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Gene: PCYT2 (phosphate cytidylyltransferase 2, ethanolamine) Pan paniscus

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Symbol:

PCYT2

Name:

phosphate cytidylyltransferase 2, ethanolamine

RGD ID:

12014870

Description:

ENCODES a protein that exhibits ethanolamine-phosphate cytidylyltransferase activity (ortholog); INVOLVED IN biosynthetic process (inferred); lipid metabolic process (inferred); phosphatidylethanolamine biosynthetic process (inferred); PARTICIPATES IN lamivudine pharmacokinetics pathway; ASSOCIATED WITH genetic disease (ortholog); hereditary spastic paraplegia 82 (ortholog); FOUND IN cytoplasm (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

ethanolamine-phosphate cytidylyltransferase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	98,440,330 - 98,447,591 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	103,341,093 - 103,348,358 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	76,309,798 - 76,317,054 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	82,010,262 - 82,018,515 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	82,010,262 - 82,018,515 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PCYT2	Bonobo	genetic disease		ISO	PCYT2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:25741868 more ...
PCYT2	Bonobo	hereditary spastic paraplegia 82		ISO	PCYT2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Spastic paraplegia 82 and autosomal recessive	ClinVar	PMID:25741868 more ...

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PCYT2	Bonobo	hereditary spastic paraplegia 82		ISO	PCYT2 (Homo sapiens)	7240710		OMIM

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PCYT2	Bonobo	biosynthetic process	involved_in	IEA	InterPro:IPR004821	150520179		InterPro	GO_REF:0000002
PCYT2	Bonobo	lipid metabolic process	involved_in	IEA	UniProtKB-KW:KW-0443	150520179		UniProt	GO_REF:0000043
PCYT2	Bonobo	phosphatidylethanolamine biosynthetic process	involved_in	IEA	UniPathway:UPA00558	150520179		UniProt	GO_REF:0000041
PCYT2	Bonobo	phosphatidylethanolamine biosynthetic process	involved_in	IEA	UniProtKB:Q99447 and ensembl:ENSP00000439245	150520179		Ensembl	GO_REF:0000107
PCYT2	Bonobo	phosphatidylethanolamine biosynthetic process	involved_in	IEA	PANTHER:PTN000077609 and PANTHER:PTN002909105	150520179		TreeGrafter	GO_REF:0000118
PCYT2	Bonobo	phosphatidylethanolamine biosynthetic process	involved_in	IEA	InterPro:IPR044608	150520179		InterPro	GO_REF:0000002
PCYT2	Bonobo	phospholipid biosynthetic process	involved_in	IEA	UniProtKB-KW:KW-0594	150520179		UniProt	GO_REF:0000043

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PCYT2	Bonobo	cytoplasm	located_in	IEA	PANTHER:PTN000077609 and PANTHER:PTN002909105	150520179		TreeGrafter	GO_REF:0000118

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PCYT2	Bonobo	catalytic activity	enables	IEA	InterPro:IPR004821	150520179		InterPro	GO_REF:0000002
PCYT2	Bonobo	ethanolamine-phosphate cytidylyltransferase activity		ISO	Pcyt2 (Rattus norvegicus)	9068941		RGD	PMID:10493918 and REF_RGD_ID:633525
PCYT2	Bonobo	ethanolamine-phosphate cytidylyltransferase activity	enables	IEA	PANTHER:PTN000077609 and PANTHER:PTN002909105	150520179		TreeGrafter	GO_REF:0000118
PCYT2	Bonobo	ethanolamine-phosphate cytidylyltransferase activity	enables	IEA	ARBA:ARBA00034148	150520179		UniProt	GO_REF:0000117
PCYT2	Bonobo	ethanolamine-phosphate cytidylyltransferase activity	enables	IEA	InterPro:IPR044608	150520179		InterPro	GO_REF:0000002
PCYT2	Bonobo	ethanolamine-phosphate cytidylyltransferase activity	enables	IEA	EC:2.7.7.14	150520179		UniProt	GO_REF:0000003
PCYT2	Bonobo	ethanolamine-phosphate cytidylyltransferase activity	enables	IEA	UniProtKB:Q99447 and ensembl:ENSP00000439245	150520179		Ensembl	GO_REF:0000107
PCYT2	Bonobo	nucleotidyltransferase activity	enables	IEA	UniProtKB-KW:KW-0548	150520179		UniProt	GO_REF:0000043
PCYT2	Bonobo	protein binding	enables	ISO	UniProtKB:O15357	9068941	PMID:28514442 and PMID:33961781	IntAct	PMID:28514442 and PMID:33961781
PCYT2	Bonobo	protein binding	enables	ISO	UniProtKB:P25786 more ...	9068941	PMID:32296183	IntAct	PMID:32296183
PCYT2	Bonobo	protein binding	enables	ISO	UniProtKB:O75400-2 more ...	9068941	PMID:32814053	IntAct	PMID:32814053

Imported Annotations - SMPDB

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PCYT2	Bonobo	lamivudine pharmacokinetics pathway		ISO	PCYT2 (Homo sapiens)	9068941		SMPDB	SMP:00649

PMID:30032202

PCYT2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	98,440,330 - 98,447,591 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	103,341,093 - 103,348,358 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	76,309,798 - 76,317,054 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	82,010,262 - 82,018,515 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	82,010,262 - 82,018,515 (-)	Ensembl	panpan1.1		panPan2

