1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	15,255,116 - 15,318,589 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	15,221,120 - 15,318,470 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666074	4,119,126 - 4,220,741 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nwd1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624908	799,402 - 828,353 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624908	797,891 - 830,857 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in NWD1
883 total Variants

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10


RefSeq Transcripts	XM_022406916	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022406917	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022406918	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022406919	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022406920	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022406921	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022406922	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038428278	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038428279	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038428280	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038428281	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038454930	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038503919	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038503920	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038503921	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038503922	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038566948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038631100	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000236	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000058	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000291	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000024761 ⟹ ENSCAFP00000022970

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	20	45,794,306 - 45,852,100 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000075227 ⟹ ENSCAFP00000065937

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	20	45,794,306 - 45,850,313 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845052571 ⟹ ENSCAFP00845041256

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	20	46,279,297 - 46,345,510 (-)	Ensembl

RefSeq Acc Id:

XM_038428278 ⟹ XP_038284206

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	20	46,279,282 - 46,345,502 (-)	NCBI

RefSeq Acc Id:

XM_038428279 ⟹ XP_038284207

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	20	46,279,282 - 46,345,502 (-)	NCBI

RefSeq Acc Id:

XM_038428280 ⟹ XP_038284208

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	20	46,279,282 - 46,339,158 (-)	NCBI

RefSeq Acc Id:

XM_038428281 ⟹ XP_038284209

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	20	46,286,272 - 46,345,502 (-)	NCBI

RefSeq Acc Id:

XM_038454930 ⟹ XP_038310858

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	20	45,706,235 - 45,772,311 (-)	NCBI

RefSeq Acc Id:

XM_038503919 ⟹ XP_038359847

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	20	45,514,886 - 45,580,998 (-)	NCBI

RefSeq Acc Id:

XM_038503920 ⟹ XP_038359848

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	20	45,514,886 - 45,580,999 (-)	NCBI

RefSeq Acc Id:

XM_038503921 ⟹ XP_038359849

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	20	45,514,886 - 45,574,358 (-)	NCBI

RefSeq Acc Id:

XM_038503922 ⟹ XP_038359850

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	20	45,521,644 - 45,581,005 (-)	NCBI

RefSeq Acc Id:

XM_038566948 ⟹ XP_038422876

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	20	46,201,195 - 46,266,989 (-)	NCBI

RefSeq Acc Id:

XM_038631100 ⟹ XP_038487028

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	20	45,925,619 - 45,991,612 (-)	NCBI


Protein RefSeqs	XP_038284206	(Get FASTA)	NCBI Sequence Viewer
	XP_038284207	(Get FASTA)	NCBI Sequence Viewer
	XP_038284208	(Get FASTA)	NCBI Sequence Viewer
	XP_038284209	(Get FASTA)	NCBI Sequence Viewer
	XP_038310858	(Get FASTA)	NCBI Sequence Viewer
	XP_038359847	(Get FASTA)	NCBI Sequence Viewer
	XP_038359848	(Get FASTA)	NCBI Sequence Viewer
	XP_038359849	(Get FASTA)	NCBI Sequence Viewer
	XP_038359850	(Get FASTA)	NCBI Sequence Viewer
	XP_038422876	(Get FASTA)	NCBI Sequence Viewer
	XP_038487028	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000022970.4
	ENSCAFP00040026587.1
	ENSCAFP00845041256
	ENSCAFP00845041256.1

Ensembl Acc Id:

ENSCAFP00000022970 ⟸ ENSCAFT00000024761

Ensembl Acc Id:

ENSCAFP00000065937 ⟸ ENSCAFT00000075227

RefSeq Acc Id:	XP_038359848 ⟸ XM_038503920
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038359847 ⟸ XM_038503919
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038359849 ⟸ XM_038503921
- Peptide Label:	isoform X3

Protein Domains

NACHT

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000015626	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00040016568	UniProtKB/TrEMBL
	ENSCAFG00845029689	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000024761.5	UniProtKB/TrEMBL
	ENSCAFT00040030586.1	UniProtKB/TrEMBL
	ENSCAFT00845052571	ENTREZGENE
	ENSCAFT00845052571.1	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
InterPro	NACHT_NTPase	UniProtKB/TrEMBL
	NWD1	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_CS	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
NCBI Gene	NWD1	ENTREZGENE
PANTHER	NACHT DOMAIN- AND WD REPEAT-CONTAINING PROTEIN 1	UniProtKB/TrEMBL
	PTHR45013	UniProtKB/TrEMBL
Pfam	NACHT	UniProtKB/TrEMBL
	WD40	UniProtKB/TrEMBL
PROSITE	WD_REPEATS_1	UniProtKB/TrEMBL
	WD_REPEATS_2	UniProtKB/TrEMBL
	WD_REPEATS_REGION	UniProtKB/TrEMBL
SMART	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50978	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	A0A8C0K8S1	ENTREZGENE
	A0A8C0YZY8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3S797	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0SJY6	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:44069	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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Imported Disease Annotations - ClinVar