PGPEP1 (pyroglutamyl-peptidase I) - Rat Genome Database

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Gene: PGPEP1 (pyroglutamyl-peptidase I) Pan paniscus
Analyze
Symbol: PGPEP1
Name: pyroglutamyl-peptidase I
RGD ID: 11882048
Description: ENCODES a protein that exhibits peptidase activity (ortholog); INVOLVED IN protein catabolic process (ortholog); ASSOCIATED WITH Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1 (ortholog); prostate cancer (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pyroglutamyl-peptidase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22023,201,216 - 23,230,535 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11922,209,543 - 22,255,014 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,819,337 - 17,848,683 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,792,335 - 18,819,031 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,792,341 - 18,812,697 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
PGPEP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22023,201,216 - 23,230,535 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11922,209,543 - 22,255,014 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,819,337 - 17,848,683 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,792,335 - 18,819,031 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,792,341 - 18,812,697 (+)Ensemblpanpan1.1panPan2
PGPEP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381918,340,598 - 18,369,950 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1918,340,598 - 18,369,950 (+)EnsemblGRCh38hg38GRCh38
GRCh371918,451,408 - 18,480,760 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,312,408 - 18,341,763 (+)NCBINCBI36Build 36hg18NCBI36
Build 341918,312,449 - 18,338,156NCBI
Celera1918,353,176 - 18,382,554 (+)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1918,015,122 - 18,044,514 (+)NCBIHuRef
CHM1_11918,451,669 - 18,480,994 (+)NCBICHM1_1
T2T-CHM13v2.01918,474,715 - 18,504,090 (+)NCBIT2T-CHM13v2.0
Pgpep1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,099,086 - 71,113,096 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl871,099,085 - 71,113,038 (-)EnsemblGRCm39 Ensembl
GRCm38870,646,436 - 70,660,446 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,646,435 - 70,660,388 (-)EnsemblGRCm38mm10GRCm38
MGSCv37873,173,010 - 73,183,580 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36873,578,100 - 73,588,670 (-)NCBIMGSCv36mm8
Celera873,205,873 - 73,216,439 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
Pgpep1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,804,408 - 18,817,466 (+)NCBIGRCr8
mRatBN7.21618,770,563 - 18,782,968 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,771,021 - 18,783,478 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,812,708 - 18,822,065 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,945,640 - 19,955,013 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,865,663 - 18,875,020 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,521,989 - 20,531,254 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,521,956 - 20,531,396 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,379,057 - 20,388,085 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,276,650 - 19,285,828 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11619,276,652 - 19,285,272 (+)NCBI
Celera1618,962,969 - 18,971,980 (+)NCBICelera
Cytogenetic Map16p14NCBI
Pgpep1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555243,138,393 - 3,148,331 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555243,138,393 - 3,148,321 (-)NCBIChiLan1.0ChiLan1.0
PGPEP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12044,666,250 - 44,695,823 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,578,117 - 44,611,462 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,149,943 - 45,182,925 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,149,948 - 45,181,833 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,387,041 - 44,420,281 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02044,797,168 - 44,830,716 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,072,579 - 45,106,156 (-)NCBIUU_Cfam_GSD_1.0