PCYT2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	81,900,958 - 81,911,399 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	81,900,958 - 81,911,432 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	79,858,834 - 79,869,275 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	77,455,384 - 77,462,586 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	17	76,464,784 - 76,473,410 (-)	NCBI		Celera
Cytogenetic Map	17	q25.3	NCBI
HuRef	17	75,262,457 - 75,287,046 (-)	NCBI		HuRef
CHM1_1	17	79,946,981 - 79,955,542 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	82,768,118 - 82,778,559 (-)	NCBI		T2T-CHM13v2.0

Pcyt2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	120,500,888 - 120,508,784 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	120,500,913 - 120,508,762 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	120,610,062 - 120,617,947 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	120,610,087 - 120,617,936 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	120,471,401 - 120,479,204 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	120,426,177 - 120,433,980 (-)	NCBI		MGSCv36	mm8
Celera	11	132,345,379 - 132,353,183 (-)	NCBI		Celera
Cytogenetic Map	11	E2	NCBI
cM Map	11	84.33	NCBI

Pcyt2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	106,387,150 - 106,394,500 (-)	NCBI		GRCr8
mRatBN7.2	10	105,888,769 - 105,896,182 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	105,888,775 - 105,896,172 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	110,992,673 - 110,999,983 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	110,455,701 - 110,463,011 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	105,809,284 - 105,816,596 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	109,788,348 - 109,795,743 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	109,788,350 - 109,795,697 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	109,381,397 - 109,388,794 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	110,002,023 - 110,009,335 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	110,016,526 - 110,023,839 (-)	NCBI
Celera	10	104,432,228 - 104,439,540 (-)	NCBI		Celera
Cytogenetic Map	10	q32.3	NCBI

Pcyt2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955506	1,256,770 - 1,266,762 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955506	1,258,993 - 1,266,108 (+)	NCBI	ChiLan1.0	ChiLan1.0

PCYT2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	383,714 - 390,164 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	376,445 - 442,919 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	985,814 - 992,258 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	977,032 - 983,475 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	977,078 - 983,469 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	1,002,181 - 1,008,623 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	1,128,807 - 1,135,219 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	1,207,457 - 1,213,883 (+)	NCBI		UU_Cfam_GSD_1.0

Pcyt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	994,046 - 1,001,014 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936594	5,410,948 - 5,417,988 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936594	5,410,975 - 5,417,958 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PCYT2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	1,084,410 - 1,091,029 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	1,084,416 - 1,091,031 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

PCYT2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	73,777,641 - 73,784,800 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	73,776,092 - 73,784,724 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	45,226,524 - 45,236,947 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pcyt2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624801	10,746,373 - 10,753,289 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624801	10,746,551 - 10,753,221 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_003831102	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034943132	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034943133	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034943134	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034943135	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034943136	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034943137	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055101166	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000041145 ⟹ ENSPPAP00000018413

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	17	82,010,262 - 82,018,515 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000041153 ⟹ ENSPPAP00000018421

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	17	82,010,263 - 82,018,509 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000041159 ⟹ ENSPPAP00000018427

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	17	82,012,193 - 82,017,026 (-)	Ensembl

RefSeq Acc Id:

XM_034943133 ⟹ XP_034799024

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	98,440,330 - 98,447,591 (-)	NCBI
NHGRI_mPanPan1	17	103,341,093 - 103,348,358 (-)	NCBI
Mhudiblu_PPA_v0	17	76,309,798 - 76,317,054 (-)	NCBI

RefSeq Acc Id:

XM_055101166 ⟹ XP_054957141

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	98,440,330 - 98,447,551 (-)	NCBI
NHGRI_mPanPan1	17	103,341,093 - 103,348,329 (-)	NCBI


Protein RefSeqs	XP_034799024	(Get FASTA)	NCBI Sequence Viewer
	XP_054957141	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000018413.1
	ENSPPAP00000018421.1
	ENSPPAP00000018427.1

RefSeq Acc Id:	XP_034799024 ⟸ XM_034943133
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9AM36 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSPPAP00000018413 ⟸ ENSPPAT00000041145

Ensembl Acc Id:

ENSPPAP00000018427 ⟸ ENSPPAT00000041159

Ensembl Acc Id:

ENSPPAP00000018421 ⟸ ENSPPAT00000041153

RefSeq Acc Id:	XP_054957141 ⟸ XM_055101166
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9AM36 (UniProtKB/TrEMBL)

Protein Domains

Cytidyltransferase-like

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000032334	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000041145.1	UniProtKB/TrEMBL
	ENSPPAT00000041153.1	UniProtKB/TrEMBL
	ENSPPAT00000041159.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.620	UniProtKB/TrEMBL
InterPro	CCT	UniProtKB/TrEMBL
	Cyt_trans-like	UniProtKB/TrEMBL
	Ect1/PCYT2	UniProtKB/TrEMBL
	Rossmann-like_a/b/a_fold	UniProtKB/TrEMBL
NCBI Gene	PCYT2	ENTREZGENE
PANTHER	ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE	UniProtKB/TrEMBL
	PTHR45780	UniProtKB/TrEMBL
Pfam	CTP_transf_like	UniProtKB/TrEMBL
Superfamily-SCOP	Nucleotidylyl transferase	UniProtKB/TrEMBL
UniProt	A0A2R9AM36	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9AM45_PANPA	UniProtKB/TrEMBL
	A0A2R9AMP0_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB