BMP1 (bone morphogenetic protein 1) - Rat Genome Database

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Gene: BMP1 (bone morphogenetic protein 1) Pan paniscus
Analyze
Symbol: BMP1
Name: bone morphogenetic protein 1
RGD ID: 11905341
Description: ENCODES a protein that exhibits calcium ion binding (inferred); hydrolase activity (inferred); identical protein binding (inferred); INVOLVED IN dorsal/ventral pattern formation (inferred); positive regulation of cartilage development (inferred); protein processing (inferred); ASSOCIATED WITH Acute Otitis Media (ortholog); Conotruncal Cardiac Defects (ortholog); genetic disease (ortholog); FOUND IN extracellular space (ortholog); vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2740,666,831 - 40,714,042 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1816,392,228 - 16,439,248 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0821,410,139 - 21,457,144 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1818,349,836 - 18,396,796 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl818,349,836 - 18,396,796 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
BMP1BonoboAcute Otitis Media  ISOBmp1 (Mus musculus)9068941mRNA:increased expression:middle ear (mouse)RGDPMID:21889218 and REF_RGD_ID:127284853
1 to 11 of 11 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
BMP1BonoboConotruncal Cardiac Defects  ISOBMP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Conotruncal heart malformationsClinVarPMID:28492532
BMP1Bonobogenetic disease  ISOBMP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
BMP1Bonoboidiopathic pulmonary fibrosis  ISOBMP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Fibrocystic pulmonary dysplasiaClinVarPMID:24033266 more ...
BMP1Bonobointerstitial lung disease 2  ISOBMP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Interstitial lung disease 2ClinVarPMID:24033266 more ...
BMP1Bonoboosteogenesis imperfecta  ISOBMP1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:22482805 more ...
BMP1Bonoboosteogenesis imperfecta  ISOBMP1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:22482805 more ...
BMP1Bonoboosteogenesis imperfecta  ISOBMP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Osteogenesis Imperfecta and RecessiveClinVarPMID:24033266 and PMID:25741868
BMP1Bonoboosteogenesis imperfecta type 13  ISOBMP1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15542026 more ...
BMP1Bonoboosteogenesis imperfecta type 3  ISOBMP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Osteogenesis imperfecta type IIIClinVarPMID:25741868
BMP1BonoboPulmonary Surfactant Metabolism Dysfunction 2  ISOBMP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Surfactant metabolism dysfunction more ...ClinVarPMID:24033266 more ...
BMP1BonoboSurfactant Dysfunction  ISOBMP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Pulmonary surfactant metabolism dysfunctionClinVarPMID:24033266 more ...
1 to 11 of 11 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
BMP1Bonoboosteogenesis imperfecta type 13  ISOBMP1 (Homo sapiens)7240710 OMIM 


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
BMP1Bonobodorsal/ventral pattern formation involved_inIEAPANTHER:PTN000013612 more ...150520179 TreeGrafterGO_REF:0000118
BMP1Bonobopositive regulation of cartilage development acts_upstream_of_or_withinIEAUniProtKB:P13497 and ensembl:ENSP00000305714150520179 EnsemblGO_REF:0000107
BMP1Bonoboprotein processing involved_inIEAPANTHER:PTN000013612 more ...150520179 TreeGrafterGO_REF:0000118
BMP1Bonoboproteolysis involved_inIEAUniProtKB:P13497 and ensembl:ENSP00000305714150520179 EnsemblGO_REF:0000107
BMP1Bonoboproteolysis involved_inIEAInterPro:IPR001506 and InterPro:IPR006026150520179 InterProGO_REF:0000002
BMP1Bonoboproteolysis involved_inIEAUniProtKB-KW:KW-0645150520179 UniProtGO_REF:0000043

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
BMP1Bonoboextracellular space  ISOBmp1 (Rattus norvegicus)9068941matrix vesicles - cell derived and extracellular vesicles that are initiation sites of mineralizationRGDPMID:18758911 and REF_RGD_ID:2301841
BMP1Bonoboextracellular space located_inIEAPANTHER:PTN000013612 more ...150520179 TreeGrafterGO_REF:0000118
BMP1Bonobovesicle  ISOBmp1 (Rattus norvegicus)9068941matrix vesicles - cell derived and extracellular vesicles that are initiation sites of mineralizationRGDPMID:18758911 and REF_RGD_ID:2301841

Molecular Function
1 to 20 of 23 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
BMP1Bonobocalcium ion binding enablesIEAInterPro:IPR001881 and InterPro:IPR018097150520179 InterProGO_REF:0000002
BMP1Bonobohydrolase activity enablesIEAUniProtKB-KW:KW-0378150520179 UniProtGO_REF:0000043
BMP1Bonoboidentical protein binding enablesIEAUniProtKB:P13497 and ensembl:ENSP00000305714150520179 EnsemblGO_REF:0000107
BMP1Bonobometal ion binding enablesIEAUniProtKB-KW:KW-0479150520179 UniProtGO_REF:0000043
BMP1Bonobometalloendopeptidase activity enablesIEAUniRule:UR000120488 and UniRule:UR000919020150520179 UniProtGO_REF:0000104
BMP1Bonobometalloendopeptidase activity enablesIEAPANTHER:PTN000013612 more ...150520179 TreeGrafterGO_REF:0000118
BMP1Bonobometalloendopeptidase activity enablesIEAInterPro:IPR001506 and InterPro:IPR015446150520179 InterProGO_REF:0000002
BMP1Bonobometalloendopeptidase activity enablesIEAUniProtKB:P98063 and ensembl:ENSMUSP00000022693150520179 EnsemblGO_REF:0000107
BMP1Bonobometallopeptidase activity enablesIEAUniProtKB-KW:KW-0482150520179 UniProtGO_REF:0000043
BMP1Bonobometallopeptidase activity enablesIEAInterPro:IPR006026 and InterPro:IPR024079150520179 InterProGO_REF:0000002
BMP1Bonobopeptidase activity enablesIEAUniProtKB:P13497 and ensembl:ENSP00000305714150520179 EnsemblGO_REF:0000107
BMP1Bonobopeptidase activity enablesIEAUniProtKB-KW:KW-0645150520179 UniProtGO_REF:0000043
BMP1Bonoboprotein binding enablesISOUniProtKB:O147939068941 PMID:23829672 more ...IntActPMID:23829672 more ...
BMP1Bonoboprotein binding enablesISOPR:P972999068941 PMID:19079247MGIPMID:19079247
BMP1Bonoboprotein binding enablesISOUniProtKB:P20908 and UniProtKB:Q151139068941 PMID:20979576IntActPMID:20979576
BMP1Bonoboprotein binding enablesISOUniProtKB:Q151139068941 PMID:20207734IntActPMID:20207734
BMP1Bonoboprotein binding enablesISOUniProtKB:P972999068941 PMID:21078975IntActPMID:21078975
BMP1Bonoboprotein binding enablesISOUniProtKB:Q9H2X09068941 PMID:19429706 and PMID:20043912IntActPMID:19429706 and PMID:20043912
BMP1Bonoboprotein binding enablesISOUniProtKB:P075859068941 PMID:20026052IntActPMID:20026052
BMP1Bonoboserine-type endopeptidase activity enablesIEAPANTHER:PTN008611213150520179 TreeGrafterGO_REF:0000118
1 to 20 of 23 rows

PMID:22301074   PMID:30032202  



BMP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2740,666,831 - 40,714,042 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1816,392,228 - 16,439,248 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0821,410,139 - 21,457,144 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1818,349,836 - 18,396,796 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl818,349,836 - 18,396,796 (+)Ensemblpanpan1.1panPan2
BMP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38822,165,372 - 22,212,326 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl822,165,140 - 22,212,326 (+)EnsemblGRCh38hg38GRCh38
GRCh37822,022,885 - 22,069,839 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36822,078,835 - 22,125,782 (+)NCBINCBI36Build 36hg18NCBI36
Celera820,984,783 - 21,032,542 (+)NCBICelera
Cytogenetic Map8p21.3NCBI
HuRef820,564,967 - 20,612,031 (+)NCBIHuRef
CHM1_1822,224,312 - 22,271,500 (+)NCBICHM1_1
T2T-CHM13v2.0822,439,316 - 22,486,280 (+)NCBIT2T-CHM13v2.0
Bmp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,711,998 - 70,758,280 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1470,711,998 - 70,757,674 (-)EnsemblGRCm39 Ensembl
GRCm381470,474,555 - 70,520,716 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1470,474,558 - 70,520,234 (-)EnsemblGRCm38mm10GRCm38
MGSCv371470,874,362 - 70,920,067 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361469,209,638 - 69,255,268 (-)NCBIMGSCv36mm8
Celera1468,015,981 - 68,061,716 (-)NCBICelera
Cytogenetic Map14D2NCBI
cM Map1436.32NCBI
Bmp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81551,961,310 - 52,005,597 (-)NCBIGRCr8
mRatBN7.21545,551,603 - 45,595,862 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1545,551,603 - 45,595,776 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1549,669,483 - 49,713,645 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01550,780,998 - 50,825,151 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01547,640,279 - 47,684,442 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01552,166,401 - 52,210,786 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1552,166,401 - 52,210,746 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01555,889,918 - 55,934,263 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41550,878,144 - 50,922,313 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11550,910,779 - 50,923,437 (-)NCBI
Celera1545,230,611 - 45,274,179 (-)NCBICelera
Cytogenetic Map15p11NCBI
Bmp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540345,660,588 - 45,693,724 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540345,660,591 - 45,693,724 (+)NCBIChiLan1.0ChiLan1.0
BMP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12535,043,594 - 35,087,282 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2535,020,751 - 35,087,545 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2535,633,298 - 35,676,927 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02535,255,039 - 35,298,679 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2535,255,044 - 35,298,662 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12535,200,533 - 35,244,157 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02535,055,062 - 35,098,676 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02535,210,570 - 35,254,197 (-)NCBIUU_Cfam_GSD_1.0
Bmp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494312,546,649 - 12,579,706 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365555,990,836 - 6,023,878 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365555,990,822 - 6,023,864 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl146,443,912 - 6,489,063 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1146,443,773 - 6,489,066 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2146,881,220 - 6,923,093 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BMP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1820,234,242 - 20,281,768 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl820,234,184 - 20,283,467 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605221,954,309 - 22,001,797 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bmp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475817,744,821 - 17,788,510 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475817,745,344 - 17,788,183 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSPPAT00000022277   ⟹   ENSPPAP00000004859
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl818,349,836 - 18,396,796 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000022280   ⟹   ENSPPAP00000004861
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl818,349,836 - 18,385,959 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000022291   ⟹   ENSPPAP00000004864
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl818,349,951 - 18,362,257 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000022295   ⟹   ENSPPAP00000004865
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl818,349,951 - 18,361,341 (+)Ensembl
RefSeq Acc Id: XM_003823603   ⟹   XP_003823651
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2740,666,849 - 40,714,042 (+)NCBI
NHGRI_mPanPan1816,392,228 - 16,439,248 (+)NCBI
Mhudiblu_PPA_v0821,410,139 - 21,457,144 (+)NCBI
PanPan1.1818,349,836 - 18,396,796 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008977243   ⟹   XP_008975491
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2740,666,839 - 40,703,216 (+)NCBI
NHGRI_mPanPan1816,392,228 - 16,428,587 (+)NCBI
Mhudiblu_PPA_v0821,410,139 - 21,446,298 (+)NCBI
PanPan1.1818,349,836 - 18,385,959 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024929869   ⟹   XP_024785637
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2740,666,831 - 40,703,216 (+)NCBI
NHGRI_mPanPan1816,392,312 - 16,428,587 (+)NCBI
Mhudiblu_PPA_v0821,410,228 - 21,446,298 (+)NCBI
PanPan1.1818,349,836 - 18,385,959 (+)NCBI
Sequence:
Protein RefSeqs XP_003823651 (Get FASTA)   NCBI Sequence Viewer  
  XP_008975491 (Get FASTA)   NCBI Sequence Viewer  
  XP_024785637 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000004859.1
  ENSPPAP00000004861.1
  ENSPPAP00000004864.1
  ENSPPAP00000004865.1
RefSeq Acc Id: XP_003823651   ⟸   XM_003823603
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZJF6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008975491   ⟸   XM_008977243
- Peptide Label: isoform X3
- UniProtKB: A0A2R8ZPX7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024785637   ⟸   XM_024929869
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSPPAP00000004864   ⟸   ENSPPAT00000022291
Ensembl Acc Id: ENSPPAP00000004865   ⟸   ENSPPAT00000022295
CUB   EGF-like   Peptidase M12A



1 to 40 of 51 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSPPAG00000020298 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000022277.1 UniProtKB/TrEMBL
  ENSPPAT00000022280.1 UniProtKB/TrEMBL
  ENSPPAT00000022291.1 UniProtKB/TrEMBL
  ENSPPAT00000022295.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.290 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro BMP_1/tolloid-like UniProtKB/TrEMBL
  CUB_dom UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/TrEMBL
  Peptidase_M12A UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/TrEMBL
  Sperma_CUB_dom_sf UniProtKB/TrEMBL
  ZnMP_TLD/BMP1 UniProtKB/TrEMBL
KEGG Report pps:100979179 UniProtKB/TrEMBL
NCBI Gene BMP1 ENTREZGENE
PANTHER BONE MORPHOGENETIC PROTEIN 1 UniProtKB/TrEMBL
  COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED UniProtKB/TrEMBL
  CUBILIN-LIKE PROTEIN UniProtKB/TrEMBL
  DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING UniProtKB/TrEMBL
Pfam Astacin UniProtKB/TrEMBL
  CUB UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  FXa_inhibition UniProtKB/TrEMBL
PIRSF BMP_1/tolloid-like UniProtKB/TrEMBL
PRINTS ASTACIN UniProtKB/TrEMBL
PROSITE ASTACIN UniProtKB/TrEMBL
  ASX_HYDROXYL UniProtKB/TrEMBL
  CUB UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
SMART CUB UniProtKB/TrEMBL
1 to 40 of 51 rows