NGLY1 (N-glycanase 1) - Rat Genome Database

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Gene: NGLY1 (N-glycanase 1) Pan paniscus
Analyze
Symbol: NGLY1
Name: N-glycanase 1
RGD ID: 11920125
Description: ENCODES a protein that exhibits hydrolase activity (inferred); peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity (inferred); INVOLVED IN glycoprotein catabolic process (inferred); ASSOCIATED WITH congenital disorder of deglycosylation (ortholog); congenital disorder of deglycosylation 1 (ortholog); Developmental Disabilities (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2225,678,406 - 25,742,623 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1325,683,169 - 25,747,391 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0325,618,768 - 25,683,293 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1325,950,189 - 26,014,998 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl325,950,701 - 26,021,504 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
membrane  (IEA)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NGLY1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2225,678,406 - 25,742,623 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1325,683,169 - 25,747,391 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0325,618,768 - 25,683,293 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1325,950,189 - 26,014,998 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl325,950,701 - 26,021,504 (-)Ensemblpanpan1.1panPan2
NGLY1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38325,718,944 - 25,790,039 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl325,718,944 - 25,790,039 (-)EnsemblGRCh38hg38GRCh38
GRCh37325,760,435 - 25,831,530 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36325,735,779 - 25,799,926 (-)NCBINCBI36Build 36hg18NCBI36
Build 34325,735,778 - 25,799,926NCBI
Celera325,697,316 - 25,768,403 (-)NCBICelera
Cytogenetic Map3p24.2NCBI
HuRef325,705,518 - 25,776,520 (-)NCBIHuRef
CHM1_1325,710,469 - 25,781,508 (-)NCBICHM1_1
T2T-CHM13v2.0325,721,799 - 25,792,805 (-)NCBIT2T-CHM13v2.0
Ngly1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39146,157,837 - 6,220,449 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl146,157,837 - 6,220,483 (-)EnsemblGRCm39 Ensembl
GRCm381416,249,314 - 16,311,926 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1416,249,280 - 16,311,926 (+)EnsemblGRCm38mm10GRCm38
MGSCv371417,081,828 - 17,144,440 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361415,042,581 - 15,105,193 (+)NCBIMGSCv36mm8
Celera1411,944,272 - 12,005,168 (+)NCBICelera
Cytogenetic Map14A1NCBI
cM Map147.08NCBI
Ngly1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81511,584,475 - 11,640,977 (-)NCBIGRCr8
mRatBN7.2159,153,738 - 9,210,228 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl159,153,738 - 9,204,630 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1511,296,510 - 11,347,084 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01512,209,299 - 12,259,873 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01510,509,774 - 10,560,348 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01510,405,453 - 10,455,973 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1510,405,164 - 10,455,956 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01514,450,836 - 14,501,356 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41510,704,196 - 10,750,564 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11510,715,806 - 10,723,084 (-)NCBI
Celera159,192,318 - 9,243,191 (-)NCBICelera
Cytogenetic Map15p16NCBI
Ngly1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543017,564,319 - 17,645,564 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543017,564,319 - 17,645,564 (-)NCBIChiLan1.0ChiLan1.0
NGLY1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12318,044,479 - 18,101,937 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2318,039,456 - 18,099,660 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2318,042,146 - 18,099,607 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02318,347,625 - 18,405,157 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2318,342,554 - 18,405,154 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12318,166,197 - 18,223,888 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02318,269,312 - 18,326,783 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02318,383,003 - 18,440,512 (+)NCBIUU_Cfam_GSD_1.0
