PGPEP1 (pyroglutamyl-peptidase I) - Rat Genome Database

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Gene: PGPEP1 (pyroglutamyl-peptidase I) Pan paniscus
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Symbol: PGPEP1
Name: pyroglutamyl-peptidase I
RGD ID: 11882048
Description: ENCODES a protein that exhibits peptidase activity (ortholog); INVOLVED IN protein catabolic process (ortholog); ASSOCIATED WITH Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1 (ortholog); prostate cancer (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pyroglutamyl-peptidase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22023,201,216 - 23,230,535 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11922,209,543 - 22,255,014 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,819,337 - 17,848,683 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,792,335 - 18,819,031 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,792,341 - 18,812,697 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PGPEP1BonoboMegalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1  ISORGD:13484118554872ClinVar Annotator: match by term: Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1ClinVarPMID:28492532
PGPEP1Bonoboprostate cancer  ISORGD:13484118554872ClinVar Annotator: match by term: Malignant tumor of prostateClinVarPMID:23265383


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PGPEP1Bonoboprotein catabolic process  ISORGD:13031339068941 RGDPMID:14600395|REF_RGD_ID:1303965
PGPEP1Bonoboproteolysis involved_inIEAUniProtKB-KW:KW-0645150520179 UniProtGO_REF:0000043
PGPEP1Bonoboproteolysis involved_inIEAInterPro:IPR000816150520179 InterProGO_REF:0000002

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PGPEP1Bonobocytoplasm located_inIEAUniProtKB-KW:KW-0963150520179 UniProtGO_REF:0000043
PGPEP1Bonobocytoplasm located_inIEAUniProtKB-SubCell:SL-0086150520179 UniProtGO_REF:0000044
PGPEP1Bonobocytosol located_inIEAInterPro:IPR000816150520179 InterProGO_REF:0000002

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PGPEP1Bonobocysteine-type peptidase activity enablesIEAUniProtKB-KW:KW-0788150520179 UniProtGO_REF:0000043
PGPEP1Bonobohydrolase activity enablesIEAUniProtKB-KW:KW-0378150520179 UniProtGO_REF:0000043
PGPEP1Bonobopeptidase activity  ISORGD:13031339068941 RGDPMID:14600395|REF_RGD_ID:1303965
PGPEP1Bonobopeptidase activity enablesIEAUniProtKB-KW:KW-0645150520179 UniProtGO_REF:0000043
PGPEP1Bonoboprotein binding enablesISOUniProtKB:P29972|UniProtKB:Q969T4|UniProtKB:Q96HA8|UniProtKB:Q96LR59068941 PMID:32296183IntActPMID:32296183
PGPEP1Bonobopyroglutamyl-peptidase activity enablesIEAEC:3.4.19.3150520179 UniProtGO_REF:0000003
PGPEP1Bonobopyroglutamyl-peptidase activity enablesIEAInterPro:IPR000816150520179 InterProGO_REF:0000002

