CYP7B1 (cytochrome P450 family 7 subfamily B member 1) - Rat Genome Database

Send us a Message



Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Grant Resources Citing RGD About Us Contact Us
Search by Genomic Position Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quantitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: CYP7B1 (cytochrome P450 family 7 subfamily B member 1) Pan paniscus
Analyze
Symbol: CYP7B1
Name: cytochrome P450 family 7 subfamily B member 1
RGD ID: 11998789
Description: ENCODES a protein that exhibits 24S-hydroxycholesterol 7-alpha-hydroxylase activity (ortholog); INVOLVED IN circadian rhythm (ortholog); memory (ortholog); negative regulation of intracellular estrogen receptor signaling pathway (ortholog); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; ASSOCIATED WITH adenocarcinoma (ortholog); cholestasis (ortholog); congenital bile acid synthesis defect 3 (ortholog); FOUND IN endoplasmic reticulum membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 25-hydroxycholesterol 7-alpha-hydroxylase; cytochrome P450 7B1; LOC100995737
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2780,323,834 - 80,531,320 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1855,962,915 - 56,170,378 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0861,135,307 - 61,335,838 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1862,806,129 - 63,006,450 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl862,806,637 - 63,006,386 (-)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CYP7B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2780,323,834 - 80,531,320 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1855,962,915 - 56,170,378 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0861,135,307 - 61,335,838 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1862,806,129 - 63,006,450 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl862,806,637 - 63,006,386 (-)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
CYP7B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38864,586,575 - 64,798,737 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl864,586,581 - 64,799,145 (-)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh37865,499,132 - 65,711,294 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36865,671,246 - 65,873,902 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34865,671,245 - 65,873,902NCBI
Celera861,498,536 - 61,701,760 (-)NCBICelera
Cytogenetic Map8q12.3NCBI
HuRef860,998,772 - 61,201,422 (-)NCBIHuRef
CHM1_1865,562,219 - 65,765,057 (-)NCBICHM1_1
T2T-CHM13v2.0865,011,997 - 65,224,254 (-)NCBIT2T-CHM13v2.0
Cyp7b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39318,126,108 - 18,298,054 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl318,117,411 - 18,297,740 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38318,071,944 - 18,243,890 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl318,071,950 - 18,243,338 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv37317,971,950 - 18,143,338 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36318,264,101 - 18,435,480 (-)NCBIMGSCv36mm8
Celera318,067,760 - 18,239,527 (-)NCBICelera
Cytogenetic Map3A1NCBI
cM Map34.98NCBI
Cyp7b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82102,419,011 - 102,586,047 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2102,419,011 - 102,451,804 (-)EnsemblGRCr8
mRatBN7.22100,502,791 - 100,669,713 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2100,502,791 - 100,669,698 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2107,017,449 - 107,190,606 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02105,138,553 - 105,311,712 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02100,132,313 - 100,164,609 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd2101,816,098 - 101,989,248 (-)NCBI
Lyon_Normotensive2101,879,014 - 102,052,168 (-)NCBI
Lyon_Hypertensive2101,736,257 - 101,909,415 (-)NCBI
F344_StmMcwi2101,541,472 - 101,714,630 (-)NCBI
Rnor_6.02102,701,903 - 102,871,257 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2102,701,903 - 102,871,257 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.02122,442,002 - 122,610,354 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42103,102,679 - 103,271,273 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera295,908,860 - 96,075,269 (-)NCBICelera
RGSC_v3.12103,048,320 - 103,073,714 (-)NCBI
RH 3.4 Map2606.1RGD
Cytogenetic Map2q24NCBI
LOC102022645
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544414,275,345 - 14,444,426 (+)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_00495544414,274,818 - 14,446,068 (+)NCBIChiLan1.0ChiLan1.0
CYP7B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12914,443,036 - 14,613,839 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2914,444,853 - 14,613,755 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2914,762,658 - 14,936,799 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02914,537,942 - 14,712,338 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2914,537,947 - 14,712,865 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12914,550,483 - 14,724,576 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02914,664,658 - 14,838,558 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02914,932,049 - 15,106,453 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cyp7b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap1765,901,625 - 66,080,159 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_02440530365,707,508 - 65,885,081 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364968,899,965 - 9,072,089 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364968,900,320 - 9,072,109 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP7B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl469,616,049 - 69,806,496 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1469,615,953 - 69,793,131 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2475,915,950 - 75,973,962 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYP7B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap1868,796,357 - 69,001,805 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366603981,044,277 - 81,069,295 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.1860,496,607 - 60,691,457 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl860,496,733 - 60,524,238 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
LOC101721563
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474426,791,829 - 26,999,584 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_00462474426,792,890 - 26,991,425 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl218,411,661 - 8,599,797 (-)Ensembl
LOC116895947
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13135,891,008 - 135,999,449 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000054356   ⟹   ENSPPAP00000031491
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl862,806,637 - 63,006,386 (-)Ensembl
RefSeq Acc Id: XM_003831378   ⟹   XP_003831426
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2780,323,834 - 80,531,317 (-)NCBI
NHGRI_mPanPan1855,962,915 - 56,168,704 (-)NCBI
Mhudiblu_PPA_v0861,135,307 - 61,335,758 (-)NCBI
PanPan1.1862,806,129 - 63,006,450 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034966160   ⟹   XP_034822051
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2780,329,947 - 80,531,320 (-)NCBI
NHGRI_mPanPan1855,975,532 - 56,170,378 (-)NCBI
Mhudiblu_PPA_v0861,142,682 - 61,335,838 (-)NCBI
RefSeq Acc Id: XM_055116599   ⟹   XP_054972574
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2780,323,834 - 80,531,316 (-)NCBI
NHGRI_mPanPan1855,962,915 - 56,168,700 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003831426 (Get FASTA)   NCBI Sequence Viewer  
  XP_034822051 (Get FASTA)   NCBI Sequence Viewer  
  XP_054972574 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000031491.1
  ENSPPAP00050018315
  ENSPPAP00050018321
RefSeq Acc Id: XP_003831426   ⟸   XM_003831378
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BP93 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034822051   ⟸   XM_034966160
- Peptide Label: isoform X3
- UniProtKB: A0A2R9BP93 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000031491   ⟸   ENSPPAT00000054356
RefSeq Acc Id: XP_054972574   ⟸   XM_055116599
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BP93 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000038686 Ensembl, UniProtKB/TrEMBL
  ENSPPAG00050013816 ENTREZGENE
Ensembl Transcript ENSPPAT00000054356.1 UniProtKB/TrEMBL
  ENSPPAT00050029064 ENTREZGENE
  ENSPPAT00050029078 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro CYP450_sterol_14alpha_dmase UniProtKB/TrEMBL
  Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CYP7A1-type UniProtKB/TrEMBL
  Cyt_P450_E_grp-IV UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
NCBI Gene LOC100995737 ENTREZGENE
PANTHER CYTOCHROME P450 7B1 UniProtKB/TrEMBL
  CYTOCHROME P450 FAMILY 7 UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PIRSF Cytochrome_CYPVIIA1 UniProtKB/TrEMBL
PRINTS EP450IV UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/TrEMBL
UniProt A0A2R9BP93 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:83064 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-02-25 CYP7B1  cytochrome P450 family 7 subfamily B member 1  LOC100995737  25-hydroxycholesterol 7-alpha-hydroxylase  Symbol and/or name change 5135510 APPROVED