Ngly1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118184,105,190 - 184,155,991 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647317,239,966 - 17,294,791 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647317,243,763 - 17,294,609 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NGLY1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1312,616,567 - 12,685,823 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11312,616,564 - 12,683,637 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21314,229,512 - 14,291,711 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NGLY1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11570,381,992 - 70,449,373 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1570,382,004 - 70,449,341 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604143,521,267 - 43,588,968 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ngly1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247883,626,893 - 3,707,680 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247883,631,142 - 3,707,725 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000065724   ⟹   ENSPPAP00000042792
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl325,950,701 - 26,021,504 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000065725   ⟹   ENSPPAP00000042793
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl325,950,701 - 26,015,030 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000065726   ⟹   ENSPPAP00000042794
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl325,950,701 - 26,015,030 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000065727   ⟹   ENSPPAP00000042795
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl325,950,811 - 26,015,030 (-)Ensembl
RefSeq Acc Id: XM_008951630   ⟹   XP_008949878
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2225,678,406 - 25,742,608 (-)NCBI
NHGRI_mPanPan1325,683,169 - 25,747,361 (-)NCBI
Mhudiblu_PPA_v0325,619,071 - 25,683,255 (-)NCBI
PanPan1.1325,950,189 - 26,014,998 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024928238   ⟹   XP_024784006
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2225,678,406 - 25,742,623 (-)NCBI
NHGRI_mPanPan1325,683,169 - 25,747,391 (-)NCBI
Mhudiblu_PPA_v0325,618,768 - 25,683,293 (-)NCBI
PanPan1.1325,950,189 - 26,014,998 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034955991   ⟹   XP_034811882
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2225,678,406 - 25,742,608 (-)NCBI
NHGRI_mPanPan1325,683,169 - 25,747,376 (-)NCBI
Mhudiblu_PPA_v0325,619,071 - 25,683,256 (-)NCBI
RefSeq Acc Id: XM_034955992   ⟹   XP_034811883
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2225,678,701 - 25,742,608 (-)NCBI
NHGRI_mPanPan1325,683,468 - 25,747,376 (-)NCBI
Mhudiblu_PPA_v0325,619,390 - 25,683,293 (-)NCBI
RefSeq Acc Id: XM_055109572   ⟹   XP_054965547
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2225,679,180 - 25,742,593 (-)NCBI
NHGRI_mPanPan1325,684,097 - 25,747,361 (-)NCBI
RefSeq Acc Id: XP_008949878   ⟸   XM_008951630
- Peptide Label: isoform X2
- UniProtKB: A0A2R9CNJ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024784006   ⟸   XM_024928238
- Peptide Label: isoform X1
- UniProtKB: A0A2R9CNJ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034811882   ⟸   XM_034955991
- Peptide Label: isoform X4
- UniProtKB: A0A2R9CLE7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034811883   ⟸   XM_034955992
- Peptide Label: isoform X5
- UniProtKB: A0A2R9CLC9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000042795   ⟸   ENSPPAT00000065727
Ensembl Acc Id: ENSPPAP00000042794   ⟸   ENSPPAT00000065726
Ensembl Acc Id: ENSPPAP00000042793   ⟸   ENSPPAT00000065725
Ensembl Acc Id: ENSPPAP00000042792   ⟸   ENSPPAT00000065724
RefSeq Acc Id: XP_054965547   ⟸   XM_055109572
- Peptide Label: isoform X3
- UniProtKB: A0A2R9CLC9 (UniProtKB/TrEMBL)
Protein Domains
PAW


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000043951 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000065724.1 UniProtKB/TrEMBL
  ENSPPAT00000065725.1 UniProtKB/TrEMBL
  ENSPPAT00000065726.1 UniProtKB/TrEMBL
  ENSPPAT00000065727.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.2190 UniProtKB/TrEMBL
  2.20.25.10 UniProtKB/TrEMBL
  2.60.120.1020 UniProtKB/TrEMBL
  3.10.620.30 UniProtKB/TrEMBL
InterPro Galactose-bd-like_sf UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/TrEMBL
  PAW_sf UniProtKB/TrEMBL
  Peptide_N_glycanase_PAW_dom UniProtKB/TrEMBL
  PNGase UniProtKB/TrEMBL
  PUB-like_dom_sf UniProtKB/TrEMBL
  PUB_domain UniProtKB/TrEMBL
  Transglutaminase-like UniProtKB/TrEMBL
NCBI Gene NGLY1 ENTREZGENE
PANTHER PEPTIDE N-GLYCANASE PNGASE -RELATED UniProtKB/TrEMBL
  PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE UniProtKB/TrEMBL
Pfam PAW UniProtKB/TrEMBL
  PUB UniProtKB/TrEMBL
  Transglut_core UniProtKB/TrEMBL
PROSITE PAW UniProtKB/TrEMBL
SMART PAW UniProtKB/TrEMBL
  PUG UniProtKB/TrEMBL
  TGc UniProtKB/TrEMBL
Superfamily-SCOP SSF143503 UniProtKB/TrEMBL
  SSF49785 UniProtKB/TrEMBL
  SSF54001 UniProtKB/TrEMBL
UniProt A0A2R9CLC9 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CLE7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CNJ2 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CT33_PANPA UniProtKB/TrEMBL