PMID:22301074  



PGPEP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22023,201,216 - 23,230,535 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11922,209,543 - 22,255,014 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,819,337 - 17,848,683 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,792,335 - 18,819,031 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,792,341 - 18,812,697 (+)Ensemblpanpan1.1panPan2
PGPEP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381918,340,598 - 18,369,950 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1918,340,598 - 18,369,950 (+)EnsemblGRCh38hg38GRCh38
GRCh371918,451,408 - 18,480,760 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,312,408 - 18,341,763 (+)NCBINCBI36Build 36hg18NCBI36
Build 341918,312,449 - 18,338,156NCBI
Celera1918,353,176 - 18,382,554 (+)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1918,015,122 - 18,044,514 (+)NCBIHuRef
CHM1_11918,451,669 - 18,480,994 (+)NCBICHM1_1
T2T-CHM13v2.01918,474,715 - 18,504,090 (+)NCBIT2T-CHM13v2.0
Pgpep1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,099,086 - 71,113,096 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl871,099,085 - 71,113,038 (-)EnsemblGRCm39 Ensembl
GRCm38870,646,436 - 70,660,446 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,646,435 - 70,660,388 (-)EnsemblGRCm38mm10GRCm38
MGSCv37873,173,010 - 73,183,580 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36873,578,100 - 73,588,670 (-)NCBIMGSCv36mm8
Celera873,205,873 - 73,216,439 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
Pgpep1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,804,408 - 18,817,466 (+)NCBIGRCr8
mRatBN7.21618,770,563 - 18,782,968 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,771,021 - 18,783,478 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,812,708 - 18,822,065 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,945,640 - 19,955,013 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,865,663 - 18,875,020 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,521,989 - 20,531,254 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,521,956 - 20,531,396 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,379,057 - 20,388,085 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,276,650 - 19,285,828 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11619,276,652 - 19,285,272 (+)NCBI
Celera1618,962,969 - 18,971,980 (+)NCBICelera
Cytogenetic Map16p14NCBI
Pgpep1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555243,138,393 - 3,148,331 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555243,138,393 - 3,148,321 (-)NCBIChiLan1.0ChiLan1.0
PGPEP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12044,666,250 - 44,695,823 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,578,117 - 44,611,462 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,149,943 - 45,182,925 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,149,948 - 45,181,833 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,387,041 - 44,420,281 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02044,797,168 - 44,830,716 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,072,579 - 45,106,156 (-)NCBIUU_Cfam_GSD_1.0
Pgpep1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,319,958 - 203,343,203 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365962,869,106 - 2,892,342 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365962,869,100 - 2,892,342 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PGPEP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,451,150 - 59,485,818 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,448,110 - 59,485,809 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PGPEP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,818,743 - 16,837,565 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl616,818,643 - 16,836,949 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660742,503,594 - 2,532,352 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pgpep1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,610,335 - 1,622,955 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249081,610,325 - 1,623,189 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Ensembl Acc Id: ENSPPAT00000035649   ⟹   ENSPPAP00000012981
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1918,792,341 - 18,812,697 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000035654   ⟹   ENSPPAP00000012986
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1918,792,341 - 18,812,636 (+)Ensembl
RefSeq Acc Id: XM_003817775   ⟹   XP_003817823
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22023,201,216 - 23,230,535 (+)NCBI
NHGRI_mPanPan11922,209,543 - 22,238,870 (+)NCBI
Mhudiblu_PPA_v01917,819,337 - 17,848,665 (+)NCBI
PanPan1.11918,792,341 - 18,819,029 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008971035   ⟹   XP_008969283
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22023,201,216 - 23,230,535 (+)NCBI
NHGRI_mPanPan11922,209,543 - 22,238,870 (+)NCBI
Mhudiblu_PPA_v01917,819,337 - 17,848,665 (+)NCBI
PanPan1.11918,792,341 - 18,819,031 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008971036   ⟹   XP_008969284
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22023,201,216 - 23,230,535 (+)NCBI
NHGRI_mPanPan11922,209,543 - 22,238,870 (+)NCBI
Mhudiblu_PPA_v01917,819,337 - 17,848,665 (+)NCBI
PanPan1.11918,792,341 - 18,819,029 (+)NCBI
Sequence:
RefSeq Acc Id: XM_014342579   ⟹   XP_014198065
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22023,201,216 - 23,224,126 (+)NCBI
NHGRI_mPanPan11922,209,543 - 22,232,459 (+)NCBI
Mhudiblu_PPA_v01917,819,337 - 17,842,254 (+)NCBI
PanPan1.11918,792,341 - 18,812,623 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024926694   ⟹   XP_024782462
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22023,201,225 - 23,230,535 (+)NCBI
NHGRI_mPanPan11922,209,552 - 22,238,870 (+)NCBI
Mhudiblu_PPA_v01917,819,346 - 17,848,665 (+)NCBI
PanPan1.11918,792,335 - 18,819,029 (+)NCBI
Sequence:
RefSeq Acc Id: XM_055104448   ⟹   XP_054960423
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22023,201,216 - 23,223,968 (+)NCBI
NHGRI_mPanPan11922,209,543 - 22,232,281 (+)NCBI
RefSeq Acc Id: XM_057300493   ⟹   XP_057156476
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22023,201,216 - 23,230,535 (+)NCBI
NHGRI_mPanPan11922,209,543 - 22,238,870 (+)NCBI
RefSeq Acc Id: XP_008969283   ⟸   XM_008971035
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_003817823   ⟸   XM_003817775
- Peptide Label: isoform X1
- UniProtKB: A0A2R9ABG4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008969284   ⟸   XM_008971036
- Peptide Label: isoform X5
- UniProtKB: A0A2R9ABG8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_014198065   ⟸   XM_014342579
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_024782462   ⟸   XM_024926694
- Peptide Label: isoform X4
- Sequence:



1 to 21 of 21 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSPPAG00000029656 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000035649.1 UniProtKB/TrEMBL
  ENSPPAT00000035654.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.630.20 UniProtKB/TrEMBL
InterPro Peptidase_C15 UniProtKB/TrEMBL
  Peptidase_C15-like UniProtKB/TrEMBL
  Peptidase_C15-like_sf UniProtKB/TrEMBL
  PGPEP1_Cys_AS UniProtKB/TrEMBL
  PGPEP1_Glu_AS UniProtKB/TrEMBL
KEGG Report pps:100977016 UniProtKB/TrEMBL
NCBI Gene PGPEP1 ENTREZGENE
PANTHER PTHR23402 UniProtKB/TrEMBL
  PTHR23402:SF16 UniProtKB/TrEMBL
Pfam Peptidase_C15 UniProtKB/TrEMBL
PIRSF Prld-crbxl_pptds UniProtKB/TrEMBL
PRINTS PYROGLUPTASE UniProtKB/TrEMBL
PROSITE PYRASE_CYS UniProtKB/TrEMBL
  PYRASE_GLU UniProtKB/TrEMBL
Superfamily-SCOP SSF53182 UniProtKB/TrEMBL
UniProt A0A2R9ABG4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9ABG8 ENTREZGENE, UniProtKB/TrEMBL
1 to 21 of 21 rows