Pgpep1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,319,958 - 203,343,203 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365962,869,106 - 2,892,342 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365962,869,100 - 2,892,342 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PGPEP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,451,150 - 59,485,818 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,448,110 - 59,485,809 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PGPEP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,818,743 - 16,837,565 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl616,818,643 - 16,836,949 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660742,503,594 - 2,532,352 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pgpep1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,610,335 - 1,622,955 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249081,610,325 - 1,623,189 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000035649   ⟹   ENSPPAP00000012981
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1918,792,341 - 18,812,697 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000035654   ⟹   ENSPPAP00000012986
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1918,792,341 - 18,812,636 (+)Ensembl
RefSeq Acc Id: XM_003817775   ⟹   XP_003817823
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22023,201,216 - 23,230,535 (+)NCBI
NHGRI_mPanPan11922,209,543 - 22,238,870 (+)NCBI
Mhudiblu_PPA_v01917,819,337 - 17,848,665 (+)NCBI
PanPan1.11918,792,341 - 18,819,029 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008971035   ⟹   XP_008969283
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22023,201,216 - 23,230,535 (+)NCBI
NHGRI_mPanPan11922,209,543 - 22,238,870 (+)NCBI
Mhudiblu_PPA_v01917,819,337 - 17,848,665 (+)NCBI
PanPan1.11918,792,341 - 18,819,031 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008971036   ⟹   XP_008969284
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22023,201,216 - 23,230,535 (+)NCBI
NHGRI_mPanPan11922,209,543 - 22,238,870 (+)NCBI
Mhudiblu_PPA_v01917,819,337 - 17,848,665 (+)NCBI
PanPan1.11918,792,341 - 18,819,029 (+)NCBI
Sequence:
RefSeq Acc Id: XM_014342579   ⟹   XP_014198065
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22023,201,216 - 23,224,126 (+)NCBI
NHGRI_mPanPan11922,209,543 - 22,232,459 (+)NCBI
Mhudiblu_PPA_v01917,819,337 - 17,842,254 (+)NCBI
PanPan1.11918,792,341 - 18,812,623 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024926694   ⟹   XP_024782462
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22023,201,225 - 23,230,535 (+)NCBI
NHGRI_mPanPan11922,209,552 - 22,238,870 (+)NCBI
Mhudiblu_PPA_v01917,819,346 - 17,848,665 (+)NCBI
PanPan1.11918,792,335 - 18,819,029 (+)NCBI
Sequence:
RefSeq Acc Id: XM_055104448   ⟹   XP_054960423
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22023,201,216 - 23,223,968 (+)NCBI
NHGRI_mPanPan11922,209,543 - 22,232,281 (+)NCBI
RefSeq Acc Id: XM_057300493   ⟹   XP_057156476
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22023,201,216 - 23,230,535 (+)NCBI
NHGRI_mPanPan11922,209,543 - 22,238,870 (+)NCBI
RefSeq Acc Id: XP_008969283   ⟸   XM_008971035
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_003817823   ⟸   XM_003817775
- Peptide Label: isoform X1
- UniProtKB: A0A2R9ABG4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008969284   ⟸   XM_008971036
- Peptide Label: isoform X5
- UniProtKB: A0A2R9ABG8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_014198065   ⟸   XM_014342579
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_024782462   ⟸   XM_024926694
- Peptide Label: isoform X4
- Sequence:
Ensembl Acc Id: ENSPPAP00000012981   ⟸   ENSPPAT00000035649
Ensembl Acc Id: ENSPPAP00000012986   ⟸   ENSPPAT00000035654
RefSeq Acc Id: XP_054960423   ⟸   XM_055104448
- Peptide Label: isoform X3
RefSeq Acc Id: XP_057156476   ⟸   XM_057300493
- Peptide Label: isoform X6


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000029656 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000035649.1 UniProtKB/TrEMBL
  ENSPPAT00000035654.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.630.20 UniProtKB/TrEMBL
InterPro Peptidase_C15 UniProtKB/TrEMBL
  Peptidase_C15-like UniProtKB/TrEMBL
  Peptidase_C15-like_sf UniProtKB/TrEMBL
  PGPEP1_Cys_AS UniProtKB/TrEMBL
  PGPEP1_Glu_AS UniProtKB/TrEMBL
KEGG Report pps:100977016 UniProtKB/TrEMBL
NCBI Gene PGPEP1 ENTREZGENE
PANTHER PTHR23402 UniProtKB/TrEMBL
  PTHR23402:SF16 UniProtKB/TrEMBL
Pfam Peptidase_C15 UniProtKB/TrEMBL
PIRSF Prld-crbxl_pptds UniProtKB/TrEMBL
PRINTS PYROGLUPTASE UniProtKB/TrEMBL
PROSITE PYRASE_CYS UniProtKB/TrEMBL
  PYRASE_GLU UniProtKB/TrEMBL
Superfamily-SCOP SSF53182 UniProtKB/TrEMBL
UniProt A0A2R9ABG4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9ABG8 ENTREZGENE, UniProtKB/TrEMBL