CASC3 (CASC3 exon junction complex subunit) - Rat Genome Database

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Gene: CASC3 (CASC3 exon junction complex subunit) Pan paniscus
Analyze
Symbol: CASC3
Name: CASC3 exon junction complex subunit
RGD ID: 11915009
Description: ENCODES a protein that exhibits enzyme binding (inferred); identical protein binding (inferred); mRNA binding (inferred); INVOLVED IN intracellular mRNA localization (ortholog); ASSOCIATED WITH hypertrophic cardiomyopathy 25 (ortholog); FOUND IN cell projection (inferred); cytoplasm (inferred); cytoplasmic stress granule (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cancer susceptibility 3; cancer susceptibility candidate 3; CASC3, exon junction complex subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21924,778,328 - 24,815,889 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11726,673,341 - 26,709,474 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01717,116,864 - 17,148,752 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11717,339,060 - 17,370,076 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1717,339,060 - 17,370,076 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CASC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21924,778,328 - 24,815,889 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11726,673,341 - 26,709,474 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01717,116,864 - 17,148,752 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11717,339,060 - 17,370,076 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1717,339,060 - 17,370,076 (-)Ensemblpanpan1.1panPan2
CASC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381740,140,537 - 40,172,171 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1740,140,318 - 40,172,183 (+)EnsemblGRCh38hg38GRCh38
GRCh371738,296,790 - 38,328,424 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,550,033 - 35,581,957 (+)NCBINCBI36Build 36hg18NCBI36
Build 341735,550,101 - 35,581,950NCBI
Celera1734,957,057 - 34,988,947 (+)NCBICelera
Cytogenetic Map17q21.1NCBI
HuRef1734,089,810 - 34,121,621 (+)NCBIHuRef
CHM1_11738,532,213 - 38,564,116 (+)NCBICHM1_1
T2T-CHM13v2.01741,004,421 - 41,036,050 (+)NCBIT2T-CHM13v2.0
Casc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,700,634 - 98,724,633 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,695,731 - 98,724,640 (+)EnsemblGRCm39 Ensembl
GRCm381198,809,808 - 98,833,807 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,804,905 - 98,833,814 (+)EnsemblGRCm38mm10GRCm38
MGSCv371198,671,122 - 98,695,121 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361198,620,995 - 98,649,897 (+)NCBIMGSCv36mm8
Celera11108,464,578 - 108,488,942 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.68NCBI
Casc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81084,264,157 - 84,286,639 (+)NCBIGRCr8
mRatBN7.21083,769,014 - 83,788,966 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,769,001 - 83,788,966 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1088,712,889 - 88,732,839 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01088,210,964 - 88,230,913 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01083,603,666 - 83,623,621 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,724,534 - 86,744,485 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,724,427 - 86,745,927 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,520,779 - 86,540,730 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,581,850 - 87,602,528 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11087,596,219 - 87,616,898 (+)NCBI
Celera1082,516,863 - 82,536,588 (+)NCBICelera
Cytogenetic Map10q31NCBI
Casc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,784,915 - 14,806,773 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,784,915 - 14,804,191 (+)NCBIChiLan1.0ChiLan1.0
CASC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,403,139 - 22,427,475 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,405,336 - 22,427,426 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha921,875,423 - 21,899,758 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,195,932 - 23,220,306 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,195,933 - 23,220,256 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1921,969,725 - 21,994,054 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,228,453 - 22,252,787 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,353,409 - 22,377,760 (-)NCBIUU_Cfam_GSD_1.0
Casc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560221,796,874 - 21,823,263 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649015,251,110 - 15,278,732 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649015,251,132 - 15,278,264 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,199,228 - 22,221,596 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,199,227 - 22,221,573 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21222,565,028 - 22,574,442 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CASC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,001,923 - 66,037,025 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1666,000,434 - 66,037,093 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607736,906,206 - 36,939,903 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Casc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247953,046,880 - 3,068,840 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247953,048,800 - 3,068,432 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000046654   ⟹   ENSPPAP00000023829
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1717,339,060 - 17,370,076 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000046658   ⟹   ENSPPAP00000023833
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1717,341,592 - 17,369,856 (-)Ensembl
RefSeq Acc Id: XM_003831424   ⟹   XP_003831472
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21924,782,687 - 24,815,884 (-)NCBI
NHGRI_mPanPan11726,677,499 - 26,709,474 (-)NCBI
Mhudiblu_PPA_v01717,116,864 - 17,148,737 (-)NCBI
PanPan1.11717,339,060 - 17,370,076 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008956770   ⟹   XP_008955018
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21924,782,687 - 24,815,884 (-)NCBI
NHGRI_mPanPan11726,677,499 - 26,709,474 (-)NCBI
Mhudiblu_PPA_v01717,116,864 - 17,148,752 (-)NCBI
PanPan1.11717,340,349 - 17,370,076 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008956771   ⟹   XP_008955019
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21924,782,687 - 24,815,888 (-)NCBI
NHGRI_mPanPan11726,677,499 - 26,709,449 (-)NCBI
Mhudiblu_PPA_v01717,116,864 - 17,148,728 (-)NCBI
PanPan1.11717,339,060 - 17,370,076 (-)NCBI
Sequence:
RefSeq Acc Id: XM_055101065   ⟹   XP_054957040
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21924,778,328 - 24,815,885 (-)NCBI
NHGRI_mPanPan11726,673,341 - 26,709,474 (-)NCBI
RefSeq Acc Id: XM_055101066   ⟹   XP_054957041
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21924,782,687 - 24,815,889 (-)NCBI
NHGRI_mPanPan11726,677,499 - 26,709,449 (-)NCBI
RefSeq Acc Id: XP_008955019   ⟸   XM_008956771
- Peptide Label: isoform X2
- UniProtKB: A0A2R9B9B7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003831472   ⟸   XM_003831424
- Peptide Label: isoform X1
- UniProtKB: A0A2R9B9B7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008955018   ⟸   XM_008956770
- Peptide Label: isoform X1
- UniProtKB: A0A2R9B9B7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000023833   ⟸   ENSPPAT00000046658
Ensembl Acc Id: ENSPPAP00000023829   ⟸   ENSPPAT00000046654
RefSeq Acc Id: XP_054957040   ⟸   XM_055101065
- Peptide Label: isoform X1
- UniProtKB: A0A2R9B9B7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054957041   ⟸   XM_055101066
- Peptide Label: isoform X2
- UniProtKB: A0A2R9B9B7 (UniProtKB/TrEMBL)
Protein Domains
Btz


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000035069 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000046654.1 UniProtKB/TrEMBL
  ENSPPAT00000046658.1 UniProtKB/TrEMBL
InterPro Btz_dom UniProtKB/TrEMBL
KEGG Report pps:100968931 UniProtKB/TrEMBL
NCBI Gene CASC3 ENTREZGENE
PANTHER PROTEIN CASC3 UniProtKB/TrEMBL
  PTHR13434 UniProtKB/TrEMBL
Pfam Btz UniProtKB/TrEMBL
SMART Btz UniProtKB/TrEMBL
UniProt A0A2R9B2Q4_PANPA UniProtKB/TrEMBL
  A0A2R9B9B7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-22 CASC3  CASC3 exon junction complex subunit    CASC3, exon junction complex subunit  Symbol and/or name change 5135510 APPROVED
2018-05-08 CASC3  CASC3, exon junction complex subunit    cancer susceptibility 3  Symbol and/or name change 5135510 APPROVED
2017-02-01 CASC3  cancer susceptibility 3    cancer susceptibility candidate 3  Symbol and/or name change 5135510 APPROVED